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	sheehan syndrome

Disease ID	1398
Disease	sheehan syndrome
Definition	An uncommon cause of hypopituitarism seen after severe postpartum hemorrhaging. Prolonged hypovolemia leads to ischemic necrosis of the pituitary. Clinical signs typically present in the puerperium and include failure to begin lactation, fatigue, hypotension and eventual amenorrhea. Clinical course is usually mild, however extreme cases may progress to adrenal failure. Prognosis is most favorable when hormone replacement is initiated soon after symptom onset.
Synonym	disease, simmonds hypopituitarism, postpartum ischaemic postpartum pituitary necrosis ischemic postpartum pituitary necrosis ischemic postpartum pituitary necrosis (disorder) ischemic postpartum pituitary necrosis (disorder) [ambiguous] panhypopituitarism, postpartum pituitary insufficiency, postpartum postpartum hypopituitarism postpartum hypopituitarism (disorder) postpartum necrosis of pituitary postpartum panhypopituitarism postpartum panhypopituitary syndrome postpartum pituitary hemorrhage postpartum pituitary infarction postpartum pituitary insufficiency postpartum pituitary necrosis reye-sheehan syndrome sheehan's syndrome sheehan's syndrome (disorder) sheehans syndrome sheehans's syndrome simmond's disease simmonds dis simmonds disease simmonds' disease syndrome, sheehan syndrome, sheehan's
Orphanet	ORPHANET:91355
DOID	DOID:9476 DOID:9410
UMLS	C0242342
SNOMED-CT	SNOMEDCT_US_2016_09_01:290653008;SNOMEDCT_US_2016_09_01:237684005
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:25) C0020635 \| hypopituitarism \| 4 C0242343 \| panhypopituitarism \| 3 C0011847 \| diabetes \| 3 C0007193 \| dilated cardiomyopathy \| 3 C1565489 \| renal insufficiency \| 2 C0687720 \| central diabetes insipidus \| 2 C0030312 \| pancytopenia \| 2 C0020635 \| pituitary deficiency \| 2 C0011848 \| diabetes insipidus \| 2 C0001623 \| adrenal insufficiency \| 2 C0041296 \| tuberculosis \| 1 C0041327 \| pulmonary tuberculosis \| 1 C0011860 \| type 2 diabetes \| 1 C0878544 \| cardiomyopathy \| 1 C0020598 \| hypoglycemia \| 1 C0011860 \| type 2 diabetes mellitus \| 1 C0002453 \| amenorrhea \| 1 C0019196 \| hepatitis c \| 1 C0020676 \| hypothyroidism \| 1 C0011849 \| diabetes mellitus \| 1 C0151740 \| raised intracranial pressure \| 1 C0019158 \| hepatitis \| 1 C0033975 \| psychoses \| 1 C0018213 \| graves' disease \| 1 C0032001 \| pituitary apoplexy \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:17) 383 \| ARG1 \| 2.289 \| DISEASES 551 \| AVP \| 3.615 \| DISEASES 554 \| AVPR2 \| 1.02 \| DISEASES 930 \| CD19 \| 1.026 \| DISEASES 1443 \| CSH2 \| 1.362 \| DISEASES 80712 \| ESX1 \| 2.003 \| DISEASES 2152 \| F3 \| 1.361 \| DISEASES 2153 \| F5 \| 1.599 \| DISEASES 2157 \| F8 \| 1.571 \| DISEASES 3030 \| HADHA \| 2.838 \| DISEASES 8022 \| LHX3 \| 2.206 \| DISEASES 4524 \| MTHFR \| 1.57 \| DISEASES 5449 \| POU1F1 \| 2.06 \| DISEASES 6152 \| RPL24 \| 1.8 \| DISEASES 6658 \| SOX3 \| 2.205 \| DISEASES 7062 \| TCHH \| 1.751 \| DISEASES 3604 \| TNFRSF9 \| 1.3 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1398
Disease	sheehan syndrome
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:49) HP:0000863 \| Central diabetes insipidus HP:0008202 \| Prolactin deficiency HP:0011734 \| Central adrenal insufficiency HP:0011748 \| Adrenocorticotropic hormone deficiency HP:0001278 \| Orthostatic hypotension HP:0002019 \| Constipation HP:0007987 \| Progressive visual field defects HP:0012432 \| Chronic fatigue HP:0001662 \| Bradycardia HP:0002225 \| Sparse pubic hair HP:0030907 \| Thunderclap headache HP:0000622 \| Blurred vision HP:0008163 \| Decreased circulating cortisol level HP:0000876 \| Oligomenorrhea HP:0002829 \| Arthralgia HP:0002018 \| Nausea HP:0002215 \| Sparse axillary hair HP:0002902 \| Hyponatremia HP:0000872 \| Hashimoto thyroiditis HP:0000871 \| Panhypopituitarism HP:0001895 \| Normochromic anemia HP:0001943 \| Hypoglycemia HP:0000407 \| Sensorineural hearing impairment HP:0003158 \| Hyposthenuria HP:0012504 \| Abnormal size of pituitary gland HP:0003493 \| Antinuclear antibody positivity HP:0003187 \| Breast hypoplasia HP:0001259 \| Coma HP:0011735 \| Adrenocorticotropin deficient adrenal insufficiency HP:0030016 \| Dyspareunia HP:0000709 \| Psychosis HP:0000651 \| Diplopia HP:0001962 \| Palpitations HP:0000802 \| Impotence HP:0004396 \| Poor appetite HP:0030018 \| Decreased female libido HP:0001513 \| Obesity HP:0002321 \| Vertigo HP:0000141 \| Amenorrhea HP:0001324 \| Muscle weakness HP:0000958 \| Dry skin HP:0008213 \| Gonadotropin deficiency HP:0008214 \| Decreased serum estradiol HP:0007041 \| Chronic lymphocytic meningitis HP:0000980 \| Pallor HP:0002315 \| Headache HP:0008240 \| Secondary growth hormone deficiency HP:0008245 \| Pituitary hypothyroidism HP:0025143 \| Chills
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:26) HP:0040075 \| Hypopituitarism \| 4 HP:0001644 \| Congestive cardiomyopathy \| 3 HP:0000871 \| Panhypopituitarism \| 3 HP:0001876 \| Low blood cell count \| 2 HP:0011734 \| Central adrenal insufficiency \| 2 HP:0000863 \| Neurohypophyseal diabetes insipidus \| 2 HP:0000846 \| Hypoadrenalism \| 2 HP:0000873 \| Diabetes insipidus \| 2 HP:0000083 \| Renal insufficiency \| 2 HP:0000821 \| Underactive thyroid \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0003201 \| Rhabdomyolysis \| 1 HP:0001649 \| Tachycardia \| 1 HP:0000869 \| Secondary amenorrhea \| 1 HP:0004756 \| Ventricular tachycardia \| 1 HP:0002902 \| Hyponatremia \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0001695 \| Cardiac arrest \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0000141 \| Abnormal absence of menstruation \| 1 HP:0011787 \| Central hypothyroidism \| 1 HP:0002917 \| Low blood magnesium levels \| 1 HP:0002148 \| Hypophosphataemia \| 1 HP:0001638 \| Cardiomyopathy \| 1 HP:0001943 \| Hypoglycemia \| 1

Disease ID	1398
Disease	sheehan syndrome
Manually Symptom	UMLS \| Name(Total Manually Symptoms:4) C0878683 \| panhypopituitarism C0206083 \| central pontine myelinolysis C0022660 \| acute renal failure C0020615 \| hypoglycemia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:6) C0242343 \| panhypopituitarism \| 3 C0020635 \| hypopituitarism \| 2 C0030312 \| pancytopenia \| 2 C0271801 \| central hypothyroidism \| 1 C0020676 \| hypothyroidism \| 1 C0033975 \| psychoses \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:12)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001895	Normochromic anemia	MP:0001585	hemolytic anemia	deficiency of red cells resulting from an increased rate of erythrocyte destruction
HP:0003493	Antinuclear antibody positivity	MP:0004762	increased anti-double stranded DNA antibody level	increase in the level of antibodies that recognize double stranded DNA
HP:0000958	Dry skin	MP:0010678	abnormal skin adnexa morphology	any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails
HP:0002215	Sparse axillary hair	MP:0004396	decreased cochlear inner hair cell number	decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti
HP:0002225	Sparse pubic hair	MP:0009575	abnormal pubic symphysis morphology	any structural anomaly of the firm fibrocartilaginous joint in the median plane between the two opposing surfaces of the pubic bones, which are united by an interpubic disc of fibrocartilage as well as the superior and arcuate pubic ligaments
HP:0000407	Sensorineural hearing impairment	MP:0006330	syndromic hearing impairment	hearing impairment that is usually associated with malformations of the external ear and other inherited signs and symptoms
HP:0001324	Muscle weakness	MP:0000746	weakness	state of being infirm or less strong than normal
HP:0007987	Progressive visual field defects	MP:0006149	decreased visual acuity	loss of visual acuity or ability to distinguish small details
HP:0008163	Decreased circulating cortisol level	MP:0005661	decreased circulating adrenaline level	less than the normal concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels
HP:0003187	Breast hypoplasia	MP:0009101	clitoris hypoplasia	underdevelopment or reduced size of the clitoris, usually due to a reduced number of cells
HP:0000622	Blurred vision	MP:0002090	abnormal vision	inability or decreased ability to see
HP:0008240	Secondary growth hormone deficiency	MP:0005418	abnormal circulating hormone level	any anomaly in the blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the blood

Mapped by homologous gene(Total Items:41)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0004396	Poor appetite	MP:0013467	diaphragmitis	inflammation of the diaphragm
HP:0008213	Gonadotropin deficiency	MP:0014051	abnormal maxillary-premaxillary suture morphology	any structural anomaly of the line of union of the two portions of the maxilla (pre- and postmaxilla)
HP:0002315	Headache	MP:0020137	decreased bone mineralization	decrease in the rate at which minerals are deposited into bone
HP:0000802	Impotence	MP:0012504	increased forebrain apoptosis	increase in the number of cells of the forebrain undergoing programmed cell death
HP:0001259	Coma	MP:0020216	decreased circulating complement protein level	less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes
HP:0003158	Hyposthenuria	MP:0011563	increased urine prostaglandin level	a greater amount of any prostaglandin in the urine compared to the normal state
HP:0001962	Palpitations	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0000622	Blurred vision	MP:0014185	cerebellum atrophy	acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal
HP:0002225	Sparse pubic hair	MP:0014198	absent pituitary infundibular stalk	absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland
HP:0000407	Sensorineural hearing impairment	MP:3000003	abnormal Ebner's gland morphology	any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l
HP:0008240	Secondary growth hormone deficiency	MP:0020137	decreased bone mineralization	decrease in the rate at which minerals are deposited into bone
HP:0008202	Prolactin deficiency	MP:0014198	absent pituitary infundibular stalk	absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland
HP:0001662	Bradycardia	MP:0020234	decreased basal metabolism	decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state
HP:0000876	Oligomenorrhea	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0011748	Adrenocorticotropic hormone deficiency	MP:0011957	decreased compensatory feeding amount	decreased amount of food consumed after a period of fasting
HP:0000863	Central diabetes insipidus	MP:0013282	urinary bladder exstrophy	a herniation of the urinary bladder through an anterior abdominal wall defect; refers to congenital absence of a portion of the lower anterior abdominal wall and the anterior urinary bladder wall, with eversion of the posterior bladder wall through the de
HP:0001324	Muscle weakness	MP:0020309	increased creatine kinase activity	increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).
HP:0000651	Diplopia	MP:0020187	altered susceptibility to prion infection	altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is
HP:0001895	Normochromic anemia	MP:0020039	increased bone ossification	increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance
HP:0002321	Vertigo	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0002018	Nausea	MP:0014185	cerebellum atrophy	acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal
HP:0002829	Arthralgia	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0001943	Hypoglycemia	MP:0020137	decreased bone mineralization	decrease in the rate at which minerals are deposited into bone
HP:0001278	Orthostatic hypotension	MP:0014178	increased brain apoptosis	increase in the number of cells of the brain undergoing programmed cell death
HP:0003493	Antinuclear antibody positivity	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0001513	Obesity	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0000709	Psychosis	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0003187	Breast hypoplasia	MP:0013886	increased CD4-negative, CD25-positive NK T cell number	increase in the number of CD4-negative NK T cells expressing the activation marker CD25
HP:0007041	Chronic lymphocytic meningitis	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0000980	Pallor	MP:0020186	altered susceptibility to bacterial infection	a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria
HP:0007987	Progressive visual field defects	MP:0014059	abnormal photoreceptor connecting cilium morphology	any structural anomaly of the nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the retinal photoreceptor inner and outer segments
HP:0000958	Dry skin	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0000872	Hashimoto thyroiditis	MP:0012431	increased lymphoma incidence	greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period
HP:0002019	Constipation	MP:0020234	decreased basal metabolism	decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state
HP:0008163	Decreased circulating cortisol level	MP:0013565	abnormal adrenal gland capsule morphology	any structural anomaly of the thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers
HP:0002902	Hyponatremia	MP:0020215	impaired blood coagulation	impaired ability of the blood to clot
HP:0008245	Pituitary hypothyroidism	MP:0020087	increased susceptibility to non-insulin-dependent diabetes	increased likelihood to develop non-insulin-dependent diabetes
HP:0002215	Sparse axillary hair	MP:0014051	abnormal maxillary-premaxillary suture morphology	any structural anomaly of the line of union of the two portions of the maxilla (pre- and postmaxilla)
HP:0011734	Central adrenal insufficiency	MP:0020154	impaired humoral immune response	impaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0000141	Amenorrhea	MP:0013395	eyelid hypoplasia	underdevelopment or reduced size of the skin folds covering the front of the eyeball, usually due to a decreased cell number
HP:0000871	Panhypopituitarism	MP:0014198	absent pituitary infundibular stalk	absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland

Disease ID	1398
Disease	sheehan syndrome
Case	(Waiting for update.)