eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | adenomatous polyposis coli |
| Symptom | C0007102|colon cancer |
| Sentences | 7 |
| PubMedID- 24139208 | Alterations in this gene have been found in most sporadic colon cancers; associated with familial adenomatous polyposis; and found in neoplasms of other organs, such as the liver, stomach, lung, breast, and cerebellar medulloblastoma. |
| PubMedID- 19966865 | Biallelic mutations of the apc gene lead tocolon cancer in familial adenomatous polyposis coli (fap) and result in the synthesis of truncated products lacking domains involved in beta-catenin degradation but still having a minimal length. |
| PubMedID- 25622583 | Results: radical total colectomy, right hemicolectomy, left hemicolectomy, sigmoidectomy, and proctectomy and were performed in 1 case of familial adenomatous polyposis with transverse colon cancer, 5 cases of cecal or asending colon cancer, 1 case of descending colon cancer, 14 cases of sigmoid colon cancer, and 14 cases of rectal cancer respectively. |
| PubMedID- 20578576 | Introduction: total colectomy is the only effective treatment for prophylaxis against colon cancer in patients with familial adenomatous polyposis (fap). |
| PubMedID- 25516682 | She had undergone a total colectomy for ascending colon cancer associated with familial adenomatous polyposis 22 years previously. |
| PubMedID- 20725517 | In late 1999 celecoxib was approved by the fda for the prevention of colon cancer in patients with familial adenomatous polyposis, which is a hereditary precancerous disease due to a loss of the adenomatous polyposis coli tumor suppressor gene. |
| PubMedID- 24204315 | Here we have generated a mir-10a knock out (ko) mouse and crossed it with the apcmin colon cancer mouse model of familial adenomatous polyposis. |
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