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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease neutropenia
Symptom C0036690|sepsis
Sentences 31
PubMedID- 22633505 In premature infants, early-onset neutropenia is correlated with sepsis, maternal hypertension, intrauterine growth restriction, severe asphyxia, and periventricular haemorrhage, and might be associated with an increase in the incidence of early-onset sepsis, nosocomial infection, and candida colonisation.
PubMedID- 22592515 Conclusions: of three markers potentially useful for diagnosing bacterial sepsis in children with fever and neutropenia, pct had comparable diagnostic accuracy to crp.
PubMedID- 25301539 Febrile neutropenia-induced sepsis resulted in the death of 1 patient with significant medical comorbidities; 2 other patients died of comorbidities unrelated to their cancer or treatment.
PubMedID- 24777705 Observed a significant higher rate of bacteraemia, potentially resulting in sepsis, in patients with neutropenia <0.5 g/l.
PubMedID- 23746966 Dose-limiting toxicities included severe neutropenia with infection and sepsis, mucositis/stomatitis, and diarrhea.
PubMedID- 21687537 The patient had multiple episodes of febrile neutropenia with concomitant sepsis producing delays and dose reduction of chemotherapy.
PubMedID- 22828545 The study concluded that before routine use of rhg-csf in neonatal sepsis with neutropenia further large scale, multi-centre, randomized, placebo controlled trial are needed to validate the beneficial effect.
PubMedID- 24027727 estimates suggest that when sepsis is associated with severe neutropenia, mortality exceeds 50%.
PubMedID- 24535696 Maltophilia pneumonia or sepsis because of chemotherapy-induced neutropenia or immunodeficiency.
PubMedID- 23259255 Efficacy and safety of doripenem for sepsis with neutropenia in japanese patients with hematologic diseases.
PubMedID- 25031945 The one patient in the 3.6-mg/kg cohort experienced febrile neutropenia complicated with presumed sepsis, which ultimately resulted in unexpected mortality (grade 5 toxicity) 14 days after receiving the initial dose (younes et al., 2010).
PubMedID- 25918250 Adverse events were graded according to the national cancer institute common terminology criteria for adverse events (ctcae), version 3.0. dlt was defined as any grade 4 toxicity (except for alopecia, or vomiting in the absence of adequate prophylaxis), fever or sepsis concurrent with grade 3-4 neutropenia, symptomatic thrombocytopenia (hemorrhage), any grade 3 cardiotoxicity and any toxicity requiring a treatment delay longer than 15 days.
PubMedID- 23935969 The third one, a 57-year old patient in group a, died from sepsis associated with febrile neutropenia and diarrhea after the completion of the third cycle.
PubMedID- 26107833 Perinatal asphyxia is understoodas a disorder of impaired gaseous exchange which results in fetal hypoxemia andhypercapnia and can predispose to early-onset sepsis, due to neutropenia and to thereduction of medullary reserves of neutrophils(2,20,22).
PubMedID- 23056733 sepsis and pneumonia owing to neutropenia and respiratory distress may occur5.
PubMedID- 23989947 Dose-limiting toxicities (dlts) were evaluated during cycle 1 and were defined as follows: anc <0.5 × 109 per l for >5 days; grade 3 neutropenia with fever (⩾38.5 °c), sepsis or other severe infection; platelet count <25.0 × 109 per l; any other grade 3/4 nonhaematological adverse event (ae) suspected to be treatment related (except for nausea/vomiting without an optimal antiemetic regimen, hypersensitivity reactions and nonclinically relevant biochemical abnormalities); and any delays in the administration of a subsequent plitidepsin dose exceeding 2 weeks, or omissions of the infusions scheduled on days 8 and 15 because of treatment-related aes.
PubMedID- 23090499 Two patients died after consolidation from sepsis in neutropenia on days 74 and 77, respectively, after start of induction therapy (table 4).
PubMedID- 23248429 She developed febrile neutropenia with sepsis during the third week of induction.
PubMedID- 21808399 These include studies on its use in determining bacterial sepsis in children with febrile neutropenia, its use as a marker of renal parenchymal infection and its use as a marker of the severity of acute pancreatitis.
PubMedID- 22367386 Background and aim: early diagnosis of sepsis in children with febrile neutropenia and cancer still remains a challenge for modern medicine because of lack of specific laboratory markers and clinical signs especially at the beginning of the infection.
PubMedID- 21894754 A male patient received non-chemotherapeutic drugs which induced deep neutropenia complicated with sepsis, bilateral pneumonia, acute respiratory insufficiency.
PubMedID- 23927433 There are two relevant risks with hcl in transplant patients: life-threatening sepsis due to severe neutropenia and immunosuppression and the risk of graft loss due to either sepsis or deferred immunosuppression.
PubMedID- 26065059 Patients The guideline development group (gdg) recognises the importance of distinguishing uncomplicated neutropenic fever from neutropenia with severe sepsis and shock, and indeed septic shock can occur without fever.
PubMedID- 22047626 She experienced numerous hospitalizations for sepsis as a consequence of her neutropenia, with white blood cell counts in the 2000-3000 range and neutrophils less than 5%, hemoglobin of 12.1 gm/dl, and platelet count of 186,000. rheumatoid factor (rf) was 67 iu, and cyclic citrullinated peptide igg antibody (ccp-igg) was > 250 u. anti-nuclear antibodies varied between negative and 1:160 with a homogeneous pattern.
PubMedID- 24983551 Serum lactate as a biomarker of severe sepsis in children with cancer, neutropenia and fever.
PubMedID- 21572797 On day 21, she developed acute renal failure and severe sepsis with neutropenia and was managed by the infectious diseases physician.
PubMedID- 25970182 Atg side effect (long-standing neutropenia leading to sepsis) was considered as cause of death in one patient.
PubMedID- 23915833 Among the several factors that contribute to a higher risk of sepsis complications in patients with cancer, chemotherapy-associated neutropenia is probably the single-most important one .
PubMedID- 25861347 However, neutropenia combined with sepsis could lead to life-threatening.
PubMedID- 22467971 Glucocorticoid-dependent hypoadrenocorticism with thrombocytopenia and neutropenia mimicking sepsis in a labrador retriever dog.
PubMedID- 20207442 Unanticipated grade 3 hepatotoxitity, hyponatremia, mental status changes, grade 3 and 4 thrombocytopenia, and grade 4 neutropenia with sepsis were observed.

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