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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease growth hormone deficiency
Symptom C0878787|growth failure
Sentences 3
PubMedID- 25904938 The use of gh is approved by the us food and drug administration for the treatment of growth failure associated with growth hormone deficiency (ghd), either isolated (ighd) or part of multiple pituitary hormone deficiency (mphd), and short stature associated with turner syndrome (ts), noonan syndrome (ns), children born small for gestational age (sga), short stature homeobox (shox) gene haploinsufficiency, prader-willi syndrome (pws), chronic kidney disease (ckd), or idiopathic short stature (iss) 1.
PubMedID- 25905365 Initially only those children with the most pronounced growth failure due to severe growth hormone deficiency (ghd) were considered appropriate candidates, but with time children with growth failure from a range of conditions have been shown to benefit from gh treatment.
PubMedID- 24021480 Objective: growth hormone deficiency (ghd) leads to growth failure and changes in body composition including increased fat accumulation and reduced lean body mass in both humans and rodents.

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