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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease carcinoid syndrome
Symptom C0011991|diarrhea
Sentences 9
PubMedID- 21678105 The classical carcinoid syndrome with flush, diarrhea and cardiac strain is observed only in 20-30% of patients.
PubMedID- 21623673 Background: diarrhea is part of the carcinoid syndrome and a significant clinical problem in neuroendocrine tumor (net) patients.
PubMedID- 25636046 Context: carcinoid syndrome (cs) is associated with elevated serotonin, diarrhea, flushing, and increased risk of valvular heart disease.
PubMedID- 25012985 Our observations suggest that telotristat etiprate has activity in controlling diarrhea associated with carcinoid syndrome.
PubMedID- 24714698 By this mechanism, somatostatin analogs prevent spontaneous and provoked flushing and secretory diarrhea in patients with carcinoid syndrome.
PubMedID- 25889934 Only one patient had symptoms of carcinoid syndrome with spurious diarrhea and flushing.
PubMedID- 24213230 Somatostatin analogues effectively inhibit hormonal secretion and ameliorate flushing and diarrhea in about 75% of patients with carcinoid syndrome (40%–100%) 7.
PubMedID- 25323816 The case highlights the importance of considering functional nets, especially carcinoid syndrome, in patients with chronic unresolving diarrhea, since early diagnosis allows for further treatment options that can prolong survival.
PubMedID- 22518322 Small bowel carcinoids, for example, produce serotonin giving rise to the classical carcinoid syndrome with flushing, diarrhea, right-sided heart disease and asthma.

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