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	schistosomiasis

Disease ID	432
Disease	schistosomiasis
Definition	Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.
Synonym	[x]schistosomiasis, unspecified [x]schistosomiasis, unspecified (disorder) bilharziases bilharziasis blood fluke infection blood flukes blood flukes nos blood flukes, nos disease caused by schistosomatidae disease caused by schistosomatidae (disorder) disease due to schistosomatidae disease due to schistosomatidae (disorder) fever, katayama haemic distomiasis hemic distomiasis infection by schistosoma infection by schistosoma (disorder) infection by schistosoma, nos infection caused by schistosoma infection caused by schistosoma (disorder) katayama fever schistosomiases schistosomiasis - bilharziasis schistosomiasis [bilharziasis] schistosomiasis [disease/finding] schistosomiasis nos schistosomiasis nos (disorder) schistosomiasis, unspecified schistosomosis snail fever
Orphanet	ORPHANET:1247
DOID	DOID:1395 DOID:0050597
ICD10	ICD10CM:B65.9
UMLS	C0036323
MeSH	D012552
SNOMED-CT	SNOMEDCT_US_2016_09_01:105661001;SNOMEDCT_US_2016_09_01:10087007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:66) C0020538 \| hypertension \| 12 C0020541 \| portal hypertension \| 12 C0005684 \| bladder cancer \| 5 C0002871 \| anemia \| 4 C0019158 \| hepatitis \| 4 C0009402 \| colorectal cancer \| 3 C0036319 \| schistosoma mansoni \| 3 C0007113 \| rectal cancer \| 3 C0002871 \| anaemia \| 3 C0042345 \| varices \| 3 C0017668 \| focal segmental glomerulosclerosis \| 2 C0020542 \| pulmonary hypertension \| 2 C0011570 \| depression \| 2 C0178664 \| glomerulosclerosis \| 2 C0022658 \| renal disease \| 2 C0023890 \| cirrhosis \| 2 C0009402 \| colorectal carcinoma \| 2 C0007137 \| squamous cell carcinoma \| 2 C0007113 \| rectal carcinoma \| 2 C0024530 \| malaria \| 2 C0036323 \| schistosomiasis \| 1 C0041696 \| major depressive disorder \| 1 C0021400 \| influenza \| 1 C0334254 \| lymphoepithelioma \| 1 C0023895 \| liver disease \| 1 C0004623 \| bacterial infection \| 1 C0014867 \| esophageal varices \| 1 C0006142 \| breast cancer \| 1 C0019163 \| hepatitis b \| 1 C0019196 \| hepatitis c \| 1 C0009186 \| coccidioidomycosis \| 1 C0013884 \| lymphatic filariasis \| 1 C0042721 \| viral hepatitis \| 1 C0242497 \| intestinal schistosomiasis \| 1 C0017658 \| glomerulonephritis \| 1 C1327709 \| rectosigmoid cancer \| 1 C0156312 \| testicular atrophy \| 1 C0162429 \| malnutrition \| 1 C0747256 \| parasitic infection \| 1 C0020532 \| hypersplenism \| 1 C0023903 \| liver cancer \| 1 C1527249 \| colorectal cancers \| 1 C0009402 \| cancer of the large intestine \| 1 C0004659 \| bacteriuria \| 1 C0007138 \| urothelial carcinoma \| 1 C0022658 \| kidney disease \| 1 C0032987 \| ectopic pregnancy \| 1 C0011991 \| diarrhea \| 1 C0021933 \| intussusception \| 1 C0021359 \| infertility \| 1 C0011991 \| diarrhoea \| 1 C0085293 \| hepatitis e \| 1 C0029001 \| onchocerciasis \| 1 C0699885 \| carcinoma of the urinary bladder \| 1 C0005716 \| blastomycosis \| 1 C0600139 \| prostate carcinoma \| 1 C0037280 \| infestation \| 1 C0005684 \| urinary bladder cancer \| 1 C0016085 \| filariasis \| 1 C1619734 \| pulmonary arterial hypertension \| 1 C0024299 \| lymphoma \| 1 C0014544 \| epilepsy \| 1 C0751498 \| sigmoid cancer \| 1 C0086692 \| benign neoplasm \| 1 C0022661 \| chronic kidney disease \| 1 C1327709 \| rectosigmoid carcinoma \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 7078 \| TIMP3 \| CTD_human 11186 \| RASSF1 \| CTD_human 5052 \| PRDX1 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:6) 3123 \| HLA-DRB1 \| CIPHER 3127 \| HLA-DRB5 \| CIPHER 6037 \| RNASE3 \| CIPHER 7078 \| TIMP3 \| CTD_human 11186 \| RASSF1 \| CTD_human 5052 \| PRDX1 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:147) 2 \| A2M \| 1.557 \| DISEASES 85320 \| ABCC11 \| 1.244 \| DISEASES 94 \| ACVRL1 \| 1.805 \| DISEASES 199800 \| ADM5 \| 2.794 \| DISEASES 174 \| AFP \| 1.449 \| DISEASES 283 \| ANG \| 1.184 \| DISEASES 316 \| AOX1 \| 3.823 \| DISEASES 383 \| ARG1 \| 2.936 \| DISEASES 659 \| BMPR2 \| 1.403 \| DISEASES 64115 \| C10orf54 \| 1.809 \| DISEASES 57010 \| CABP4 \| 1.337 \| DISEASES 777 \| CACNA1E \| 2.327 \| DISEASES 785 \| CACNB4 \| 1.135 \| DISEASES 801 \| CALM1 \| 1.371 \| DISEASES 811 \| CALR \| 1.958 \| DISEASES 912 \| CD1D \| 1.963 \| DISEASES 940 \| CD28 \| 2.092 \| DISEASES 958 \| CD40 \| 1.664 \| DISEASES 959 \| CD40LG \| 4.502 \| DISEASES 942 \| CD86 \| 2.191 \| DISEASES 56882 \| CDC42SE1 \| 3.256 \| DISEASES 9425 \| CDYL \| 2.237 \| DISEASES 78989 \| COLEC11 \| 1.862 \| DISEASES 1490 \| CTGF \| 1.992 \| DISEASES 1508 \| CTSB \| 3.4 \| DISEASES 1520 \| CTSS \| 1.778 \| DISEASES 1524 \| CX3CR1 \| 1.106 \| DISEASES 2919 \| CXCL1 \| 1.332 \| DISEASES 9547 \| CXCL14 \| 1.093 \| DISEASES 2920 \| CXCL2 \| 1.664 \| DISEASES 4283 \| CXCL9 \| 1.135 \| DISEASES 2833 \| CXCR3 \| 1.448 \| DISEASES 347487 \| CXorf66 \| 2.809 \| DISEASES 1528 \| CYB5A \| 2.771 \| DISEASES 1555 \| CYP2B6 \| 1.624 \| DISEASES 1650 \| DDOST \| 1.004 \| DISEASES 51428 \| DDX41 \| 2.2 \| DISEASES 2009 \| EML1 \| 1.426 \| DISEASES 255324 \| EPGN \| 6.522 \| DISEASES 132884 \| EVC2 \| 1.435 \| DISEASES 646480 \| FABP9 \| 1.092 \| DISEASES 9679 \| FAM53B \| 3.283 \| DISEASES 100302740 \| FAS-AS1 \| 1.854 \| DISEASES 64319 \| FBRS \| 3.982 \| DISEASES 50943 \| FOXP3 \| 2.764 \| DISEASES 85569 \| GALP \| 1.019 \| DISEASES 728441 \| GGT2 \| 1.989 \| DISEASES 29933 \| GPR132 \| 2.012 \| DISEASES 23560 \| GTPBP4 \| 1.067 \| DISEASES 9563 \| H6PD \| 1.515 \| DISEASES 55869 \| HDAC8 \| 2.593 \| DISEASES 3149 \| HMGB3 \| 1.574 \| DISEASES 3190 \| HNRNPK \| 1.824 \| DISEASES 3240 \| HP \| 1.032 \| DISEASES 3208 \| HPCA \| 1.262 \| DISEASES 3339 \| HSPG2 \| 2.5 \| DISEASES 23308 \| ICOSLG \| 2.03 \| DISEASES 3459 \| IFNGR1 \| 1.355 \| DISEASES 7866 \| IFRD2 \| 2.154 \| DISEASES 3586 \| IL10 \| 4.615 \| DISEASES 3605 \| IL17A \| 2.904 \| DISEASES 90865 \| IL33 \| 2.11 \| DISEASES 54617 \| INO80 \| 1.534 \| DISEASES 3684 \| ITGAM \| 1.487 \| DISEASES 50618 \| ITSN2 \| 4.551 \| DISEASES 5641 \| LGMN \| 3.197 \| DISEASES 10288 \| LILRB2 \| 1.775 \| DISEASES 497634 \| LINC00293 \| 3.161 \| DISEASES 3996 \| LLGL1 \| 1.847 \| DISEASES 28986 \| MAGEH1 \| 2.702 \| DISEASES 55201 \| MAP1S \| 1.534 \| DISEASES 4134 \| MAP4 \| 1.95 \| DISEASES 4153 \| MBL2 \| 1.349 \| DISEASES 4190 \| MDH1 \| 2.003 \| DISEASES 4318 \| MMP9 \| 1.478 \| DISEASES 116534 \| MRGPRE \| 2.325 \| DISEASES 51734 \| MSRB1 \| 1.52 \| DISEASES 22921 \| MSRB2 \| 1.459 \| DISEASES 4512 \| MT-CO1 \| 3.09 \| DISEASES 4534 \| MTM1 \| 1.038 \| DISEASES 4535 \| MT-ND1 \| 2.258 \| DISEASES 4538 \| MT-ND4 \| 1.308 \| DISEASES 4539 \| MT-ND4L \| 1.263 \| DISEASES 4540 \| MT-ND5 \| 1.163 \| DISEASES 4553 \| MT-TA \| 1.464 \| DISEASES 4511 \| MT-TC \| 1.758 \| DISEASES 4558 \| MT-TF \| 1.364 \| DISEASES 4573 \| MT-TR \| 1.596 \| DISEASES 594857 \| NPS \| 1.904 \| DISEASES 93034 \| NT5C1B \| 1.083 \| DISEASES 4521 \| NUDT1 \| 1.327 \| DISEASES 56288 \| PARD3 \| 1.764 \| DISEASES 80380 \| PDCD1LG2 \| 1.49 \| DISEASES 5251 \| PHEX \| 1.371 \| DISEASES 11201 \| POLI \| 2.817 \| DISEASES 5478 \| PPIA \| 2.089 \| DISEASES 5522 \| PPP2R2C \| 1.538 \| DISEASES 5557 \| PRIM1 \| 2.048 \| DISEASES 100169750 \| PRINS \| 1.083 \| DISEASES 5831 \| PYCR1 \| 1.417 \| DISEASES 54734 \| RAB39A \| 1.473 \| DISEASES 10181 \| RBM5 \| 1.135 \| DISEASES 6016 \| RIT1 \| 1.177 \| DISEASES 6014 \| RIT2 \| 2.058 \| DISEASES 8635 \| RNASET2 \| 1.432 \| DISEASES 6129 \| RPL7 \| 1.366 \| DISEASES 84816 \| RTN4IP1 \| 1.7 \| DISEASES 6280 \| S100A9 \| 1.172 \| DISEASES 23513 \| SCRIB \| 1.244 \| DISEASES 6401 \| SELE \| 1.123 \| DISEASES 5271 \| SERPINB8 \| 2.398 \| DISEASES 462 \| SERPINC1 \| 1.628 \| DISEASES 5345 \| SERPINF2 \| 1.22 \| DISEASES 23408 \| SIRT5 \| 1.123 \| DISEASES 51547 \| SIRT7 \| 1.089 \| DISEASES 1811 \| SLC26A3 \| 1.592 \| DISEASES 160728 \| SLC5A8 \| 2.68 \| DISEASES 6541 \| SLC7A1 \| 1.788 \| DISEASES 4088 \| SMAD3 \| 1.349 \| DISEASES 4093 \| SMAD9 \| 1.153 \| DISEASES 677825 \| SNORA44 \| 1.784 \| DISEASES 6677 \| SPAM1 \| 1.691 \| DISEASES 6714 \| SRC \| 1.014 \| DISEASES 6752 \| SSTR2 \| 1.331 \| DISEASES 6753 \| SSTR3 \| 2.075 \| DISEASES 246744 \| STH \| 3.926 \| DISEASES 6491 \| STIL \| 1.807 \| DISEASES 6863 \| TAC1 \| 2.896 \| DISEASES 51347 \| TAOK3 \| 1.646 \| DISEASES 7062 \| TCHH \| 2.053 \| DISEASES 26136 \| TES \| 1.073 \| DISEASES 7058 \| THBS2 \| 4.145 \| DISEASES 54106 \| TLR9 \| 1.375 \| DISEASES 7124 \| TNF \| 3.697 \| DISEASES 8784 \| TNFRSF18 \| 1.603 \| DISEASES 7156 \| TOP3A \| 1.123 \| DISEASES 10103 \| TSPAN1 \| 2.091 \| DISEASES 10100 \| TSPAN2 \| 4.237 \| DISEASES 27229 \| TUBGCP4 \| 1.063 \| DISEASES 7295 \| TXN \| 2.879 \| DISEASES 114112 \| TXNRD3 \| 6.225 \| DISEASES 7378 \| UPP1 \| 1.096 \| DISEASES 8725 \| URI1 \| 1.765 \| DISEASES 7419 \| VDAC3 \| 1.616 \| DISEASES 7432 \| VIP \| 2.094 \| DISEASES 7433 \| VIPR1 \| 1.255 \| DISEASES 53349 \| ZFYVE1 \| 1.397 \| DISEASES
Locus	(Waiting for update.)

Disease ID	432
Disease	schistosomiasis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:50) HP:0001409 \| Portal hypertension \| 13 HP:0000822 \| Hypertension \| 13 HP:0030731 \| Carcinoma \| 9 HP:0001541 \| Ascites \| 7 HP:0001903 \| Anemia \| 7 HP:0006580 \| Portal fibrosis \| 6 HP:0009725 \| Bladder neoplasm \| 6 HP:0001405 \| Periportal fibrosis \| 6 HP:0001395 \| Hepatic fibrosis \| 4 HP:0012115 \| Liver inflammation \| 4 HP:0001744 \| Splenomegaly \| 4 HP:0002860 \| Squamous cell carcinoma \| 3 HP:0000790 \| Hematuria \| 2 HP:0000716 \| Depression \| 2 HP:0000099 \| Glomerular nephritis \| 2 HP:0001394 \| Hepatic cirrhosis \| 2 HP:0000010 \| Frequent urinary tract infections \| 2 HP:0000096 \| Glomerulosclerosis \| 2 HP:0002092 \| Pulmonary artery hypertension \| 2 HP:0000097 \| focal glomerulosclerosis \| 2 HP:0100518 \| Painful or difficult urination \| 2 HP:0001433 \| Enlarged liver and spleen \| 2 HP:0001880 \| Eosinophilia \| 2 HP:0002576 \| Intussusception \| 1 HP:0002955 \| Granulomatosis \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0002896 \| Liver cancer \| 1 HP:0009027 \| Foot drop \| 1 HP:0002665 \| Lymphoma \| 1 HP:0001945 \| Fever \| 1 HP:0001873 \| Low platelet count \| 1 HP:0012592 \| Albuminuria \| 1 HP:0000789 \| Infertility \| 1 HP:0100743 \| Rectal tumor \| 1 HP:0100820 \| Glomerulopathy \| 1 HP:0200119 \| Acute liver inflammation \| 1 HP:0002014 \| Diarrhea \| 1 HP:0012622 \| Chronic kidney disease \| 1 HP:0001250 \| Seizures \| 1 HP:0000029 \| Testicular degeneration \| 1 HP:0001397 \| Hepatic steatosis \| 1 HP:0012594 \| High urine albumin levels \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0004395 \| Malnutrition \| 1 HP:0002240 \| Enlarged liver \| 1 HP:0002385 \| Paraparesis \| 1 HP:0001892 \| Bleeding diathesis \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0012461 \| Bacteria in urine \| 1 HP:0001971 \| Hypersplenism \| 1

Disease ID	432
Disease	schistosomiasis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:86) C2707258 \| infections C2632116 \| stenosis C2364133 \| infection C2240374 \| eosinophilia C2186532 \| liver disease C1963220 \| pulmonary hypertension C1963088 \| cystitis C1963078 \| brachial plexopathy C1962972 \| proteinuria C1868851 \| portopulmonary hypertension C1623038 \| cirrhosis C1555769 \| pulmonary disease C1550639 \| fistula C1546654 \| granuloma C1402315 \| vascular lesions C1398810 \| glomerulopathy C0949022 \| rectal cancer C0752303 \| urological manifestations C0748483 \| salmonella bacteraemia C0748159 \| pulmonary involvement C0744251 \| gallbladder calcification C0699885 \| carcinoma of the urinary bladder C0699885 \| bladder carcinoma C0699885 \| bladder cancer C0580174 \| portal hypertensive gastropathy C0521173 \| granulomatosis C0341439 \| chronic liver disease C0334108 \| polyposis C0302592 \| carcinoma of the uterine cervix C0279682 \| adenocarcinoma of the urinary bladder C0279681 \| squamous cell carcinoma of the bladder C0279681 \| squamous cell carcinoma of bladder C0275524 \| mixed infection C0272249 \| polyclonal gammopathy C0271148 \| secondary open-angle glaucoma C0239946 \| liver fibrosis C0239946 \| hepatic fibrosis C0238122 \| fallopian tube carcinoma C0238074 \| cor pulmonale C0238074 \| chronic cor pulmonale C0235329 \| small bowel obstruction C0235328 \| colonic obstruction C0221505 \| cerebral lesion C0178879 \| obstructive uropathy C0162316 \| iron deficiency anaemia C0155789 \| bleeding esophageal varices C0037997 \| splenic disorders C0037997 \| splenic disease C0037928 \| myelopathy C0037090 \| pulmonary symptoms C0036329 \| katayama syndrome C0036117 \| salmonelloses C0035333 \| retinitis C0034895 \| rectovaginal fistula C0034888 \| rectal prolapse C0034887 \| rectal polyp C0032568 \| pseudopolyp C0030354 \| papillomata C0026848 \| myopathy C0023903 \| hepatoma C0023895 \| liver diseases C0023890 \| liver cirrhosis C0022661 \| chronic renal failure C0022660 \| acute renal failure C0022658 \| renal disease C0021843 \| intestinal obstruction C0020541 \| portal hypertension C0020456 \| hyperglycemia C0020295 \| hydronephrosis C0019214 \| hepatosplenomegaly C0019209 \| hepatomegaly C0019080 \| hemorrhage C0017658 \| glomerulonephritis C0015652 \| fascioliasis C0014867 \| oesophageal varices C0014867 \| esophageal varices C0009402 \| colorectal carcinoma C0007137 \| squamous cell carcinoma C0005684 \| bladder cancers C0004610 \| bacteremia C0003864 \| arthritis C0002897 \| splenic anemia C0002871 \| anaemia C0002438 \| amebiasis C0001418 \| adenocarcinoma C0000727 \| acute abdomen
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:26) C0009450 \| infection \| 44 C0020541 \| portal hypertension \| 13 C0005684 \| bladder cancer \| 6 C0239946 \| hepatic fibrosis \| 4 C0002871 \| anaemia \| 3 C0007113 \| rectal cancer \| 3 C0239946 \| liver fibrosis \| 3 C0007137 \| squamous cell carcinoma \| 3 C0021311 \| infections \| 2 C0014457 \| eosinophilia \| 2 C0022658 \| renal disease \| 2 C0017658 \| glomerulonephritis \| 2 C0009402 \| colorectal carcinoma \| 2 C0023890 \| cirrhosis \| 2 C0020542 \| pulmonary hypertension \| 2 C1398810 \| glomerulopathy \| 1 C0521173 \| granulomatosis \| 1 C0275524 \| mixed infection \| 1 C0178879 \| obstructive uropathy \| 1 C0019080 \| hemorrhage \| 1 C0023895 \| liver disease \| 1 C0004610 \| bacteremia \| 1 C0019214 \| hepatosplenomegaly \| 1 C0037997 \| splenic disease \| 1 C0014867 \| esophageal varices \| 1 C0018188 \| granuloma \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1884444	24912586	149233	IL23R	umls:C0036323	BeFree	A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory Syndrome in a Kenyan population.	0.000271442	2014	IL23R	1	67168129	G	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	432
Disease	schistosomiasis
Case	(Waiting for update.)

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