eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | neutropenia |
| Symptom | C0021311|infections |
| Sentences | 58 |
| PubMedID- 26543528 | A study that evaluated pct in neutropenic hematological patients with mucositis revealed that it represents an important tool to predict the occurrence of major infections in patients with febrile neutropenia, even in the presence of associated complicating conditions, such as mucositis and gvhd.29 a lower threshold value (e.g. |
| PubMedID- 23297642 | Aim: determine the frequency of opportunistic infections among children with immune neutropenia and their mothers. |
| PubMedID- 24887148 | neutropenia can lead to life-threatening pyogenic infections whose severity is roughly inversely proportional to the circulating neutrophil counts. |
| PubMedID- 22526211 | Cns patients had severe neutropenia early with frequent infections causing high morbidity and mortality. |
| PubMedID- 26392781 | This drug has been approved for the prevention of invasive fungal infections in patients with neutropenia and for the treatment of invasive fungal infections in hematopoietic stem cell transplant recipients with graft-versus-host disease. |
| PubMedID- 21353103 | Objective: this meta-analysis was conducted to estimate the effect of systemic antifungal prophylaxis on the frequency of invasive fungal infections in patients with neutropenia and the mortality associated with these infections. |
| PubMedID- 21595885 | neutropenia can lead to life-threatening pyogenic infections, acute gingivostomatitis and chronic parodontal disease, and each successive infection may leave permanent sequelae. |
| PubMedID- 24608733 | Toxicity and most importantly neutropenia with associated infections were substantial in this study. |
| PubMedID- 26239201 | Conclusion: the study results suggest that daptomycin is an effective therapeutic option for the treatment of a broad range of gram-positive infections in patients with neutropenia, and has a good safety profile. |
| PubMedID- 22783359 | Since severe neutropenia leads to life-threatening infections, which is the most common cause of death in saa patients, we wonder whether we should put the same weight on each of the 3 components of camitta's criteria. |
| PubMedID- 23730310 | Economic evaluation of posaconazole versus standard azole therapy as prophylaxis against invasive fungal infections in patients with prolonged neutropenia in canada. |
| PubMedID- 24260074 | infections may be due to underlying neutropenia or to transfusional iron overload (5). |
| PubMedID- 21449626 | Because of the difficult diagnosis and the significant morbidity and mortality of fungal infections in patients with neutropenia, systemic antifungal agents are used as empiric antifungal therapy in patients with febrile neutropenia who are not responding to antibacterial therapy. |
| PubMedID- 23249920 | We describe the incidence and characteristics of infections in children with severe congenital neutropenia (scn), autoimmune neutropenia (an) and idiopathic neutropenia (in). |
| PubMedID- 26034214 | Escherichia coli is a major cause of life-threatening infections in patients with neutropenia, particularly those receiving chemotherapy for the treatment of cancer. |
| PubMedID- 25595699 | It is approved for the prophylaxis of invasive fungal infections in patients with neutropenia or in haematopoietic stem cell transplant recipients undergoing high-dose immunosuppressive therapy for graft-versus-host disease, and for the treatment of fungal infections. |
| PubMedID- 24575280 | Background: in cancer patients, various infections were developed due to severe neutropenia resulted from chemotherapy. |
| PubMedID- 24778999 | Organ infiltration by mc may lead not only to organomegaly, but also to impairment or even loss of organ function and in severe (high grade) disease, bone marrow failure with anemia, thrombocytopenia, and/or recurrent infections (due to neutropenia) may occur. |
| PubMedID- 22735899 | The remaining 487 patients had infections that were associated with hematologic malignancies, neutropenia, prior exposure to antibiotics, and a decreased cvc removal rate. |
| PubMedID- 22269211 | Laboratory findings highlight severe, persistent and non-cyclic neutropenia, leading to recurrent respiratory infections, which are sometimes resistant to standard antibiotic treatments. |
| PubMedID- 21375212 | During treatment he developed recurrent infections with neutropenia requiring prolonged antibiotics and subsequently developed invasive aspergillosis. |
| PubMedID- 22563238 | Leukopenia with infections due to neutropenia is rarely found in patients with access to modern health care, but it may complicate extreme hypersplenism and severe disease. |
| PubMedID- 21477703 | Gram-positive microorganisms can cause more than half of the bacterial infections in patients with febrile neutropenia, especially bacteremias. |
| PubMedID- 21533222 | Its essential role in sepsis is demonstrated by the recurrence of life-threatening infections in patients with neutropenia or with leukocyte defects . |
| PubMedID- 22612259 | No association of neutropenia with more infections was observed. |
| PubMedID- PMC4126035 | The neutropenia was not associated with infections commonly causing neutropenia or with autoimmune manifestations. |
| PubMedID- 23928096 | neutropenia can lead to recurrent bacterial infections, which represent an indication of initiating a treatment in most of the cases. |
| PubMedID- 21838907 | neutropenia has been associated with medications, infections, autoimmune diseases, and deficiencies of vitamin b12 and folate 1. |
| PubMedID- 22410384 | The incidence of infections was not associated with neutropenia (hcv-mono: p = 0.584; hiv-hcv: p = 0.23) or with cd4+ cell counts <200/mul (hiv-hcv: p = 0.29). |
| PubMedID- 25391451 | Both the patients share profound neutropenia with severe infections early in life; in one case non-hematopoietic stigmata of the syndrome, including evident facial dysmorphism and vascular anomalies, appeared gradually over time, prominently in the second decade. |
| PubMedID- 20386986 | Increasing glucose requirements, worsening lipid profile, neutropenia associated with multiple infections, and anemia were noted. |
| PubMedID- 26572736 | With the advent of granulocyte colony-stimulating factor (g-csf) to mobilize neutrophils in healthy donors, granulocyte transfusions have been broadly used to prevent and/or treat life-threatening infections in patients with severe febrile neutropenia and/or neutrophil dysfunction. |
| PubMedID- 24750901 | The distribution of pitt bacteremia score by infecting species isshown in figure 2, panel a. patients infected with s.mitis were significantly more likely to have a higher pitt bacteremia score (p<0.01).one possible explanation for this observation is that s. mitis strains mainlycaused infections in patients with neutropenia who, compared with patients without neutropenia,might be more likely to have serious infections. |
| PubMedID- 21635189 | Several studies suggest that respiratory infections can be associated with leukopenia, or decreased wbc counts in peripheral blood, in humans. |
| PubMedID- 21371308 | Nevertheless, there is some indication that steroid- or g-csf-stimulated high-yield granulocyte-donations might result in better survival in severe infections associated with neutropenia and cancer . |
| PubMedID- 20529258 | neutropenia with subsequent infections and sepsis have been reported and may contribute to patient mortality . |
| PubMedID- 25654114 | S. maltophilia contaminated central venous catheters and tap water faucets have been implicated in cutaneous and soft tissue infections in patients with neutropenia 2. |
| PubMedID- 23295563 | Distribution of pathogens in central line-associated bloodstream infections among patients with and without neutropenia following chemotherapy: evidence for a proposed modification to the current surveillance definition. |
| PubMedID- 21694893 | Posaconazole has been shown to be more effective than fluconazole or itraconazole for prevention of invasive fungal infections in patients with neutropenia from chemotherapy, leukemia, or myelodysplastic syndrome. |
| PubMedID- 22431927 | The most common adverse events associated to tocilizumab treatment were infections, gastrointestinal symptoms, alteration of liver enzymes, hypercholesterolemia, neutropenia, and infusion reactions. |
| PubMedID- 22178143 | neutropenia is often associated with infections, which are major causes of morbidity and mortality in patients with cancer. |
| PubMedID- 21618407 | We report the case of a premature male infant with congenital neutropenia, associated with multiple infections, refractory to treatment with granulocyte colony stimulating factor who subsequently underwent matched sibling donor stem-cell transplant. |
| PubMedID- 24280867 | Clinical presentation is dominated by recurrent infections associated with neutropenia, anemia, splenomegaly and autoimmune diseases, particularly rheumatoid arthritis.1, 2, 3, 4 recently, stat3 and stat5 mutations have been detected in t-lgl and in nk-lgl leukemias.5, 6, 7, 8 these somatic mutations, coupled to other intrinsic and extrinsic mechanisms, are likely to induce constitutive activation of the jak/stat pathway thus contributing to maintenance of leukemic lgl survival.9 these findings strongly suggest a common specific pathogenic pattern in t-lgl and nk-lgl leukemias and provide justification for consideration of the same treatment options. |
| PubMedID- 20301655 | Cohen syndrome is characterized by failure to thrive in infancy and childhood; truncal obesity in the teen years; early-onset hypotonia and developmental delays; microcephaly developing during the first year of life; moderate to profound psychomotor retardation; progressive retinochoroidal dystrophy and high myopia; neutropenia in many with recurrent infections and aphthous ulcers in some; a cheerful disposition; joint hypermobility; and characteristic facial features. |
| PubMedID- 21879654 | In those patients treatment generally involves preventing infections, managing of febrile neutropenia with broad spectrum antibiotics and antifungal drugs, treatment with recombinant granulocyte hematopoetic factor, rarely transfusions of granulocyte concentrates and intravenous immunoglobulins. |
| PubMedID- 25374720 | Should be considered for the differential diagnosis of pleuro-pulmonary infections of patients with prolonged neutropenia due to severe chc treatment. |
| PubMedID- 22929189 | The signs of cbl malabsorption are general weakness, slow growth, developmental delays and learning difficulties, dementia, psychological problems, neurodegeneration of the spinal cord, increased rate of infections due to neutropenia, thrombocytopenia, and megaloblastic anemia with lethal consequences if not treated 9. |
| PubMedID- 24505525 | He had frequent infections because of leukopenia and had a history of hospitalization. |
| PubMedID- 23580879 | However, clinical manifestations of infections due to neutropenia may be mild, or even absent, a situation that complicates diagnosis, initial treatment and the follow-up of patients with febrile neutropenia (4,5). |
| PubMedID- 21645173 | In conclusion, rituximab monotherapy with eight weekly infusions is effective in relapsed patients with indolent b-nhl, with acceptable toxicities, including in patients pretreated with rituximab; however, careful monitoring is recommended for infections associated with late-onset neutropenia and hypogammaglobulinemia. |
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