eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | klinefelter syndrome |
| Symptom | C0021359|infertile |
| Sentences | 4 |
| PubMedID- 21465155 | Small supernumerary marker chromosome (ssmc) derived from chromosome 22 in an infertile man with hypogonadotropic hypogonadism. |
| PubMedID- 25518839 | Hormonal therapy (hcg and rhfsh) for infertile men with adult-onset idiopathic hypogonadotropic hypogonadism. |
| PubMedID- 21093546 | Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (kiss1) or kisspeptin receptor (kiss1r) are infertile due to hypogonadotropic hypogonadism. |
| PubMedID- 24396593 | Thus, although spontaneous fertility can occur, the majority of females with btm is infertile due to hypogonadotropic hypogonadism (hh) and need assisted reproductive techniques. |
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