eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | american trypanosomiasis |
| Symptom | C0878544|cardiomyopathy |
| Sentences | 8 |
| PubMedID- 21734249 | The transfer of the parasite mitochondrial kinetoplast dna (kdna) minicircle to the genome of chagasic patients can explain the pathogenesis of the disease; in cases of chagas' disease with evident cardiomyopathy, the kdna minicircles integrate mainly into retrotransposons at several chromosomes, but the minicircles are also detected in coding regions of genes that regulate cell growth, differentiation, and immune responses. |
| PubMedID- 23357302 | chagas' disease (cd) often leads to dilated cardiomyopathy (dcm), and during its chronic stage hematopoietic stem or progenitor cells are involved in its pathological process. |
| PubMedID- 23451183 | Elevated serum levels of macrophage migration inhibitory factor are associated with progressive chronic cardiomyopathy in patients with chagas disease. |
| PubMedID- 24472559 | Chronic t. cruzi infection, resulting in chronic chagas disease can lead to cardiomyopathy due to the immune response damaging the tissues of the heart. |
| PubMedID- 24282718 | In its chronic stage, chagas disease can lead to a severe cardiomyopathy for which there is currently no cure. |
| PubMedID- 22545173 | As we suspected, cd4+cd25+ t cells from chagas' disease patients with severe cardiomyopathy presented reduced capacity to suppress t cell proliferation when compared to free/mild cardiomyopathy patients and healthy individuals. |
| PubMedID- 21408088 | The same group compared 166 chronic chagas disease patients with cardiomyopathy to 80 asymptomatic patients, but observed no significant association with tnf polymorphisms . |
| PubMedID- 25993486 | Background: chagas disease is a cause of dilated cardiomyopathy, and information about left atrial (la) function in this disease still lacks. |
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