eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cystic fibrosis |
| Symptom | |infections |
| Sentences | 163 |
| PubMedID- 24363931 | Home self-collection of nasal swabs for diagnosis of acute respiratory virus infections in children with cystic fibrosis. |
| PubMedID- 24119232 | Strains of the burkholderia cepacia complex (bcc) are opportunistic pathogens that cause life-threatening infections in patients with cystic fibrosis (cf) and chronic granulomatous disease (cgd). |
| PubMedID- 21811611 | Burkholderia cenocepacia is an important opportunistic pathogen causing respiratory infections in individuals with cystic fibrosis (cf). |
| PubMedID- 21942255 | All approved antimicrobial agents for administration by inhalation are indicated for pseudomonas aeruginosa infections in patients with cystic fibrosis. |
| PubMedID- 21781329 | Background: burkholderia cenocepacia is a member of the burkholderia cepacia complex group of bacteria that cause infections in individuals with cystic fibrosis. |
| PubMedID- 25474359 | Burkholderia species infections in patients with cystic fibrosis in british columbia, canada. |
| PubMedID- 24454693 | P. aeruginosa is also widely studied as an opportunistic pathogen of plants, animals and humans and in particular, as a pathogen causing persistent and frequently fatal lung infections in patients with cystic fibrosis (cf) 8. |
| PubMedID- 25657265 | Pandoraea is an emerging respiratory pathogen capable of causing chronic lung infections in people with cystic fibrosis (cf), but the clinical significance of this infection is ambiguous. |
| PubMedID- 23844246 | B. cenocepacia is an environmental, opportunistic pathogen that causes serious infections in patients with cystic fibrosis and expresses high-level multidrug resistance 2. |
| PubMedID- 19918014 | Potential risk factors for death measured at baseline included age, sex, ethnicity, bmi, pulmonary function, diabetes, respiratory infections, class of cystic fibrosis transmembrane conductance regulator (cftr) alleles, diagnosis of cystic fibrosis by neonatal screening, prior organ transplantation, and other medical interventions as described below. |
| PubMedID- 25036925 | Chronic bacterial lung infections associated with non-cystic fibrosis bronchiectasis represent a substantial and growing health-care burden. |
| PubMedID- 24136845 | Pseudomonas aeruginosa frequently establishes chronic infections in the airways of patients suffering from cystic fibrosis (cf). |
| PubMedID- 23503622 | The non-motile forms are very difficult to eradicate and are often associated with the establishment of persistent infections, especially in patients with cystic fibrosis. |
| PubMedID- 20829108 | Burkholderia cepacia complex (bcc) is a group of gram-negative pulmonary pathogens associated with life-threatening infections in patients with cystic fibrosis (cf). |
| PubMedID- 23533140 | Overproduction of alginate, also known as mucoidy, affords the bacterium protection from the host's defenses and facilitates the establishment of chronic lung infections in individuals with cystic fibrosis. |
| PubMedID- 22196973 | Pseudomonas aeruginosa is the major pathogen in chronic lung infections of individuals with cystic fibrosis (cf). |
| PubMedID- 24223216 | Members of the burkholderia cepacia complex (bcc) have emerged in recent decades as problematic pulmonary pathogens of cystic fibrosis (cf) patients, with severe infections progressing to acute necrotizing pneumonia and sepsis. |
| PubMedID- 21178134 | Tobramycin inhalation solution usp (tobi), a therapy developed to treat lung infections associated with cystic fibrosis (cf), was presented as a demonstration case for collaborative pharmaceutical development at a clinical and translational science awards industry forum on "promoting efficient and effective collaborations among academia, government, and industry" held in february 2010. |
| PubMedID- 24526633 | The bcc have the potential to cause chronic and severe airway infections in persons with cystic fibrosis (cf) (2). |
| PubMedID- 25680398 | We believe that manuka honey may have a role to play in the management of cystic fibrosis patients with chronic respiratory infections, and in the future, we intend to investigate the activity of honey with a much larger range of bacteria and antibiotic combinations and to determine the susceptibilities of biofilms, as well as suspension cultures. |
| PubMedID- 21151973 | It is a cause of life-threatening lung infections in individuals with cystic fibrosis (cf), which are impossible to eradicate due to the biofilm lifestyle, adopted by this microorganism . |
| PubMedID- 21303421 | Biofilm-associated chronic pseudomonas aeruginosa lung infections in patients with cystic fibrosis are virtually impossible to eradicate with antibiotics because biofilm-growing bacteria are highly tolerant to antibiotics and host defense mechanisms. |
| PubMedID- 25147668 | One of the most medically important biofilm-forming species is pseudomonas aeruginosa, which is commonly associated with lung infections in patients with cystic fibrosis. |
| PubMedID- 25861288 | During the last 2 decades, colistin was mainly restricted to treat acute exacerbations of lung infections in patients with cystic fibrosis . |
| PubMedID- 24565502 | Reports from the united states, france, and israel have shown that the m. abscessus group accounts for a major proportion of ntm infections in patients with cystic fibrosis; prevalence rates range from 16% to 48% (1–3). |
| PubMedID- 24393536 | Members of the burkholderia cepacia complex (bcc) can cause severe respiratory infections in individuals with cystic fibrosis (cf) 1. |
| PubMedID- 23281188 | In chronic lung infections of people with cystic fibrosis, p. aeruginosa inhabits viscous, adhesive mucus, which likely retards the diffusion of secreted molecules. |
| PubMedID- 24068273 | The objective of this review was to address current concepts related to the clinical impact, diagnosis, and treatment of pseudomonas aeruginosa infections in patients with cystic fibrosis. |
| PubMedID- 25488299 | Pseudomonas aeruginosa is an opportunistic human pathogen and a major cause of chronic infections in individuals with cystic fibrosis (cf). |
| PubMedID- 24527289 | Sequence analysis of clinical isolates obtained from seven cystic fibrosis (cf) patients with chronic infections that were collected over 16.3 years identified loss-of-function mutants for 7 of these 15 genes. |
| PubMedID- 25669133 | cystic fibrosis patients with p. aeruginosa infections have highly viscous sputum with edna concentrations of 3–14 mg/ml and pyocyanin concentrations up to 27 μg/ml (~130 μm)1819. recently, pyocyanin was shown to facilitate edna binding to p. aeruginosa cell surfaces to affect cellular aggregation20. |
| PubMedID- 22767545 | Burkholderia cenocepacia is a member of the burkholderia cepacia complex (bcc), a group of gram-negative opportunistic pathogens that cause severe lung infections in patients with cystic fibrosis and display extreme intrinsic resistance to antibiotics, including antimicrobial peptides. |
| PubMedID- 25653647 | Pseudomonas aeruginosa is the most common cause of chronic lung infections affecting individuals with cystic fibrosis (cf). |
| PubMedID- 21935381 | P. aeruginosa is often the cause of life-threatening infections in people with cystic fibrosis, burns victims and immuno-compromised individuals . |
| PubMedID- 20300602 | The opportunistic pathogen pseudomonas aeruginosa is responsible for chronic infections in the airways of cystic fibrosis (cf) patients and for much of the associated morbidity and mortality 1. |
| PubMedID- 21991261 | For example, p. aeruginosa isolates obtained from chronic pulmonary infections of patients with cystic fibrosis (cf) are often mucoid. |
| PubMedID- 22069491 | Pseudomonas aeruginosa is an opportunistic pathogen that causes both acute pneumonitis in immunocompromised patients and chronic lung infections in individuals with cystic fibrosis and other bronchiectasis. |
| PubMedID- 20161732 | P. aeruginosa causes lethal chronic airway infections in patients with cystic fibrosis and bronchiectasis. |
| PubMedID- 23233287 | In humans, p. aeruginosa causes serious, and often chronic, infections in those with cystic fibrosis and in immunocompromised individuals, such as those with aids, patients undergoing chemotherapy and those with severe burns (lyczak et al. |
| PubMedID- 20093293 | Pseudomonas aeruginosa is the major aetiological agent of chronic pulmonary infections in patients with cystic fibrosis (cf). |
| PubMedID- 26360059 | It often causes opportunistic infections in hospitalized patients of cystic fibrosis and burn victim who are immunosuppressed or immunocompromised . |
| PubMedID- 24015228 | Given the increasing prevalence of multi-antibiotic resistant strains of p. aeruginosa bacteria, novel therapeutic approaches for the treatment of chronic infections in individuals with cystic fibrosis will be essential to ensure the continued health of these patients in the coming years. |
| PubMedID- 26253522 | Pseudomonas aeruginosa causes chronic lung infections in people with cystic fibrosis (cf) and acute opportunistic infections in people without cf. |
| PubMedID- 21395432 | Abstract at present, the only approved inhaled antipseudomonal antibiotics for chronic pulmonary infections in patients with cystic fibrosis (cf) are nebulized solutions. |
| PubMedID- 24737619 | Why is a healthy person protected from pseudomonas aeruginosa infections, while individuals with cystic fibrosis or damaged epithelium are particularly susceptible to this opportunistic pathogen. |
| PubMedID- 22919658 | Burkholderia cepacia complex (bcc) bacteria can cause devastating chronic infections in people with cystic fibrosis. |
| PubMedID- 22848588 | Burkholderia cepacia complex (bcc) bacteria are a problematic group of microorganisms causing severe infections in patients with cystic fibrosis. |
| PubMedID- 23287542 | Burkholderia cenocepacia may cause serious infections in patients with cystic fibrosis, and this microorganism can be highly transmissible. |
| PubMedID- 21949654 | However, how bacteria establish chronic infections, as observed in patients with cystic fibrosis (cf), and the reasons that these infective agents cannot be eliminated by the immune system are still largely unclear . |
| PubMedID- 20625718 | Aeruginosa even in mature biofilms and cationic steroid antibiotics can thus be considered as potential candidates for the treatment of chronic pulmonary infections of patients with cystic fibrosis. |