eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| pyoderma gangrenosum | ||||
| Disease ID | 318 |
|---|---|
| Disease | pyoderma gangrenosum |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:27) C2073625 | pleural effusion C1562901 | peripheral ulcerative keratitis C1555769 | pulmonary disease C1304219 | rheumatoid neutrophilic dermatitis C1257847 | hemorrhagic rectocolitis C1136085 | monoclonal gammopathy C0748159 | pulmonary involvement C0586407 | skin symptoms C0566602 | primary sclerosing cholangitis C0497156 | lymphadenopathy C0339194 | nodular scleritis C0272396 | lymph node abscess C0206061 | interstitial pneumonia C0178703 | hypertrophic osteoarthropathy C0155354 | scleromalacia perforans C0086438 | hypogammaglobulinemia C0039263 | takayasu's arteritis C0037928 | myelopathy C0037284 | skin lesions C0032305 | pneumocystis carinii pneumonia C0032285 | pneumonitis C0024205 | adenitis C0023223 | leg ulcers C0022408 | articular disease C0010346 | crohn's disease C0009324 | ulcerative colitis C0003864 | arthritis |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:10) C0009324 | ulcerative colitis | 12 C0010346 | crohn's disease | 5 C0748159 | pulmonary involvement | 4 C0023223 | leg ulcers | 2 C0003864 | arthritis | 1 C0339194 | nodular scleritis | 1 C0037284 | skin lesions | 1 C1304219 | rheumatoid neutrophilic dermatitis | 1 C1562901 | peripheral ulcerative keratitis | 1 C0039263 | takayasu's arteritis | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
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| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
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| (Waiting for update.) | |
All Snps(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Annotation(Total Genotypes:0) | |
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| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
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| (Waiting for update.) | |
Mapped by lexical matching(Total Items:3) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0010702 | Increased antibody level in blood | MP:0012336 | decreased vitamin D level | reduced level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalci |
| HP:0002037 | Inflammation of the large intestine | MP:0004842 | abnormal large intestine crypts of Lieberkuhn morphology | any structural anomaly of the tubular intestinal glands found in the mucosal membranes of the large intestine |
| HP:0008066 | Abnormal blistering of the skin | MP:0009536 | abnormal interstitial cell of Cajal morphology | any structural anomaly in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which |
Mapped by homologous gene(Total Items:14) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0200034 | Papule | MP:0013745 | abnormal eyelid margin morphology | any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium |
| HP:0100614 | Myositis | MP:0011635 | abnormal mitochondrial crista morphology | Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, whe |
| HP:0001075 | Atrophic scars | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0001945 | Fever | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0002829 | Arthralgia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002037 | Inflammation of the large intestine | MP:0013803 | increased IgG2 level | greater than normal immunoglobulin class G2 level |
| HP:0010702 | Increased antibody level in blood | MP:0013696 | increased granulocyte monocyte progenitor cell number | increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1 |
| HP:0200042 | Skin ulcer | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0008066 | Abnormal blistering of the skin | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0002863 | Myelodysplasia | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0003326 | Myalgia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0001370 | Rheumatoid arthritis | MP:0011882 | enlarged duodenum | increased size of the portion of the small intestine that extends from the pyloris to the junction with the jejunum |
| HP:0200039 | Pustule | MP:0013745 | abnormal eyelid margin morphology | any structural anomaly of the confluence of the mucosal surface of the conjunctiva, the edge of the orbicularis, and the cutaneous epithelium |
| HP:0200037 | Skin vesicle | MP:0011094 | embryonic lethality before implantation, complete penetrance | death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5) |
| Disease ID | 318 |
|---|---|
| Disease | pyoderma gangrenosum |
| Case | (Waiting for update.) |