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	sarcoma, synovial

Disease ID	1650
Disease	sarcoma, synovial
Definition	A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
Synonym	[m]synovial sarcoma nos [m]synovioma nos malignant synovioma sarcoma synovial sarcoma, synovial [disease/finding] sarcoma, synovial, malignant sarcomas, synovial ss synovial sarcoma synovial sarcoma (disorder) synovial sarcoma (morphologic abnormality) synovial sarcoma, nos synovial sarcoma, not otherwise specified synovial sarcomas synovioma synovioma, malignant synovioma, nos synoviomas
Orphanet	ORPHANET:3273
OMIM	OMIM:300813 OMIM:608068
DOID	DOID:5485
UMLS	C0039101
MeSH	D013584
SNOMED-CT	SNOMEDCT_US_2016_09_01:302851001
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:19) C1261473 \| sarcoma \| 3 C1261473 \| sarcomas \| 3 C0220650 \| brain metastasis \| 2 C0751690 \| malignant peripheral nerve sheath tumor \| 1 C0206093 \| primitive neuroectodermal tumor \| 1 C0879615 \| stromal tumor \| 1 C0034065 \| pulmonary embolism \| 1 C0024299 \| lymphoma \| 1 C0032326 \| pneumothorax \| 1 C0018922 \| hemangiopericytoma \| 1 C0023269 \| leiomyosarcomas \| 1 C1261473 \| soft tissue sarcoma \| 1 C1261473 \| soft tissue sarcomas \| 1 C0856761 \| budd-chiari syndrome \| 1 C0018099 \| gout \| 1 C0024301 \| follicular lymphoma \| 1 C0022354 \| obstructive jaundice \| 1 C0023827 \| liposarcoma \| 1 C0206093 \| neuroectodermal tumors \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 596 \| BCL2 \| CTD_human 7431 \| VIM \| CTD_human 6757 \| SSX2 \| CTD_human;ORPHANET 6756 \| SSX1 \| CTD_human;ORPHANET 6760 \| SS18 \| CTD_human;ORPHANET
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:102) 238 \| ALK \| 1.763 \| DISEASES 55107 \| ANO1 \| 3.089 \| DISEASES 369 \| ARAF \| 2.843 \| DISEASES 85316 \| BAGE5 \| 1.989 \| DISEASES 54880 \| BCOR \| 2.795 \| DISEASES 648 \| BMI1 \| 1.687 \| DISEASES 56244 \| BTNL2 \| 1.046 \| DISEASES 800 \| CALD1 \| 1.552 \| DISEASES 29126 \| CD274 \| 1.327 \| DISEASES 4267 \| CD99 \| 4.063 \| DISEASES 157313 \| CDCA2 \| 1.974 \| DISEASES 1029 \| CDKN2A \| 1.41 \| DISEASES 1364 \| CLDN4 \| 1.184 \| DISEASES 283971 \| CLEC18C \| 2.124 \| DISEASES 90993 \| CREB3L1 \| 1.461 \| DISEASES 64764 \| CREB3L2 \| 4.387 \| DISEASES 1485 \| CTAG1B \| 3.62 \| DISEASES 1499 \| CTNNB1 \| 3.037 \| DISEASES 26052 \| DNM3 \| 1.551 \| DISEASES 100288687 \| DUX4 \| 2.241 \| DISEASES 653545 \| DUX4L5 \| 2.241 \| DISEASES 1978 \| EIF4EBP1 \| 1.155 \| DISEASES 1999 \| ELF3 \| 2.737 \| DISEASES 2114 \| ETS2 \| 1.308 \| DISEASES 2115 \| ETV1 \| 1.569 \| DISEASES 2118 \| ETV4 \| 1.331 \| DISEASES 2120 \| ETV6 \| 1.943 \| DISEASES 2130 \| EWSR1 \| 4.792 \| DISEASES 2314 \| FLII \| 1.669 \| DISEASES 221937 \| FOXK1 \| 1.844 \| DISEASES 2300 \| FOXL1 \| 1.387 \| DISEASES 2308 \| FOXO1 \| 2.776 \| DISEASES 53827 \| FXYD5 \| 1.369 \| DISEASES 2591 \| GALNT3 \| 1.616 \| DISEASES 10672 \| GNA13 \| 1.525 \| DISEASES 3039 \| HBA1 \| 1.747 \| DISEASES 3052 \| HCCS \| 1.721 \| DISEASES 8091 \| HMGA2 \| 2.068 \| DISEASES 3481 \| IGF2 \| 1.557 \| DISEASES 80333 \| KCNIP4 \| 1.612 \| DISEASES 56660 \| KCNK12 \| 2.224 \| DISEASES 9928 \| KIF14 \| 1.361 \| DISEASES 257240 \| KLHL34 \| 3.07 \| DISEASES 3880 \| KRT19 \| 2.146 \| DISEASES 3850 \| KRT3 \| 1.027 \| DISEASES 3855 \| KRT7 \| 3.839 \| DISEASES 4100 \| MAGEA1 \| 1.678 \| DISEASES 728239 \| MAGED4 \| 1.407 \| DISEASES 55534 \| MAML3 \| 1.925 \| DISEASES 4151 \| MB \| 1.855 \| DISEASES 4193 \| MDM2 \| 1.864 \| DISEASES 2315 \| MLANA \| 1.385 \| DISEASES 4311 \| MME \| 1.555 \| DISEASES 4585 \| MUC4 \| 1.006 \| DISEASES 139221 \| MUM1L1 \| 3.544 \| DISEASES 4609 \| MYC \| 1.092 \| DISEASES 23054 \| NCOA6 \| 1.489 \| DISEASES 10763 \| NES \| 1.311 \| DISEASES 4916 \| NTRK3 \| 1.93 \| DISEASES 4942 \| OAT \| 2.321 \| DISEASES 126014 \| OSCAR \| 2.249 \| DISEASES 5077 \| PAX3 \| 3.19 \| DISEASES 5081 \| PAX7 \| 2.795 \| DISEASES 7849 \| PAX8 \| 1.291 \| DISEASES 5155 \| PDGFB \| 1.575 \| DISEASES 5241 \| PGR \| 1.559 \| DISEASES 23532 \| PRAME \| 2.784 \| DISEASES 8842 \| PROM1 \| 1.284 \| DISEASES 5728 \| PTEN \| 1.202 \| DISEASES 5788 \| PTPRC \| 1.487 \| DISEASES 117177 \| RAB3IP \| 2.097 \| DISEASES 64926 \| RASAL3 \| 3.258 \| DISEASES 11186 \| RASSF1 \| 1.495 \| DISEASES 9185 \| REPS2 \| 2.1 \| DISEASES 6297 \| SALL2 \| 2.548 \| DISEASES 54938 \| SARS2 \| 2.049 \| DISEASES 9805 \| SCRN1 \| 1.983 \| DISEASES 6597 \| SMARCA4 \| 2.471 \| DISEASES 23583 \| SMUG1 \| 2.282 \| DISEASES 6663 \| SOX10 \| 2.925 \| DISEASES 6657 \| SOX2 \| 1.792 \| DISEASES 11166 \| SOX21 \| 2.096 \| DISEASES 6660 \| SOX5 \| 1.023 \| DISEASES 55553 \| SOX6 \| 1.045 \| DISEASES 6760 \| SS18 \| 7.357 \| DISEASES 26039 \| SS18L1 \| 4.623 \| DISEASES 6756 \| SSX1 \| 7.708 \| DISEASES 727837 \| SSX2B \| 8.104 \| DISEASES 117178 \| SSX2IP \| 3.734 \| DISEASES 6759 \| SSX4 \| 5.756 \| DISEASES 548313 \| SSX4B \| 5.763 \| DISEASES 6847 \| SYCP1 \| 1.869 \| DISEASES 4943 \| TBC1D25 \| 4.933 \| DISEASES 7088 \| TLE1 \| 5.962 \| DISEASES 127262 \| TPRG1L \| 1.32 \| DISEASES 7247 \| TSN \| 1.999 \| DISEASES 7317 \| UBA1 \| 2.214 \| DISEASES 7321 \| UBE2D1 \| 2.031 \| DISEASES 7422 \| VEGFA \| 1.18 \| DISEASES 7490 \| WT1 \| 3.828 \| DISEASES 81030 \| ZBP1 \| 1.031 \| DISEASES 347344 \| ZNF81 \| 3.132 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1650
Disease	sarcoma, synovial
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:1) HP:0012570 \| Synovial sarcoma
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:18) HP:0002664 \| Neoplasia \| 6 HP:0100242 \| Sarcoma \| 3 HP:0002835 \| Aspiration \| 2 HP:0012531 \| Pain \| 1 HP:0001997 \| Gout \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0002202 \| Pleural effusion \| 1 HP:0002639 \| Budd-Chiari syndrome \| 1 HP:0012034 \| Liposarcoma \| 1 HP:0004736 \| Crossed fused renal ectopia \| 1 HP:0030448 \| Soft tissue sarcoma \| 1 HP:0030065 \| Primitive neuroectodermal tumor \| 1 HP:0000952 \| Yellow skin \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0000086 \| Ectopic kidney \| 1 HP:0002665 \| Lymphoma \| 1 HP:0100697 \| Neurofibrosarcoma \| 1 HP:0002176 \| Spinal cord compression \| 1

Disease ID	1650
Disease	sarcoma, synovial
Manually Symptom	(Waiting for update.)
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0012570	Synovial sarcoma	MP:0011110	preweaning lethality, incomplete penetrance	the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)

Disease ID	1650
Disease	sarcoma, synovial
Case	(Waiting for update.)

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