eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | multiple myeloma |
| Symptom | C0238792|bone lesion |
| Sentences | 12 |
| PubMedID- 21607019 | In contrast, multiple myeloma patients without bone lesions display balanced bone remodeling with increased osteoclastogenesis and normal or increased bone formation rates. |
| PubMedID- 25889851 | As a consequence, different consultants used different radiation regimens ranging from 1×8 gy to 20×2 gy in the palliative treatment of painful bone lesions and in patients with multiple myeloma. |
| PubMedID- 20639624 | Bisphosphonates (bps) are the current standard of care for bone lesions in patients with multiple myeloma (mm) but they are associated with a number of side effects such as osteonecrosis of the jaw. |
| PubMedID- 26062672 | We describe a 67-year-old female demonstrating symptomatic multiple myeloma (mm) with anemia and bone lesions initially diagnosed in 2009. |
| PubMedID- 22792345 | Increased dkk1 levels in bone marrow plasma and peripheral blood from patients with multiple myeloma are associated with focal bone lesions . |
| PubMedID- 23812074 | (usa) has developed the drug, and it is now utilized in japan for treatment of cancerous bone lesions associated with multiple myeloma and bone metastasis. |
| PubMedID- 26579531 | The level of ccl3, produced directly by the human myeloma cells, correlates with the osteolytic bone lesions in mm patients . |
| PubMedID- 20843343 | Initially increased dkk1 expression was found to be associated with the lytic bone lesions in patients with multiple myeloma, suggesting that dkk1 might inhibit osteoblast differentiation or function . |
| PubMedID- 24074647 | Diagnostic value of whole-body low-dose computed tomography (wbldct) in bone lesions detection in patients with multiple myeloma (mm). |
| PubMedID- 22425892 | Furthermore, histomorphometric studies demonstrate that myeloma patients with osteolytic bone lesions have fewer osteoblasts and decreased bone formation (2, 3), suggesting that myeloma cells suppress osteoblasts and inhibit bone formation. |
| PubMedID- 25289928 | Recent findings suggest that the life span of osteocytes is compromised in multiple myeloma patients with bone lesions. |
| PubMedID- 19874086 | (59) in addition, increased dkk1 expression in bone marrow also has been associated with lytic bone lesions in patients with multiple myeloma. |
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