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encyclopedia of Rare Disease Annotation for Precision Medicine

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	scleritis

Disease ID	1564
Disease	scleritis
Definition	Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
Synonym	inflammation of the outer white part of the eye inflammation of white of eye scleritides scleritis (disorder) scleritis [disease/finding] scleritis nos scleritis, nos scleritis, unspecified unspecified scleritis unspecified scleritis (disorder)
DOID	DOID:13452
UMLS	C0036416
MeSH	D015423
SNOMED-CT	SNOMEDCT_US_2016_09_01:78370002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:41) C0003873 \| rheumatoid arthritis \| 7 C0042164 \| uveitis \| 3 C0021053 \| immune disorder \| 2 C0021053 \| immune disorders \| 2 C0003864 \| arthritis \| 2 C0035305 \| retinal detachment \| 2 C0034212 \| pyoderma \| 2 C0042384 \| vasculitis \| 2 C0085652 \| pyoderma gangrenosum \| 2 C0154841 \| central retinal vein occlusion \| 2 C0035328 \| retinal vein occlusion \| 2 C0017601 \| glaucoma \| 2 C0009782 \| connective tissue disease \| 2 C0086543 \| cataract \| 1 C0035333 \| retinitis \| 1 C0032453 \| relapsing polychondritis \| 1 C0409974 \| lupus erythematosus \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0014236 \| endophthalmitis \| 1 C0024141 \| systemic lupus erythematosus \| 1 C0023493 \| adult t-cell leukemia \| 1 C1136085 \| monoclonal gammopathy \| 1 C0024299 \| lymphoma \| 1 C0007570 \| coeliac disease \| 1 C0003873 \| rheumatoid disease \| 1 C0023493 \| adult t-cell leukemia/lymphoma \| 1 C0042164 \| intraocular inflammation \| 1 C0281658 \| intraocular lymphoma \| 1 C0017661 \| iga nephropathy \| 1 C0026470 \| monoclonal gammopathy of undetermined significance \| 1 C0017605 \| angle closure glaucoma \| 1 C0154733 \| multiple cranial nerve palsies \| 1 C0042165 \| anterior uveitis \| 1 C0022658 \| nephropathy \| 1 C0023492 \| t-cell leukemia \| 1 C0004106 \| astigmatism \| 1 C0730306 \| ocular lymphoma \| 1 C0023448 \| lymphocytic leukemia \| 1 C0019196 \| hepatitis c \| 1 C0008513 \| retinochoroiditis \| 1 C0010346 \| crohn disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:19) 633 \| BGN \| 1.314 \| DISEASES 959 \| CD40LG \| 1.66 \| DISEASES 7913 \| DEK \| 1.658 \| DISEASES 1810 \| DR1 \| 1.987 \| DISEASES 5394 \| EXOSC10 \| 1.737 \| DISEASES 3605 \| IL17A \| 1.326 \| DISEASES 50616 \| IL22 \| 1.437 \| DISEASES 4312 \| MMP1 \| 1.186 \| DISEASES 4318 \| MMP9 \| 1.003 \| DISEASES 4512 \| MT-CO1 \| 1.274 \| DISEASES 6295 \| SAG \| 2.024 \| DISEASES 6539 \| SLC6A12 \| 1.943 \| DISEASES 6540 \| SLC6A13 \| 1.643 \| DISEASES 8651 \| SOCS1 \| 1.912 \| DISEASES 7062 \| TCHH \| 1.643 \| DISEASES 7124 \| TNF \| 3.093 \| DISEASES 7133 \| TNFRSF1B \| 3.52 \| DISEASES 7390 \| UROS \| 3.352 \| DISEASES 7454 \| WAS \| 1.082 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1564
Disease	scleritis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:25) HP:0001370 \| Rheumatoid arthritis \| 8 HP:0001369 \| Arthritis \| 3 HP:0002960 \| Autoimmune condition \| 3 HP:0000554 \| Uveitis \| 3 HP:0012531 \| Pain \| 3 HP:0000501 \| Glaucoma \| 2 HP:0001059 \| Pterygium \| 2 HP:0002633 \| Vasculitis \| 2 HP:0002664 \| Neoplasia \| 2 HP:0000541 \| Detached retina \| 2 HP:0012636 \| Retinal vein occlusion \| 2 HP:0002955 \| Granulomatosis \| 2 HP:0100533 \| Ocular inflammation \| 2 HP:0000999 \| Pyoderma \| 2 HP:0006824 \| Cranial nerve palsy \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0010783 \| Erythema \| 1 HP:0002665 \| Lymphoma \| 1 HP:0012122 \| Anterior uveitis \| 1 HP:0000518 \| Cataract \| 1 HP:0012231 \| Exudative retinal detachment \| 1 HP:0012219 \| Erythema nodosum \| 1 HP:0000483 \| Astigmatism \| 1 HP:0000112 \| Nephropathy \| 1 HP:0002725 \| Systemic lupus erythematosus \| 1

Disease ID	1564
Disease	scleritis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:10) C2598155 \| pain C2350476 \| orbital myositis C1963266 \| uveitis C1963229 \| retinal detachment C1962986 \| glaucoma C1373218 \| immunosuppression C0035305 \| retinal detachments C0029896 \| ent disease C0027092 \| myopia C0022568 \| keratitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:4) C0030193 \| pain \| 3 C0042164 \| uveitis \| 3 C0017601 \| glaucoma \| 2 C0035305 \| retinal detachment \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1564
Disease	scleritis
Case	(Waiting for update.)

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