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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease pancytopenia
Symptom C0040034|thrombocytopenia
Sentences 6
PubMedID- 23690288 Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of tpo receptor agonists in aplastic anemia and myelodysplastic syndromes.
PubMedID- 21316823 Platelet transfusions are mainly used for patients with thrombocytopenia due to bone marrow failure, especially cancer patients developing severe chemotherapy-induced thrombocytopenia (e.g.
PubMedID- 21327404 Increased requirement for platelet transfusions concurrent with enhanced bleeding during romiplostim treatment in a patient with thrombocytopenia due to bone marrow failure.
PubMedID- 24778999 Organ infiltration by mc may lead not only to organomegaly, but also to impairment or even loss of organ function and in severe (high grade) disease, bone marrow failure with anemia, thrombocytopenia, and/or recurrent infections (due to neutropenia) may occur.
PubMedID- 24273485 Larger groups in need are patients with myelodysplastic syndrome, chemotherapy-induced thrombocytopenia, other forms of hereditary and acquired bone marrow failure, hepatitis c infections, or liver cirrhosis.
PubMedID- 23284257 (7,8) this is achieved in transfusion medicine using platelet concentrates (pcs), which allow the infusion of large quantities of platelets in small volumes of fluid; this is especially indicated for thrombocytopenia due to bone marrow failure.

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