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	premature ovarian failure

Disease ID	414
Disease	premature ovarian failure
Definition	The premature cessation of menses (MENSTRUATION) when the last menstrual period occurs in a woman under the age of 40. It is due to the depletion of OVARIAN FOLLICLES. Premature MENOPAUSE can be caused by diseases; OVARIECTOMY; RADIATION; chemicals; and chromosomal abnormalities.
Synonym	early menopause menopause - premature menopause early menopause praecox menopause praecox (qualifier value) menopause premature menopause, premature menopause, premature [disease/finding] pof precocious menopause premature menopause premature menopause (finding) premature menopause nos premature menopause nos (qualifier value)
OMIM	OMIM:311360
DOID	DOID:5426 DOID:10787
UMLS	C0025322
MeSH	D008594
SNOMED-CT	SNOMEDCT_US_2016_09_01:373717006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:25) C0006142 \| breast cancer \| 4 C0041408 \| turner syndrome \| 3 C0007222 \| cardiovascular disease \| 3 C0021359 \| infertile \| 3 C0021359 \| infertility \| 3 C0042373 \| vascular disease \| 3 C1527336 \| sjogren syndrome \| 2 C0001403 \| addison's disease \| 2 C0011847 \| diabetes \| 2 C0010068 \| coronary heart disease \| 1 C0019158 \| hepatitis \| 1 C0018799 \| heart disease \| 1 C0019196 \| hepatitis c \| 1 C0023520 \| leukodystrophy \| 1 C0014130 \| endocrine disorders \| 1 C0011860 \| type 2 diabetes \| 1 C0302592 \| cervical ca \| 1 C0004509 \| azoospermia \| 1 C0162429 \| poor nutrition \| 1 C0007847 \| cervical cancer \| 1 C0154208 \| ovarian dysfunction \| 1 C0271737 \| autoimmune addison's disease \| 1 C0677607 \| hashimoto's thyroiditis \| 1 C0029456 \| osteoporosis \| 1 C0004153 \| atherosclerosis \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:14) 2074 \| ERCC6 \| UniProtKB-KW 2516 \| NR5A1 \| UniProtKB-KW 57505 \| AARS2 \| UniProtKB-KW 9210 \| BMP15 \| UniProtKB-KW 135935 \| NOBOX \| UniProtKB-KW 2332 \| FMR1 \| UniProtKB-KW 10734 \| STAG3 \| UniProtKB-KW 79983 \| POF1B \| UniProtKB-KW 668 \| FOXL2 \| UniProtKB-KW 344018 \| FIGLA \| UniProtKB-KW 1730 \| DIAPH2 \| UniProtKB-KW 84515 \| MCM8 \| UniProtKB-KW 93426 \| SYCE1 \| UniProtKB-KW 164045 \| HFM1 \| UniProtKB-KW
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:13) 7421 \| VDR \| CIPHER 9210 \| BMP15 \| CIPHER 117154 \| DACH2 \| CIPHER 2332 \| FMR1 \| CIPHER 668 \| FOXL2 \| CIPHER 2477 \| FRAXA \| CIPHER 2492 \| FSHR \| CIPHER 2592 \| GALT \| CIPHER 2661 \| GDF9 \| CIPHER 3623 \| INHA \| CIPHER 3624 \| INHBA \| CIPHER 342977 \| NANOS3 \| CIPHER 79983 \| POF1B \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:182) 2334 \| AFF2 \| 2.92 \| DISEASES 367 \| AR \| 2.281 \| DISEASES 653 \| BMP5 \| 1.142 \| DISEASES 659 \| BMPR2 \| 1.106 \| DISEASES 672 \| BRCA1 \| 3.151 \| DISEASES 672 \| BRCA1 \| 1.868 \| DISEASES 675 \| BRCA2 \| 3.089 \| DISEASES 675 \| BRCA2 \| 1.831 \| DISEASES 796 \| CALCA \| 1.635 \| DISEASES 1041 \| CDSN \| 1.068 \| DISEASES 23562 \| CLDN14 \| 1.25 \| DISEASES 9074 \| CLDN6 \| 1.302 \| DISEASES 64084 \| CLSTN2 \| 1.147 \| DISEASES 100272147 \| CMC4 \| 2.524 \| DISEASES 9276 \| COPB2 \| 2.172 \| DISEASES 51004 \| COQ6 \| 1.755 \| DISEASES 1363 \| CPE \| 1.833 \| DISEASES 64506 \| CPEB1 \| 3.248 \| DISEASES 64506 \| CPEB1 \| 2.857 \| DISEASES 10675 \| CSPG5 \| 1.079 \| DISEASES 1586 \| CYP17A1 \| 3.373 \| DISEASES 1589 \| CYP21A2 \| 1.443 \| DISEASES 1555 \| CYP2B6 \| 1.227 \| DISEASES 1557 \| CYP2C19 \| 1.285 \| DISEASES 117154 \| DACH2 \| 3.719 \| DISEASES 147906 \| DACT3 \| 2.954 \| DISEASES 80067 \| DCAF17 \| 1.277 \| DISEASES 55827 \| DCAF6 \| 2.763 \| DISEASES 1644 \| DDC \| 1.74 \| DISEASES 11218 \| DDX20 \| 1.266 \| DISEASES 54514 \| DDX4 \| 3.135 \| DISEASES 1730 \| DIAPH2 \| 4.547 \| DISEASES 23405 \| DICER1 \| 1.671 \| DISEASES 1750 \| DLX6 \| 2.495 \| DISEASES 1761 \| DMRT1 \| 1.155 \| DISEASES 151871 \| DPPA2 \| 1.557 \| DISEASES 359787 \| DPPA3 \| 2.668 \| DISEASES 55211 \| DPPA4 \| 2.095 \| DISEASES 29102 \| DROSHA \| 1.971 \| DISEASES 338599 \| DUPD1 \| 2.724 \| DISEASES 1967 \| EIF2B1 \| 2.562 \| DISEASES 8891 \| EIF2B3 \| 2.438 \| DISEASES 56478 \| EIF4ENIF1 \| 1.902 \| DISEASES 2058 \| EPRS \| 1.472 \| DISEASES 2100 \| ESR2 \| 2.179 \| DISEASES 159091 \| FAM122C \| 4.085 \| DISEASES 728215 \| FAM155A \| 3.003 \| DISEASES 654463 \| FER1L6 \| 3.042 \| DISEASES 2274 \| FHL2 \| 1.92 \| DISEASES 344018 \| FIGLA \| 5.636 \| DISEASES 2332 \| FMR1 \| 6.75 \| DISEASES 2332 \| FMR1 \| 3.041 \| DISEASES 100126270 \| FMR1-AS1 \| 2.208 \| DISEASES 64778 \| FNDC3B \| 1.537 \| DISEASES 2304 \| FOXE1 \| 1.812 \| DISEASES 668 \| FOXL2 \| 6.611 \| DISEASES 668 \| FOXL2 \| 1.683 \| DISEASES 2308 \| FOXO1 \| 1.216 \| DISEASES 2309 \| FOXO3 \| 3.861 \| DISEASES 4303 \| FOXO4 \| 1.244 \| DISEASES 2492 \| FSHR \| 5.722 \| DISEASES 2492 \| FSHR \| 3.035 \| DISEASES 2592 \| GALT \| 4.984 \| DISEASES 2626 \| GATA4 \| 1.413 \| DISEASES 25801 \| GCA \| 2.221 \| DISEASES 9247 \| GCM2 \| 1.015 \| DISEASES 9573 \| GDF3 \| 1.081 \| DISEASES 199720 \| GGN \| 1.038 \| DISEASES 2701 \| GJA4 \| 1.646 \| DISEASES 2827 \| GPR3 \| 4.327 \| DISEASES 79712 \| GTDC1 \| 2.505 \| DISEASES 3014 \| H2AFX \| 1.343 \| DISEASES 164045 \| HFM1 \| 3.341 \| DISEASES 90161 \| HS6ST2 \| 1.952 \| DISEASES 3293 \| HSD17B3 \| 2.637 \| DISEASES 3295 \| HSD17B4 \| 3.27 \| DISEASES 3283 \| HSD3B1 \| 1.443 \| DISEASES 3326 \| HSP90AB1 \| 1.55 \| DISEASES 3482 \| IGF2R \| 1.156 \| DISEASES 3486 \| IGFBP3 \| 1.634 \| DISEASES 83943 \| IMMP2L \| 1.557 \| DISEASES 79191 \| IRX3 \| 1.147 \| DISEASES 3748 \| KCNC3 \| 1.213 \| DISEASES 3814 \| KISS1 \| 2.686 \| DISEASES 3980 \| LIG3 \| 1.062 \| DISEASES 8825 \| LIN7A \| 1.358 \| DISEASES 4000 \| LMNA \| 1.102 \| DISEASES 4038 \| LRP4 \| 1.003 \| DISEASES 4047 \| LSS \| 1.814 \| DISEASES 10046 \| MAMLD1 \| 2.632 \| DISEASES 84515 \| MCM8 \| 3.923 \| DISEASES 84515 \| MCM8 \| 3.22 \| DISEASES 4194 \| MDM4 \| 1.292 \| DISEASES 219541 \| MED19 \| 1.17 \| DISEASES 644890 \| MEIG1 \| 3.697 \| DISEASES 4439 \| MSH5 \| 2.783 \| DISEASES 4508 \| MT-ATP6 \| 2.606 \| DISEASES 4509 \| MT-ATP8 \| 1.112 \| DISEASES 4512 \| MT-CO1 \| 1.007 \| DISEASES 2475 \| MTOR \| 1.666 \| DISEASES 340719 \| NANOS1 \| 2.76 \| DISEASES 339345 \| NANOS2 \| 2.613 \| DISEASES 342977 \| NANOS3 \| 4.303 \| DISEASES 26151 \| NAT9 \| 1.188 \| DISEASES 4745 \| NELL1 \| 1.332 \| DISEASES 79840 \| NHEJ1 \| 1.451 \| DISEASES 126206 \| NLRP5 \| 1.895 \| DISEASES 135935 \| NOBOX \| 6.298 \| DISEASES 9241 \| NOG \| 1.525 \| DISEASES 190 \| NR0B1 \| 1.13 \| DISEASES 2516 \| NR5A1 \| 5.202 \| DISEASES 2516 \| NR5A1 \| 1.658 \| DISEASES 2494 \| NR5A2 \| 1.806 \| DISEASES 8204 \| NRIP1 \| 2.448 \| DISEASES 170685 \| NUDT10 \| 2.599 \| DISEASES 56001 \| NXF2 \| 1.711 \| DISEASES 728343 \| NXF2B \| 1.711 \| DISEASES 56000 \| NXF3 \| 2.346 \| DISEASES 55998 \| NXF5 \| 3.19 \| DISEASES 8761 \| PABPC4 \| 2.409 \| DISEASES 5069 \| PAPPA \| 1.342 \| DISEASES 84612 \| PARD6B \| 2.293 \| DISEASES 27328 \| PCDH11X \| 1.32 \| DISEASES 5108 \| PCM1 \| 1.678 \| DISEASES 5110 \| PCMT1 \| 1.847 \| DISEASES 5170 \| PDPK1 \| 1.543 \| DISEASES 57107 \| PDSS2 \| 1.652 \| DISEASES 267004 \| PGBD3 \| 2.695 \| DISEASES 5321 \| PLA2G4A \| 1.994 \| DISEASES 5366 \| PMAIP1 \| 1.394 \| DISEASES 100996331 \| POTEB \| 3.074 \| DISEASES 639 \| PRDM1 \| 1.669 \| DISEASES 5557 \| PRIM1 \| 2.371 \| DISEASES 5618 \| PRLR \| 1.103 \| DISEASES 29893 \| PSMC3IP \| 3.04 \| DISEASES 5728 \| PTEN \| 2.452 \| DISEASES 27316 \| RBMX \| 1.631 \| DISEASES 342931 \| RFPL4A \| 3.322 \| DISEASES 9921 \| RNF10 \| 2.856 \| DISEASES 6194 \| RPS6 \| 2.421 \| DISEASES 284654 \| RSPO1 \| 1.818 \| DISEASES 54809 \| SAMD9 \| 1.69 \| DISEASES 23098 \| SARM1 \| 2.528 \| DISEASES 81929 \| SEH1L \| 2.457 \| DISEASES 8991 \| SELENBP1 \| 1.436 \| DISEASES 26135 \| SERBP1 \| 1.774 \| DISEASES 166929 \| SGMS2 \| 1.897 \| DISEASES 6462 \| SHBG \| 3.657 \| DISEASES 6462 \| SHBG \| 1.957 \| DISEASES 6473 \| SHOX \| 2.582 \| DISEASES 84068 \| SLC10A7 \| 1.239 \| DISEASES 4090 \| SMAD5 \| 1.732 \| DISEASES 27127 \| SMC1B \| 2.27 \| DISEASES 402381 \| SOHLH1 \| 4.827 \| DISEASES 54937 \| SOHLH2 \| 3.592 \| DISEASES 6657 \| SOX2 \| 1.166 \| DISEASES 80320 \| SP6 \| 1.486 \| DISEASES 10615 \| SPAG5 \| 1.686 \| DISEASES 10927 \| SPIN1 \| 1.722 \| DISEASES 23626 \| SPO11 \| 2.7 \| DISEASES 6736 \| SRY \| 3.99 \| DISEASES 6736 \| SRY \| 1.854 \| DISEASES 6818 \| SULT1A3 \| 2.061 \| DISEASES 445329 \| SULT1A4 \| 2.086 \| DISEASES 93426 \| SYCE1 \| 4.452 \| DISEASES 93426 \| SYCE1 \| 3.749 \| DISEASES 6925 \| TCF4 \| 1.165 \| DISEASES 90316 \| TGIF2LX \| 2.256 \| DISEASES 8718 \| TNFRSF25 \| 1.525 \| DISEASES 84969 \| TOX2 \| 2.671 \| DISEASES 391712 \| TRIM61 \| 4.099 \| DISEASES 7225 \| TRPC6 \| 2.775 \| DISEASES 388951 \| TSPYL6 \| 3.078 \| DISEASES 7316 \| UBC \| 1.969 \| DISEASES 7329 \| UBE2I \| 1.531 \| DISEASES 89766 \| UMODL1 \| 2.311 \| DISEASES 7490 \| WT1 \| 1.717 \| DISEASES 7503 \| XIST \| 1.683 \| DISEASES 7512 \| XPNPEP2 \| 3.465 \| DISEASES 201501 \| ZBTB7C \| 2.794 \| DISEASES 23414 \| ZFPM2 \| 2.576 \| DISEASES 7784 \| ZP3 \| 4.305 \| DISEASES
Locus	(Waiting for update.)

Disease ID	414
Disease	premature ovarian failure
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:17) HP:0003002 \| Breast carcinoma \| 4 HP:0000789 \| Infertility \| 3 HP:0008207 \| Addison's disease \| 2 HP:0030731 \| Carcinoma \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0000286 \| Palpebronasal fold \| 1 HP:0002415 \| Degeneration of white matter of brain \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0000537 \| Epicanthus inversus \| 1 HP:0002960 \| Autoimmune condition \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0012531 \| Pain \| 1 HP:0000027 \| Azoospermia \| 1 HP:0030016 \| Dyspareunia \| 1 HP:0001297 \| Cerebral vascular events \| 1 HP:0002621 \| Atherosclerosis \| 1 HP:0000872 \| Hashimoto's thyroiditis \| 1

Disease ID	414
Disease	premature ovarian failure
Manually Symptom	UMLS \| Name(Total Manually Symptoms:12) C2219717 \| amenorrhea C0426768 \| o sign C0232940 \| secondary amenorrhea C0152151 \| triplet pregnancy C0040188 \| tic disorders C0032357 \| poland's syndrome C0027126 \| steinert's disease C0026896 \| myasthenia gravis C0021361 \| female infertility C0021359 \| infertility C0004364 \| autoimmune disorder C0002453 \| amenorrhoea
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0021359 \| infertility \| 3 C0007222 \| cardiovascular disease \| 3 C0600142 \| hot flashes \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:23)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs121909658	9757892	2492	FSHR	umls:C0025322	BeFree	No evidence of the inactivating mutation (C566T) in the follicle-stimulating hormone receptor gene in Brazilian women with premature ovarian failure.	0.004614512	1998	FSHR	2	48983125	G	A
rs121913529	22197887	3845	KRAS	umls:C0025322	BeFree	This review summarizes studies providing evidence (1) that endogenous RAS activation regulates important physiological events during ovulation and luteinization (2) that expression of the mutant, active KRAS(G12D) in granulosa cells in vivo causes abnormal follicle growth arrest leading to premature ovarian failure and (3) that KRAS(G12D) expression in ovarian surface epithelial (OSE) cells renders them susceptible to the pathological outcome of transformation and tumor formation.	0.000271442	2012	KRAS	12	25245350	C	T,G,A
rs12611091	24103315	84446	BRSK1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.000271442	2013	BRSK1	19	55288961	T	C
rs12611091	24103315	2099	ESR1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.002442977	2013	BRSK1	19	55288961	T	C
rs12720062	15227735	3623	INHA	umls:C0025322	BeFree	G769A variation of inhibin alpha-gene in korean women with premature ovarian failure.	0.002714419	2004	INHA	2	219575194	G	A
rs12720062	17933751	3623	INHA	umls:C0025322	BeFree	Functional analysis of the human inhibin alpha subunit variant A257T and its potential role in premature ovarian failure.	0.002714419	2007	INHA	2	219575194	G	A
rs150634562	10634424	326	AIRE	umls:C0025322	BeFree	One of the patients, a woman with Addison's disease, autoimmune thyroiditis, and premature menopause was heterozygous for a point mutation (G1021A, Val301Met) in the first plant homeodomain zinc finger domain of the autoimmune regulator (AIRE) gene.	0.000271442	2000	AIRE	21	44291116	G	A
rs1801282	22537818	5468	PPARG	umls:C0025322	BeFree	Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women.	0.000271442	2012	PPARG	3	12351626	C	G
rs1801282	22537818	3952	LEP	umls:C0025322	BeFree	Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women.	0.000271442	2012	PPARG	3	12351626	C	G
rs2120825	22537818	5468	PPARG	umls:C0025322	BeFree	Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women.	0.000271442	2012	PPARG	3	12371840	T	G
rs2120825	22537818	3952	LEP	umls:C0025322	BeFree	Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women.	0.000271442	2012	PPARG	3	12371840	T	G
rs2167270	22537818	3952	LEP	umls:C0025322	BeFree	Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women.	0.000271442	2012	LEP	7	128241296	G	A
rs2167270	22537818	5468	PPARG	umls:C0025322	BeFree	Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women.	0.000271442	2012	LEP	7	128241296	G	A
rs2234693	24103315	84446	BRSK1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.000271442	2013	ESR1	6	151842200	T	C
rs2234693	24103315	2099	ESR1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.002442977	2013	ESR1	6	151842200	T	C
rs2278493	24103315	84446	BRSK1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.000271442	2013	HK3	5	176887433	C	T
rs2278493	24103315	2099	ESR1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.002442977	2013	HK3	5	176887433	C	T
rs3108910	24103315	84446	BRSK1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.000271442	2013	NA	8	100800465	G	A
rs3108910	24103315	2099	ESR1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.002442977	2013	NA	8	100800465	G	A
rs3847153	24103315	84446	BRSK1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.000271442	2013	NA	8	100800928	A	G
rs3847153	24103315	2099	ESR1	umls:C0025322	BeFree	To identify whether variants found in a large Han Chinese cohort - 8q22.3 SNPs rs3847153 and rs3108910; and one SNP each in HK3 (rs2278493), ESR1 (rs2234693) and BRSK1 (rs12611091) - are associated with premature ovarian failure (POF) in a different ethnic group (Serbian).	0.002442977	2013	NA	8	100800928	A	G
rs3856806	22537818	5468	PPARG	umls:C0025322	BeFree	Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women.	0.000271442	2012	PPARG	3	12434058	C	T
rs3856806	22537818	3952	LEP	umls:C0025322	BeFree	Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women.	0.000271442	2012	PPARG	3	12434058	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:251)
CHR	POS	SNPID	REF	ALT	ORI_SNPID	PMID	P_VALUE	P_VALUE_TEXT	OR/BETA	CI95_TEXT	GWAS_INITIAL_SAMPLE_SIZE	SUB_POPULATION	SUPER_POPULATION	GWAS_TRAIT	HPO_ID	HPO_TERM	DO_ID	DO_TERM	MESH_ID	MESH_TERM	EFO_ID	EFO_TERM	DOLITE_TERM	RISK_ALLELE	PUBLICATION_TYPE	AA	GENE_SYMBOL	TYPE	REFGENE
1	27688633	rs1138294	G	A	rs1138294	19508998	6.79E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	MAP3K6
1	34284118	rs3842834	G	A	rs3842834	19508998	5.19E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	CSMD2
1	63452789	rs6696619	T	C	rs6696619	19508998	1.89E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
1	64981488	rs764457	C	T	rs764457	19508998	5.19E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	CACHD1
1	71255441	rs2260454	G	A	rs2260454	19508998	3.31E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
1	80277272	rs11577790	C	A	rs11577790	19508998	4.63E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
1	80537217	rs1572349	A	G	rs1572349	19508998	8.93E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
1	80586993	rs4384179	G	A	rs4384179	19508998	1.09E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
1	80613215	rs7544729	A	G	rs7544729	19508998	7.56E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
1	95330372	rs859098	G	A	rs859098	19508998	6.04E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	SLC44A3
1	118531980	rs749003	C	T	rs749003	19508998	4.81E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	SPAG17
1	119293640	rs17185832	A	G	rs17185832	19508998	1.02E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
1	157879294	rs7524095	C	T	rs7524095	19508998	9.20E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T,C	NA
1	159629021	rs1891186	A	G	rs1891186	19508998	8.34E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
1	159635021	rs2794500	C	T	rs2794500	19508998	8.34E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
1	168524895	rs1933107	A	G	rs1933107	19508998	2.23E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
1	181006930	rs1411479	A	G	rs1411479	19508998	5.46E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	MR1
1	190577336	rs584161	T	G	rs584161	19508998	4.48E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
1	208558547	rs696979	T	C	rs696979	19508998	3.04E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
1	211176922	rs1501551	C	T	rs1501551	19508998	2.92E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	KCNH1
1	224599977	rs12121977	G	T	rs12121977	19508998	3.81E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	WDR26
1	240137811	rs10495451	C	T	rs10495451	19508998	2.03E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
2	15297306	rs4294976	G	T	rs4294976	19508998	6.66E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
2	20472847	rs10164749	G	A	rs10164749	19508998	9.95E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	PUM2
2	22712316	rs937932	T	G	rs937932	19508998	5.62E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
2	22918437	rs719503	G	A	rs719503	19508998	4.00E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
2	34283170	rs1425005	G	A	rs1425005	19508998	4.93E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
2	52083589	rs13035243	A	G	rs13035243	19508998	1.09E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
2	67155259	rs1420369	A	G	rs1420369	19508998	5.66E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
2	103617979	rs7587833	G	T	rs7587833	19508998	7.44E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
2	103619483	rs9308861	T	C	rs9308861	19508998	8.66E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
2	113985170	rs4849179	C	T	rs4849179	19508998	6.07E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	PAX8
2	123663290	rs1850585	T	C	rs1850585	19508998	4.88E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
2	123704606	rs1527978	C	T	rs1527978	19508998	4.88E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
2	127137005	rs359688	G	A	rs359688	19508998	7.48E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
2	133661411	rs1020429	T	C	rs1020429	19508998	5.80E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NCKAP5
2	142437151	rs7560557	G	A	rs7560557	19508998	4.00E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	LRP1B
2	156926773	rs10497174	C	T	rs10497174	19508998	3.34E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
2	175127653	rs4350713	A	G	rs4350713	19508998	7.55E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
2	193232686	rs1446397	G	A	rs1446397	19508998	4.76E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
2	205969220	rs2289025	G	A	rs2289025	19508998	5.36E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	PARD3B
2	205992964	rs10497881	C	T	rs10497881	19508998	8.61E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	PARD3B
2	217980433	rs12466929	G	A	rs12466929	19508998	1.50E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
2	222211083	rs1025369	T	C	rs1025369	19508998	3.59E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
2	222295760	rs3770205	C	A	rs3770205	19508998	2.01E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	EPHA4
2	239013662	rs7565244	A	G	rs7565244	19508998	7.61E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	ESPNL
3	9217383	rs446975	G	T	rs446975	19508998	1.72E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	SRGAP3
3	27725605	rs9846205	G	A	rs9846205	19508998	6.37E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
3	49524236	rs3924462	T	G	rs3924462	19508998	5.38E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	DAG1
3	49538799	rs11130199	T	C	rs11130199	19508998	5.38E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	DAG1
3	83945963	rs4276197	A	G	rs4276197	19508998	6.14E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
3	85281802	rs2034619	G	A	rs2034619	19508998	2.92E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	CADM2
3	107116139	rs11709763	T	C	rs11709763	19508998	7.96E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
3	117162784	rs4075039	C	T	rs4075039	19508998	8.88E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
3	124764110	rs2981534	A	G	rs2981534	19508998	3.26E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	HEG1
3	131060915	rs9861674	G	A	rs9861674	19508998	9.09E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NEK11
3	142987912	rs2289492	C	T	rs2289492	19508998	4.18E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	SLC9A9
3	142991226	rs7641350	T	C	rs7641350	19508998	3.31E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	SLC9A9
3	143013203	rs6806500	G	A	rs6806500	19508998	3.81E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	SLC9A9
3	167530444	rs2055027	C	T	rs2055027	19508998	8.17E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	SERPINI1
3	169617405	rs16854522	T	C	rs16854522	19508998	4.84E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
3	169741291	rs9868633	C	T	rs9868633	19508998	4.80E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
3	172091717	rs4894544	G	A	rs4894544	19508998	1.93E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	FNDC3B
3	173229774	rs1523344	C	T	rs1523344	19508998	6.75E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NLGN1
3	173281266	rs1080310	A	C	rs1080310	19508998	6.84E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NLGN1
3	189004818	rs9682650	C	T	rs9682650	19508998	7.58E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	TPRG1
4	13099816	rs542309	A	G	rs542309	19508998	6.14E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
4	39989369	rs7677857	C	T	rs7677857	19508998	3.73E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
4	48509050	rs6447641	T	C	rs6447641	19508998	5.88E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	FRYL
4	61210768	rs10517498	C	T	rs10517498	19508998	5.09E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
4	84374480	rs1494961	C	T	rs1494961	19508998	6.25E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	HELQ
4	84455601	rs6535481	G	A	rs6535481	19508998	7.13E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
4	94594199	rs10516940	C	T	rs10516940	19508998	5.34E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	GRID2
4	100651270	rs13150420	A	G	rs13150420	19508998	3.40E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
4	100657673	rs2866168	A	G	rs2866168	19508998	8.14E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
4	105988057	rs195148	T	C	rs195148	19508998	2.84E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
4	126524825	rs1864363	C	A	rs1864363	19508998	8.87E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
4	166474584	rs7679286	A	G	rs7679286	19508998	6.33E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
4	175458289	rs2251316	C	A	rs2251316	19508998	6.73E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
4	190328590	rs6553315	T	C	rs6553315	19508998	1.60E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
5	4936235	rs654685	G	A	rs654685	19508998	5.23E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
5	15082673	rs2121183	G	A	rs2121183	19508998	1.12E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
5	31410306	rs3805521	C	T	rs3805521	19508998	7.36E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	DROSHA
5	33690120	rs4866362	G	A	rs4866362	19508998	5.99E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	ADAMTS12
5	63288619	rs1364041	T	G	rs1364041	19508998	1.40E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
5	106563875	rs6862168	C	A	rs6862168	19508998	3.55E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
5	112310396	rs33557	T	C	rs33557	19508998	1.47E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
5	112318928	rs33551	C	T	rs33551	19508998	1.29E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	DCP2
5	112323738	rs2112454	A	G	rs2112454	19508998	7.08E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	DCP2
5	112325869	rs9784647	C	T	rs9784647	19508998	7.51E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	DCP2
5	112328267	rs3733968	C	T	rs3733968	19508998	4.78E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	DCP2
5	112358131	rs9122	T	C	rs9122	19508998	4.50E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	MCC
5	129036516	rs32796	C	A	rs32796	19508998	1.12E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	ADAMTS19
5	129056759	rs246246	G	T	rs246246	19508998	5.98E-07	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	ADAMTS19
5	129097638	rs6866940	A	G	rs6866940	19508998	6.96E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
5	130187390	rs10477723	G	A	rs10477723	19508998	1.35E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
5	149611793	rs3822607	G	A	rs3822607	19508998	7.94E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	CAMK2A
5	149625087	rs3756578	T	C	rs3756578	19508998	8.78E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	CAMK2A
5	153960485	rs12655409	G	A	rs12655409	19508998	8.80E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
5	161925856	rs1484363	A	G	rs1484363	19508998	5.19E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
5	161955116	rs2170903	G	T	rs2170903	19508998	7.95E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
5	169356831	rs2546507	C	A	rs2546507	19508998	6.72E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	DOCK2
5	171068259	rs254870	A	G	rs254870	19508998	1.33E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
5	171081906	rs257352	C	A	rs257352	19508998	7.88E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
5	171093383	rs26408	C	A	rs26408	19508998	3.72E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
5	174860699	rs265973	T	C	rs265973	19508998	1.96E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
6	1214888	rs369656	C	T	rs369656	19508998	5.04E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
6	2898596	rs318491	A	G	rs318491	19508998	6.44E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	SERPINB9
6	2912277	rs318497	G	A	rs318497	19508998	2.86E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
6	11466011	rs10498677	T	G	rs10498677	19508998	4.77E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
6	36065185	rs851006	T	C	rs851006	19508998	3.79E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	MAPK14
6	38408223	rs12208647	G	A	rs12208647	19508998	6.32E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	BTBD9
6	42892834	rs6901007	G	T	rs6901007	19508998	4.88E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	PTCRA
6	43832177	rs4714706	A	G	rs4714706	19508998	7.30E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
6	88680458	rs2466413	C	T	rs2466413	19508998	3.87E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
6	108412714	rs7769514	T	G	rs7769514	19508998	2.65E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
6	121084577	rs12194792	C	T	rs12194792	19508998	1.24E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
6	121087489	rs2817939	T	C	rs2817939	19508998	8.66E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
6	138415087	rs666769	C	T	rs666769	19508998	1.09E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	PERP
6	139013015	rs9321669	G	A	rs9321669	19508998	9.99E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
6	139042338	rs4896391	G	A	rs4896391	19508998	5.11E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
6	148825030	rs1618036	C	T	rs1618036	19508998	5.67E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	SASH1
6	158006856	rs16900289	T	G	rs16900289	19508998	6.89E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	ZDHHC14
6	160519276	rs600324	T	C	rs600324	19508998	5.72E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	IGF2R
7	7317960	rs1638210	T	C	rs1638210	19508998	7.39E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
7	7328775	rs2141911	G	A	rs2141911	19508998	5.82E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
7	7846920	rs7801961	G	A	rs7801961	19508998	5.92E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	LOC729852
7	10423884	rs12670345	G	A	rs12670345	19508998	4.84E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
7	10904755	rs10269406	G	A	rs10269406	19508998	3.29E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
7	31755670	rs34198	T	C	rs34198	19508998	8.70E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
7	49700411	rs4917075	A	C	rs4917075	19508998	4.06E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
7	63966166	rs11768782	C	T	rs11768782	19508998	3.81E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
8	2092484	rs10503170	C	T	rs10503170	19508998	8.46E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	MYOM2
8	3215497	rs1348267	G	A	rs1348267	19508998	1.69E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	CSMD1
8	8344127	rs2979202	T	C	rs2979202	19508998	5.93E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
8	17283970	rs10503595	G	T	rs10503595	19508998	6.00E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
8	27767066	rs17058204	G	A	rs17058204	19508998	7.15E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	SCARA5
8	28641187	rs241192	G	A	rs241192	19508998	7.81E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	INTS9
8	90637625	rs160414	T	C	rs160414	19508998	3.42E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
8	101813156	rs3847153	A	G	rs3847153	21989058	9.00E-08	NA	1.42	NA	391 Chinese ancestry cases; 895 Chinese ancestry controls	Chinese(1286)	ALL(1286)	ASN(1286)	ALL(1286)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
8	124177121	rs1670178	A	G	rs1670178	19508998	7.71E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
8	128815029	rs4410871	T	C	rs4410871	19508998	4.85E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	PVT1
8	143686995	rs9324593	A	G	rs9324593	19508998	3.14E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
9	7539001	rs2890755	A	G	rs2890755	19508998	5.32E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
9	7579004	rs1485184	A	G	rs1485184	19508998	4.87E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
9	72036369	rs11138566	C	T	rs11138566	19508998	2.44E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
9	72056397	rs2781530	C	T	rs2781530	19508998	2.60E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	APBA1
9	72058021	rs1831555	T	C	rs1831555	19508998	2.60E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	APBA1
9	72059114	rs1977552	G	T	rs1977552	19508998	3.86E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	APBA1
9	79582862	rs1929539	C	A	rs1929539	19508998	7.94E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
9	87450766	rs1867283	G	A	rs1867283	19508998	4.62E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NTRK2
9	98918219	rs4743597	T	C	rs4743597	19508998	6.82E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
10	4259123	rs10508277	T	C	rs10508277	19508998	7.87E-06	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
10	20163833	rs752318	T	C	rs752318	19508998	2.02E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	PLXDC2
10	20276131	rs10508606	T	G	rs10508606	19508998	6.39E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	PLXDC2
10	24742828	rs11014094	C	T	rs11014094	19508998	1.45E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	KIAA1217
10	44196101	rs10751332	C	T	rs10751332	19508998	4.97E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
10	48628441	rs786792	T	C	rs786792	19508998	4.13E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
10	48637416	rs786806	C	T	rs786806	19508998	3.87E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
10	48639880	rs2790937	A	G	rs2790937	19508998	9.73E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
10	48658479	rs786781	G	A	rs786781	19508998	1.14E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
10	53975769	rs1406476	A	G	rs1406476	19508998	4.73E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	PRKG1
10	65887214	rs10740149	A	G	rs10740149	19508998	2.95E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
10	75786395	rs7914469	C	A	rs7914469	19508998	2.28E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	VCL
10	75793372	rs4745730	C	T	rs4745730	19508998	4.52E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	VCL
10	75808313	rs4414157	A	G	rs4414157	19508998	5.34E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	VCL
10	83392668	rs7918647	C	T	rs7918647	19508998	7.60E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
10	118528593	rs1630816	A	G	rs1630816	19508998	1.34E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
10	127215932	rs6597713	T	C	rs6597713	19508998	4.00E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
10	128779958	rs10741150	C	T	rs10741150	19508998	3.89E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	DOCK1
11	2050558	rs7940766	G	A	rs7940766	19508998	6.91E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
11	2068717	rs7479065	A	G	rs7479065	19508998	7.69E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	NA	NA
11	3808138	rs10767587	T	G	rs10767587	19508998	3.30E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NUP98
11	5392484	rs728925	T	C	rs728925	19508998	7.47E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	OR51B5
11	6556895	rs2344929	C	T	rs2344929	19508998	8.62E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	DNHD1
11	18974860	rs1842921	G	A	rs1842921	19508998	3.95E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
11	27667202	rs925946	T	G	rs925946	19508998	8.57E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	BDNF-AS1
11	69837751	rs733224	A	G	rs733224	19508998	8.75E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	LOC100127946
11	73044243	rs625572	A	G	rs625572	19508998	4.15E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	ARHGEF17
11	80033297	rs10501463	A	G	rs10501463	19508998	4.85E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
11	103884797	rs722355	A	C	rs722355	19508998	4.95E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	PDGFD
11	108995326	rs989595	A	G	rs989595	19508998	7.68E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
12	27015543	rs12372288	T	C	rs12372288	19508998	3.75E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
12	45160864	rs1901147	C	T	rs1901147	19508998	5.92E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NELL2
12	45168910	rs7295947	G	A	rs7295947	19508998	5.92E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NELL2
12	70794570	rs710650	T	C	rs710650	19508998	8.95E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	KCNMB4
12	115533823	rs35461	C	T	rs35461	19508998	2.20E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
13	23996765	rs10507330	A	G	rs10507330	19508998	3.14E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	SACS
13	26544369	rs912514	C	T	rs912514	19508998	5.44E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	ATP8A2
13	46946157	rs1408184	C	T	rs1408184	19508998	6.33E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	KIAA0226L
13	55737834	rs3120865	G	A	rs3120865	19508998	6.18E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
13	85166320	rs9546775	T	G	rs9546775	19508998	8.14E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
13	105552973	rs3916952	C	A	rs3916952	19508998	7.18E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
14	51292535	rs3759526	C	T	rs3759526	19508998	4.09E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NIN
14	56563894	rs241519	A	C	rs241519	19508998	4.88E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
14	57822216	rs7144649	G	A	rs7144649	19508998	2.69E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
15	24924729	rs12902295	T	C	rs12902295	19508998	2.84E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	C15orf2
15	47895214	rs999128	T	C	rs999128	19508998	7.01E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	SEMA6D
15	50342224	rs4522364	T	C	rs4522364	19508998	6.36E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	ATP8B4
15	53288387	rs2414223	C	A	rs2414223	19508998	6.89E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
15	54289389	rs11856192	T	C	rs11856192	19508998	2.25E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
15	58452907	rs7167911	T	G	rs7167911	19508998	4.13E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	AQP9
15	96552691	rs1450495	T	G	rs1450495	19508998	6.57E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
16	12961120	rs10500391	T	G	rs10500391	19508998	8.95E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
16	24308825	rs9652580	C	T	rs9652580	19508998	6.13E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	CACNG3
16	51658435	rs2647967	C	T	rs2647967	19508998	4.04E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
16	51722029	rs1461928	C	T	rs1461928	19508998	6.17E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
16	51767734	rs1564002	G	A	rs1564002	19508998	7.21E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
16	51771624	rs8045957	C	T	rs8045957	19508998	6.00E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
16	51813861	rs2169430	T	C	rs2169430	19508998	3.16E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
16	51822621	rs2126337	C	T	rs2126337	19508998	3.50E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
16	56321119	rs899239	A	G	rs899239	19508998	2.88E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	GNAO1
16	78577582	rs2667646	C	T	rs2667646	19508998	8.12E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	WWOX
17	1120797	rs11867310	A	G	rs11867310	19508998	8.77E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
17	65363813	rs17648225	T	G	rs17648225	19508998	1.34E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
17	75070799	rs894573	T	G	rs894573	19508998	5.45E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
17	79375998	rs1701	C	A	rs1701	19508998	4.16E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	BAHCC1
18	7329035	rs569629	C	T	rs569629	19508998	5.89E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
18	26059307	rs8099735	T	G	rs8099735	19508998	3.31E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
18	26092129	rs11876069	T	C	rs11876069	19508998	5.83E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
18	26120683	rs17749815	C	T	rs17749815	19508998	2.52E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
18	26176918	rs8095062	C	A	rs8095062	19508998	4.91E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	NA
18	43149976	rs2543025	T	C	rs2543025	19508998	2.84E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	SLC14A2
18	43162894	rs10775478	T	G	rs10775478	19508998	3.99E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	SLC14A2
18	43167421	rs4890552	A	C	rs4890552	19508998	8.00E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	SLC14A2
18	44204073	rs11662257	T	C	rs11662257	19508998	6.47E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	LOXHD1
18	55784763	rs554192	A	G	rs554192	19508998	2.24E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NEDD4L
19	30322301	rs1862541	G	T	rs1862541	19508998	1.04E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
19	41524153	rs1042389	T	C	rs1042389	19508998	8.18E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	CYP2B6
20	4617391	rs6037908	A	G	rs6037908	19508998	2.18E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
20	9574063	rs6056725	C	A	rs6056725	19508998	2.02E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	PAK7
20	9807527	rs6056909	T	C	rs6056909	19508998	2.20E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	PAK7
20	12039845	rs7268377	T	G	rs7268377	19508998	7.07E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
20	12049197	rs6041067	T	G	rs6041067	19508998	7.47E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
20	12052533	rs6033294	T	C	rs6033294	19508998	7.47E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
20	41399171	rs6072869	A	G	rs6072869	19508998	8.95E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	PTPRT
20	57790618	rs6070744	T	C	rs6070744	19508998	1.67E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	ZNF831
20	60365079	rs11907516	G	A	rs11907516	19508998	1.97E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	CDH4
21	27847903	rs2830246	C	T	rs2830246	19508998	7.01E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	CYYR1
21	33347434	rs9305481	T	C	rs9305481	19508998	4.22E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	C	HUNK
21	34497748	rs2834091	G	A	rs2834091	19508998	5.00E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
21	40919955	rs2837074	G	A	rs2837074	19508998	3.76E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
21	40937929	rs523372	T	G	rs523372	19508998	6.15E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
21	40942788	rs4818059	G	A	rs4818059	19508998	6.82E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
21	40946124	rs1734930	G	A	rs1734930	19508998	1.36E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
22	18609046	rs362195	G	A	rs362195	19508998	6.65E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	TUBA8
22	22694486	rs6001881	A	G	rs6001881	19508998	5.72E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
X	34532174	rs5973212	G	A	rs5973212	19508998	9.43E-05	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A	NA
X	34788482	rs5973249	C	T	rs5973249	19508998	7.52E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	T	NA
X	41252835	rs1794648	A	G	rs1794648	19508998	7.36E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	G	NA
X	142305364	rs2207571	C	T	rs2207571	19508998	5.81E-04	Premature ovarian failure	NA	NA	99 European ancestry cases; 235 European ancestry controls	European(334)	ALL(334)	EUR(334)	ALL(334)	Premature ovarian failure	HPOID:0008209	Premature ovarian failure	DOID:5426	premature ovarian failure	D016649	Primary Ovarian Insufficiency	NA	NA	Ovarian failure	NA	Research Support, Non-U.S. Gov't	A,G	NA

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	414
Disease	premature ovarian failure
Case	(Waiting for update.)