eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | portal hypertension |
| Symptom | C0023890|cirrhosis |
| Sentences | 129 |
| PubMedID- 22441510 | Conclusion: hscrp is elevated in patients with cirrhosis and is associated with portal hypertension and decreased survival. |
| PubMedID- 20951924 | This article reviews the pathophysiologic bases of the different pharmacologic treatments for portal hypertension in patients with cirrhosis and places them in the context of the natural history of varices and variceal hemorrhage. |
| PubMedID- 23831908 | The natural history of cirrhotic patients is highly variable due to several factors including hepatic synthetic function, presence and degree of portal hypertension, the cause of cirrhosis, the possibility of resolution of the underlying damaging process, and the occurrence of liver cancer. |
| PubMedID- 21423905 | Color doppler evaluation of left gastric vein hemodynamics in cirrhosis with portal hypertension and its correlation with esophageal varices and variceal bleed. |
| PubMedID- 26058680 | Bacterial translocation is associated with portal hypertension in cirrhosis but this is almost unexplored in hepatosplenic schistosomiasis. |
| PubMedID- 25417057 | Lsm of cirrhosis patients with portal hypertension was significantly higher compared to those without portal hypertension (p < 0.05). |
| PubMedID- 20500867 | • childs b or c cirrhosis or with evidence of severe portal hypertension by history, endoscopy, or radiologic studies or with evidence of moderate to severe ascites. |
| PubMedID- 25561775 | Patient has a hcv cirrhosis with portal hypertension and esophageal varices f1. |
| PubMedID- 19918014 | We defined liver disease as one of the following: 1) abnormal liver function tests, 2) cirrhosis with portal hypertension, or 3) use of supplementary bile acids. |
| PubMedID- 21699820 | Tips has been used to manage the complications of portal hypertension in cirrhosis, including variceal hemorrhage and refractory ascites. |
| PubMedID- 25539572 | Most portal hypertension results from cirrhosis but extra hepatic portal vein obstruction is the single commonest cause. |
| PubMedID- 21801303 | Currently, nothing is known about isoform-specific characteristics in cirrhosis with portal hypertension, including any information as to which isoform is up-regulated/down-regulated. |
| PubMedID- 24502094 | Results: sixteen patients were found to have liver cirrhosis, three of them with portal hypertension. |
| PubMedID- 24678881 | Clinical studies showed that the markers bgm, elastin mmp-generated neo-epitope fragment (elm) c1m, c3m, c4m c5m, collagen type vi mmp-generated neo-epitope fragment (c6m), pro-c3 and p4np 7s were associated with portal hypertension in patients with cirrhosis, reflecting the degree of liver dysfunction. |
| PubMedID- 24324910 | For a definitive diagnosis of hps, patients must meet three criteria: (1) room air po2 < 80 mmhg or a-a gradient > 15 mmhg, (2) evidence of intrapulmonary shunting (typically on contrast-enhanced echocardiography or a lung perfusion scan), and (3) portal hypertension with or without cirrhosis 1. |
| PubMedID- 20921950 | portal hypertension in cirrhosis depends on increased intrahepatic vascular resistance, which is explained by fibrosis and intrahepatic hyperresponsiveness to vasoconstrictors. |
| PubMedID- 23056756 | Liver involvement might progress toward the cirrhosis, accompanied with portal hypertension, ascites and esophageal varicosities, but these manifestations were otherwise mainly absent in our group. |
| PubMedID- 24748895 | Meanwhile, a clinical trial demonstrated that prophylactic use of ppis did not improve the portal hypertension-related bleeding in patients with cirrhosis (41). |
| PubMedID- 21606920 | The experimental study of liver cirrhosis with portal hypertension syndrome, modeled in 38 dogs, has been performed. |
| PubMedID- 25469784 | Purpose: to prospectively compare the technical success rate and accuracy of shear-wave elastography (swe) and transient elastography (te) for the detection of clinically significant portal hypertension (ph) in patients with advanced cirrhosis who are undergoing hepatic vein pressure gradient (hvpg) measurements. |
| PubMedID- 23228021 | Further investigations revealed cirrhosis with portal hypertension. |
| PubMedID- 24775062 | Pathology such as myeloproliferative disorder, liver cirrhosis with portal hypertension, deficiency of natural anticoagulant proteins such as protein c or antithrombin iii as well as hepatocellular carcinoma also could contribute to pvt. |
| PubMedID- 24339715 | Severe chronic illness included liver cirrhosis with portal hypertension, new york heart association class iv congestive heart failure, chronic respiratory disease, end-stage renal disease, or an immune-compromised state (e.g., leukemia, lymphoma, or aids). |
| PubMedID- 21176011 | Although poph is most commonly observed in the setting of cirrhosis, patients with non-cirrhotic portal hypertension are also at risk of developing the disorder. |
| PubMedID- 25038804 | Estimation of the severity of portal hypertension in patients with liver cirrhosis is another major use of liver stiffness measurements. |
| PubMedID- 24505457 | If untreated, ba progresses to cirrhosis, with portal hypertension and liver failure leading to death within two to three years. |
| PubMedID- 21223822 | Methods: the rats of hepatic cirrhosis with portal hypertension were randomly assigned into 1 control group, 1 model group and 4 treatment groups (ns, hgf, ins, hgf + ins). |
| PubMedID- 23984413 | Spleen stiffness, but not liver stiffness, was positively correlated with the presence of ascites as a representative marker of portal hypertension in patients with liver cirrhosis and the spleen stiffness did not correlate with the presence of esophageal varices in chronic hepatitis c patients. |
| PubMedID- 23547461 | The protective effect of n-acetylcysteine magnesium against liver cirrhosis with portal hypertension in rat. |
| PubMedID- 25263269 | Successful pregnancy is possible in well-compensated cirrhosis or with mild portal hypertension, although the maternal and foetal mortality and morbidity are higher than in the general population. |
| PubMedID- 20425483 | Presentations range from incidentally discovered cirrhosis to complications of advanced portal hypertension and hepatocellular cancer. |
| PubMedID- 24949616 | Partial splenic embolization is an effective interventional procedure performed in liver cirrhosis complicated with portal hypertension to improve the low platelet count. |
| PubMedID- 24459641 | Lsm could be a non-invasive method to predict clinically significant and severe portal hypertension in patients with liver cirrhosis in korea. |
| PubMedID- 23999681 | Combined biliovascular injuries, segmental atrophy, and secondary biliary cirrhosis with portal hypertension are special circumstances which are best managed by a multidisciplinary team at an experienced center for optimal outcomes. |
| PubMedID- 21994871 | Since ascites in cirrhosis develops due to portal hypertension, it would seem logical to decompress the portal system to reduce the ascites. |
| PubMedID- 24829653 | However the normal platelet count and serum albumin in the patient is not in favor of advanced cirrhosis as the cause of portal hypertension. |
| PubMedID- 26357616 | Liver damage can be progressive, leading to cirrhosis, complications of portal hypertension, and liver-related death, and, therefore, must be accurately identified. |
| PubMedID- 24331694 | Non-invasive assessment of portal hypertension in patients with liver cirrhosis using fibroscan transient elastography. |
| PubMedID- 23812828 | Histopathological evaluation remains critical in excluding cirrhosis and other causes of portal hypertension, and is the only way of definitively establishing the diagnosis of opv. |
| PubMedID- 24820919 | Case background: ascites appears mainly as a consequence of portal hypertension in patients with liver cirrhosis, or can be caused by several other causes, such us congestive heart failure, peritoneal malignancy, or tuberculosis. |
| PubMedID- 23670970 | Liver disease was defined by clinician diagnosis in two studies (tss and cgs), whereas the gms study required documentation of portal hypertension attributable to cirrhosis (15). |
| PubMedID- 25793622 | Blockade of nitric oxide during perfusion of the hepatic arteries in cirrhosis with portal hypertension corrects the vasoconstrictive response to normal. |
| PubMedID- 26385087 | Thus, jak2 inhibitors, already in clinical use for other indications, might be a new approach to treat cirrhosis with portal hypertension. |
| PubMedID- 24587847 | Patients with nash have the potential to develop fibrosis and cirrhosis leading to portal hypertension, liver decompensation, and hepatocellular carcinoma 4. |
| PubMedID- 25657603 | Progressive cirrhosis, with portal hypertension, is characterized by the development of portosystemic shunts and inadequately cleared circulating vasoactive substances eg, nitric oxide, vasoactive intestinal peptide, endocannabinoids, and bile salts, which create a state of splanchnic and arterial vasodilation, leading to ineffective central blood volume, initially compensated by high cardiac output.3,8 with worsening cirrhosis, systemic vascular resistance continues to fall, but cardiac compensation reaches a maximum. |
| PubMedID- 25606379 | Additionally, the authors reported that determination of low pon1 activity may serve as a useful additional test in assessing liver diseases including acute viral hepatitis b, chronic alcoholic hepatitis, cirrhosis with portal hypertension, hcv-related cirrhosis, hereditary hemochromatosis, and non-alcoholic fatty liver disease (nafld) (keskin et al., 2009; matineli et al., 2013; mogarekar and talekar, 2013). |
| PubMedID- 22568417 | This study considers a possible role of fibrosis evaluation by transient elastography (fibroscan((r))) and its correlation with portal hypertension in patients with cirrhosis, and discusses the use of this technique in planning therapeutic options in patients with hepatocellular carcinoma (hcc). |
| PubMedID- 25543221 | Liver cirrhosis with portal hypertension is also associated with the presence of pahs in 1-2% of cases. |
| PubMedID- 25912838 | However, it is not clear to what extent the progression of hepatitis c is modified once patients develop cirrhosis with severe portal hypertension (csph) (hvpg >/= 10 mm hg). |
| PubMedID- 20583425 | Background/aims: endosonography (eus) is rarely used in the routine diagnostic of portal hypertension in patients with cirrhosis even though it has significantly higher sensitivity for detection of varices than gastroduodenoscopy. |