eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cleft palate |
| Symptom | C0008924|cleft lip |
| Sentences | 274 |
| PubMedID- 21462296 | Background: nonsyndromic cleft lip with or without cleft palate (cl/p) is a common complex birth defect caused by the interaction between multiple genes and environmental factors. |
| PubMedID- 20099315 | The dataset included 5821 controls, 1567 cases of cleft lip with or without cleft palate (cl+/-p) and 835 cases of cleft palate only. |
| PubMedID- 22887868 | Nonsyndromic cleft lip with or without cleft palate (nscl/p) is a complex disorder with a worldwide incidence estimated at 1:700. |
| PubMedID- 23044548 | An application to a sequencing study for non-syndromic cleft lip with or without cleft palate (nscl/p) demonstrates its practical relevance. |
| PubMedID- 21834038 | Moreover, the apparent protection against cleft lip with or without cleft palate (cl/p), cleft lip with cleft palate (clp), and cleft lip only (clo) was also identified in stratified analysis. |
| PubMedID- 23580168 | Association between msx1 snps and nonsyndromic cleft lip with or without cleft palate in the korean population. |
| PubMedID- 22492558 | Investigation of sumo pathway genes in the etiology of nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 20210635 | Objective: to delineate inherent differences in the microbial milieu in cleft palate patients compared with cleft lip patients and to document changes in microbial flora before and after cleft lip and palate repair. |
| PubMedID- 23991581 | Association between single nucleotide polymorphism in wnt3 and nonsyndromic cleft lip with or without cleft palate in hui and han population of ningxia autonomous region. |
| PubMedID- 25535458 | Results: the difference in median cleft lip with or without cleft palate among the three groups was significant. |
| PubMedID- 23555592 | Background: facial cleft deformities, including cleft lip with or without cleft palate (cl/p) and cleft palate (cp), are common congenital birth anomalies, especially in asia. |
| PubMedID- 25303326 | Background: non-syndromic cleft lip with or without cleft palate (nscl/p) is a common disorder with complex etiology. |
| PubMedID- 22345991 | Background: cleft lip with or without cleft palate (cl/p) is the most frequent craniofacial malformation seen in man. |
| PubMedID- 22514733 | Background: the bone morphogenetic protein 4 gene (bmp4) is located in chromosome 14q22-q23 which has shown evidence of linkage for isolated nonsyndromic cleft lip with or without cleft palate (nscl/p) in a genome wide linkage analysis of human multiplex families. |
| PubMedID- 26507587 | Interactions between rad51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 20946971 | Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (cl/p) in europe. |
| PubMedID- 22984993 | Non-syndromic cleft lip with or without cleft palate (nscl/p) is one of the most common of all congenital malformations and has a multifactorial etiology. |
| PubMedID- 20924451 | 1 the prevalence per 1000 total birth of cleft lip and/or with cleft palate ranges from around two in mongoloid populations to about 0.5 in negroid groups, and in caucasian populations the prevalence is about 1.2 per 1000 total birth. |
| PubMedID- 23166094 | Nonsyndromic cleft lip with or without cleft palate (nscl/p) is one of the most common craniofacial malformation in humans. |
| PubMedID- 24361572 | Evidence of the involvement of the dhfr gene in nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 22674314 | Results: in the multivariate model, the following risk factors were identified: 1) low socioeconomic status; 2) birth in the southern region of campeche state; 3) home delivery or delivery in a publicly funded hospital; 4) occurrence of prior non-syndromic cleft lip with or without cleft palate cases in the father's or mother's family: 5) having a sibling with non-syndromic cleft lip with or without cleft palate; 6) the proband having another malformation, and 7) a history of infections during pregnancy. |
| PubMedID- 20544801 | Background: cleft lip with or without cleft palate (cl/p) is one of the most common craniofacial malformations, with a complex and multifactorial etiology. |
| PubMedID- 26361024 | The most common cranial defect was medial cleft lip with cleft palate (27.3%), bilateral cleft lip (11%) or both (38.2%), cyclopia (14%), single nostril (10.9%) and proboscis (9.1%). |
| PubMedID- 23735067 | Ten patients of >/= 8 years to cleft palate, with or without cleft lip, with no other systemic illness and normal intelligent quotient level, were selected and managed by palatal lift prosthesis. |
| PubMedID- 24437584 | Objective: nonsyndromic cleft lip with or without cleft palate (nscl+/-p) is a common craniofacial anomaly of complex etiology in people. |
| PubMedID- 25300891 | Non-syndromic cleft lip with or without cleft palate (nscl/p) is one of the most common defects in the human facial structure. |
| PubMedID- 21254359 | Background: nonsyndromic cleft lip with or without cleft palate (nsclp) is a common complex birth defect. |
| PubMedID- 20020508 | Nonsyndromic cleft lip with or without cleft palate (clp) is a frequent craniofacial malformation caused by both genetic and environmental factors. |
| PubMedID- 20531946 | Four congenital birth defects were diagnosed in neonates born from mother reporting ili during pregnancy, one in the pdm flu group (ventricular septal defect, n = 1), three in the non pdm ili group (cleft lip without cleft palate, n = 1, cleft lip with cleft palate, n = 1, hypospadias, n = 1). |
| PubMedID- 23136939 | Results: there were 2989 controls (3.5% exposed), 805 cases of cleft lip with or without cleft palate (5.8% exposed), and 439 cases of cleft palate alone (4.6% exposed). |
| PubMedID- 22522387 | Background: nonsyndromic cleft lip with or without cleft palate (nscl/p) is a common congenital malformation associated with genetic and environmental risk factors. |
| PubMedID- 21423016 | Probandwise concordance rates and heritability for twins were estimated for 2 phenotypes--cleft lip with or without cleft palate (cl/p) and cleft palate (cp). |
| PubMedID- 26436110 | Nonsyndromic cleft lip with or without cleft palate (nsclp) is a common birth defect affecting 135,000 newborns worldwide each year. |
| PubMedID- 23008150 | Background: nonsyndromic cleft lip with or without cleft palate (nscl/p) is a common birth defect with complex etiology reflecting the action of multiple genetic and environmental factors. |
| PubMedID- 19691087 | cleft lip with or without cleft palate showed a different pattern by gender, urban-rural classification, and geographic location when compared to cleft palate, particularly for nonsyndromic cases. |
| PubMedID- 21244519 | No evidence for a role of crispld2 in non-syndromic cleft lip with or without cleft palate in an italian population. |
| PubMedID- 25444729 | cleft lip with or without cleft palate is the most common congenital malformation of the head and neck. |
| PubMedID- 25953455 | Objective: non-syndromic cleft lip, with or without cleft palate (nscl/p) is a common craniofacial birth defect, characterised by an incomplete separation between nasal and oral cavities without any other congenital anomaly in humans. |
| PubMedID- 24634360 | Nonsyndromic cleft lip with or without cleft palate in arab populations: genetic analysis of 15 risk loci in a novel case-control sample recruited in yemen. |
| PubMedID- 26043427 | Association between polymorphisms at the grem1 locus and the risk of nonsyndromic cleft lip with or without cleft palate in the polish population. |
| PubMedID- 26110153 | Background: non-syndromic cleft lip with or without cleft palate (nscl/p) is one of the most common congenital abnormalities of the orofacial region with a multifactorial etiology. |
| PubMedID- 22074045 | Background : isolated, nonsyndromic cleft lip with or without cleft palate is a common human congenital malformation with a complex and heterogeneous etiology. |
| PubMedID- 26322296 | Oral and maxillofacial surgeons can use ultrasonographic imaging of fetal cleft lip with or without cleft palate to provide information regarding treatment protocols and outcomes to the parent. |
| PubMedID- 23226815 | Objective: cleft lip with or without cleft palate is the most common orofacial congenital anomaly among live births. |
| PubMedID- 20087401 | Two genes (stk32b and evc) yielded consistent evidence from cleft lip, with or without cleft palate, trios in all four populations. |
| PubMedID- 22887353 | Background: nonsyndromic cleft lip with or without cleft palate (nscl/p) is one of the most common congenital anomalies, with a complex and still not fully understood etiology. |
| PubMedID- 23679094 | Background: nonsyndromic cleft lip with or without cleft palate (nscl/p) is the most common orofacial birth defect with a wide range prevalence among different populations. |
| PubMedID- 24134478 | A significantly increasing trend over the 25-year period was observed for cleft lip with or without cleft palate associated with syndromes or chromosomal anomalies among mothers younger than 35 years but not in those older than 35 years. |
| PubMedID- 23385809 | Lower incidence of nonsyndromic cleft lip with or without cleft palate in females: is homocysteine a factor. |
| PubMedID- 25045080 | Background: the etiology of nonsyndromic cleft lip with or without cleft palate (nscl/p) is very complex and still not well elucidated. |