eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| vipoma | ||||
| Disease ID | 744 |
|---|---|
| Disease | vipoma |
| Definition | A tumor that secretes VASOACTIVE INTESTINAL PEPTIDE, a neuropeptide that causes VASODILATION; relaxation of smooth muscles; watery DIARRHEA; HYPOKALEMIA; and HYPOCHLORHYDRIA. Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. In most cases, Vipomas are located in the PANCREAS but can be found in extrapancreatic sites. |
| Synonym | adenoma, pancreatic alpha-d islet cell diarrheogenic islet cell tumor diarrheogenic tumor diarrheogenic tumors islet cell, alpha-d, pancreatic adenoma pancreatic alpha-d islet cell adenoma pancreatic vipoma pancreatic vipomas tumor, diarrheogenic tumor, vip-secreting (vipoma) tumors, diarrheogenic tumors, vip-secreting (vipoma) vasoactive intestinal peptide (vip) tumor vasoactive intestinal peptide producing adenoma vasoactive intestinal peptide producing neoplasm vasoactive intestinal peptide producing tumor vasoactive intestinal peptide secreting adenoma vasoactive intestinal peptide secreting neoplasm vasoactive intestinal peptide-producing tumor vasoactive intestinal peptide-secreting tumor vasoactive intestinal peptide-secreting tumor (disorder) vasoactive intestinal peptide-secreting tumour vip producing adenoma vip producing neoplasm vip secreting adenoma vip secreting tumor (vipoma) vip- secreting neoplasm vip- secreting tumor vip-oma - vasoactive intestinal peptide-secreting tumor vip-oma - vasoactive intestinal peptide-secreting tumour vip-producing net vip-producing neuroendocrine tumor vip-secreting tumor (vipoma) vip-secreting tumors (vipoma) vipoma (morphologic abnormality) vipoma [disease/finding] vipoma, pancreatic vipomas vipomas, pancreatic |
| Orphanet | |
| DOID | |
| UMLS | C0011993 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:5) |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:3) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:13) 415 | ARSE | 1.69 | DISEASES 796 | CALCA | 1.356 | DISEASES 1114 | CHGB | 2.007 | DISEASES 2520 | GAST | 3.601 | DISEASES 2641 | GCG | 2.321 | DISEASES 51738 | GHRL | 1.167 | DISEASES 3274 | HRH2 | 2.154 | DISEASES 4221 | MEN1 | 4.51 | DISEASES 6611 | SMS | 2.853 | DISEASES 11005 | SPINK5 | 1.65 | DISEASES 6752 | SSTR2 | 1.3 | DISEASES 7432 | VIP | 5.88 | DISEASES 7433 | VIPR1 | 1.904 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 744 |
|---|---|
| Disease | vipoma |
| Integrated Phenotype | HPO | Name(Total Integrated Phenotypes:41) HP:0001438 | Abnormality of the abdomen HP:0005208 | Secretory diarrhea HP:0002896 | Neoplasm of the liver HP:0001824 | Weight loss HP:0000845 | Growth hormone excess HP:0012432 | Chronic fatigue HP:0003005 | Ganglioneuroma HP:0006731 | Follicular thyroid carcinoma HP:0002573 | Hematochezia HP:0010783 | Erythema HP:0001031 | Subcutaneous lipoma HP:0000837 | Increased circulating gonadotropin level HP:0002017 | Nausea and vomiting HP:0003394 | Muscle cramps HP:0001895 | Normochromic anemia HP:0012334 | Extrahepatic cholestasis HP:0001944 | Dehydration HP:0002574 | Episodic abdominal pain HP:0008200 | Primary hyperparathyroidism HP:0001541 | Ascites HP:0002024 | Malabsorption HP:0008256 | Adrenocortical adenoma HP:0003528 | Elevated calcitonin HP:0001406 | Intrahepatic cholestasis HP:0002893 | Pituitary adenoma HP:0002900 | Hypokalemia HP:0002747 | Respiratory insufficiency due to muscle weakness HP:0002240 | Hepatomegaly HP:0001578 | Hypercortisolism HP:0000820 | Abnormality of the thyroid gland HP:0003072 | Hypercalcemia HP:0004396 | Poor appetite HP:0001046 | Intermittent jaundice HP:0000870 | Prolactin excess HP:0002894 | Neoplasm of the pancreas HP:0000819 | Diabetes mellitus HP:0030895 | Abnormal gastrointestinal motility HP:0003324 | Generalized muscle weakness HP:0006719 | Benign gastrointestinal tract tumors HP:0002039 | Anorexia HP:0002897 | Parathyroid adenoma |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:8) HP:0002664 | Neoplasia | 2 HP:0030731 | Carcinoma | 1 HP:0003002 | Breast carcinoma | 1 HP:0100568 | Endocrine neoplasia | 1 HP:0001297 | Cerebral vascular events | 1 HP:0002014 | Diarrhea | 1 HP:0002140 | Ischemic stroke | 1 HP:0030404 | Glucagonoma | 1 |
| Disease ID | 744 |
|---|---|
| Disease | vipoma |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:4) |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:1) |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:16) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0002897 | Parathyroid adenoma | MP:0013383 | increased sebaceous gland adenoma incidence | greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period |
| HP:0000845 | Growth hormone excess | MP:0003497 | insensitivity to parathyroid hormone | no changes in calcium homeostasis in response to endogenous or exogenous hormone |
| HP:0001895 | Normochromic anemia | MP:0001585 | hemolytic anemia | deficiency of red cells resulting from an increased rate of erythrocyte destruction |
| HP:0002893 | Pituitary adenoma | MP:0013383 | increased sebaceous gland adenoma incidence | greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period |
| HP:0000837 | Increased circulating gonadotropin level | MP:0011533 | increased urine major urinary protein level | increased amount in the urine of a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | MP:0000748 | progressive muscle weakness | increasing loss of muscle strength over time |
| HP:0003324 | Generalized muscle weakness | MP:0000747 | muscle weakness | loss of muscle strength |
| HP:0008256 | Adrenocortical adenoma | MP:0013383 | increased sebaceous gland adenoma incidence | greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period |
| HP:0006731 | Follicular thyroid carcinoma | MP:0005314 | absent thyroid gland | lack of the endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin |
| HP:0000820 | Abnormality of the thyroid gland | MP:0020010 | decreased bone mineral density of femur | reduction in the quatitative measurment value of mineral content of bone in the long bone of the thigh |
| HP:0006719 | Benign gastrointestinal tract tumors | MP:0010279 | increased gastrointestinal tumor incidence | greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period |
| HP:0001406 | Intrahepatic cholestasis | MP:0005415 | intrahepatic cholestasis | impairment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts |
| HP:0002017 | Nausea and vomiting | MP:0010426 | abnormal heart and great artery attachment | any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta |
| HP:0002894 | Neoplasm of the pancreas | MP:0008261 | arrest of male meiosis | cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell |
| HP:0001438 | Abnormality of the abdomen | MP:0008261 | arrest of male meiosis | cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell |
| HP:0001824 | Weight loss | MP:0005114 | premature hair loss | release of fur at an earlier than expected time |
Mapped by homologous gene(Total Items:37) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001578 | Hypercortisolism | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0004396 | Poor appetite | MP:0013467 | diaphragmitis | inflammation of the diaphragm |
| HP:0000845 | Growth hormone excess | MP:0014169 | decreased brown adipose tissue mass | decreased physical bulk or volume of brown adipose tissue |
| HP:0000837 | Increased circulating gonadotropin level | MP:0014193 | decreased epididymal cell proliferation | decrease in the expansion rate of any epididymal cell population by cell division |
| HP:0001046 | Intermittent jaundice | MP:0013504 | increased embryonic tissue cell apoptosis | increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death |
| HP:0001944 | Dehydration | MP:0014206 | decreased intestinal epithelial sodium ion transmembrane transport | |
| HP:0002893 | Pituitary adenoma | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
| HP:0010783 | Erythema | MP:0013781 | abnormal mammary gland luminal epithelium morphology | any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective ti |
| HP:0000820 | Abnormality of the thyroid gland | MP:0020169 | increased thyroid gland weight | higher than average weight of the thyroid gland |
| HP:0003394 | Muscle cramps | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002240 | Hepatomegaly | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0002024 | Malabsorption | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001031 | Subcutaneous lipoma | MP:0014171 | increased fatty acid oxidation | increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydr |
| HP:0002900 | Hypokalemia | MP:0014206 | decreased intestinal epithelial sodium ion transmembrane transport | |
| HP:0006731 | Follicular thyroid carcinoma | MP:0012080 | chylous ascites | the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms |
| HP:0003072 | Hypercalcemia | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0000819 | Diabetes mellitus | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0002897 | Parathyroid adenoma | MP:0013602 | abnormal Leydig cell differentiation | atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development |
| HP:0003528 | Elevated calcitonin | MP:0013006 | abnormal enteric neural crest cell migration | any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal t |
| HP:0003324 | Generalized muscle weakness | MP:0020234 | decreased basal metabolism | decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state |
| HP:0001541 | Ascites | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0002017 | Nausea and vomiting | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002573 | Hematochezia | MP:0013745 | abnormal eyelid margin morphology | any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium |
| HP:0002039 | Anorexia | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0002574 | Episodic abdominal pain | MP:0012504 | increased forebrain apoptosis | increase in the number of cells of the forebrain undergoing programmed cell death |
| HP:0001895 | Normochromic anemia | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0002894 | Neoplasm of the pancreas | MP:0014126 | increased mammary gland apoptosis | increase in the number of any cells of a mammary gland undergoing programmed cell death |
| HP:0008200 | Primary hyperparathyroidism | MP:0013572 | abnormal parathyroid gland chief cell morphology | any structural anomaly of an epithelial cell that are collectively arranged in wide, irregular interconnecting columns in the parathyroid gland, that is responsible for the synthesis and secretion of parathyroid hormone (PTH) |
| HP:0001406 | Intrahepatic cholestasis | MP:0020134 | abnormal gallbladder size | an anomaly in the size of the gall bladder compared to average, the organ that serves as a storage reservoir for bile |
| HP:0001824 | Weight loss | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0000870 | Prolactin excess | MP:0014167 | ectopic bone | the appearance of an extra bone structure at an atypical location |
| HP:0005208 | Secretory diarrhea | MP:0011105 | embryonic lethality between implantation and placentation, incomplete penetrance | the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9) |
| HP:0003005 | Ganglioneuroma | MP:0013795 | abnormal colon goblet cell morphology | any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0006719 | Benign gastrointestinal tract tumors | MP:0012431 | increased lymphoma incidence | greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period |
| HP:0008256 | Adrenocortical adenoma | MP:0013602 | abnormal Leydig cell differentiation | atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development |
| HP:0001438 | Abnormality of the abdomen | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| Disease ID | 744 |
|---|---|
| Disease | vipoma |
| Case | (Waiting for update.) |