eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | pancytopenia |
| Symptom | C0002871|anemia |
| Sentences | 7 |
| PubMedID- 23547077 | Purpose: allogeneic hematopoietic cell transplantation (hct) can cure bone marrow failure in patients with fanconi anemia (fa). |
| PubMedID- 20661450 | bone marrow failure in children with fanconi anemia is attributed to excessive apoptosis and subsequent failure of the hematopoietic stem cell compartment (reviewed in ). |
| PubMedID- 24829696 | Currently, the immune-mediated suppression of hematopoiesis has been considered as a potential etiology for bone marrow failure in patient’s with aplastic anemia, because more than half of aplastic anemia patients respond to immunosuppressive therapies, such as treatment with antithymocyte globulin or antilymphocyte globulin and cya. |
| PubMedID- 24960628 | Hematopoietic cell transplantation (hct) can cure bone marrow failure in patients with fanconi anemia (fa), and it is generally accepted that these patients should receive low-intensity conditioning because of the underlying dna repair defect in their cells. |
| PubMedID- 24763404 | Targeted resequencing of 52 bone marrow failure genes in patients with aplastic anemia reveals an increased frequency of novel variants of unknown significance only in slx4. |
| PubMedID- 24778999 | Organ infiltration by mc may lead not only to organomegaly, but also to impairment or even loss of organ function and in severe (high grade) disease, bone marrow failure with anemia, thrombocytopenia, and/or recurrent infections (due to neutropenia) may occur. |
| PubMedID- 22291499 | On the other hand, pharmacological androgen therapy, such as for anemia due to bone marrow failure, or for endometriosis, is aimed at producing specific effects on specific tissues. |
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