eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | retinopathy, diabetic |
| Symptom | C0020456|hyperglycemia |
| Sentences | 6 |
| PubMedID- 21916837 | Also, reducing such stress by various means, including drugs and reducing hyperglycemia, decreases the rate of development of diabetic retinopathy (dr). |
| PubMedID- 20302881 | Increased microvascular permeability contributes to the development of diabetic retinopathy and is associated with hyperglycemia and accumulation of advanced glycation end products (ages). |
| PubMedID- 22272370 | The diabetic retinopathy cascade begins with chronic hyperglycemia affecting the normal progression of glycolysis. |
| PubMedID- 20873150 | The pupillary dilatation test in the dark and 2.5% irifrin and 1% mydriacyl tests revealed a reduction in the papillary dilatation amplitude in hyperglycemia in patients with diabetic retinopathy. |
| PubMedID- 23448719 | Objective: diabetic retinopathy (dr) is associated with hyperglycemia-driven microvascular pathology and neuronal compromise in the retina. |
| PubMedID- 22346115 | The hyperglycemia-induced pathogenesis of diabetic retinopathy is related to four main biochemical alterations such as: (i) increased polyol pathway flux; (ii) increased advanced glycation end-product (age) formation; (iii) activation of protein kinase c (pkc) isoforms; and (iv) increased hexosamine pathway flux.10 these pathways terminate in increased oxidative stress, inflammation, and vascular dysfunction that result in eventual increased permeability, vascular occlusion, and local ischemia. |
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