eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hypothyroidism |
| Symptom | C0086132|depressive symptoms |
| Sentences | 4 |
| PubMedID- 21485752 | Disorders of the thyroid axis have been closely linked to psychiatric disorders.1 while hyperthyroidism may present with a heterogenous range of psychiatric symptoms and syndromes, clinical hypothyroidism is invariably associated with depressive symptoms.1 although extensive research has shown that the vast majority of patients who present with major depression are euthyroid,2 the close association between depression and hypothyroidism led to a large database of studies in which various hormones of the thyroid axis have been used to treat depression as monotherapy or, more commonly, as adjunct to standard antidepressants. |
| PubMedID- 26572720 | Typically there are depressive symptoms in hypothyroidism and manic symptoms in hyperthyroidism, there have been a few cases of depressive symptoms (depressed mood, asthenia and apathy) reported in patients with hyperthyroidism. |
| PubMedID- 25775223 | depressive symptoms in patients with subclinical hypothyroidism--the effect of treatment with levothyroxine: a double-blind randomized clinical trial. |
| PubMedID- 26202797 | Background: subclinical hypothyroidism has been associated with depressive symptoms in cross-sectional studies, but prospective data and data on subclinical hyperthyroidism are scarce. |
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