eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | lyme disease |
| Symptom | C0422833|ent symptoms |
| Sentences | 9 |
| PubMedID- 22922244 | Antibiotic retreatment of lyme disease in patients with persistent symptoms: a biostatistical review of randomized, placebo-controlled, clinical trials. |
| PubMedID- 25490690 | Summary: patients with persistent symptoms possibly associated with lyme disease often provide a challenge for clinicians. |
| PubMedID- 21694904 | In summary, extensive evidence now shows that persistent symptoms of lyme disease are due to chronic infection with the lyme spirochete in conjunction with other tick-borne coinfections. |
| PubMedID- 26385994 | Long-term assessment of post-treatment symptoms in patients with culture-confirmed early lyme disease. |
| PubMedID- 20670707 | Persistent symptoms following treatment of early lyme disease: false hope. |
| PubMedID- 21437061 | Furthermore, female predominance has been noted in patients with persistent symptoms of lyme disease.14 gender differences in human disease susceptibility are usually attributed to either physiologic or sociologic causes. |
| PubMedID- 25318999 | Persistent lyme empiric antibiotic study europe (please)--design of a randomized controlled trial of prolonged antibiotic treatment in patients with persistent symptoms attributed to lyme borreliosis. |
| PubMedID- 22853630 | Among the remaining patients, 36 (15%) had a history of prior, physician-documented and treated early lyme disease with persistent or recurrent symptoms. |
| PubMedID- 21941449 | Numerous studies have documented persistent b. burgdorferi infection in patients with persistent symptoms of neurologic lyme disease following short-course antibiotic therapy.1–4 furthermore, animal models have demonstrated that short-course antibiotic therapy may fail to eradicate the lyme spirochete.24–26 persistent spirochetal infection appears to be a more likely explanation for chronic symptoms of lyme disease than the autoimmune hypotheses that have been postulated but never substantiated, and recent evidence has shed more light on the complex strategies that allow b. burgdorferi to evade both the immune response and antibiotic agents.27–29 the use of prolonged antibiotic therapy to eradicate ongoing spirochetal infection is consistent with the evidence for persistent b. burgdorferi infection outlined in these studies, and our results support this therapeutic approach. |
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