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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease lynch syndrome
Symptom C0009402|colorectal cancer
Sentences 42
PubMedID- 22262812 colorectal cancers associated with lynch syndrome are characterized by deficient dna mismatch repair (mmr) function.
PubMedID- 24056992 Some studies reported since publication of the egapp analysis have added to the evidence regarding clinical utility to the relatives of colorectal cancer patients diagnosed with lynch syndrome.
PubMedID- 25213040 Aim: colonic surveillance reduces the lifetime risk of colorectal cancer in patients with lynch syndrome (hereditary nonpolyposis colorectal cancer) from 60 to 80% to 10% and confers a 7-year survival advantage.
PubMedID- 25323653 Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for lynch syndrome in adults with colorectal cancer.
PubMedID- 25583420 Relationship between smoking and multiple colorectal cancers in patients with japanese lynch syndrome: a cross-sectional study conducted by the japanese society for cancer of the colon and rectum.
PubMedID- 23508345 The surgical management of the lynch syndrome patient with colorectal cancer needs to be individualized.
PubMedID- 22237445 Implementing screening for lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.
PubMedID- 21743847 The american college of gastroenterology found moderate quality evidence for their recommendation that colorectal cancer patients with lynch syndrome undergo colonoscopy every 2 years beginning at age 20-25 and then annually after age 40 9.
PubMedID- 25534380 Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.
PubMedID- 26473097 Testing for lynch syndrome in patients with newly-diagnosed colorectal cancer and their relatives.
PubMedID- 25754680 Fertility after young-onset colorectal cancer: a study of subjects with lynch syndrome.
PubMedID- 20010342 Prevention of metachronous colorectal cancer in patients with lynch syndrome.
PubMedID- 25731324 Effect of chemotherapy on the inoperable or recurrent colorectal cancers in patients with lynch syndrome.
PubMedID- 25910169 The objective of this project was to estimate the cost–utility of strategies to identify lynch syndrome in individuals with early-onset colorectal cancer in the nhs.
PubMedID- 23073952 Identification of lynch syndrome among patients with colorectal cancer.
PubMedID- 26249337 Lower prevalence of lynch syndrome in colorectal cancer patients in a japanese hospital-based population.
PubMedID- 22480969 Background: recommended strategies to screen for lynch syndrome in colorectal cancer are not applied in daily practice and most of lynch cases remain undiagnosed.
PubMedID- 21768580 Strategies to identify the lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis.
PubMedID- 22175017 However, there have been fewer studies on endometrial cancer compared to colorectal cancer in patients with lynch syndrome.
PubMedID- PMC2876284 This study analyzes precursor polyp burdens occurring within patients with msi-h colorectal cancers associated with lynch syndrome (ls) or those with a methylator pathway cancer phenotype.
PubMedID- 20704743 About 3% of all colorectal cancers is due to lynch syndrome, an autosomal dominant condition caused by germline mutations in one of the dna mismatch repair (mmr) genes, mlh1, msh2, msh6 and pms2 1.
PubMedID- 25816162 However, a higher frequency of mmr-dcf was observed in lynch syndrome patients with distal colorectal cancer localisation.
PubMedID- 23245329 Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with fcctx from lynch syndrome, which likely signifies different preferred tumourigenic pathways.
PubMedID- 23896635 Although variable, the lifetime risk of developing colorectal cancer (crc) in patients with lynch syndrome is approximately 80 %, with male carriers having a higher cumulative risk than female carriers 2.
PubMedID- 24415879 Epithelial-mesenchymal transition in colorectal cancer tissue of patients with lynch syndrome.
PubMedID- 25081898 Background: recognising colorectal cancer (crc) patients with lynch syndrome (ls) can increase life expectancy of these patients and their close relatives.
PubMedID- 23470269 Background: colorectal cancer (crc) associated with lynch syndrome usually presents at a relatively young age.
PubMedID- 23073955 lynch syndrome in patients with colorectal cancer: finding the needle in the haystack.
PubMedID- 23733757 Purpose: molecular screening techniques are available to identify hereditary lynch syndrome in people with newly diagnosed colorectal cancer (crc).
PubMedID- 23598716 Purpose: routine screening for evidence of dna mismatch repair abnormalities can identify colorectal cancer patients with lynch syndrome, but impact in usual care settings requires study.
PubMedID- 23125224 Cell cycle-related genes as modifiers of age of onset of colorectal cancer in lynch syndrome: a large-scale study in non-hispanic white patients.
PubMedID- 20206180 One to 2-year surveillance intervals reduce risk of colorectal cancer in families with lynch syndrome.
PubMedID- PMC3288925 Msi is present in 80-85% of colorectal cancers associated with lynch syndrome.
PubMedID- 22411104 Daily aspirin reduces colorectal cancer incidence in patients with lynch syndrome.
PubMedID- 19957108 Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with lynch syndrome.
PubMedID- 24225971 Molecular tumor testing for lynch syndrome in patients with colorectal cancer.
PubMedID- 20495877 Magnetic resonance colonography for colorectal cancer screening in patients with lynch syndrome gene mutation.
PubMedID- 21159521 Perspectives for tailored chemoprevention and treatment of colorectal cancer in lynch syndrome.
PubMedID- 26284327 The lifetime risk of colorectal cancer for males with lynch syndrome generally is significantly higher and the age of first manifestation significantly earlier compared to females.
PubMedID- 22056658 Interpretation of genetic testing for lynch syndrome in patients with putative familial colorectal cancer.
PubMedID- 25794514 Approximately 3% of colorectal cancers are associated with lynch syndrome.
PubMedID- 25142628 The percentage of cancers revealed in 1st (2%) and 2nd degree (8%) relatives were increasing through surveys, especially colorectal cancer related with lynch syndrome (4%).

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