eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | nephrotic syndrome |
| Symptom | C0398623|hypercoagulable state |
| Sentences | 6 |
| PubMedID- 25607275 | nephrotic syndrome (ns) is associated with a hypercoagulable state due to the increasein the plasma levels of fibrinogen and coagulation factors v and viii, urinary loss ofantithrombin iii, changes in the fibrinolytic system, thrombocytosis and increasedplatelet activation and aggregation. |
| PubMedID- 23580806 | described two adult patients, 34 and 36 years of age, who presented with acute cerebral infarction and were found to have a hypercoagulable state due to nephrotic syndrome. |
| PubMedID- 23439670 | Cvst in nephrotic syndrome is associated with a hypercoagulable state arising due to alteration in blood levels of various factors involved in coagulation, fibrinolytic system, alteration in platelet function, hemoconcentration, increased blood viscosity, and possibly administration of steroids and diuretics. |
| PubMedID- 21917124 | hypercoagulable state associated with nephrotic syndrome and antiphospholipid syndrome can lead to the development of occlusive coronary artery thrombus in absence of atherosclerotic coronary artery disease. |
| PubMedID- 21886984 | 7 steroids shorten prothrombin as well as accelerate partial thromboplastin times that aggravate the hypercoagulable state of nephrotic syndrome. |
| PubMedID- 25984105 | In fact, despite the underlying causes of the hypercoagulable state in patients with nephrotic syndrome that are not well understood, a variety of haemostatic abnormalities have been described, including decreased levels of antithrombin and plasminogen (due to urinary losses), increased platelet activation, hyperfibrinogenaemia, inhibition of plasminogen activation, and the presence of high-molecular-weight fibrinogen moieties in the circulation . |
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