eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | oral leukoplakia |
| Symptom | C1608408|malignant transformation |
| Sentences | 7 |
| PubMedID- 26064958 | In particular, we identified some key genes that play crucial roles in the malignant transformation of oral leukoplakia to oral cancer, including 4 hub genes (stat5b, egfr, pdgfrb, stat5a), 5 intra-maoc genes (raf1, pdgfrb, src, prkaca, egfr), 5 inter-maoc genes (prkca, mapk1, mapk3, esr1, fyn) and 8 mirnas (hsa-mir-499-5p, hsa-mir-549, hsa-mir-205, hsa-mir-525-5p, hsa-mir-21, hsa-mir-323-3p, hsa-mir-423-3p, hsa-mir-491-3p). |
| PubMedID- 24345883 | Moreover, ezh2 has been found to promote malignant transformation of oral leukoplakia, epithelial to mesenchymal transition and cancer stem cell maintenance in head neck cancers . |
| PubMedID- 21743397 | malignant transformation of oral leukoplakia occurs on average in 1% of cases per year (2). |
| PubMedID- 24403051 | Loh on 9p, combined with tp53 mutations, have been recently associated with malignant transformation of oral leukoplakia, and suggested as biomarkers of progression (35). |
| PubMedID- 23814570 | Histopathologically, oral epithelial dysplasia currently is the most important prognostic indicator for determining the malignant transformation risk of oral leukoplakia. |
| PubMedID- 22623931 | 1 the malignant transformation rates of oral leukoplakia have been reported from 1 to 17% with highest transformation rate for the lesions on floor of the mouth, soft palate and tongue. |
| PubMedID- 22471854 | The aim of our study was to assess whether podoplanin expression in pretreatment biopsies could serve as a biomarker to predict the risk of malignant transformation in patients with oral leukoplakia. |
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