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encyclopedia of Rare Disease Annotation for Precision Medicine

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	rabies

Disease ID	912
Disease	rabies
Definition	Acute VIRAL CNS INFECTION affecting mammals, including humans. It is caused by RABIES VIRUS and usually spread by contamination with virus-laden saliva of bites inflicted by rabid animals. Important animal vectors include the dog, cat, bat, fox, raccoon, skunk, and wolf.
Synonym	[x]rabies, unspecified [x]rabies, unspecified (disorder) hydrophobia hydrophobia (finding) lyssa lyssa - rabies lyssas rabies (& hydrophobia) rabies (& hydrophobia) (disorder) rabies (disorder) rabies - hydrophobia rabies [disease/finding] rabies, nos
Orphanet	ORPHANET:770
DOID	DOID:11260
UMLS	C0034494
MeSH	D011818
SNOMED-CT	SNOMEDCT_US_2016_09_01:14168008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:17) C0027765 \| neurological disease \| 2 C0034494 \| hydrophobia \| 2 C0034494 \| rabies \| 2 C0019348 \| herpes simplex \| 1 C0013884 \| lymphatic filariasis \| 1 C0038362 \| stomatitis \| 1 C0042075 \| urological disorders \| 1 C0014742 \| erythema multiforme \| 1 C0042769 \| viral infection \| 1 C0042769 \| viral disease \| 1 C0016085 \| filariasis \| 1 C0042769 \| viral infections \| 1 C0027765 \| neurological disorder \| 1 C0023281 \| leishmaniasis \| 1 C0042769 \| viral diseases \| 1 C0027819 \| neuroblastoma \| 1 C0027765 \| neurological disorders \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:98) 7920 \| ABHD16A \| 2.275 \| DISEASES 3267 \| AGFG1 \| 3.06 \| DISEASES 10541 \| ANP32B \| 2.818 \| DISEASES 7917 \| BAG6 \| 1.229 \| DISEASES 54828 \| BCAS3 \| 3.45 \| DISEASES 815 \| CAMK2A \| 2.011 \| DISEASES 834 \| CASP1 \| 1.392 \| DISEASES 57091 \| CASS4 \| 2.154 \| DISEASES 81669 \| CCNL2 \| 2.169 \| DISEASES 959 \| CD40LG \| 2.831 \| DISEASES 1103 \| CHAT \| 1.752 \| DISEASES 57019 \| CIAPIN1 \| 2.14 \| DISEASES 51727 \| CMPK1 \| 2.278 \| DISEASES 10675 \| CSPG5 \| 1.811 \| DISEASES 1641 \| DCX \| 1.451 \| DISEASES 1791 \| DNTT \| 1.065 \| DISEASES 1859 \| DYRK1A \| 1.82 \| DISEASES 1915 \| EEF1A1 \| 1.185 \| DISEASES 133584 \| EGFLAM \| 3.895 \| DISEASES 2035 \| EPB41 \| 2.554 \| DISEASES 2060 \| EPS15 \| 1.795 \| DISEASES 30816 \| ERVW-1 \| 4.096 \| DISEASES 7430 \| EZR \| 1.423 \| DISEASES 356 \| FASLG \| 1.12 \| DISEASES 2242 \| FES \| 1.204 \| DISEASES 2314 \| FLII \| 1.312 \| DISEASES 2316 \| FLNA \| 2.069 \| DISEASES 2760 \| GM2A \| 1.82 \| DISEASES 2804 \| GOLGB1 \| 1.204 \| DISEASES 7918 \| GPANK1 \| 2.554 \| DISEASES 84706 \| GPT2 \| 1.743 \| DISEASES 51454 \| GULP1 \| 2.482 \| DISEASES 2996 \| GYPE \| 1.086 \| DISEASES 8091 \| HMGA2 \| 1.195 \| DISEASES 84525 \| HOPX \| 1.476 \| DISEASES 3399 \| ID3 \| 1.144 \| DISEASES 3418 \| IDH2 \| 1.231 \| DISEASES 3433 \| IFIT2 \| 2.828 \| DISEASES 8519 \| IFITM1 \| 1.463 \| DISEASES 3441 \| IFNA4 \| 2.88 \| DISEASES 3456 \| IFNB1 \| 1.919 \| DISEASES 9641 \| IKBKE \| 1.774 \| DISEASES 3664 \| IRF6 \| 1.299 \| DISEASES 9636 \| ISG15 \| 1.017 \| DISEASES 3840 \| KPNA4 \| 3.289 \| DISEASES 3916 \| LAMP1 \| 1.448 \| DISEASES 126364 \| LRRC25 \| 2.067 \| DISEASES 23764 \| MAFF \| 2.207 \| DISEASES 4099 \| MAG \| 1.448 \| DISEASES 23139 \| MAST2 \| 1.15 \| DISEASES 4155 \| MBP \| 3.154 \| DISEASES 9968 \| MED12 \| 2.092 \| DISEASES 79104 \| MEG8 \| 3.859 \| DISEASES 4519 \| MT-CYB \| 1.548 \| DISEASES 4599 \| MX1 \| 1.775 \| DISEASES 4734 \| NEDD4 \| 2.188 \| DISEASES 11188 \| NISCH \| 1.138 \| DISEASES 58484 \| NLRC4 \| 1.024 \| DISEASES 4881 \| NPR1 \| 1.413 \| DISEASES 8021 \| NUP214 \| 1.277 \| DISEASES 4938 \| OAS1 \| 1.476 \| DISEASES 4948 \| OCA2 \| 2.897 \| DISEASES 100506658 \| OCLN \| 1.069 \| DISEASES 4976 \| OPA1 \| 2.258 \| DISEASES 5030 \| P2RY4 \| 1.984 \| DISEASES 5077 \| PAX3 \| 1.955 \| DISEASES 5256 \| PHKA2 \| 1.682 \| DISEASES 55361 \| PI4K2A \| 2.067 \| DISEASES 139728 \| PNCK \| 1.325 \| DISEASES 5455 \| POU3F3 \| 1.674 \| DISEASES 56980 \| PRDM10 \| 1.5 \| DISEASES 10549 \| PRDX4 \| 1.547 \| DISEASES 5664 \| PSEN2 \| 2.316 \| DISEASES 5670 \| PSG2 \| 2.88 \| DISEASES 57111 \| RAB25 \| 1.769 \| DISEASES 23543 \| RBFOX2 \| 1.95 \| DISEASES 343035 \| RD3 \| 1.633 \| DISEASES 83695 \| RHNO1 \| 1.189 \| DISEASES 6050 \| RNH1 \| 2.145 \| DISEASES 404552 \| SCGB1D4 \| 1.151 \| DISEASES 9728 \| SECISBP2L \| 2.071 \| DISEASES 5104 \| SERPINA5 \| 2.678 \| DISEASES 1811 \| SLC26A3 \| 1.925 \| DISEASES 94161 \| SNORD46 \| 2.158 \| DISEASES 26793 \| SNORD56 \| 4.055 \| DISEASES 6772 \| STAT1 \| 1.55 \| DISEASES 26136 \| TES \| 2.195 \| DISEASES 51284 \| TLR7 \| 1.174 \| DISEASES 340061 \| TMEM173 \| 1.869 \| DISEASES 7124 \| TNF \| 1.764 \| DISEASES 8794 \| TNFRSF10C \| 1.088 \| DISEASES 121278 \| TPH2 \| 1.565 \| DISEASES 51592 \| TRIM33 \| 1.589 \| DISEASES 7318 \| UBA7 \| 1.997 \| DISEASES 8725 \| URI1 \| 1.685 \| DISEASES 6375 \| XCL1 \| 1.221 \| DISEASES 7784 \| ZP3 \| 1.786 \| DISEASES 57829 \| ZP4 \| 2.263 \| DISEASES
Locus	(Waiting for update.)

Disease ID	912
Disease	rabies
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:19) HP:0001250 \| Seizures HP:0003401 \| Paresthesia HP:0000708 \| Behavioral abnormality HP:0001645 \| Sudden cardiac death HP:0003781 \| Excessive salivation HP:0002014 \| Diarrhea HP:0100021 \| Cerebral palsy HP:0001604 \| Vocal cord paresis HP:0000738 \| Hallucinations HP:0000716 \| Depression HP:0002017 \| Nausea and vomiting HP:0100785 \| Insomnia HP:0001945 \| Fever HP:0004372 \| Reduced consciousness/confusion HP:0007018 \| Attention deficit hyperactivity disorder HP:0002039 \| Anorexia HP:0100776 \| Recurrent pharyngitis HP:0002076 \| Migraine HP:0000739 \| Anxiety
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:12) HP:0003470 \| Inability to move \| 2 HP:0010783 \| Erythema \| 2 HP:0003287 \| Abnormality of mitochondrial metabolism \| 1 HP:0002719 \| infections, recurrent \| 1 HP:0001289 \| Confusion \| 1 HP:0003006 \| Neuroblastoma \| 1 HP:0001541 \| Ascites \| 1 HP:0000989 \| pruritis \| 1 HP:0010280 \| Stomatitis \| 1 HP:0000718 \| Aggressive behaviour \| 1 HP:0000708 \| Behavioral problems \| 1 HP:0000211 \| Trismus \| 1

Disease ID	912
Disease	rabies
Manually Symptom	UMLS \| Name(Total Manually Symptoms:21) C2711548 \| infectious process C2364133 \| infection C2127436 \| ascending paralysis C1962971 \| myocarditis C1518296 \| neuropathogenesis C1264606 \| persistent infection C0751378 \| neurologic signs C0426359 \| urinary symptoms C0277551 \| enzootic disease C0262471 \| ent problem C0235031 \| neurological symptoms C0042749 \| viraemia C0035222 \| acute respiratory distress syndrome C0033117 \| priapism C0032285 \| pneumonitis C0022660 \| acute renal failure C0021051 \| immunodeficiency C0020453 \| hyperesthesia C0014070 \| encephalomyelitis C0014038 \| encephalitis C0004936 \| mental disorders
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0009450 \| infection \| 43 C0751378 \| neurologic signs \| 2 C0235031 \| neurological symptoms \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:4)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0007018	Attention deficit hyperactivity disorder	MP:0001399	hyperactivity	general restlessness or excessive movement; more frequent movement from one place to another or having an increased state of activity
HP:0003781	Excessive salivation	MP:0000622	increased salivation	greater than normal amounts of flowing saliva
HP:0002017	Nausea and vomiting	MP:0010426	abnormal heart and great artery attachment	any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta
HP:0001645	Sudden cardiac death	MP:0012557	decreased calcium uptake by cardiac muscle	decreased directed movement of calcium ions into cardiac muscle; decreased or disrupted uptake may give rise to energetic deficit and oxidative stress. leading to cardiac disease

Mapped by homologous gene(Total Items:19)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0100021	Cerebral palsy	MP:0013026	decreased Ly6C low monocyte number	decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes
HP:0001945	Fever	MP:0020254	decreased collagen level	decreased level of the main structural protein of the various connective tissues in animals
HP:0000739	Anxiety	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0000738	Hallucinations	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0002076	Migraine	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0000716	Depression	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0001250	Seizures	MP:3000003	abnormal Ebner's gland morphology	any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l
HP:0004372	Reduced consciousness/confusion	MP:0013405	increased circulating lactate level	greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase
HP:0100776	Recurrent pharyngitis	MP:0013716	hypolactation	partial failure, or reduced ability to produce or secrete milk from the mammary gland
HP:0000708	Behavioral abnormality	MP:0020316	decreased vascular endothelial cell proliferation	decrease in the expansion rate of any vascular endothelial cell population by cell division
HP:0001645	Sudden cardiac death	MP:0020329	decreased capillary density	reduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0002014	Diarrhea	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye
HP:0003401	Paresthesia	MP:0014185	cerebellum atrophy	acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal
HP:0100785	Insomnia	MP:0020187	altered susceptibility to prion infection	altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is
HP:0007018	Attention deficit hyperactivity disorder	MP:0020169	increased thyroid gland weight	higher than average weight of the thyroid gland
HP:0002039	Anorexia	MP:0020137	decreased bone mineralization	decrease in the rate at which minerals are deposited into bone
HP:0003781	Excessive salivation	MP:0012559	decreased forebrain volume	decrease from the average range of forebrain volume compared to normal
HP:0001604	Vocal cord paresis	MP:0013438	dysmyelination	reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin
HP:0002017	Nausea and vomiting	MP:0020220	decreased tear production	decreased production of the amount of fluid produced in the eye

Disease ID	912
Disease	rabies
Case	(Waiting for update.)