eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | neuropathy, peripheral |
| Symptom | C0004093|weakness |
| Sentences | 8 |
| PubMedID- 22379454 | Clinically, gbs manifests as an acute peripheral neuropathy with symmetric weakness reaching a peak by 4 weeks from onset, hyporeflexia or areflexia, and cytoalbuminemic dissociation in the cerebrospinal fluid (csf) with an elevated protein content and normal cell count 5. |
| PubMedID- 26434167 | One case had severe peripheral neuropathy with muscle weakness, atrophy in left arm, and wasting on left hand. |
| PubMedID- 22392734 | Mice expressing the mutant kinesin superfamily member kif1bβ show transport defects for synaptic vesicles and progressive muscle weakness attributable to a peripheral neuropathy. |
| PubMedID- 20736187 | One patient exhibited a sensorimotor peripheral neuropathy with associated weakness of distal muscle groups in the upper and lower limbs, including weakness of thumb and finger abduction, ankle dorsiflexion and flexion and extension of the toes, all exhibiting an mrc grade 4.table 1clinical details for the 18 patients with acquired neuromyotoniapatientsage (years) sexfasciculations/ neuromyotoniacns features (mood disturbance, insomnia and confusion)anti-vgkc antibodiesautoimmune accompaniments140mpresentyesnegativeyes274mpresentyesnegativeyes371mpresentnonegativeno458mpresentyesnegativeyes517mpresentyespositiveno635mpresentyesnegativeyes743fpresentnonegativeno859mpresentyesnegativeyes958mpresentnonegativeyes1061fpresentnonegativeno1138mpresentyesnegativeyes1252mpresentnonegativeno1351fpresentnonegativeno1423mpresentnopositiveyes1547fpresentyespositiveyes1653fpresentnopositiveno1756mpresentnopositiveno1855mpresentyespositivenomean (sem)50 (5.6)fasciculation potentials and neuromyotonia were evident in all patients with acquired neuromyotonia. |
| PubMedID- 21687623 | The most frequent clinical manifestation of acute attacks include vomiting, hypertension and tachycardia , and peripheral neuropathy with muscle weakness (42%–68%). |
| PubMedID- 25473575 | Nearly all css patients have been reported to show long-lasting and steroid-resistant neuralgia together with muscle weakness due to peripheral neuropathy 3. |
| PubMedID- 21694941 | Chronic colchicine toxicity takes the form not of diarrhea, but rather of myoneuropathy which combines symptoms of peripheral neuropathy with muscle weakness and usually mildly elevated creatine kinase.161,176–178 unfortunately, a few individuals cannot take even 0.3 mg/day of colchicine without severe diarrhea. |
| PubMedID- 24084719 | Dm is a multi-systemic disease and it is characterized by a generalized muscle weakness and wasting, associated with peripheral neuropathy, heart rhythm defects, and cataracts. |
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