eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | macular degeneration |
| Symptom | C0456909|blindness |
| Sentences | 28 |
| PubMedID- 23049424 | (45) started two prospective clinical studies to establish the safety and tolerability of subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium in patients with stargardt's macular dystrophy and dry age-related macular degeneration the leading cause of blindness in the developed world. |
| PubMedID- 24479434 | We reviewed published population-based data from ssa and other relevant populations on the leading psed, specifically glaucoma, diabetic retinopathy and age-related macular degeneration, as causes of blindness and visual impairment in adults. |
| PubMedID- 26472075 | For example, quantitative cell imaging is potentially a powerful tool for qualifying cell therapy products such as those that can cure macular degeneration, the leading cause of blindness in adults (7 million us patients, gross domestic product loss $30 billion 2). |
| PubMedID- 23233789 | Meanwhile, to make ophthalmological application of ips cells a reality, a japanese group plans to cure blindness in patients with macular degeneration within the next 3 years using ips-derived rpe transplants. |
| PubMedID- 24169698 | Lipofuscin accumulation in retinal pigment epithelial (rpe) cells of the eye implicates the etiologies of stargardt disease and age-related macular degeneration, a leading cause of blindness in the elderly. |
| PubMedID- 26260587 | In the eye, choroidal neovascularization (cnv) causes blindness in patients with age-related macular degeneration (amd). |
| PubMedID- 24982737 | Dysfunctional rpe is believed to be an underlying pathological condition in age-related macular degeneration, a leading cause of blindness in the elderly in developed countries. |
| PubMedID- 26307969 | macular degenerations represent leading causes of central blindness or low vision in developed countries. |
| PubMedID- 24801942 | Monogenic as well as complex rpe-related diseases, such as age-related macular degeneration, are common causes of blindness while therapeutic options are limited (lim et al. |
| PubMedID- 24450440 | Photodynamic therapy is also used in ophthalmology . |
| PubMedID- 24358235 | Dicer is decreased in geographic atrophy (ga), a form of age-related macular degeneration leading to blindness . |
| PubMedID- 22590627 | Dysfunction and death of retinal pigment epithelium (rpe) constitute the final common pathway in age-related macular degeneration, the leading cause of legal blindness among the elderly (reviewed by binder et al. |
| PubMedID- 20846177 | Not surprisingly, rpe cell damage is a major cause of human blindness worldwide, with age-related macular degeneration a prevalent example. |
| PubMedID- 20887885 | This year's lasker debakey clinical research award goes to napoleone ferrara for the discovery of vascular endothelial growth factor (vegf) as a major mediator of angiogenesis and for the development of an effective anti-vegf therapy for wet macular degeneration, a leading cause of blindness in the elderly. |
| PubMedID- 24868138 | There are also indications that type vi collagen assemblies are associated with eye disorders, such as age-related macular degeneration, the leading cause of blindness in the western world, and sorsby's fundus dystrophy . |
| PubMedID- 24759774 | A good example is age related macular degeneration, the leading cause of blindness in the u.k 1. |
| PubMedID- 22281388 | Methods: we started two prospective clinical studies to establish the safety and tolerability of subretinal transplantation of hesc-derived retinal pigment epithelium (rpe) in patients with stargardt's macular dystrophy and dry age-related macular degeneration--the leading cause of blindness in the developed world. |
| PubMedID- 23132794 | Retinitis pigmentosa, other inherited retinal diseases, and age-related macular degeneration lead to untreatable blindness because of the loss of photoreceptors. |
| PubMedID- 23627893 | Introduction: glaucoma is one of the major causes of blindness, affecting together with age-related macular degeneration > 70 million people worldwide. |
| PubMedID- 21437192 | The first trial is for the treatment of advanced stargardt's macular dystrophy, a form of juvenile macular degeneration that often leads to blindness, and the second trial is for dry age-related macular degeneration. |
| PubMedID- 23521856 | Aging contributes to the appearance of several retinopathies and is the largest risk factor for aged-related macular degeneration, major cause of blindness in the elderly population. |
| PubMedID- 22882737 | Currently, it is well established that a deregulated and persistent angiogenesis is one of the hallmarks of cancer 10,11. furthermore, there is overwhelming evidence on the involvement of deregulated angiogenesis in many other pathological situations, which are currently described as angiogenesis-dependent diseases 12. the interest and impact of angiogenesis as a new therapeutical target from the treatment of non-oncological angiogenesis-dependent diseases is well represented by the recent concession of the lasker-debakey clinical medical research award 2010 to dr. napoleone ferrara for the discovery of vegf as a major mediator of angiogenesis and the development of an effective anti-vegf therapy for wet macular degeneration, a leading cause of blindness in the elderly 13. this is a type of age-related macular degeneration, included as a rare disease in the orphanet website with the orpha number orpha279. |
| PubMedID- 22938801 | Lutein, the primary carotenoid present in the central area of the retina of eye appears to be associated with the protection against age-related macular degeneration (the leading cause of blindness in older adults). |
| PubMedID- 22754971 | Since 2005, patients and their ophthalmologists have faced a dilemma in treating age-related macular degeneration (amd)--the leading cause of blindness in the united states. |
| PubMedID- 22801846 | Impact of availability of anti-vascular endothelial growth factor therapy on visual impairment and blindness due to neovascular age-related macular degeneration. |
| PubMedID- 24955576 | Specific testing will be required to understand the mechanisms involved and to establish whether there is clinical potential in combining neuroprotectants, to improve the quality of life of people affected by retinal pathology, such as age-related macular degeneration, the major cause of blindness and visual impairment in older adults. |
| PubMedID- 24319332 | Age-related macular degeneration, a common cause of blindness after the age of 65, is characterized by either the presence of drusen (dry amd) or vegf-induced choroidal endothelial cell proliferation with associated leakage (wet exudative form of amd) . |
| PubMedID- 22664333 | In therapeutic dosages, zinc has been used for the treatment of acute diarrhea in infants and children, common cold, wilson's disease, sickle cell disease and for prevention of blindness in patients with age related macular degeneration. |
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