eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | pre-eclampsia |
| Symptom | C0856169|endothelial dysfunction |
| Sentences | 13 |
| PubMedID- 21103027 | This prevents their interaction with endothelial cell surface receptors and subsequently results in endothelial dysfunction leading to preeclampsia . |
| PubMedID- 20428613 | Background: the preeclampsia syndrome is associated with endothelial dysfunction and the differential diagnosis between pure preeclampsia (pe) and superimposed preeclampsia (spe) can be only be attained 12 weeks after delivery. |
| PubMedID- 23297376 | Vascular endothelial dysfunction in preeclampsia has been partially attributed to changes in endothelin-1 (et-1). |
| PubMedID- 22175025 | Several relatively small-scale studies have also demonstrated vascular dysfunction after pregnancy complicated by preeclampsia with evidence of endothelial dysfunction in the macrocirculation up to a median of 3 years and the microcirculation up to 25 years later , as well as increased arterial stiffness up to almost 5 years after the index pregnancy and atherosclerosis over 3 months postpartum . |
| PubMedID- 26105255 | Introduction: failure of the trophoblast to appropriately invade uterine spiral arteries is thought to be an initiating event in preeclampsia, a disorder associated with endothelial dysfunction. |
| PubMedID- 20852449 | Many of the overt symptoms of preeclampsia are attributable to the systemic endothelial dysfunction observed in the uteroplacental and systemic circulation, leading to a generalized vasoconstriction, hypertension and inadequate placental perfusion. |
| PubMedID- 25614597 | preeclampsia (pe) is associated with endothelial dysfunction and impaired autonomic function, which is hypothesized to cause cerebral hemodynamic abnormalities. |
| PubMedID- 26105420 | Maternal obesity has been considered to have important impact on the genesis of preeclampsia as lipotoxicity leads to maternal endothelial dysfunction and chronic inflammation. |
| PubMedID- 25784365 | preeclampsia is associated with severe endothelial dysfunction, and these endothelial changes might increase the risk of later cardiovascular disease 8. |
| PubMedID- 24485669 | Biomarkers of endothelial dysfunction in preeclampsia and neonatal morbidity: a case-control study. |
| PubMedID- 24109515 | However, the level of free vegf decreased in preeclampsia subjects possibly because of endothelial dysfunction . |
| PubMedID- 22428059 | Indeed, preeclampsia is associated with an endothelial dysfunction , that is characterized by increased endothelial cell-mediated vasoconstriction, increased vascular permeability and increased endothelium-mediated platelet aggregation. |
| PubMedID- 26283041 | As endothelial dysfunction is associated with preeclampsia, we assessed retinal flicker response during pregnancy and postpartum. |
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