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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease malaria
Symptom C0035309|retinopathy
Sentences 9
PubMedID- 21056005 Methods: between 2005 and 2007, we did a prospective cohort study of survivors of cerebral malaria with malaria retinopathy in blantyre, malawi.
PubMedID- 20595476 Among patients who had cerebral malaria with retinopathy, there was no significant difference in the platelet counts between those who had full recovery and those who either died or had sequela (see table 1).
PubMedID- 22125593 Graphs showing median and scatter of plasma vwf and vwf propeptide levels in retinopathy positive children with cerebral malaria who died (died) or recovered (recovered) as measured by elisa (mann whitney u test, p = 0.873, p = 1.000, respectively).
PubMedID- 25686067 The retinopathy in association with malaria fever described so far includes retinal hemorrhages, vessel changes, retinal discoloration/whitening and papilledema.
PubMedID- 20704742 Finally, this study used bedside ophthalmoscopy to test the clinical relevance of retinopathy in patients with severe malaria without fundus photography.
PubMedID- PMC2963213 Severity of retinopathy correlated with severity of malaria, coma recovery time and markers of, and rheological factors important in, microcirculatory obstruction.
PubMedID- 24578549 The retina may be a good source of surrogate markers of cerebrovascular injury because paediatric cerebral malaria is associated with a retinopathy (‘malarial retinopathy’) that accurately predicts cerebral sequestration (taylor et al., 2004), correlates with severity of brain involvement (white et al., 2001), and is associated with mortality (beare et al., 2004).
PubMedID- 21212217 Studies by looareesuwan and others14 and davis and others15 using direct ophthalmoscopy reported the prevalence of retinopathy in patients with cerebral malaria as 14.6% and 28%, respectively, predominantly as retinal hemorrhages.
PubMedID- 25378888 Another likely explanation is anemic retinopathy induced by anemia of chronic malaria, which is well known to cause retinal vascular anomalies and pre-retinal hemorrhages.

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