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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease pre-eclampsia
Symptom C0033687|proteinuria
Sentences 16
PubMedID- 24130940 New onset of hypertension and doubling 24-h urinary proteins or urine/creatinine ratio after 20th week of pregnancy was considered superimposed preeclampsia in those with proteinuria >300 mg/day and no hypertension at baseline.
PubMedID- 25693057 We report here that all at1-aa-positive hypertensive pregnant women exhibited decreased aldosterone levels, and early-onset preeclampsia patients with high proteinuria showed an inverse correlation of aldosterone levels with at1-aa.
PubMedID- 21808734 Reported that proteinuria in patients with preeclampsia is associated with downregulation of podocyte foot process proteins, as nephrin and synaptopodin .
PubMedID- 23554789 Hypertensive disorders during pregnancy were divided into three specific subtypes: 1) gestational hypertension (blood pressure < 140/90 mmhg without proteinuria after 20 weeks of gestation); 2) mild preeclampsia (blood pressure ≥ 140/90 mmhg with proteinuria of 1+ on dipstick in two samples taken 6 h apart or > 300 mg in a 24 h urine collection); 3) severe preeclampsia (blood pressure ≥ 160/110 mmhg with proteinuria of 2+ on the dipstick in two samples taken 6 h apart or > 2 g total protein within a 24 hous urine collection).
PubMedID- 22384039 preeclampsia (with documented proteinuria and edema) was reported in 18% of women, and eclampsia in 3%, and these did not differ by hiv status.
PubMedID- 24712704 Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in sub-saharan africa: a 6-months cohort study.
PubMedID- 25181538 Low molecular weight heparin improves proteinuria in rats with l-name induced preeclampsia by decreasing the expression of nephrin, but not podocin.
PubMedID- 24551572 preeclampsia is manifested with hypertension, proteinuria, and edema.
PubMedID- 25628644 Nevertheless, preeclampsia (i.e., hypertension with proteinuria) is a major cause of both maternal and fetal mortality and morbidity (haig, 1993).
PubMedID- 25242976 preeclampsia associated with heavy proteinuria ≥5gr/24hour or ≥+3 on two dipsticks, oliguria ≤500cc/24hour, platelet count ≤100'000, elevated liver enzymes with persistent epigastric or right upper quadrant pain, pulmonary edema, blood pressure ≥160/110, severe headache or visual disturbance recognized as severe preeclampsia.
PubMedID- 24639802 Therefore, in order to get a practical use out of the results, the present study was intended to determine the 4-hour urine collection values for the detection of proteinuria in women with preeclampsia who referred to alzahra center.
PubMedID- 20385595 Placental overproduction of sflt1 may contribute to the syndrome of preeclampsia with proteinuria and hypertension since recombinant sflt1 induces proteinuria in pregnant and non-pregnant rodents (6–8).
PubMedID- 24779244 Conclusion: the authors concluded that proteinuria in patients with preeclampsia is associated with adverse outcome in pregnancy, although it is not an adequate predictor.
PubMedID- 25995814 preeclampsia is characterized with hypertension and proteinuria during pregnancy, and can have serious consequences about maternal and fetal health.
PubMedID- 24883213 Characterized by the core symptoms hypertension and proteinuria after 20 weeks of gestation, preeclampsia is a leading cause of maternal and fetal morbidity and mortality .
PubMedID- 26405111 In conclusion, therapeutic apheresis reduced circulating sflt-1 and proteinuria in women with very preterm preeclampsia and appeared to prolong pregnancy without major adverse maternal or fetal consequences.

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