eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | neutropenia |
| Symptom | C0009450|infection |
| Sentences | 59 |
| PubMedID- 25929615 | Only few reports have looked into the risk of invasive bacterial infection in children with neutropenia that is not malignancy related. |
| PubMedID- 21595885 | neutropenia can lead to life-threatening pyogenic infections, acute gingivostomatitis and chronic parodontal disease, and each successive infection may leave permanent sequelae. |
| PubMedID- 24891274 | The most common nonhematological toxicities possibly related to decitabine or vorinostat were infection with neutropenia (grade 3; n = 4) and fever/neutropenia (grade 3, n = 4; grade 4, n = 1). |
| PubMedID- 22093149 | Trichosporon fungemia is a rare and fatal fungal infection that occurs in patients with prolonged neutropenia associated with hematologic malignancies. |
| PubMedID- 23056756 | Platelet count never reached levels under 50×103/mm3 in any of our patients, and no secondary infection due to leucopenia was met. |
| PubMedID- 20178634 | Wiskott-aldrich syndrome is an x-linked disorder characterized by current infection, thrombocytopenia (with small platelets), neutropenia, eczema, high ige levels, a very high prevalence of autoimmunity (including arthropathy, vasculitis, and inflammatory bowel disease) and malignancy. |
| PubMedID- 21838182 | Conclusions: leukopenia consisting of lymphopenia and later neutropenia was common in patients with a/h1n1 infection but was not correlated with disease severity or clinical course, which were similar in both groups. |
| PubMedID- 25780346 | Three adult cases of hpv-b19 infection with concomitant leukopenia and low platelet counts. |
| PubMedID- 24396442 | Despite aggressive treatment, the survival rate of the fusarium infection in patients with persistent neutropenia is only 4% (8). |
| PubMedID- 26451262 | Despite its enormous therapeutic effects, gleevec has very common adverse effects including nausea, fluid retention, lowered resistance to infection (due to neutropenia), and, sometimes, congestive cardiac failure. |
| PubMedID- 21949519 | Thus, vsga or sga infants are particularly vulnerable to bleeding with thrombocytopenia or infection associated with neutropenia especially early after birth. |
| PubMedID- 21347238 | Inhibition of cox-2 (celecoxib), but not cox-1(asa), prevented the thrombocytopenia and leukopenia associated with acute infection and increased reticulocyte counts in response to infection . |
| PubMedID- 20960028 | They were defined as drug-related toxicities of grade 3 or 4, including neutropenia (grade 3 with infection, grade 4 for ≥7 days, or febrile for >24 h), thrombocytopenia (grade ≥ 3 with bleeding or grade 4 for ≥7 days), lymphopenia accompanied by an opportunistic infection, or any nonhematologic toxicity of grade 3 or 4 for ≥7 days. |
| PubMedID- 24747529 | Ir-induced acute bone marrow injury leads to a decrease in the number of circulating blood cells, and most of the post-radiation hematopoietic morbidity and mortality is attributed to infection and hemorrhage due to leukopenia and thrombocytopenia 2. |
| PubMedID- 25959847 | In a further analysis using a multivariate regression to demonstrate the independent predictors of p aeruginosa infection, patients with neutropenia remained as an independent risk factors (odds ratio, 7.48; p < .001). |
| PubMedID- 24829759 | Toxicities were evaluated using national cancer institute’s common terminology criteria for adverse events (ctcae) version 3.0. dose-limiting toxicity (dlt) was designated during treatment course 1 and was defined as any treatment-related clinical adverse event (ae) ≥ grade 3 (except fatigue, fever or transient rigors, nausea or vomiting without antiemetic therapy) or any treatment-related grade 4 (or grade 3 lasting >3 days) laboratory abnormalities (except lymphopenia, leukopenia, transient neutropenia not associated with infection, asymptomatic electrolyte abnormalities and asymptomatic elevations in amylase/lipase). |
| PubMedID- 21876446 | Background: pegylated-interferon (peg-ifn) and ribavirin (rbv), current standard treatment for hepatitis c virus (hcv) infection, are frequently associated with neutropenia and anemia, leading to high treatment discontinuation rates in hiv/hcv-coinfected patients. |
| PubMedID- 20007525 | The seborrheic region was the most prevalent site of infection, and patients with leukopenia had higher risk for infection than patients who did not have leukopenia (p = .005). |
| PubMedID- 25729741 | 3gcr-enterobacteriaceae colonization or infection of patients with febrile neutropenia has been reported with increased frequency during the last decade. |
| PubMedID- 23746966 | Dose-limiting toxicities included severe neutropenia with infection and sepsis, mucositis/stomatitis, and diarrhea. |
| PubMedID- 21701623 | In the toward study, 29% of patients in the tocilizumab group had neutrophil levels below the normal range, compared to 4% of patients in the control group.65 importantly, neutropenia was not associated with any infection-related adverse events. |
| PubMedID- 24138072 | The positive predictive value for laboratory-confirmed dengue infection with combination of leukopenia (< 4000/cmm), thrombocytopenia (< 150 × 103/cmm), prolonged aptt (> 38 sec), elevated aminotransferase (ast/alt > 1.5) and low crp (< 20 mg/l) is 93.1%. |
| PubMedID- 22935584 | The latter was defined as infection with g3/4 neutropenia or any ivl-related infection. |
| PubMedID- 24616599 | Patient 3 has not had any stomatitis, lymphadenitis or other significant infection despite with severe neutropenia since her early 20s. |
| PubMedID- 24778656 | The cutaneous involvement includes development of skin rash as purpuric papules, ecchymosis, and skin necrosis often having a “retiform,” “reticular,” or “stellate” pattern leading to ulceration and secondary infection and associated with leukopenia and autoantibody production . |
| PubMedID- 22123661 | Clinical decision rules (cdrs) have been proposed to help predict the risk of severe infection in children with chemotherapy-induced febrile neutropenia, but none has been fully validated. |
| PubMedID- 21804612 | Primary graft failure after allogeneic hematopoietic cell transplantation is a life-threatening complication because patients are at a high risk of severe infection owing to prolonged neutropenia after the initial transplantation. |
| PubMedID- 23975584 | In this report, we describe the current spectrum of infection in patients with malignancies and neutropenia, and emphasize the fact that local and geographic differences are not infrequent. |
| PubMedID- 21804462 | Cmv-related symptoms were classified as viral syndrome if the patient showed unexplained fever for more than 2 days accompanied by active cmv infection, and 1 of the following symptoms: leucopenia (<3×109/l), thrombocytopenia (<100×109/l), or arthralgia. |
| PubMedID- 25027517 | Grade 3/4 aes (24%) were mostly related to hematologic toxicity (18%), including dose-dependent neutropenia, both with and without infection, and thrombocytopenia. |
| PubMedID- 24327737 | It was hypothesized that acute postnatal bovine viral diarrhea virus 1 (bvdv-1) infection leads to leukopenia and lymphoid depletion of gut-associated lymphoid tissues similar to acute disease in calves. |
| PubMedID- 21829769 | In the nsabp-07 trial, infection associated with grade 3/4 neutropenia was seen in 1.0% of patients receiving the fulv regimen and in 2.2% of patients receiving the flox regimen . |
| PubMedID- 22678568 | Adjusted neutropenia is associated with early serious infection in systemic lupus erythematosus. |
| PubMedID- 21971375 | It remains unclear whether neutropenia is associated with infection in chc. |
| PubMedID- 22258705 | Treatment of persistent neutropenia (anc 1,0 × 109/l) in patients with advanced hiv infection in order to reduce the risk of bacterial infections when other therapeutic options are inappropriate. |
| PubMedID- 26089739 | Regarding safety issues, the most common grade 3/4 was noncumulative neutropenia (16/20 patients) associated with infection in one patient. |
| PubMedID- 22312337 | Despite the long treatment period, the patient relapsed at day 211 post-transplantation and had severe systemic infection with leukopenia, renal failure, and bleeding. |
| PubMedID- 24347836 | While it has been largely accepted that aspergillus species is recognized by cellular receptors and attacked by neutrophils, the radiological and macroscopic findings linking infection with neutropenia remain unconfirmed. |
| PubMedID- 21687649 | The incidence of grade 3 infection (with or without neutropenia) in a calgb study was 2% . |
| PubMedID- 22111760 | Third, this study was a retrospective cohort; some limitations such as concurrent infection in patients with febrile neutropenia cannot be completely excluded. |
| PubMedID- 23580872 | Thus, rubor, erythema and pustules may not be seen in neutropenia associated with a cutaneous infection, just as pulmonary infections may fail to present classical signs and symptoms such as cough, dyspnea and characteristic physical examination findings(2). |
| PubMedID- 22204495 | Systemic toxycoses were limited to one cat that experienced a severe neutropenia (grade 3) leading to infection (grade 3) that required hospitalization and antibiotic therapy. |
| PubMedID- 25572607 | The patients are at risk of infection and hemorrhage due to neutropenia and thrombocytopenia and suffer from symptoms of anemia. |
| PubMedID- 21319286 | Reductions because of leucopenia with respiratory tract infection, or because of leucopenia, anemia and/or thrombocytopenia were four (p = 0.007) and five (p = 0.03) times more common, respectively. |
| PubMedID- 21610706 | Dose-limiting toxicity was defined as one of the following adverse events (aes) occurring during cycle 1: grade 4 haematological toxicity; grade 3 neutropenia with infection or fever ⩾38.5°c; grade ⩾3 non-haematological treatment-related toxicity, except toxicities which had not been maximally treated (such as nausea, vomiting and diarrhoea) or that the patient considered tolerable (such as skin rash); confirmed grade 3 qtc prolongation (qtc >500 ms) persisting after correction of other possible causes such as electrolyte imbalance or hypoxia; or inability to receive the next dose of pd 0332991 within 1 week (±1 day) of the last dose because of lack of haematological recovery or prolonged non-haematological toxicity grade ⩾3. |
| PubMedID- 25701436 | Purpose: the study aims to determine the usefulness of procalcitonin (pct) and other blood markers for identification of bacterial infection among patients with febrile neutropenia (fn). |
| PubMedID- 25682797 | Moderate neutropenia was not associated with infection, suggesting that current dose reduction guidelines might be too strict. |
| PubMedID- 24872818 | While it is an infection occasionally seen in patients with severe neutropenia, it can also be seen in patients with other immune deficiencies. |
| PubMedID- 22457622 | The sentinel animal (wts) housed together with the vp447 infected pigs developed febrile temperatures from day 14 after infection until the end of the experiment and leukopenia was present on day 21 and 28 of the experiment. |
| PubMedID- 22264334 | Most of the post-radiation hematopoietic morbidity and mortality is attributed to infection and hemorrhage due to leukopenia and thrombocytopenia resulting from loss of bone marrow cells. |
Page: 1 2