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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease nephrotic syndrome
Symptom C0033687|proteinuria
Sentences 46
PubMedID- 25834748 At the age of 35, he had proteinuria and was diagnosed with nephrotic syndrome and kidney injury.
PubMedID- 21534236 Clinically, lg is characterized by proteinuria generally associated with nephrotic syndrome and progressive renal insufficiency.
PubMedID- 24798567 Rituximab, a chimeric monoclonal antibody against the cd20 antigen on b cells, safely reduced proteinuria in patients with nephrotic syndrome secondary to membranous nephropathy, minimal change disease, or focal segmental glomerulosclerosis.
PubMedID- 20649959 As previously reported , a single injection of pan (150 mg/kg body wt) to rats induced a marked nephrotic syndrome with severe proteinuria (~10 g/mmol creatinine) and decreased sodium excretion (< 5 mmol/mmol creatinine) (figure 4a).
PubMedID- 21844386 Mice developed a nephrotic syndrome with severe edema, proteinuria, hypoalbuminemia, and elevated cholesterol and triglycerides.
PubMedID- 24749114 A year after the beginning of the symptoms she sought medical attention: a diagnosis of nephrotic syndrome with proteinuria >10 g/l was made.
PubMedID- 25886386 Studies also showed that as-iv can attenuate podocyte injury and ameliorate proteinuria in adults with idiopathic nephrotic syndrome .
PubMedID- 24886259 Mutations in the podocin gene cause severe structural podocyte alterations and massive proteinuria leading to nephrotic syndrome .
PubMedID- 24282415 Due to persistent activation of the chronic inflammatory process, whether clinically manifested orsubclinically, excess saa is deposited in the form of fibrils in various organs, particularly the kidneys, with the consequent progressive development of severe proteinuria, leading to nephrotic syndrome and kidney failure.
PubMedID- 22909024 They are characterized by heavy proteinuria, with nephrotic syndrome and impaired renal function in half of the patients.
PubMedID- 25688242 Lupus nephritis is a frequent and potentially serious complication among patient with systemic lupus erythematosus whose clinical manifestations are varied being the most common manifestations proteinuria (commonly leading to nephrotic syndrome), microscopic hematuria, and reduced gfr.
PubMedID- 26447100 Background: proteinuria leading to nephrotic syndrome is a rare adverse event arising from treatment with bevacizumab.
PubMedID- 23275781 In february 2011, the patient was referred to the department of nephrology for the appearance of edema, increase of the serum creatinine up to 1.5 mg/dl (egfr 45.0 ml/min/1.73 m2), weight gain (weight was 67.5 kg), nephrotic syndrome with proteinuria of 12 g/24 h, dyslipidemia, and hypoalbuminemia.
PubMedID- 21904677 The development of nephrotic-range proteinuria, without full nephrotic syndrome, is consistent with the role of b4 as a minor podocyte integrin.
PubMedID- 22534961 In 129x1/svj mice, proteinuria, chemical indices of nephrotic syndrome and glomerular and tubulointerstitial accumulation of type-i collagen and fibronectin occur sequentially after adr administration.
PubMedID- 24294005 At the time of biopsy, six (75%) of them had nephrotic syndrome with mean proteinuria of 3.8 ± 2.24 g/day.
PubMedID- 21502717 Renal amyloidosis is typically characterized by nephrotic syndrome, often with massive proteinuria and refractory peripheral edema.
PubMedID- 25874088 Here we report an association between collapsing glomerulopathy and an acute ebv syndrome, manifesting itself clinically as nephrotic syndrome with massive proteinuria, hypoalbuminemia, anasarca and hypercholesterolemia.
PubMedID- 22661128 Because of a lack of ultrastructural detail (the electron microscopy was not invented until 50 years later) and limited by only a superficial insight in renal inflammatory processes, the authors failed to recognize the glomerulus as the origin of proteinuria in patients with the nephrotic syndrome and placed too much emphasis on tubular reabsorption patterns coined lipoid nephrosis.
PubMedID- 23006339 In september 2010, her nephrotic syndrome returned with proteinuria (9.5 g/d), anasarca (11.3 kg weight gain), hyperlipidemia (total cholesterol 332 mg/dl, ldl 229 mg/dl, triglycerides 270 mg/dl), and a cr of 1.9 mg/dl.
PubMedID- PMC4044283 Subsequently, the patient developed proteinuria with nephrotic syndrome.
PubMedID- 24860853 Although sirolimus is not generally thought to be nephrotoxic, it can be associated with proteinuria, which can lead to nephrotic syndrome and subsequent kidney injury (25).
PubMedID- 21151138 Therefore, treatment with sialic acid precursors constitute a potential therapeutic tool to reduce proteinuria in some forms of nephrotic syndrome.
PubMedID- 23670304 Podocyte loss correlated with lower selectivity of proteinuria in patients with minimal change nephrotic syndrome and focal segmental glomerulosclerosis (r = -0.90; p < 0.001).
PubMedID- 22078716 Hypo-albuminemia accompanied by significant proteinuria is a component of the nephrotic syndrome that may accompany active lupus renal disease.
PubMedID- 23162265 The limited evidence suggested that dfz appeared to be equally effective in inducing remission or decreasing proteinuria in patients with nephrotic syndrome.
PubMedID- 20419132 Mutations of the nephrin gene lead to congenital nephrotic syndrome with proteinuria and renal failure .
PubMedID- 21497573 Renal manifestations are frequent, mostly characterized by heavy proteinuria, with nephrotic syndrome and renal failure in more than half of the patients at diagnosis.
PubMedID- 21403411 Although a moderate degree of proteinuria is common in patients with igan, nephrotic syndrome is considered uncommon in these patients.3 the course of igan is variable, and 15% to 40% of patients progress to end-stage renal disease over a period of 10 to 20 years.4 the pathogenesis of igan is complex and not completely understood.
PubMedID- 24611049 In the systemic loop, it binds to glomerular endothelial αvβ5 integrin and reduces proteinuria, the principal driver of nephrotic syndrome.
PubMedID- 24317117 Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome.
PubMedID- 24404368 During the follow-up period on allopurinole and anti-proteinuirc treatment, the patient had normal renal function with mild to moderate proteinuria and no recurrence of nephrotic syndrome.
PubMedID- 26395882 In the first year of life, 66 % of the patients suffering from hypoalbuminemia and severe proteinuria are diagnosed with genetic nephrotic syndrome (gns) 1.
PubMedID- 19773419 Recurrence of nephrotic-range proteinuria in patients with idiopathic nephrotic syndrome (ins) and focal and segmental glomerulosclerosis (fsgs) on native kidneys is associated with poor graft survival.
PubMedID- 23878704 They further described a glomerulopathy, which was characterised by heavy proteinuria, biochemical features of nephrotic syndrome, renal impairment that rapidly progressed to end stage renal disease (rao et al., 1984).
PubMedID- 23559294 Background: collapsing glomerulopathy is a cause of nephrotic syndrome with massive proteinuria secondary to podocyte proliferation and glomerular collapse.
PubMedID- 25558821 Immunosuppressive agents should be used for patients who suffer from refractory proteinuria or complications associated with nephrotic syndrome.
PubMedID- 20483511 Diagnostic strategy relies on the clinical presentation: acute renal failure, chronic kidney disease, glomerular proteinuria with or without nephrotic syndrome, tubular proteinuria, hydroelectrolytic disorders.
PubMedID- 21335185 Post-olt 3 patients developed proteinuria, 2 of whom showed increasing nephrotic syndrome.
PubMedID- 26551740 Focal segmental glomerulosclerosis (fsgs) is a pathologic entity that is a common cause of nephrotic syndrome with severe proteinuria in both adults and children.
PubMedID- 23759297 Results: all patients presented with proteinuria, associated with nephrotic syndrome (41%), hematuria (73%), and hypertension (70%).
PubMedID- 23197960 In conclusion, bilateral rae is an alternative, effective, rapid, and safe procedure for the treatment of heavy proteinuria with nephrotic syndrome.
PubMedID- 21132650 A 47-year-old woman was referred to our unit for evaluation of proteinuria associated with nephrotic syndrome.
PubMedID- 23295293 Nephropathy in fs consists in nephrotic syndrome (ns) with proteinuria that begins early in childhood and progressively increases with age, mainly due to nonspecific focal and segmental glomerular sclerosis (fsgs).
PubMedID- 26054711 Conclusions: serum half-life of rtx can be extremely short, partly due to excessive urinary losses in therapy-resistant nephrotic syndrome with non-selective proteinuria, as seen in our patient.
PubMedID- 22461531 Results: initially, 95% of patients had nephrotic syndrome with proteinuria of 3-12 g per 24 hours, creatinine levels of 0.6-9.6 mg/dl, positive lupus serologies, and normal complement levels in 63%.

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