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	relapsing fever

Disease ID	737
Disease	relapsing fever
Definition	An acute infection characterized by recurrent episodes of PYREXIA alternating with asymptomatic intervals of apparent recovery. This condition is caused by SPIROCHETES of the genus BORRELIA. It is transmitted by the BITES of either the body louse (PEDICULUS humanus corporis), for which humans are the reservoir, or by soft ticks of the genus ORNITHODOROS, for which rodents and other animals are the principal reservoirs.
Synonym	[x]relapsing fever, unspecified [x]relapsing fever, unspecified (disorder) fever recurrent fever relapsing fever, famine fever, relapsing fevers recurrent fevers, relapsing recurrent fever recurrent fever due to borrelia recurrent fever, nos relapsing fever (disorder) relapsing fever [disease/finding] relapsing fever [dup] (disorder) relapsing fever due to borrelia relapsing fever nos relapsing fever nos (disorder) relapsing fever, nos relapsing fever, unspecified relapsing fevers
Orphanet	ORPHANET:91547
DOID	DOID:13034
ICD10	ICD10CM:A68.9
UMLS	C0035021
MeSH	D012061
SNOMED-CT	SNOMEDCT_US_2016_09_01:420079008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:12) C0035022 \| tick-borne relapsing fever \| 14 C0040425 \| tonsillitis \| 2 C0015230 \| rash \| 2 C0080151 \| saids \| 1 C0878675 \| erdheim-chester disease \| 1 C0029443 \| osteomyelitis \| 1 C1417508 \| mevalonic aciduria \| 1 C0032285 \| pneumonitis \| 1 C0021400 \| influenza \| 1 C0042109 \| urticarial \| 1 C0022408 \| arthropathy \| 1 C0001768 \| agammaglobulinemia \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:35) 159 \| ADSS \| 2.693 \| DISEASES 11214 \| AKAP13 \| 3.991 \| DISEASES 57016 \| AKR1B10 \| 1.694 \| DISEASES 340075 \| ARSI \| 3.952 \| DISEASES 7917 \| BAG6 \| 1.941 \| DISEASES 721 \| C4B \| 3.384 \| DISEASES 959 \| CD40LG \| 1.771 \| DISEASES 1447 \| CSN2 \| 1.744 \| DISEASES 51428 \| DDX41 \| 2.287 \| DISEASES 1810 \| DR1 \| 2.072 \| DISEASES 9846 \| GAB2 \| 1.883 \| DISEASES 3329 \| HSPD1 \| 2.394 \| DISEASES 5654 \| HTRA1 \| 1.676 \| DISEASES 3586 \| IL10 \| 2.336 \| DISEASES 92399 \| MRRF \| 2.476 \| DISEASES 57380 \| MRS2 \| 3.227 \| DISEASES 4519 \| MT-CYB \| 1.303 \| DISEASES 140767 \| NRSN1 \| 7.376 \| DISEASES 5158 \| PDE6B \| 1.477 \| DISEASES 5478 \| PPIA \| 1.456 \| DISEASES 5813 \| PURA \| 4.012 \| DISEASES 5814 \| PURB \| 5.131 \| DISEASES 5888 \| RAD51 \| 2.054 \| DISEASES 23221 \| RHOBTB2 \| 2.756 \| DISEASES 6231 \| RPS26 \| 2.748 \| DISEASES 51750 \| RTEL1 \| 1.814 \| DISEASES 862 \| RUNX1T1 \| 1.387 \| DISEASES 25870 \| SUMF2 \| 2.516 \| DISEASES 6892 \| TAPBP \| 1.969 \| DISEASES 50945 \| TBX22 \| 3.258 \| DISEASES 7072 \| TIA1 \| 1.182 \| DISEASES 7124 \| TNF \| 2.109 \| DISEASES 7133 \| TNFRSF1B \| 1.433 \| DISEASES 51592 \| TRIM33 \| 1.388 \| DISEASES 9278 \| ZBTB22 \| 1.89 \| DISEASES
Locus	(Waiting for update.)

Disease ID	737
Disease	relapsing fever
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:19) HP:0011110 \| Inflammation of tonsils \| 2 HP:0012531 \| Pain \| 2 HP:0002829 \| Arthralgias \| 1 HP:0002373 \| Febrile convulsions \| 1 HP:0004432 \| Agammaglobulinaemia \| 1 HP:0012735 \| Coughing \| 1 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0000873 \| Diabetes insipidus \| 1 HP:0002754 \| Bone infection \| 1 HP:0012072 \| Aciduria \| 1 HP:0002046 \| Heat intolerance \| 1 HP:0001944 \| Dehydration \| 1 HP:0100963 \| Hyperesthesia \| 1 HP:0000010 \| Frequent urinary tract infections \| 1 HP:0045073 \| Serositis \| 1 HP:0003040 \| Arthropathy \| 1 HP:0001250 \| Seizures \| 1 HP:0100749 \| Thoracic pain \| 1 HP:0003326 \| Muscle pain \| 1

Disease ID	737
Disease	relapsing fever
Manually Symptom	UMLS \| Name(Total Manually Symptoms:5) C0235031 \| neurologic symptoms C0042928 \| vocal cord paralysis C0040034 \| thrombocytopenia C0026827 \| hypotonia C0004610 \| bacteremia
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0004610 \| bacteremia \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs28940578	15805719	4210	MEFV	umls:C0035021	BeFree	Here, we report a Japanese female FMF patient with heterozygosity for the compound pyrin E148Q/M694I showing recurrent fever, serositis or delay in skin wound healing.	0.000814326	2005	MEFV	16	3243405	C	T
rs3743930	15805719	4210	MEFV	umls:C0035021	BeFree	Here, we report a Japanese female FMF patient with heterozygosity for the compound pyrin E148Q/M694I showing recurrent fever, serositis or delay in skin wound healing.	0.000814326	2005	MEFV	16	3254626	C	G

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	737
Disease	relapsing fever
Case	(Waiting for update.)

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