eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | progressive multifocal leukoencephalopathy |
| Symptom | C0009450|infection |
| Sentences | 6 |
| PubMedID- 24763718 | Jc virus infection can lead to progressive multifocal leukoencephalopathy in individuals with a compromised immune system, such as during hiv infections or when treated with immunosuppressive or immunomodulating therapies. |
| PubMedID- 22930304 | A 33-year-old man who developed progressive multifocal leukoencephalopathy (pml) with hiv infection is reported. |
| PubMedID- 26409284 | Il-7 has clinically been used for patients with progressive multifocal leukoencephalopathy resulting from infection by the john cunningham virus with icl. |
| PubMedID- 23248732 | On the other hand, it is well knowing the association of jc virus infection with progressive multifocal leukoencephalopathy in immunocompromised patients (such as those with aids) . |
| PubMedID- 24790453 | There have been a few reports of john cunningham (jc) virus infection leading to progressive multifocal leukoencephalopathy following rituximab, although these cases have involved patients exposed to significant immunosuppression over a period of time.92 the other long-term complication ascribed to rituximab is hypogammaglobulinemia, which again seems to be related to cumulative exposure to immunosuppression.93 there is an obligation therefore to try to avoid excessive immunosuppression, even in patients at risk of relapse, and means to better predict relapse are urgently required. |
| PubMedID- 24515530 | Importance: progressive multifocal leukoencephalopathy results from lytic infection of the glia by the jc polyomavirus (jcv); jcv granule cell neuronopathy is caused by infection with a mutated form of jcv, leading to a shift in viral tropism from the glia to cerebellar granule cells. |
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