eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| tick-borne encephalitis | ||||
| Disease ID | 1225 |
|---|---|
| Disease | tick-borne encephalitis |
| Definition | Encephalitis caused by neurotropic viruses that are transmitted via the bite of TICKS. In Europe, the diseases are caused by ENCEPHALITIS VIRUSES, TICK-BORNE, which give rise to Russian spring-summer encephalitis, central European encephalitis, louping ill encephalitis, and related disorders. Powassan encephalitis occurs in North America and Russia and is caused by the Powassan virus. ASEPTIC MENINGITIS and rarely encephalitis may complicate COLORADO TICK FEVER which is endemic to mountainous regions of the western United States. (From Joynt, Clinical Neurology, 1996, Ch26, pp14-5) |
| Synonym | [x]tick-borne viral encephalitis, unspecified [x]tick-borne viral encephalitis, unspecified (disorder) enceph tick borne encephalitides, tick-borne encephalitis due to tick-borne encephalitis virus (disorder) encephalitis due to tick-borne encephalitis virus (navigational concept) encephalitis, tick borne encephalitis, tick-borne encephalitis, tick-borne [disease/finding] tick borne enceph tick borne encephalitis tick-borne enceph nos tick-borne encephalitides tick-borne viral encephalitis tick-borne viral encephalitis (disorder) tick-borne viral encephalitis nos tick-borne viral encephalitis nos (disorder) tick-borne viral encephalitis, nos tick-borne viral encephalitis, unspecified viral encephalitis transmitted by tick viral encephalitis transmitted by tick (disorder) viral encephalitis transmitted by tick (navigational concept) |
| Orphanet | |
| DOID | |
| UMLS | C0014061 |
| MeSH | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:3) |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | Entrez_id | Symbol | Score | Resource(Total Genes:41) 79872 | CBLL1 | 2.918 | DISEASES 959 | CD40LG | 5.154 | DISEASES 10521 | DDX17 | 2.207 | DISEASES 1667 | DEFA1 | 2.284 | DISEASES 728358 | DEFA1B | 2.284 | DISEASES 1668 | DEFA3 | 2.058 | DISEASES 1660 | DHX9 | 1.455 | DISEASES 10938 | EHD1 | 1.45 | DISEASES 2048 | EPHB2 | 1.291 | DISEASES 30816 | ERVW-1 | 3.463 | DISEASES 10146 | G3BP1 | 1.932 | DISEASES 2934 | GSN | 1.736 | DISEASES 2996 | GYPE | 1.797 | DISEASES 3384 | ICAM2 | 1.536 | DISEASES 3455 | IFNAR2 | 2.096 | DISEASES 3456 | IFNB1 | 1.094 | DISEASES 3586 | IL10 | 1.95 | DISEASES 3638 | INSIG1 | 1.676 | DISEASES 5641 | LGMN | 1.825 | DISEASES 92399 | MRRF | 2.079 | DISEASES 4513 | MT-CO2 | 1.391 | DISEASES 136319 | MTPN | 2.548 | DISEASES 4600 | MX2 | 1.601 | DISEASES 4938 | OAS1 | 2.793 | DISEASES 4939 | OAS2 | 3.815 | DISEASES 5116 | PCNT | 3.135 | DISEASES 23221 | RHOBTB2 | 2.358 | DISEASES 26766 | RNU105C | 2.647 | DISEASES 862 | RUNX1T1 | 1.947 | DISEASES 55576 | STAB2 | 2.606 | DISEASES 55342 | STRBP | 2.993 | DISEASES 6892 | TAPBP | 1.571 | DISEASES 26136 | TES | 1.352 | DISEASES 7019 | TFAM | 1.038 | DISEASES 7037 | TFRC | 1.23 | DISEASES 10618 | TGOLN2 | 1.128 | DISEASES 7073 | TIAL1 | 2.288 | DISEASES 7124 | TNF | 1.567 | DISEASES 51175 | TUBE1 | 3.427 | DISEASES 117608 | ZNF354B | 3.682 | DISEASES 57541 | ZNF398 | 3.12 | DISEASES |
| Locus | (Waiting for update.) |
| Disease ID | 1225 |
|---|---|
| Disease | tick-borne encephalitis |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:3) HP:0001945 | Fever | 2 HP:0002383 | Encephalitis | 1 HP:0010628 | Facial palsy, unilateral or bilateral | 1 |
| Disease ID | 1225 |
|---|---|
| Disease | tick-borne encephalitis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:13) C2707258 | infections C2364133 | infection C1611280 | allergy C1401790 | kozhevnikov's epilepsy C0752303 | urological manifestation C0458385 | localized skin infection C0275524 | mixed infection C0235031 | neurological symptoms C0042749 | viremia C0033774 | pruritus C0032587 | polyradiculoneuropathy C0025289 | meningitis C0018799 | cardiac diseases |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:2) |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:5) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs3775291 | 23721942 | 7098 | TLR3 | umls:C0014061 | BeFree | Association of single nucleotide polymorphism rs3775291 in the coding region of the TLR3 gene with predisposition to tick-borne encephalitis in a Russian population. | 0.003724241 | 2013 | TLR3 | 4 | 186082920 | C | T,G |
| rs3775291 | 23962581 | 7098 | TLR3 | umls:C0014061 | BeFree | A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection. | 0.003724241 | 2013 | TLR3 | 4 | 186082920 | C | T,G |
| rs3775291 | 23721942 | 1234 | CCR5 | umls:C0014061 | BeFree | A possible association between predisposition to TBE in a Russian population and two polymorphisms, a 32bp deletion in the coding region of the chemokine receptor CCR5 gene and the rs3775291 single nucleotide polymorphism (SNP) (G/A, Leu412Phe) in exon 4 of the toll-like receptor TLR3 gene, was investigated. | 0.002909916 | 2013 | TLR3 | 4 | 186082920 | C | T,G |
| rs386586050 | 23962581 | 7098 | TLR3 | umls:C0014061 | BeFree | A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection. | 0.003724241 | 2013 | NA | NA | NA | NA | NA |
| rs386586050 | 23721942 | 1234 | CCR5 | umls:C0014061 | BeFree | A possible association between predisposition to TBE in a Russian population and two polymorphisms, a 32bp deletion in the coding region of the chemokine receptor CCR5 gene and the rs3775291 single nucleotide polymorphism (SNP) (G/A, Leu412Phe) in exon 4 of the toll-like receptor TLR3 gene, was investigated. | 0.002909916 | 2013 | NA | NA | NA | NA | NA |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:0) |
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| (Waiting for update.) |
Mapped by homologous gene(Total Items:0) |
|---|
| (Waiting for update.) |
| Disease ID | 1225 |
|---|---|
| Disease | tick-borne encephalitis |
| Case | (Waiting for update.) |