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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease muscular atrophy
Symptom C0004093|weakness
Sentences 23
PubMedID- 22179310 muscle wasting can lead to muscle weakness that can result in hypoventilation, prolongation of dependence on mechanical ventilation, prolonged rehabilitation and even death (16–19).
PubMedID- 23319993 muscle wasting may lead to weakness and fatigue that negatively affects ambulation and increases the risk for thromboembolic complications.
PubMedID- 22915887 The copy number of this weakly expressed homolog may be an important determinant of the severity of the disease.3 consequently, sma can display various degrees of skeletal muscle atrophy with progressive muscle weakness of the limbs and trunk, pulmonary insufficiency due to scoliosis and chest wall muscle weakness, autonomic dysfunction, and dysphagia, resulting in severe physical disability.
PubMedID- 21723884 Due to axonal retraction from neuromuscular junctions, the animals suffer from muscle wasting leading to weakness and paralysis of the extremities, which in early stages can be detected by measuring weight loss.
PubMedID- 24529944 Neurological findings on examination included chorea of the face and tongue, and lower limb muscle weakness with muscle wasting.
PubMedID- 24251822 This argued in favour of muscle weakness being solely associated with muscle wasting but ‘quality’ of cachectic muscle being unaltered 30. with a dynamometer approach, similar results were recently obtained in vivo in quadriceps femoris muscle from cachectic patients with gastrointestinal cancer compared with healthy volunteers.
PubMedID- 25799359 This effect was probably due to their more severe muscle weakness phenotype, leading to extra muscle wasting necessary to complete the exercise regime, rather than to intrinsic muscle membrane permeability of the model.
PubMedID- 20127636 Thenar muscle atrophy with corresponding muscle weakness is a late manifestation of advanced disease.
PubMedID- 21264243 These experiments provide important mechanistic insights into why mdx mice, as well as dmd patients, experience progressive muscle weakness associated with muscle atrophy.
PubMedID- 20680172 Patient presented symptoms such as swallowing difficulties for liquids and solids, bulbar weakness signs of hoarseness, muscle atrophy and weakness in the trunk, neck, back and both proximal upper limbs for lower motor signs.
PubMedID- 20945946 This extended period in a bedridden state during the acute and subacute phases of stroke is the likely cause of lower limb disuse muscle atrophy in association with leg motor weakness, thus accelerating the development of leg locomotor dysfunction in the chronic phase.
PubMedID- 21933392 Part of this weakness is due to muscle atrophy and part due to ami.
PubMedID- 20431600 Controversy still surrounds the pathogenesis of the dm1 muscle distress, characterized by myotonia, weakness and wasting with distal muscle atrophy.
PubMedID- 21642948 Edmd is characterized by contractures of the elbows and achilles, muscle wasting with humeroperoneal weakness and cardiomyopathy with conduction disease.
PubMedID- 26074962 Either patients or control subjects were studied as outpatients and they underwent careful clinical and history examination; none of them displayed specific signs or symptoms of hypercortisolism, such as weakness associated with proximal muscle wasting, skin atrophy, ecchymoses, or purple striae.
PubMedID- 25147753 Poststroke plantar flexor muscle weakness has been attributed to muscle atrophy and impaired activation, which cannot collectively explain the limitations in force-generating capability of the entire muscle group.
PubMedID- 26316996 Distinctive clinical features in patients with dm2 include the propensity for less severity, proximal rather than distal weakness, and lack of prominent muscle wasting.
PubMedID- 20613516 Recent findings: worldwide studies confirm three major phenotypes in musk antibody positive myasthenia gravis (mmg) patients: indistinguishable from acetylcholine receptor antibody positive patients, prominent faciopharyngeal weakness, usually with marked muscle atrophy, and relatively isolated neck extensor and respiratory weakness.
PubMedID- 24562058 He has profound muscle atrophy with severe weakness and contractures in both upper and lower limbs.
PubMedID- 24682581 Typical clinical features are proximal bilateral limb weakness with muscle atrophy.
PubMedID- 23179371 Cmt2b is clinically characterized by prominent sensory loss, distal muscle weakness leading to muscle atrophy, high frequency of foot ulcers and infections that often results in toe amputations.
PubMedID- 20301727 Other findings can include weakness with muscle wasting of the lower limbs, urinary urgency, and decreased vibration sense.
PubMedID- 24600395 The studies discussed here concluded the role of sarcalumenin in soce function may be useful in reducing or reversing weakness associated with various muscle wasting disorders.

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