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	progressive multifocal leukoencephalopathy

Disease ID	351
Disease	progressive multifocal leukoencephalopathy
Definition	An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Synonym	enceph jc polyomavirus encephalitis, jc polyomavirus encephalopathies, jc polyomavirus encephalopathy, jc polyomavirus jc polyomavirus enceph jc polyomavirus encephalitis jc polyomavirus encephalopathy leukoenceph progressive multifocal leukoencephalopathies, progressive multifocal leukoencephalopathy, progressive multifocal leukoencephalopathy, progressive multifocal [disease/finding] multifocal leucoencephalopathy multifocal leukoencephalopathies, progressive multifocal leukoencephalopathy multifocal leukoencephalopathy nos multifocal leukoencephalopathy, nos multifocal leukoencephalopathy, progressive pml pml - progressive multifocal leucoencephalopathy pml - progressive multifocal leukoencephalopathy pmle - progressive multifocal leucoencephalopathy pmle - progressive multifocal leukoencephalopathy prog multifoc leukoencep progressive multifocal leucoencephalopathy progressive multifocal leukoenceph progressive multifocal leukoencephalopathies progressive multifocal leukoencephalopathy (disorder)
Orphanet	ORPHANET:217260
OMIM	OMIM:102578
DOID	DOID:643
ICD10	ICD10CM:A81.2
UMLS	C0023524
MeSH	D007968
SNOMED-CT	SNOMEDCT_US_2016_09_01:22255007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:36) C0026769 \| multiple sclerosis \| 22 C0024299 \| lymphoma \| 6 C0019829 \| hodgkin lymphoma \| 5 C0024305 \| non-hodgkin lymphoma \| 4 C0221027 \| good's syndrome \| 3 C0003873 \| rheumatoid arthritis \| 3 C0010346 \| crohn's disease \| 3 C0023434 \| chronic lymphocytic leukemia \| 2 C0409974 \| lupus erythematosus \| 2 C0009447 \| common variable immunodeficiency \| 2 C0042769 \| virus infection \| 2 C0021053 \| immune disease \| 2 C0024141 \| systemic lupus erythematosus \| 2 C0026764 \| multiple myeloma \| 2 C0023891 \| alcoholic cirrhosis \| 1 C0751967 \| relapsing-remitting multiple sclerosis \| 1 C0376545 \| hematological malignancy \| 1 C0023470 \| myeloid leukaemia \| 1 C0022658 \| nephropathy \| 1 C0024419 \| waldenstrom macroglobulinemia \| 1 C0206744 \| cd4 lymphocytopenia \| 1 C0036920 \| sezary syndrome \| 1 C0038220 \| status epilepticus \| 1 C0003864 \| arthritis \| 1 C0023418 \| leukaemia \| 1 C0035435 \| rheumatic diseases \| 1 C0008312 \| primary biliary cirrhosis \| 1 C0024299 \| malignant lymphoma \| 1 C0023448 \| lymphocytic leukemia \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0035435 \| rheumatic disease \| 1 C0021831 \| intestinal disease \| 1 C0036205 \| pulmonary sarcoidosis \| 1 C0008312 \| biliary cirrhosis \| 1 C0023467 \| acute myeloid leukaemia \| 1 C0017178 \| gastrointestinal disease \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 7157 \| TP53 \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:61) 240 \| ALOX5 \| 1.985 \| DISEASES 573 \| BAG1 \| 2.021 \| DISEASES 9531 \| BAG3 \| 2.727 \| DISEASES 388372 \| CCL4L1 \| 1.34 \| DISEASES 1237 \| CCR8 \| 1.479 \| DISEASES 10803 \| CCR9 \| 1.303 \| DISEASES 930 \| CD19 \| 2.239 \| DISEASES 50489 \| CD207 \| 1.08 \| DISEASES 959 \| CD40LG \| 1.841 \| DISEASES 1043 \| CD52 \| 2.069 \| DISEASES 1499 \| CTNNB1 \| 1.102 \| DISEASES 399697 \| CTXN2 \| 3.173 \| DISEASES 2833 \| CXCR3 \| 1.644 \| DISEASES 199699 \| DAND5 \| 1.267 \| DISEASES 81704 \| DOCK8 \| 2.398 \| DISEASES 2060 \| EPS15 \| 1.873 \| DISEASES 8928 \| FOXH1 \| 1.917 \| DISEASES 5348 \| FXYD1 \| 2.168 \| DISEASES 3356 \| HTR2A \| 3.789 \| DISEASES 3434 \| IFIT1 \| 1.498 \| DISEASES 3456 \| IFNB1 \| 4.823 \| DISEASES 3476 \| IGBP1 \| 4.116 \| DISEASES 3605 \| IL17A \| 1.115 \| DISEASES 10379 \| IRF9 \| 1.707 \| DISEASES 3676 \| ITGA4 \| 3.397 \| DISEASES 3683 \| ITGAL \| 2.851 \| DISEASES 10219 \| KLRG1 \| 1.907 \| DISEASES 4099 \| MAG \| 2.147 \| DISEASES 4155 \| MBP \| 3.529 \| DISEASES 4204 \| MECP2 \| 1.085 \| DISEASES 56955 \| MEPE \| 1.394 \| DISEASES 10608 \| MXD4 \| 5.916 \| DISEASES 4763 \| NF1 \| 2.67 \| DISEASES 246734 \| NPCDR1 \| 1.999 \| DISEASES 4948 \| OCA2 \| 1.016 \| DISEASES 5450 \| POU2AF1 \| 2.686 \| DISEASES 5453 \| POU3F1 \| 2.823 \| DISEASES 5813 \| PURA \| 4.32 \| DISEASES 5888 \| RAD51 \| 1.691 \| DISEASES 146713 \| RBFOX3 \| 1.194 \| DISEASES 55147 \| RBM23 \| 3.053 \| DISEASES 9939 \| RBM8A \| 3.036 \| DISEASES 91543 \| RSAD2 \| 1.94 \| DISEASES 404552 \| SCGB1D4 \| 2.747 \| DISEASES 23583 \| SMUG1 \| 1.685 \| DISEASES 6663 \| SOX10 \| 1.622 \| DISEASES 6664 \| SOX11 \| 1.327 \| DISEASES 6672 \| SP100 \| 1.132 \| DISEASES 6689 \| SPIB \| 4.629 \| DISEASES 23648 \| SSBP3 \| 1.345 \| DISEASES 6772 \| STAT1 \| 1.382 \| DISEASES 7042 \| TGFB2 \| 1.187 \| DISEASES 7124 \| TNF \| 3.106 \| DISEASES 7133 \| TNFRSF1B \| 2.722 \| DISEASES 10673 \| TNFSF13B \| 1.037 \| DISEASES 7150 \| TOP1 \| 2.01 \| DISEASES 9094 \| UNC119 \| 3.265 \| DISEASES 7441 \| VPREB1 \| 1.33 \| DISEASES 4904 \| YBX1 \| 1.773 \| DISEASES 9278 \| ZBTB22 \| 1.257 \| DISEASES 26036 \| ZNF451 \| 2.027 \| DISEASES
Locus	(Waiting for update.)

Disease ID	351
Disease	progressive multifocal leukoencephalopathy
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:28) HP:0002665 \| Lymphoma \| 6 HP:0012189 \| Hodgkin disease \| 5 HP:0002721 \| Immunodeficiency \| 4 HP:0012539 \| Non-Hodgkin lymphoma \| 4 HP:0006775 \| Multiple myeloma \| 3 HP:0001370 \| Rheumatoid arthritis \| 3 HP:0100280 \| Morbus Crohn \| 3 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0005550 \| Chronic lymphatic leukemia \| 2 HP:0011096 \| Demyelination \| 1 HP:0009733 \| Glioma \| 1 HP:0002169 \| Clonus \| 1 HP:0001369 \| Arthritis \| 1 HP:0000112 \| Nephropathy \| 1 HP:0000572 \| Visual loss \| 1 HP:0011448 \| Ankle clonus \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0001410 \| Decreased liver function \| 1 HP:0001888 \| Lymphocytopenia \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0002133 \| Status epilepticus \| 1 HP:0000969 \| Dropsy \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0001337 \| Tremor \| 1 HP:0005403 \| Decreased numbers of circulating T cells \| 1 HP:0002613 \| Biliary cirrhosis \| 1 HP:0005508 \| Waldenstrom macroglobulinemia \| 1

Disease ID	351
Disease	progressive multifocal leukoencephalopathy
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C2364133 \| infection C1619738 \| immune reconstitution syndrome C1619738 \| immune reconstitution inflammatory syndrome C0857836 \| jc virus infection C0235031 \| neurological symptoms C0085543 \| epilepsia partialis continua C0042769 \| virus infection C0026764 \| multiple myeloma C0007684 \| central nervous system infections
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:5) C0009450 \| infection \| 6 C1619738 \| immune reconstitution inflammatory syndrome \| 4 C0042769 \| virus infection \| 3 C0026764 \| multiple myeloma \| 3 C0857836 \| jc virus infection \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	351
Disease	progressive multifocal leukoencephalopathy
Case	(Waiting for update.)

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