eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | neuropathy, peripheral |
| Symptom | C0030193|pain |
| Sentences | 77 |
| PubMedID- 25503082 | Results of this pooled analysis indicate that tapentadol extended release (er) is effective and well tolerated for the management of neuropathic pain associated with diabetic peripheral neuropathy (dpn) in adults.tapentadol er is associated with improvements in measures of health-related quality of life in patients with painful dpn.tapentadol er provides consistent efficacy across different patient subgroups divided by age, sex, race, opioid experience and pain intensity. |
| PubMedID- 20236533 | In mice with established neuropathic pain due to diabetic peripheral neuropathy, neither intranasal/intraperitoneal cannabidiol nor sr144528 had any effect upon already present and chronic thermal hypersensitivity or tactile allodynia (figure 7). |
| PubMedID- 24856674 | The nts2 preferring peptide jmv-431 (2) and the nts2 selective nonpeptide compound levocabastine (6) have been shown to be effective in relieving the pain associated with peripheral neuropathies. |
| PubMedID- 24797167 | In doing so, we considered that the only peripheral neuropathies invariably associated with neuropathic pain are mononeuritis multiplex and small-fiber neuropathies. |
| PubMedID- 26073181 | Mirogabalin (ds-5565) is an alpha2delta-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia. |
| PubMedID- 24062949 | Agents such as anticonvulsants, antidepressants, and opioids are commonly prescribed for treatment of neuropathic pain in individuals with peripheral neuropathy. |
| PubMedID- 22574283 | Spinal application of cb2r agonists to control allodynia produced by cci, a widely used and well-characterized rodent model of chronic peripheral neuropathy with related pain-like behaviors (bennett and xie 1988). |
| PubMedID- 21087411 | An open-label comparison of nabilone and gabapentin as adjuvant therapy or monotherapy in the management of neuropathic pain in patients with peripheral neuropathy. |
| PubMedID- 24438877 | Pdpn may impair sleep and quality of life compared with non-pdpn, and physicians should carefully consider pain symptoms in patients with diabetic peripheral neuropathy. |
| PubMedID- 20547213 | The present studies explored whether daily intrathecal treatment of rats with ceftriaxone, a beta-lactam antibiotic that upregulates glt-1 expression, could prevent development of hyperalgesia and allodynia following repeated morphine, reverse pain arising from central or peripheral neuropathy, and reduce glial activation in these models. |
| PubMedID- 25272094 | Pregabalin has been shown to be a safe, effective treatment for neuropathic pain associated with painful diabetic peripheral neuropathy (dpn) or postherpetic neuralgia (phn), with average time to reduction in pain of 2 days. |
| PubMedID- 23294138 | This method could be applicable to the control of pain in patients with peripheral neuropathy. |
| PubMedID- 24708659 | Current therapeutic approaches are only partially successful and they are only thought to reduce the pain associated with peripheral neuropathy. |
| PubMedID- 20393345 | Overall, for patients who will respond to pregabalin, statistically significant and sustained reduction of pain associated with diabetic peripheral neuropathy and posttherapeutic neuralgia occurs early, usually by the end of 2 days of pregabalin treatment. |
| PubMedID- 20812792 | Methods: medline and isi web of knowledge databases were searched for randomized double-blind, placebo-controlled clinical trials of pregabalin reporting sleep measures in addition to pain endpoints in patients with painful diabetic peripheral neuropathy and postherpetic neuralgia published from inception through march 2009. |
| PubMedID- 21676163 | Background: pregabalin and duloxetine are two fda-approved medications for the treatment of pain associated with diabetic peripheral neuropathy (pdpn). |
| PubMedID- 26587405 | Sympathectomy with radiofrequency (rf) is a minimally invasive procedure with a low incidence of adverse effects that can alleviate pain associated with peripheral neuropathies. |
| PubMedID- 22351288 | Duloxetine (cymbalta) is a potent serotonin norepinephrine reuptake inhibitor used for the management of major depression and pain associated with diabetic peripheral neuropathy. |
| PubMedID- 24829909 | Investigated the effect of gabapentin monotherapy on pain associated with diabetic peripheral neuropathy by titrating from 900 to 3600 mg per day or maximum tolerated dosage or placebo . |
| PubMedID- 22172451 | Perspective: this article validates a model that describes the qualities of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. |
| PubMedID- 21479990 | The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (cipn) as measured by the eortc qlq-cipn20 instrument, n06ca. |
| PubMedID- 22156827 | Objective: to identify and describe the response profile of pregabalin on the qualities of pain associated with peripheral neuropathy. |
| PubMedID- 24385423 | Background: duloxetine is a balanced serotonin and noradrenaline reuptake inhibitor licensed for the treatment of major depressive disorders, urinary stress incontinence and the management of neuropathic pain associated with diabetic peripheral neuropathy. |
| PubMedID- 20487567 | Methods: sixty participants with plantar cutaneous (foot sole) pain due to all cause peripheral neuropathy were recruited from the community. |
| PubMedID- 24121454 | Recently, the antidepressant drug venlafaxine, which is also used to manage pain associated with diabetic peripheral neuropathy, has been reported to significantly decrease the incidence of acute opn in a placebo-controlled, randomized, phase 3 trial; however, grade 1–2 vomiting was observed more frequently in patients who received venlafaxine . |
| PubMedID- 23541708 | Background: in patients with chronic pain due to diabetic peripheral neuropathy (dpn) or postherpetic neuralgia (phn), pregabalin treatment results in pain relief and improved patient function/quality of life (qol). |
| PubMedID- 25969689 | All diabetic rats which showed the blood sugar level more than 250 mg·dl−1 were selected for further study by inducing peripheral neuropathy with neuropathic pain by using the chronic constriction injury (cci) of sciatic nerve . |
| PubMedID- 22082033 | Objective: to perform an economic evaluation of duloxetine, pregabalin, and both branded and generic gabapentin for managing pain in patients with painful diabetic peripheral neuropathy (pdpn) in mexico. |
| PubMedID- 20487048 | Methods: a prospective, multicentre, open-label, non-comparative study included patients age >or= 18 years diagnosed with neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, chemotherapy-induced peripheral neuropathic pain (pnp), or human immunodeficiency virus-related pnp. |
| PubMedID- 20373255 | Avanir pharmaceuticals inc, under license from irisys research & development, is developing avp-923 (zenvia, neurodex) for the treatment of pseudobulbar affect (pba; in collaboration with medison pharma ltd) and neuropathic pain associated with diabetic peripheral neuropathy. |
| PubMedID- 26141332 | Easily defined clinical patterns of involvement are used to identify patients in need of neurologic consultation, the yield of laboratory and other diagnostic testing is reviewed for the evaluation of length-dependent, sensorimotor peripheral neuropathies (the most common form of neuropathy), and an algorithmic approach with dosing recommendations is provided for the treatment of neuropathic pain associated with peripheral neuropathy. |
| PubMedID- 21197308 | An open-label, non-randomized comparison of venlafaxine and gabapentin as monotherapy or adjuvant therapy in the management of neuropathic pain in patients with peripheral neuropathy. |
| PubMedID- 21786301 | Muscle pain in models of chemotherapy-induced and alcohol-induced peripheral neuropathy. |
| PubMedID- 22189061 | pain hypersensitivity associated with peripheral neuropathy was attenuated by the tnfα antagonist etanercept . |
| PubMedID- 20701403 | In addition, the analgesic efficacy of tramadol/paracetamol did not differ significantly from that of gabapentin in patients with chronic pain associated with diabetic peripheral neuropathy. |
| PubMedID- 21178594 | Conclusions: no influence from 8 mg of ondansetron could be shown on the intensity of brush-evoked or spontaneous ongoing pain in patients with peripheral neuropathy, indicating the lack of involvement of 5ht3-receptors in an earlier proposed spinobulbospinal loop with descending facilitation acting on spinal mechanisms related to dynamic mechanical allodynia. |
| PubMedID- 21166852 | Efficacy and safety of pregabalin for treating neuropathic pain associated with diabetic peripheral neuropathy: a 14 week, randomized, double-blind, placebo-controlled trial. |
| PubMedID- 21719618 | Objective: to determine whether duloxetine is noninferior to (as good as) pregabalin in the treatment of pain associated with diabetic peripheral neuropathy. |
| PubMedID- 23186035 | A randomized, controlled trial of gabapentin enacarbil in subjects with neuropathic pain associated with diabetic peripheral neuropathy. |
| PubMedID- 22461274 | Charcot arthropathy is an acute or subacute, often indolent, non-infectious or tumorous osteoarticular destruction of weightbearing skeletal structures in patients with reduced pain perception due to peripheral neuropathy. |
| PubMedID- 21075912 | Introduction: the pain associated with peripheral neuropathy (pn) observed in patients living with hiv/aids represents a difficult complication to manage. |
| PubMedID- 21091395 | Evaluation of healthcare resource utilization and costs in employees with pain associated with diabetic peripheral neuropathy treated with pregabalin or duloxetine. |
| PubMedID- 22745903 | Nearly 70 percent of those with diabetes have diabetic peripheral neuropathy, which can lead to severe neuropathic pain of the distal extremities. |
| PubMedID- 21353106 | Conclusion: flexible-dose pregabalin (150-600 mg/d for 8 weeks) was associated with a significant, although modest, reduction in mean dprs score; an improvement in anxiety and subjective sleep; and generally good tolerability compared with placebo in these korean patients with neuropathic pain due to diabetic peripheral neuropathy, postherpetic neuralgia, or posttraumatic neuropathic pain. |
| PubMedID- 23756650 | Thus, nts2 agonists may offer new treatment avenues for limiting pain associated with peripheral neuropathies and improve functional rehabilitation and well-being. |
| PubMedID- 24804094 | Before treatment start, after 30 and 60 days the following parameters were assessed: painful symptoms of diabetic peripheral neuropathy using the michigan neuropathy screening instrument; intensity of symptoms characteristic of diabetic neuropathic pain by the total symptom score; and intensity of different subcategories of neuropathic pain by the neuropathic pain symptoms inventory. |
| PubMedID- 21887118 | The submission included a number of large-scale, randomized, active comparator-controlled and placebo-controlled phase iii studies that evaluated the safety and efficacy of tapentadol in patients with chronic osteoarthritis, low back pain, or pain associated with diabetic peripheral neuropathy. |
| PubMedID- 21668963 | Duloxetine is a potent serotonin and norepinephrine reuptake inhibitor that has been approved by the us food and drug administration for treatment of major depressive disorder (mdd) and generalized anxiety disorder (gad) and for the management of pain associated with diabetic peripheral neuropathy, management of chronic musculoskeletal pain, and management of fibromyalgia. |
| PubMedID- 24941666 | Recent advances in the use of high-dose topical capsaicin preparations hold promise in managing a wide range of painful conditions associated with peripheral neuropathies and may in fact help reduce suffering by reversing progressive changes in the nervous system associated with chronic neuropathic pain conditions. |
| PubMedID- 24848284 | Objective: this study evaluated the efficacy and tolerability of tapentadol extended release (er) for the management of chronic pain associated with diabetic peripheral neuropathy (dpn). |
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