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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease hypercalcemia
Symptom C0020502|hyperparathyroidism
Sentences 39
PubMedID- 25926120 The presence of isolated primary hyperparathyroidism, as a cause of hypercalcemia in cancer patients, has been described in approximately 5-10% of the patients.
PubMedID- 21660912 Hypocalcemia, frequently seen in the setting of chronic renal insufficiency, results in prolonged st segment and qt interval while hypercalcemia, usually seen with hyperparathyroidism, results in shortening of both intervals.
PubMedID- 20145928 If left untreated, hyperparathyroidism can lead to symptoms of hypercalcemia, renal complications, and bone disease connected to hyperparathyroidism, which is characterized by high turnover and remodeling rates leading to osteoporosis and increased fracture risk.
PubMedID- 21234416 Most patients with primary hyperparathyroidism are diagnosed because of routine findings of hypercalcemia .
PubMedID- 24251127 We describe a case of hyperparathyroidism with concomitant hypercalcemia accompanied by central pontine myelinosis without hyponatremia/hyperosmolality or associated rapid corrections of sodium, which developed as a consequence of severe hypokalaemia.
PubMedID- 22577545 In addition to the previous mechanism, several other factors like uremic toxins, increased circulating endogenous nos inhibitors like asymmetric dimethylarginine, secondary hyperparathyroidism leading to hypercalcemia, and increased expression of endothelin a receptors have also been implicated in the pathogenesis of hypertension in ckd.
PubMedID- 20191460 It has long been thought that parathyroidectomy was the only way to solve the problem of stabilized hypercalcemia associated with moderate-severe persistent hyperparathyroidism after kidney transplant.
PubMedID- 22840059 Today, primary hyperparathyroidism usually presents with mild hypercalcemia (within 1 mg/dl above the upper limit of normal), is usually asymptomatic, and diagnosed incidentally on routine investigations for minor non-specific complains.
PubMedID- 24736147 A 28 year-old girl admitted for a bone tumor of the knee, the blood test shows hypercalcemia with hyperparathyroidism, bone biopsy revealed giant cell lesions characteristic of brown tumors.
PubMedID- 21394466 Elevated pth values may also persist in some patients and hypercalcemia, in combination with hyperparathyroidism, has been traditionally considered a sign of autonomous pth secretion and an indication for parathyroidectomy in transplant recipients .
PubMedID- 23026597 Conclusions: cinacalcet is an effective alternative for the treatment of hypercalcemia in patients with persistent hyperparathyroidism after kt.
PubMedID- 23198183 A 71 yo woman with primary hyperparathyroidism awaiting surgery because of significant hypercalcemia and hypercalciuria presented to the local emergency department with the chief complaints of discomfort in her neck, sore throat, and difficulty swallowing.
PubMedID- 23232684 A very rare type of primary hyperparathyroidism with severe hypercalcemia in an infant.
PubMedID- 20510722 hypercalcemia associated with primary hyperparathyroidism has frequently resulted in the development of pancreatitis and peptic ulcer disease; however, the pathophysiologic mechanism of this association remains uncertain.
PubMedID- 24736693 Great majority of patients with severe hypercalcemia is attributable to either primary hyperparathyroidism or malignancy.
PubMedID- 25741940 Antenatal bartter syndrome presenting as hyperparathyroidism with hypercalcemia and hypercalciuria: a case report and review.
PubMedID- 21151209 Diagnosis: severe persistent hyperparathyroidism associated with mild hypercalcemia following renal transplantation.
PubMedID- 26019872 A de novo heterozygous inactivating mutation of calcium-sensing receptor (casr) gene typically causes neonatal hyperparathyroidism (nhpt) with moderate hypercalcemia and hyperparathyroid bone disease.
PubMedID- 24251163 On follow-up she is diagnosed to have primary hyperparathyroidism with hypercalcemia due to left inferior parathyroid adenoma which improved with intravenous (iv) zolindronic acid therapy and now she is planned to undergo parathyroidectomy.
PubMedID- 25861621 hypercalcemia associated with hyperparathyroidism is a common complication after kidney transplantation 1.
PubMedID- 21391355 Primary hyperparathyroidism as a cause of hypercalcemia in a patient with breast cancer.
PubMedID- 24334568 Metastatic calcification occurs in the setting of hypercalcemia, most commonly attributable to hyperparathyroidism, often secondary to renal dysfunction.
PubMedID- 23225300 Introduction: hyperparathyroidism often presents with asymptomatic hypercalcemia or minimal, unspecific symptoms and the middle-age female is the predominant population.
PubMedID- 21112866 Although the safety and efficacy of this drug in treating hypercalcemia associated with hyperparathyroidism have not yet been established in clinically controlled trials, its off-label use is not uncommon.
PubMedID- 25641446 hypercalcemia with hyperparathyroidism (hpt) was present in 5 patients and hyperuricemia in 3.
PubMedID- 22876055 Patients with secondary or tertiary hyperparathyroidism, or other causes of hypercalcemia such as malignancy, vitamin d intoxication, immobilization, medications, hyperthyroidism, and other endocrine diseases, were excluded.
PubMedID- 23146456 Persistent hyperparathyroidism associated with hypercalcemia and hyperphosphatemia have been associated with poor graft and patient survivals.
PubMedID- 25817305 Biochemical tests for malignancy and metabolic disease were negative for all patients except patient 8. initial investigations during her admission had shown normocalcemia, but she was found to have hypercalcemia with possible hyperparathyroidism 1 year after fixation of her peri-implant fracture.
PubMedID- 24251162 Acute pancreatitis due to hypercalcemia associated with hyperparathyroidism (hpt) is not very common.
PubMedID- 22431942 Functional parathyroid cyst: a rare cause of malignant hypercalcemia with primary hyperparathyroidism-a case report and review of the literature.
PubMedID- 24959180 Cinacalcet (sensipar), a calcimimetic drug, is available for the treatment of secondary hyperparathyroidism associated with renal failure, hypercalcemia in parathyroid cancer, and the treatment of severe hypercalcemia in patients with primary hyperparathyroidism unable to undergo parathyroidectomy .
PubMedID- 22620673 In the neonatal period, homozygous inactivating mutations result in neonatal severe hyperparathyroidism (nshpt) with severe symptomatic hypercalcemia, undermineralized bones, rib cage deformity, and long-bone and rib fractures 3.
PubMedID- 23764372 In patients with primary hyperparathyroidism, the state of hyperparathyroid hypercalcemia is associated with reduced muscle strength and impaired quality of life (qol).
PubMedID- 21879659 In primary hyperparathyroidism, repercussions of pronounced hypercalcemia on organs and systems are of essential importance.
PubMedID- 23330456 Cinacalcet is also expected to be useful in the treatment of intractable hypercalcemia in patients with primary hyperparathyroidism for whom parathyroidectomy is indicated but surgery is clinically inappropriate or contraindicated.
PubMedID- 25505684 hypercalcemia associated with lithium-induced hyperparathyroidism (lih) is a common, but easily overlooked, complication of lithium treatment.
PubMedID- 23199021 In 1996 a total parathyroidectomy with autotransplantation into the right brachioradial muscle was performed for severe hyperparathyroidism with a pth of 820 pg/ml, hypercalcemia and hyperphosphatemia.
PubMedID- 21078161 Parathyroid carcinoma (pc) is a rare cause of primary hyperparathyroidism with characteristic marked hypercalcemia and highly elevated parathyroid hormone levels.
PubMedID- 21286893 A case of acute pancreatitis as a first symptom of primary hyperparathyroidism with severe hypercalcemia is reported.

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