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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease monoclonal gammopathy of uncertain significance
Symptom C0032927|premalignant condition
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PubMedID- 26366868 Mm develops from a premalignant condition, monoclonal gammopathy of undetermined significance (mgus), often through an intermediate stage termed smoldering multiple myeloma, which differs from active myeloma by the absence of disease-related end-organ damage.
PubMedID- 22522905 Of relevance to this study, others have used ighv sequence analysis to better understand the relationship between mm and its known premalignant condition monoclonal gammopathy of undetermined significance (mgus) and have shown that while there is evidence for intraclonal heterogeneity in mgus, mm pcs are homogeneous .

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