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	severe pre-eclampsia

Disease ID	1707
Disease	severe pre-eclampsia
Definition	Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.(NICHD)
Synonym	edema severe pet - severe pre-eclamptic toxaemia pet - severe pre-eclamptic toxemia pre-eclampsia, severe pre-eclamptic, severe preeclampsia severe preeclampsia with severe features severe edema severe oedema severe pre-eclampsia (disorder) severe pre-eclampsia nos severe pre-eclampsia nos (disorder) severe pre-eclampsia unspecified severe pre-eclampsia unspecified (disorder) severe pre-eclamptic toxaemia severe pre-eclamptic toxemia severe preeclampsia severe proteinuric hypertension of pregnancy severe proteinuric hypertension of pregnancy (disorder)
DOID	DOID:13129
UMLS	C0341950
SNOMED-CT	SNOMEDCT_US_2016_09_01:46764007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:25) C0162739 \| hellp syndrome \| 11 C0020538 \| hypertension \| 7 C0027726 \| nephrotic syndrome \| 4 C0040053 \| thrombosis \| 3 C0034063 \| pulmonary edema \| 3 C0032914 \| preeclampsia \| 2 C0033687 \| proteinuria \| 2 C0000832 \| abruptio placenta \| 1 C0030305 \| pancreatitis \| 1 C0035305 \| retinal detachment \| 1 C0032285 \| pneumonia \| 1 C0023890 \| cirrhosis \| 1 C0013537 \| eclampsia \| 1 C0002871 \| anaemia \| 1 C0023890 \| liver cirrhosis \| 1 C0035078 \| renal failure \| 1 C0000832 \| abruptio placentae \| 1 C0547030 \| visual disturbance \| 1 C0020538 \| vascular hypertension \| 1 C0020676 \| hypothyroidism \| 1 C0026896 \| myasthenia gravis \| 1 C0020538 \| hypertensive disorder \| 1 C0031099 \| periodontitis \| 1 C0020545 \| renovascular hypertension \| 1 C0002766 \| analgesia \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 7124 \| TNF \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:107) 8038 \| ADAM12 \| 2.766 \| DISEASES 81792 \| ADAMTS12 \| 2.509 \| DISEASES 11093 \| ADAMTS13 \| 3.282 \| DISEASES 9370 \| ADIPOQ \| 1.119 \| DISEASES 174 \| AFP \| 2.356 \| DISEASES 183 \| AGT \| 1.995 \| DISEASES 8644 \| AKR1C3 \| 1.27 \| DISEASES 283 \| ANG \| 1.476 \| DISEASES 353322 \| ANKRD37 \| 3.109 \| DISEASES 408 \| ARRB1 \| 1.305 \| DISEASES 23192 \| ATG4B \| 1.475 \| DISEASES 80114 \| BICC1 \| 1.412 \| DISEASES 959 \| CD40LG \| 1.79 \| DISEASES 3075 \| CFH \| 1.218 \| DISEASES 3426 \| CFI \| 1.327 \| DISEASES 94027 \| CGB7 \| 1.03 \| DISEASES 91612 \| CHURC1 \| 2.874 \| DISEASES 1312 \| COMT \| 1.583 \| DISEASES 1325 \| CORT \| 1.282 \| DISEASES 8804 \| CREG1 \| 1.033 \| DISEASES 1443 \| CSH2 \| 2.5 \| DISEASES 1471 \| CST3 \| 1.889 \| DISEASES 115908 \| CTHRC1 \| 1.072 \| DISEASES 10072 \| DPP3 \| 1.916 \| DISEASES 285193 \| DUSP28 \| 1.697 \| DISEASES 1906 \| EDN1 \| 2.925 \| DISEASES 2022 \| ENG \| 4.304 \| DISEASES 132884 \| EVC2 \| 1.666 \| DISEASES 2152 \| F3 \| 3.471 \| DISEASES 2153 \| F5 \| 3.134 \| DISEASES 2155 \| F7 \| 1.497 \| DISEASES 2157 \| F8 \| 1.214 \| DISEASES 356 \| FASLG \| 1.22 \| DISEASES 2268 \| FGR \| 2.86 \| DISEASES 2358 \| FPR2 \| 1.495 \| DISEASES 2621 \| GAS6 \| 2.229 \| DISEASES 2805 \| GOT1 \| 1.138 \| DISEASES 2938 \| GSTA1 \| 1.419 \| DISEASES 2950 \| GSTP1 \| 1.389 \| DISEASES 3033 \| HADH \| 1.976 \| DISEASES 3030 \| HADHA \| 6.258 \| DISEASES 3032 \| HADHB \| 1.932 \| DISEASES 3055 \| HCK \| 1.383 \| DISEASES 101101692 \| HELLPAR \| 3.953 \| DISEASES 3105 \| HLA-A \| 1.787 \| DISEASES 3106 \| HLA-B \| 1.439 \| DISEASES 3107 \| HLA-C \| 1.446 \| DISEASES 3115 \| HLA-DPB1 \| 1.088 \| DISEASES 3133 \| HLA-E \| 2.484 \| DISEASES 3135 \| HLA-G \| 2.756 \| DISEASES 3240 \| HP \| 3.707 \| DISEASES 3586 \| IL10 \| 1.681 \| DISEASES 3570 \| IL6R \| 1.058 \| DISEASES 8284 \| KDM5D \| 1.01 \| DISEASES 3811 \| KIR3DL1 \| 1.61 \| DISEASES 3812 \| KIR3DL2 \| 2.627 \| DISEASES 3814 \| KISS1 \| 1.668 \| DISEASES 3821 \| KLRC1 \| 1.409 \| DISEASES 3822 \| KLRC2 \| 1.978 \| DISEASES 100506243 \| KRBOX1 \| 3.613 \| DISEASES 3939 \| LDHA \| 1.716 \| DISEASES 3953 \| LEPR \| 1.401 \| DISEASES 56891 \| LGALS14 \| 2.517 \| DISEASES 148003 \| LGALS16 \| 3.646 \| DISEASES 23566 \| LPAR3 \| 1.051 \| DISEASES 131578 \| LRRC15 \| 1.531 \| DISEASES 57134 \| MAN1C1 \| 1.243 \| DISEASES 4146 \| MATN1 \| 1.013 \| DISEASES 56955 \| MEPE \| 1.627 \| DISEASES 196410 \| METTL7B \| 1.36 \| DISEASES 8972 \| MGAM \| 1.405 \| DISEASES 4326 \| MMP17 \| 1.379 \| DISEASES 64386 \| MMP25 \| 1.119 \| DISEASES 4318 \| MMP9 \| 2.124 \| DISEASES 4524 \| MTHFR \| 3.957 \| DISEASES 115677 \| NOSTRIN \| 2.089 \| DISEASES 4868 \| NPHS1 \| 1.74 \| DISEASES 5069 \| PAPPA \| 3.984 \| DISEASES 60676 \| PAPPA2 \| 4.526 \| DISEASES 55742 \| PARVA \| 1.158 \| DISEASES 5094 \| PCBP2 \| 1.307 \| DISEASES 5228 \| PGF \| 5.401 \| DISEASES 191585 \| PLAC4 \| 2.748 \| DISEASES 9374 \| PPT2 \| 1.103 \| DISEASES 112724 \| RDH13 \| 2.697 \| DISEASES 6129 \| RPL7 \| 1.597 \| DISEASES 6338 \| SCNN1B \| 1.067 \| DISEASES 6401 \| SELE \| 2.134 \| DISEASES 57556 \| SEMA6A \| 1.21 \| DISEASES 5265 \| SERPINA1 \| 1.289 \| DISEASES 5104 \| SERPINA5 \| 2.092 \| DISEASES 462 \| SERPINC1 \| 4.866 \| DISEASES 5345 \| SERPINF2 \| 2.397 \| DISEASES 8879 \| SGPL1 \| 1.324 \| DISEASES 9644 \| SH3PXD2A \| 1.403 \| DISEASES 946 \| SIGLEC6 \| 3.648 \| DISEASES 10165 \| SLC25A13 \| 1.353 \| DISEASES 85360 \| SYDE1 \| 2.286 \| DISEASES 7056 \| THBD \| 3.483 \| DISEASES 7099 \| TLR4 \| 1.334 \| DISEASES 79022 \| TMEM106C \| 2.323 \| DISEASES 7124 \| TNF \| 2.554 \| DISEASES 2837 \| UTS2R \| 1.05 \| DISEASES 57216 \| VANGL2 \| 2.529 \| DISEASES 7422 \| VEGFA \| 3.065 \| DISEASES 11326 \| VSIG4 \| 2.605 \| DISEASES 23038 \| WDTC1 \| 1.379 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1707
Disease	severe pre-eclampsia
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:47) HP:0000822 \| Hypertension \| 8 HP:0000969 \| Dropsy \| 6 HP:0001250 \| Seizures \| 5 HP:0001511 \| Prenatal onset growth retardation \| 5 HP:0000100 \| Nephrosis \| 4 HP:0001541 \| Ascites \| 3 HP:0100598 \| Pulmonary oedema \| 3 HP:0100602 \| Pre-eclampsia \| 3 HP:0002315 \| Headaches \| 2 HP:0002664 \| Neoplasia \| 2 HP:0001510 \| Growth deficiency \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0000093 \| Proteinuria \| 2 HP:0010783 \| Erythema \| 2 HP:0100601 \| Eclampsia \| 1 HP:0000622 \| Blurred vision \| 1 HP:0001518 \| Small for gestational age \| 1 HP:0002615 \| Low blood pressure \| 1 HP:0100817 \| Renovascular hypertension \| 1 HP:0012027 \| Laryngeal edema \| 1 HP:0002516 \| Intracranial pressure elevation \| 1 HP:0001680 \| Coarctation of aorta \| 1 HP:0004936 \| Blood clot in vein \| 1 HP:0002090 \| Pneumonia \| 1 HP:0002625 \| Blood clot in a deep vein \| 1 HP:0100615 \| Neoplasm of the ovary \| 1 HP:0002140 \| Ischemic stroke \| 1 HP:0002910 \| Elevated transaminases \| 1 HP:0000821 \| Underactive thyroid \| 1 HP:0002094 \| Dyspnea \| 1 HP:0000252 \| Small head circumference \| 1 HP:0000541 \| Detached retina \| 1 HP:0011419 \| Abruptio placentae \| 1 HP:0001903 \| Anemia \| 1 HP:0000704 \| Pyorrhea \| 1 HP:0001873 \| Low platelet count \| 1 HP:0012231 \| Exudative retinal detachment \| 1 HP:0001394 \| Hepatic cirrhosis \| 1 HP:0003473 \| Fatigable weakness \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0003010 \| Increased bleeding time \| 1 HP:0001622 \| Premature delivery \| 1 HP:0005305 \| Cerebral vein thrombosis \| 1 HP:0000105 \| Renal enlargement \| 1 HP:0100537 \| Inflammation of the fascia \| 1 HP:0000572 \| Visual loss \| 1

Disease ID	1707
Disease	severe pre-eclampsia
Manually Symptom	UMLS \| Name(Total Manually Symptoms:11) C2203646 \| jaundice C1963229 \| retinal detachment C1963138 \| hypertension C1268935 \| microangiopathic hemolytic anemia C0456909 \| blindness C0398623 \| hypercoagulable state C0036572 \| convulsion C0035305 \| retinal detachments C0034063 \| pulmonary edema C0028961 \| oliguria C0020312 \| hydrothorax
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:2) C0020538 \| hypertension \| 2 C0034063 \| pulmonary edema \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1707
Disease	severe pre-eclampsia
Case	(Waiting for update.)

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