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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine



   pre-eclampsia
  

Disease ID 182
Disease pre-eclampsia
Definition
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Synonym
1, preeclampsia eclampsia
1s, preeclampsia eclampsia
eclampsia 1, preeclampsia
eclampsia 1s, preeclampsia
edema proteinuria hypertension gestosis
edema-proteinuria-hypertension gestosis
eph - edema, proteinuria and hypertension of pregnancy
eph - oedema, proteinuria and hypertension of pregnancy
eph complex
eph gestosis
eph toxemia
eph toxemias
gestosis, edema-proteinuria-hypertension
gestosis, eph
gestosis, hypertension-edema-proteinuria
gestosis, proteinuria-edema-hypertension
hypertension edema proteinuria gestosis
hypertension-edema-proteinuria gestosis
hypertensive disorder of pregnancy
maternal toxemia
of pregnancies, toxemia
of pregnancy, toxemia
pe - pre-eclampsia
pee
pee1
pet - pre-eclamptic toxaemia
pet - pre-eclamptic toxemia
pre eclampsia
pre-eclampsia (disorder)
pre-eclampsia [disease/finding]
pre-eclampsia nos
pre-eclampsia nos (disorder)
pre-eclampsia, nos
pre-eclampsia, unspecified
pre-eclamptic nos
pre-eclamptic toxaemia
pre-eclamptic toxemia
pre-eclamptic toxemia, nos
preeclampsia
preeclampsia eclampsia 1
preeclampsia eclampsia 1s
preeclampsia/eclampsia 1
preg1
pregn toxemias
pregnancies, toxemia of
pregnancy toxaemia
pregnancy toxemia
pregnancy toxemia/hypertension
pregnancy toxemias
pregnancy, toxemia of
proteinuria edema hypertension gestosis
proteinuria-edema-hypertension gestosis
proteinuric hypertension of pregnancy
proteinuric hypertension of pregnancy (disorder)
toxaemia nos
toxaemia of pregnancy
toxaemia of pregnancy, nos
toxaemia pregnancy
toxemia
toxemia (pre)eclampsia
toxemia in pregnancy
toxemia nos
toxemia nos (disorder)
toxemia of pregnancies
toxemia of pregnancy
toxemia of pregnancy (disorder)
toxemia of pregnancy, nos
toxemia pregnancy
toxemia, eph
toxemia, pregnancy
toxemias, eph
toxemias, pregnancy
Orphanet
OMIM
DOID
UMLS
C0032914
MeSH
SNOMED-CT
Comorbidity
UMLS | Disease | Sentences' Count(Total Sentences:100)
C0020538  |  hypertension  |  40
C0162739  |  hellp syndrome  |  15
C0033687  |  proteinuria  |  14
C0011847  |  diabetes  |  12
C0042373  |  vascular disease  |  8
C0007222  |  cardiovascular disease  |  8
C0020538  |  hypertensive disorder  |  6
C0042870  |  vitamin d deficiency  |  5
C0042870  |  vitamin d defic  |  5
C0085207  |  gestational diabetes  |  5
C0340274  |  gestational hypertension  |  5
C0028754  |  obesity  |  5
C0032051  |  placental insufficiency  |  4
C0011854  |  type 1 diabetes  |  4
C0022876  |  preterm labor  |  4
C0022658  |  kidney disease  |  4
C0022116  |  ischemia  |  3
C0878544  |  cardiomyopathy  |  3
C0013537  |  eclampsia  |  3
C0020676  |  hypothyroidism  |  3
C0040034  |  thrombocytopenia  |  3
C0740394  |  hyperuricemia  |  2
C0018799  |  heart disease  |  2
C0000786  |  miscarriage  |  2
C0022661  |  chronic kidney disease  |  2
C0040053  |  thrombosis  |  2
C0264832  |  peripartum cardiomyopathy  |  2
C0948265  |  metabolic syndrome  |  2
C0011570  |  depression  |  2
C0018801  |  heart failure  |  2
C0031099  |  periodontitis  |  2
C0034063  |  pulmonary edema  |  2
C0006142  |  breast cancer  |  2
C0020538  |  hypertensive disease  |  2
C0011849  |  diabetes mellitus  |  2
C0022658  |  renal disease  |  2
C0035309  |  retinopathy  |  2
C0398623  |  hypercoagulable state  |  2
C0004096  |  asthma  |  2
C0547030  |  visual disturbance  |  2
C0020538  |  high blood pressure  |  2
C0031090  |  periodontal disease  |  2
C0020598  |  hypoglycemia  |  1
C0085113  |  neurofibromatosis  |  1
C0014175  |  endometriosis  |  1
C0020538  |  vascular hypertension  |  1
C0038436  |  post-traumatic stress disorder  |  1
C0021053  |  immune disease  |  1
C0270612  |  leukoencephalopathy  |  1
C0017661  |  iga nephropathy  |  1
C0000832  |  placental abruption  |  1
C0011603  |  dermatitis  |  1
C0035078  |  renal failure  |  1
C0012739  |  disseminated intravascular coagulation  |  1
C0032914  |  preeclampsia  |  1
C0032460  |  polycystic ovary  |  1
C0085580  |  essential hypertension  |  1
C0022658  |  nephropathy  |  1
C0085207  |  gestational diabetes mellitus  |  1
C0007789  |  cerebral palsy  |  1
C0027947  |  neutropenia  |  1
C0020550  |  hyperthyroidism  |  1
C0520679  |  obstructive sleep apnea  |  1
C0037315  |  sleep-disordered breathing  |  1
C0000786  |  spontaneous abortion  |  1
C0002766  |  analgesia  |  1
C0037354  |  smallpox  |  1
C0031511  |  pheochromocytoma  |  1
C0035258  |  restless legs  |  1
C0085278  |  antiphospholipid syndrome  |  1
C0079924  |  oligohydramnios  |  1
C0023895  |  liver disease  |  1
C0027051  |  myocardial infarction  |  1
C0026896  |  myasthenia gravis  |  1
C0032993  |  prolonged pregnancy  |  1
C0022658  |  kidney diseases  |  1
C0149931  |  migraine  |  1
C0028866  |  third nerve palsy  |  1
C0023895  |  liver diseases  |  1
C0007194  |  hypertrophic cardiomyopathy  |  1
C0002871  |  anaemia  |  1
C0085697  |  chronic pyelonephritis  |  1
C0011615  |  atopic dermatitis  |  1
C0034186  |  pyelonephritis  |  1
C0042373  |  vascular diseases  |  1
C0035078  |  kidney failure  |  1
C0034063  |  lung edema  |  1
C0343386  |  clostridium difficile infection  |  1
C0035258  |  restless legs syndrome  |  1
C0037315  |  sleep apnea  |  1
C0020545  |  renovascular hypertension  |  1
C0006287  |  bronchopulmonary dysplasia  |  1
C0007222  |  cardiovascular diseases  |  1
C0398623  |  thrombophilia  |  1
C0027051  |  myocardial infarct  |  1
C0271355  |  abducens nerve palsy  |  1
C0152095  |  trisomy 13  |  1
C0001973  |  alcoholism  |  1
C0030446  |  paralytic ileus  |  1
C0008148  |  chlamydia  |  1
Curated Gene
Entrez_id | Symbol | Resource(Total Genes:19)
1356  |  CP  |  CTD_human
3162  |  HMOX1  |  CTD_human
4846  |  NOS3  |  CTD_human
6337  |  SCNN1A  |  CTD_human
2259  |  FGF14  |  GWASCAT
1636  |  ACE  |  CTD_human
183  |  AGT  |  CTD_human
1906  |  EDN1  |  CTD_human
2052  |  EPHX1  |  CTD_human;GHR
308  |  ANXA5  |  CTD_human
5054  |  SERPINE1  |  CTD_human
219736  |  STOX1  |  CTD_human;ORPHANET;GHR
150142  |  ZNF295-AS1  |  GWASCAT
10699  |  CORIN  |  ORPHANET;GHR
3624  |  INHBA  |  CTD_human
2321  |  FLT1  |  CTD_human
23564  |  DDAH2  |  CTD_human
5177  |  PEE1  |  CTD_human;OMIM
23077  |  MYCBP2  |  GWASCAT
Inferring Gene
Entrez_id | Symbol | Resource(Total Genes:131)
1636  |  ACE  |  CIPHER;CTD_human
9370  |  ADIPOQ  |  CIPHER
155  |  ADRB3  |  CIPHER
183  |  AGT  |  CIPHER;CTD_human
185  |  AGTR1  |  CIPHER
186  |  AGTR2  |  CIPHER
308  |  ANXA5  |  CIPHER;CTD_human
348  |  APOE  |  CIPHER
929  |  CD14  |  CIPHER
1277  |  COL1A1  |  CIPHER
1361  |  CPB2  |  CIPHER
1493  |  CTLA4  |  CIPHER
1543  |  CYP1A1  |  CIPHER
1565  |  CYP2D6  |  CIPHER
1571  |  CYP2E1  |  CIPHER
23576  |  DDAH1  |  CIPHER
1815  |  DRD4  |  CIPHER
1909  |  EDNRA  |  CIPHER
5167  |  ENPP1  |  CIPHER
2052  |  EPHX1  |  CIPHER;CTD_human
2099  |  ESR1  |  CIPHER
2100  |  ESR2  |  CIPHER
2162  |  F13A1  |  CIPHER
2147  |  F2  |  CIPHER
2153  |  F5  |  CIPHER
2155  |  F7  |  CIPHER
355  |  FAS  |  CIPHER
356  |  FASLG  |  CIPHER
2244  |  FGB  |  CIPHER
2944  |  GSTM1  |  CIPHER
2950  |  GSTP1  |  CIPHER
2952  |  GSTT1  |  CIPHER
3030  |  HADHA  |  CIPHER
3105  |  HLA-A  |  CIPHER
3117  |  HLA-DQA1  |  CIPHER
3119  |  HLA-DQB1  |  CIPHER
3123  |  HLA-DRB1  |  CIPHER
3135  |  HLA-G  |  CIPHER
3240  |  HP  |  CIPHER
3303  |  HSPA1A  |  CIPHER
3304  |  HSPA1B  |  CIPHER
3305  |  HSPA1L  |  CIPHER
3458  |  IFNG  |  CIPHER
3479  |  IGF1  |  CIPHER
3586  |  IL10  |  CIPHER
3552  |  IL1A  |  CIPHER
3557  |  IL1RN  |  CIPHER
3566  |  IL4R  |  CIPHER
3569  |  IL6  |  CIPHER
3623  |  INHA  |  CIPHER
3690  |  ITGB3  |  CIPHER
3805  |  KIR2DL4  |  CIPHER
3952  |  LEP  |  CIPHER
3953  |  LEPR  |  CIPHER
4023  |  LPL  |  CIPHER
4314  |  MMP3  |  CIPHER
4318  |  MMP9  |  CIPHER
4353  |  MPO  |  CIPHER
4524  |  MTHFR  |  CIPHER
4567  |  MT-TL1  |  CIPHER
10  |  NAT2  |  CIPHER
4846  |  NOS3  |  CIPHER;CTD_human
4306  |  NR3C2  |  CIPHER
5444  |  PON1  |  CIPHER
5547  |  PRCP  |  CIPHER
5972  |  REN  |  CIPHER
6338  |  SCNN1B  |  CIPHER
5054  |  SERPINE1  |  CIPHER;CTD_human
6648  |  SOD2  |  CIPHER
219736  |  STOX1  |  CIPHER;CTD_human
6890  |  TAP1  |  CIPHER
6891  |  TAP2  |  CIPHER
7040  |  TGFB1  |  CIPHER
7056  |  THBD  |  CIPHER
7124  |  TNF  |  CIPHER
7422  |  VEGFA  |  CIPHER
92  |  ACVR2A  |  CIPHER
328  |  APEX1  |  CIPHER
11132  |  CAPN10  |  CIPHER
3075  |  CFH  |  CIPHER
1312  |  COMT  |  CIPHER
1524  |  CX3CR1  |  CIPHER
1585  |  CYP11B2  |  CIPHER
1586  |  CYP17A1  |  CIPHER
1906  |  EDN1  |  CIPHER;CTD_human
1950  |  EGF  |  CIPHER
2022  |  ENG  |  CIPHER
2068  |  ERCC2  |  CIPHER
2321  |  FLT1  |  CIPHER;CTD_human
2324  |  FLT4  |  CIPHER
2492  |  FSHR  |  CIPHER
2784  |  GNB3  |  CIPHER
2868  |  GRK4  |  CIPHER
283120  |  H19  |  CIPHER
3091  |  HIF1A  |  CIPHER
3113  |  HLA-DPA1  |  CIPHER
3620  |  IDO1  |  CIPHER
3459  |  IFNGR1  |  CIPHER
3553  |  IL1B  |  CIPHER
3565  |  IL4  |  CIPHER
3630  |  INS  |  CIPHER
3643  |  INSR  |  CIPHER
3667  |  IRS1  |  CIPHER
3674  |  ITGA2B  |  CIPHER
3812  |  KIR3DL2  |  CIPHER
3990  |  LIPC  |  CIPHER
4153  |  MBL2  |  CIPHER
1728  |  NQO1  |  CIPHER
5468  |  PPARG  |  CIPHER
9475  |  ROCK2  |  CIPHER
6550  |  SLC9A3  |  CIPHER
6647  |  SOD1  |  CIPHER
7039  |  TGFA  |  CIPHER
7054  |  TH  |  CIPHER
7097  |  TLR2  |  CIPHER
7099  |  TLR4  |  CIPHER
10673  |  TNFSF13B  |  CIPHER
10911  |  UTS2  |  CIPHER
7423  |  VEGFB  |  CIPHER
7424  |  VEGFC  |  CIPHER
7450  |  VWF  |  CIPHER
7515  |  XRCC1  |  CIPHER
3162  |  HMOX1  |  CTD_human
780908  |  PEE2  |  CTD_human
780909  |  PEE3  |  CTD_human
3624  |  INHBA  |  CTD_human
23526  |  HMHA1  |  CTD_human
23564  |  DDAH2  |  CTD_human
5177  |  PEE1  |  CTD_human
1356  |  CP  |  CTD_human
6337  |  SCNN1A  |  CTD_human
Text Mined Gene
Entrez_id | Symbol | Score | Resource(Total Genes:325)
2  |  A2M  |  1.409  |  DISEASES
19  |  ABCA1  |  1.352  |  DISEASES
60  |  ACTB  |  2.685  |  DISEASES
93  |  ACVR2B  |  1.608  |  DISEASES
8038  |  ADAM12  |  4.488  |  DISEASES
11085  |  ADAM30  |  1.296  |  DISEASES
81792  |  ADAMTS12  |  2.367  |  DISEASES
11093  |  ADAMTS13  |  3.149  |  DISEASES
9370  |  ADIPOQ  |  3.384  |  DISEASES
79924  |  ADM2  |  1.37  |  DISEASES
155  |  ADRB3  |  1.09  |  DISEASES
174  |  AFP  |  3.632  |  DISEASES
183  |  AGT  |  4.781  |  DISEASES
186  |  AGTR2  |  2.477  |  DISEASES
197  |  AHSG  |  1.227  |  DISEASES
8644  |  AKR1C3  |  1.128  |  DISEASES
283  |  ANG  |  2.39  |  DISEASES
284  |  ANGPT1  |  2.848  |  DISEASES
353322  |  ANKRD37  |  2.099  |  DISEASES
302  |  ANXA2  |  2.041  |  DISEASES
221079  |  ARL5B  |  1.705  |  DISEASES
405  |  ARNT  |  1.654  |  DISEASES
408  |  ARRB1  |  2.482  |  DISEASES
51666  |  ASB4  |  1.445  |  DISEASES
430  |  ASCL2  |  1.016  |  DISEASES
23192  |  ATG4B  |  1.378  |  DISEASES
10159  |  ATP6AP2  |  1.556  |  DISEASES
551  |  AVP  |  2.494  |  DISEASES
567  |  B2M  |  1.755  |  DISEASES
25825  |  BACE2  |  1.105  |  DISEASES
153579  |  BTNL9  |  1.569  |  DISEASES
716  |  C1S  |  1.036  |  DISEASES
721  |  C4B  |  1.389  |  DISEASES
730  |  C7  |  1.341  |  DISEASES
23705  |  CADM1  |  1.62  |  DISEASES
10203  |  CALCRL  |  2.413  |  DISEASES
801  |  CALM1  |  1.063  |  DISEASES
813  |  CALU  |  1.109  |  DISEASES
834  |  CASP1  |  1.164  |  DISEASES
841  |  CASP8  |  1.022  |  DISEASES
857  |  CAV1  |  1.208  |  DISEASES
875  |  CBS  |  1.998  |  DISEASES
9332  |  CD163  |  1.43  |  DISEASES
930  |  CD19  |  1.12  |  DISEASES
911  |  CD1C  |  1.066  |  DISEASES
4345  |  CD200  |  1.062  |  DISEASES
940  |  CD28  |  1.224  |  DISEASES
958  |  CD40  |  1.153  |  DISEASES
959  |  CD40LG  |  3.227  |  DISEASES
966  |  CD59  |  1.416  |  DISEASES
1003  |  CDH5  |  2.772  |  DISEASES
1028  |  CDKN1C  |  2.529  |  DISEASES
629  |  CFB  |  1.795  |  DISEASES
1675  |  CFD  |  1.283  |  DISEASES
3075  |  CFH  |  1.384  |  DISEASES
94115  |  CGB8  |  1.705  |  DISEASES
91612  |  CHURC1  |  1.775  |  DISEASES
170482  |  CLEC4C  |  1.784  |  DISEASES
9022  |  CLIC3  |  1.951  |  DISEASES
1266  |  CNN3  |  1.158  |  DISEASES
728577  |  CNTNAP3B  |  1.452  |  DISEASES
22796  |  COG2  |  2.055  |  DISEASES
1307  |  COL16A1  |  1.114  |  DISEASES
80781  |  COL18A1  |  1.492  |  DISEASES
1284  |  COL4A2  |  1.944  |  DISEASES
1312  |  COMT  |  3.027  |  DISEASES
1369  |  CPN1  |  1.544  |  DISEASES
27297  |  CRCP  |  1.191  |  DISEASES
1394  |  CRHR1  |  1.107  |  DISEASES
1400  |  CRMP1  |  1.08  |  DISEASES
1443  |  CSH2  |  4.096  |  DISEASES
1471  |  CST3  |  2.684  |  DISEASES
1486  |  CTBS  |  4.085  |  DISEASES
1491  |  CTH  |  2.263  |  DISEASES
29119  |  CTNNA3  |  1.775  |  DISEASES
1506  |  CTRL  |  1.784  |  DISEASES
404093  |  CUEDC1  |  1.842  |  DISEASES
6387  |  CXCL12  |  1.418  |  DISEASES
1585  |  CYP11B2  |  2.526  |  DISEASES
1573  |  CYP2J2  |  2.098  |  DISEASES
3491  |  CYR61  |  2.259  |  DISEASES
147906  |  DACT3  |  1.174  |  DISEASES
28988  |  DBNL  |  1.104  |  DISEASES
23564  |  DDAH2  |  2.414  |  DISEASES
9704  |  DHX34  |  1.588  |  DISEASES
28514  |  DLL1  |  1.103  |  DISEASES
1747  |  DLX3  |  1.041  |  DISEASES
9166  |  EBAG9  |  1.133  |  DISEASES
1889  |  ECE1  |  1.204  |  DISEASES
1906  |  EDN1  |  5.049  |  DISEASES
1907  |  EDN2  |  1.495  |  DISEASES
1910  |  EDNRB  |  1.729  |  DISEASES
2022  |  ENG  |  6.175  |  DISEASES
219670  |  ENKUR  |  2.086  |  DISEASES
2050  |  EPHB4  |  2.134  |  DISEASES
64167  |  ERAP2  |  2.813  |  DISEASES
405754  |  ERVFRD-1  |  3.813  |  DISEASES
100271846  |  ERVV-2  |  1.829  |  DISEASES
30816  |  ERVW-1  |  3.14  |  DISEASES
11082  |  ESM1  |  2.046  |  DISEASES
2104  |  ESRRG  |  1.334  |  DISEASES
132884  |  EVC2  |  1.547  |  DISEASES
2149  |  F2R  |  1.518  |  DISEASES
2152  |  F3  |  4.037  |  DISEASES
2153  |  F5  |  3.222  |  DISEASES
2155  |  F7  |  2.024  |  DISEASES
2157  |  F8  |  1.542  |  DISEASES
387742  |  FAM99A  |  2.164  |  DISEASES
355  |  FAS  |  1.025  |  DISEASES
356  |  FASLG  |  2.141  |  DISEASES
2209  |  FCGR1A  |  1.661  |  DISEASES
2214  |  FCGR3A  |  2.279  |  DISEASES
8823  |  FGF16  |  1.535  |  DISEASES
2268  |  FGR  |  3.49  |  DISEASES
2316  |  FLNA  |  1.408  |  DISEASES
2335  |  FN1  |  1.361  |  DISEASES
50943  |  FOXP3  |  2.696  |  DISEASES
2621  |  GAS6  |  1.697  |  DISEASES
2638  |  GC  |  1.15  |  DISEASES
2689  |  GH2  |  1.34  |  DISEASES
2811  |  GP1BA  |  1.085  |  DISEASES
2876  |  GPX1  |  1.393  |  DISEASES
2878  |  GPX3  |  1.813  |  DISEASES
2879  |  GPX4  |  1.485  |  DISEASES
2938  |  GSTA1  |  1.322  |  DISEASES
2950  |  GSTP1  |  1.46  |  DISEASES
404672  |  GTF2H5  |  1.19  |  DISEASES
3033  |  HADH  |  1.266  |  DISEASES
3030  |  HADHA  |  5.861  |  DISEASES
3039  |  HBA1  |  2.526  |  DISEASES
3055  |  HCK  |  2.203  |  DISEASES
352990  |  HCP5B  |  1.478  |  DISEASES
101101692  |  HELLPAR  |  3.385  |  DISEASES
3091  |  HIF1A  |  3.394  |  DISEASES
3105  |  HLA-A  |  1.96  |  DISEASES
3106  |  HLA-B  |  1.128  |  DISEASES
3107  |  HLA-C  |  3.472  |  DISEASES
3133  |  HLA-E  |  2.606  |  DISEASES
3135  |  HLA-G  |  4.963  |  DISEASES
3146  |  HMGB1  |  1.967  |  DISEASES
3240  |  HP  |  3.386  |  DISEASES
3283  |  HSD3B1  |  1.571  |  DISEASES
3309  |  HSPA5  |  1.633  |  DISEASES
3316  |  HSPB2  |  1.708  |  DISEASES
3363  |  HTR7  |  2.145  |  DISEASES
5654  |  HTRA1  |  1.495  |  DISEASES
3384  |  ICAM2  |  1.053  |  DISEASES
414328  |  IDNK  |  1.459  |  DISEASES
3620  |  IDO1  |  1.274  |  DISEASES
3481  |  IGF2  |  2.494  |  DISEASES
3486  |  IGFBP3  |  2.253  |  DISEASES
8518  |  IKBKAP  |  1.349  |  DISEASES
3586  |  IL10  |  3.84  |  DISEASES
3605  |  IL17A  |  2.416  |  DISEASES
133396  |  IL31RA  |  1.649  |  DISEASES
90865  |  IL33  |  1.255  |  DISEASES
3640  |  INSL3  |  1.496  |  DISEASES
11172  |  INSL6  |  1.187  |  DISEASES
3676  |  ITGA4  |  2.061  |  DISEASES
3683  |  ITGAL  |  1.236  |  DISEASES
3684  |  ITGAM  |  2.29  |  DISEASES
9358  |  ITGBL1  |  1.272  |  DISEASES
9452  |  ITM2A  |  1.026  |  DISEASES
23210  |  JMJD6  |  1.664  |  DISEASES
3725  |  JUN  |  1.077  |  DISEASES
102723508  |  KANTR  |  2.23  |  DISEASES
3767  |  KCNJ11  |  1.217  |  DISEASES
3802  |  KIR2DL1  |  1.476  |  DISEASES
3805  |  KIR2DL4  |  2.365  |  DISEASES
3811  |  KIR3DL1  |  1.085  |  DISEASES
3812  |  KIR3DL2  |  1.962  |  DISEASES
3814  |  KISS1  |  3.205  |  DISEASES
9365  |  KL  |  1.064  |  DISEASES
11279  |  KLF8  |  1.186  |  DISEASES
9622  |  KLK4  |  2.544  |  DISEASES
3821  |  KLRC1  |  1.245  |  DISEASES
3822  |  KLRC2  |  1.453  |  DISEASES
3824  |  KLRD1  |  1.347  |  DISEASES
100506243  |  KRBOX1  |  2.603  |  DISEASES
3875  |  KRT18  |  2.054  |  DISEASES
3855  |  KRT7  |  2.235  |  DISEASES
51520  |  LARS  |  1.463  |  DISEASES
3939  |  LDHA  |  1.63  |  DISEASES
3953  |  LEPR  |  2.112  |  DISEASES
56891  |  LGALS14  |  2.331  |  DISEASES
148003  |  LGALS16  |  2.547  |  DISEASES
3980  |  LIG3  |  1.507  |  DISEASES
4018  |  LPA  |  1.877  |  DISEASES
53353  |  LRP1B  |  2.505  |  DISEASES
347731  |  LRRTM3  |  1.156  |  DISEASES
4049  |  LTA  |  1.049  |  DISEASES
130574  |  LYPD6  |  1.496  |  DISEASES
57134  |  MAN1C1  |  1.101  |  DISEASES
4128  |  MAOA  |  1.049  |  DISEASES
5599  |  MAPK8  |  1.16  |  DISEASES
4153  |  MBL2  |  1.192  |  DISEASES
84879  |  MFSD2A  |  1.093  |  DISEASES
8972  |  MGAM  |  3.482  |  DISEASES
10724  |  MGEA5  |  1.546  |  DISEASES
100073347  |  MIMT1  |  1.081  |  DISEASES
4312  |  MMP1  |  2.304  |  DISEASES
4318  |  MMP9  |  3.611  |  DISEASES
57504  |  MTA3  |  1.347  |  DISEASES
4524  |  MTHFR  |  4.643  |  DISEASES
4648  |  MYO7B  |  1.55  |  DISEASES
400746  |  NCMAP  |  1.543  |  DISEASES
55967  |  NDUFA12  |  1.026  |  DISEASES
4780  |  NFE2L2  |  1.941  |  DISEASES
114548  |  NLRP3  |  1.029  |  DISEASES
4843  |  NOS2  |  1.425  |  DISEASES
115677  |  NOSTRIN  |  2.596  |  DISEASES
4855  |  NOTCH4  |  1.059  |  DISEASES
4868  |  NPHS1  |  3.268  |  DISEASES
7827  |  NPHS2  |  2.653  |  DISEASES
4878  |  NPPA  |  1.296  |  DISEASES
4879  |  NPPB  |  2.042  |  DISEASES
10062  |  NR1H3  |  1.748  |  DISEASES
100506658  |  OCLN  |  1.067  |  DISEASES
203569  |  PAGE2  |  1.711  |  DISEASES
5069  |  PAPPA  |  6.311  |  DISEASES
60676  |  PAPPA2  |  4.668  |  DISEASES
56034  |  PDGFC  |  1.051  |  DISEASES
553115  |  PEF1  |  2.371  |  DISEASES
23089  |  PEG10  |  1.449  |  DISEASES
5228  |  PGF  |  7.377  |  DISEASES
55361  |  PI4K2A  |  1.309  |  DISEASES
5294  |  PIK3CG  |  1.951  |  DISEASES
10761  |  PLAC1  |  3.487  |  DISEASES
191585  |  PLAC4  |  3.137  |  DISEASES
5329  |  PLAUR  |  1.073  |  DISEASES
5406  |  PNLIP  |  2.729  |  DISEASES
5420  |  PODXL  |  1.506  |  DISEASES
9374  |  PPT2  |  1.521  |  DISEASES
5547  |  PRCP  |  1.273  |  DISEASES
10216  |  PRG4  |  2.597  |  DISEASES
8842  |  PROM1  |  1.181  |  DISEASES
5671  |  PSG3  |  1.473  |  DISEASES
5672  |  PSG4  |  1.141  |  DISEASES
5742  |  PTGS1  |  1.765  |  DISEASES
5743  |  PTGS2  |  1.926  |  DISEASES
5788  |  PTPRC  |  1.513  |  DISEASES
284119  |  PTRF  |  1.329  |  DISEASES
9364  |  RAB28  |  1.071  |  DISEASES
11186  |  RASSF1  |  2.099  |  DISEASES
5950  |  RBP4  |  2.07  |  DISEASES
112724  |  RDH13  |  1.687  |  DISEASES
6007  |  RHD  |  2.004  |  DISEASES
6019  |  RLN2  |  1.886  |  DISEASES
6093  |  ROCK1  |  1.6  |  DISEASES
84268  |  RPAIN  |  1.32  |  DISEASES
23212  |  RRS1  |  1.954  |  DISEASES
795  |  S100G  |  1.401  |  DISEASES
23328  |  SASH1  |  1.301  |  DISEASES
677780  |  SCARNA11  |  2.502  |  DISEASES
6401  |  SELE  |  3.753  |  DISEASES
8991  |  SELENBP1  |  1.268  |  DISEASES
57556  |  SEMA6A  |  1.024  |  DISEASES
5265  |  SERPINA1  |  1.79  |  DISEASES
5104  |  SERPINA5  |  1.021  |  DISEASES
866  |  SERPINA6  |  1.175  |  DISEASES
6906  |  SERPINA7  |  1.621  |  DISEASES
5268  |  SERPINB5  |  1.186  |  DISEASES
462  |  SERPINC1  |  5.053  |  DISEASES
5345  |  SERPINF2  |  2.51  |  DISEASES
871  |  SERPINH1  |  4.113  |  DISEASES
10603  |  SH2B2  |  1.322  |  DISEASES
9467  |  SH3BP5  |  1.344  |  DISEASES
9644  |  SH3PXD2A  |  1.306  |  DISEASES
6462  |  SHBG  |  2.621  |  DISEASES
946  |  SIGLEC6  |  3.911  |  DISEASES
117247  |  SLC16A10  |  1.818  |  DISEASES
6510  |  SLC1A5  |  1.301  |  DISEASES
57419  |  SLC24A3  |  1.729  |  DISEASES
6513  |  SLC2A1  |  1.026  |  DISEASES
254428  |  SLC41A1  |  1.917  |  DISEASES
54946  |  SLC41A3  |  2.251  |  DISEASES
6546  |  SLC8A1  |  1.581  |  DISEASES
139065  |  SLITRK4  |  1.55  |  DISEASES
677837  |  SNORA60  |  2.502  |  DISEASES
9021  |  SOCS3  |  1.129  |  DISEASES
10580  |  SORBS1  |  1.065  |  DISEASES
6676  |  SPAG4  |  1.39  |  DISEASES
139886  |  SPIN4  |  1.94  |  DISEASES
6692  |  SPINT1  |  1.355  |  DISEASES
100642175  |  SPRY4-IT1  |  1.898  |  DISEASES
6710  |  SPTB  |  3.502  |  DISEASES
27286  |  SRPX2  |  1.878  |  DISEASES
6736  |  SRY  |  2.433  |  DISEASES
6772  |  STAT1  |  1.218  |  DISEASES
7341  |  SUMO1  |  1.306  |  DISEASES
85360  |  SYDE1  |  2.189  |  DISEASES
84144  |  SYDE2  |  2.059  |  DISEASES
11346  |  SYNPO  |  1.593  |  DISEASES
6863  |  TAC1  |  1.071  |  DISEASES
6949  |  TCOF1  |  1.249  |  DISEASES
7005  |  TEAD3  |  1.318  |  DISEASES
7010  |  TEK  |  2.536  |  DISEASES
7018  |  TF  |  1.87  |  DISEASES
7037  |  TFRC  |  1.454  |  DISEASES
7042  |  TGFB2  |  1.415  |  DISEASES
7056  |  THBD  |  3.803  |  DISEASES
7099  |  TLR4  |  2.795  |  DISEASES
54106  |  TLR9  |  1.139  |  DISEASES
79022  |  TMEM106C  |  3.624  |  DISEASES
131920  |  TMEM207  |  1.306  |  DISEASES
7124  |  TNF  |  4.425  |  DISEASES
7133  |  TNFRSF1B  |  1.135  |  DISEASES
7137  |  TNNI3  |  1.7  |  DISEASES
6399  |  TRAPPC2  |  1.689  |  DISEASES
140803  |  TRPM6  |  1.274  |  DISEASES
55503  |  TRPV6  |  1.334  |  DISEASES
7106  |  TSPAN4  |  1.461  |  DISEASES
7258  |  TSPY1  |  2.84  |  DISEASES
100289087  |  TSPY10  |  2.732  |  DISEASES
7295  |  TXN  |  1.512  |  DISEASES
51366  |  UBR5  |  1.282  |  DISEASES
114131  |  UCN3  |  1.537  |  DISEASES
23376  |  UFL1  |  1.128  |  DISEASES
25972  |  UNC50  |  1.548  |  DISEASES
57216  |  VANGL2  |  4.643  |  DISEASES
7421  |  VDR  |  2.125  |  DISEASES
7422  |  VEGFA  |  5.172  |  DISEASES
11326  |  VSIG4  |  2.036  |  DISEASES
23038  |  WDTC1  |  2.617  |  DISEASES
100128252  |  ZNF667-AS1  |  1.551  |  DISEASES
Locus(Waiting for update.)
Disease ID 182
Disease pre-eclampsia
Integrated Phenotype
HPO | Name(Total Integrated Phenotypes:10)
HP:0002910  |  Elevated transaminases
HP:0100601  |  Eclampsia
HP:0001873  |  Low platelet count
HP:0001250  |  Seizures
HP:0000822  |  Hypertension
HP:0100602  |  Pre-eclampsia
HP:0000969  |  Dropsy
HP:0008071  |  Maternal hypertension
HP:0000093  |  Proteinuria
HP:0001511  |  Prenatal onset growth retardation
Text Mined Phenotype
HPO | Name | Sentences' Count(Total Phenotypes:100)
HP:0000822  |  Hypertension  |  43
HP:0001511  |  Prenatal onset growth retardation  |  31
HP:0000093  |  Proteinuria  |  16
HP:0001622  |  Premature delivery  |  9
HP:0001250  |  Seizures  |  8
HP:0001510  |  Growth deficiency  |  7
HP:0000855  |  Insulin resistance  |  6
HP:0100512  |  Vitamin D deficiency  |  5
HP:0000969  |  Dropsy  |  5
HP:0009800  |  gestational diabetes  |  5
HP:0001513  |  Obesity  |  5
HP:0001873  |  Low platelet count  |  4
HP:0000821  |  Underactive thyroid  |  4
HP:0001518  |  Small for gestational age  |  3
HP:0002315  |  Headaches  |  3
HP:0100601  |  Eclampsia  |  3
HP:0100598  |  Pulmonary oedema  |  3
HP:0002647  |  Aortic dissection  |  2
HP:0002099  |  Asthma  |  2
HP:0000704  |  Pyorrhea  |  2
HP:0000819  |  Diabetes mellitus  |  2
HP:0001788  |  Premature rupture of membranes  |  2
HP:0001635  |  Congestive heart failure  |  2
HP:0001541  |  Ascites  |  2
HP:0002181  |  Cerebral edema  |  2
HP:0003002  |  Breast carcinoma  |  2
HP:0002149  |  Hyperuricemia  |  2
HP:0000488  |  Noninflammatory retina disease  |  2
HP:0012622  |  Chronic kidney disease  |  2
HP:0001638  |  Cardiomyopathy  |  2
HP:0001298  |  Encephalopathy  |  1
HP:0011106  |  Depleted blood volume  |  1
HP:0001067  |  Neurofibromas  |  1
HP:0001875  |  Neutropenia  |  1
HP:0012594  |  High urine albumin levels  |  1
HP:0000105  |  Renal enlargement  |  1
HP:0001631  |  Atria septal defect  |  1
HP:0002069  |  Generalized tonic clonic seizures  |  1
HP:0005268  |  Spontaneous abortion  |  1
HP:0100806  |  Sepsis  |  1
HP:0001397  |  Hepatic steatosis  |  1
HP:0002573  |  Bloody diarrhea  |  1
HP:0100817  |  Renovascular hypertension  |  1
HP:0003124  |  Elevated serum cholesterol  |  1
HP:0012597  |  Heavy proteinuria  |  1
HP:0012452  |  Restless legs  |  1
HP:0000047  |  Hypospadias  |  1
HP:0006859  |  Posterior leukoencephalopathy  |  1
HP:0100699  |  Scarring  |  1
HP:0001562  |  Oligohydramnios  |  1
HP:0003613  |  Antiphospholipid antibodies  |  1
HP:0002666  |  Pheochromocytoma  |  1
HP:0000572  |  Visual loss  |  1
HP:0000147  |  Sclerocystic ovaries  |  1
HP:0100602  |  Pre-eclampsia  |  1
HP:0012649  |  Increased inflammatory response  |  1
HP:0000952  |  Yellow skin  |  1
HP:0002076  |  Migraine headaches  |  1
HP:0002960  |  Autoimmune condition  |  1
HP:0001297  |  Cerebral vascular events  |  1
HP:0011419  |  Abruptio placentae  |  1
HP:0002094  |  Dyspnea  |  1
HP:0002870  |  Obstructive sleep apnea  |  1
HP:0001047  |  Atopic dermatitis  |  1
HP:0002155  |  Increased triglycerides  |  1
HP:0010535  |  Sleep apnea  |  1
HP:0012167  |  Trichotillomania  |  1
HP:0000083  |  Renal insufficiency  |  1
HP:0012330  |  Pyelonephritis  |  1
HP:0001263  |  Developmental retardation  |  1
HP:0100520  |  Oliguria  |  1
HP:0100021  |  Cerebral palsy  |  1
HP:0002098  |  Respiratory distress  |  1
HP:0002084  |  Bifid skull  |  1
HP:0100555  |  Asymmetric growth  |  1
HP:0002615  |  Low blood pressure  |  1
HP:0006266  |  Small placenta  |  1
HP:0000752  |  Hyperactive behavior  |  1
HP:0030005  |  Capillary leak  |  1
HP:0001558  |  Decreased fetal movement  |  1
HP:0001276  |  Hypertonia  |  1
HP:0002590  |  Paralytic ileus  |  1
HP:0002018  |  Nausea  |  1
HP:0002017  |  Nausea and vomiting  |  1
HP:0001907  |  Thromboembolic disease  |  1
HP:0002721  |  Immunodeficiency  |  1
HP:0007663  |  Central visual loss  |  1
HP:0001943  |  Hypoglycemia  |  1
HP:0002910  |  Elevated transaminases  |  1
HP:0100724  |  Hypercoagulability  |  1
HP:0001903  |  Anemia  |  1
HP:0000836  |  Overactive thyroid  |  1
HP:0100603  |  Toxemia of pregnancy  |  1
HP:0003473  |  Fatigable weakness  |  1
HP:0000252  |  Small head circumference  |  1
HP:0002597  |  Abnormality of blood vessels  |  1
HP:0002352  |  Leukoencephalopathy  |  1
HP:0000112  |  Nephropathy  |  1
HP:0005521  |  Disseminated intravascular coagulation  |  1
HP:0030127  |  Endometriosis  |  1
Disease ID 182
Disease pre-eclampsia
Manually Symptom
UMLS  | Name(Total Manually Symptoms:53)
C2364133  |  infection
C2364072  |  depression
C1963229  |  retinal detachment
C1963138  |  hypertension
C1962972  |  proteinuria
C1962958  |  hematoma
C1959583  |  myocardial failure
C1660219  |  analgesia
C1412610  |  antithrombin iii deficiency
C1405749  |  hepatorenal syndrome
C1402315  |  vascular lesions
C1268935  |  microangiopathic hemolytic anemia
C1142517  |  lupus anticoagulant
C0948265  |  metabolic syndrome
C0917798  |  cerebral ischaemia
C0877035  |  oestrogenic effect
C0856169  |  endothelial dysfunction
C0796095  |  c syndrome
C0752303  |  urological manifestations
C0740394  |  hyperuricemia
C0730345  |  microalbuminuria
C0553681  |  hypofibrinogenaemia
C0456909  |  blindness
C0398623  |  hypercoagulable state
C0392549  |  cerebral palsy
C0376288  |  amaurosis
C0341697  |  renal impairment
C0271355  |  abducens nerve palsy
C0269286  |  rudimentary horn pregnancy
C0162429  |  malnutrition
C0155320  |  cortical blindness
C0151864  |  pregnancy disorder
C0085616  |  vasospasm
C0040034  |  thrombocytopenia
C0035305  |  retinal detachments
C0034063  |  pulmonary edema
C0032227  |  pleural effusions
C0032051  |  placental insufficiency
C0031190  |  fetal circulation
C0028961  |  oliguria
C0022116  |  ischemia
C0021308  |  infarction
C0020649  |  hypotension
C0020625  |  hyponatremia
C0020599  |  hypocalciuria
C0020538  |  high blood pressure
C0019270  |  herniation
C0018681  |  headaches
C0017668  |  focal glomerular sclerosis
C0015930  |  foetal distress
C0015927  |  intrauterine death
C0012739  |  disseminated intravascular coagulation
C0000832  |  abruptio placentae
Text Mined Symptom
UMLS | Name | Sentences' Count(Total Symptoms:27)
C0020538  |  hypertension  |  43
C0033687  |  proteinuria  |  16
C0856169  |  endothelial dysfunction  |  13
C0162739  |  hellp syndrome  |  11
C0036572  |  seizures  |  8
C0340274  |  gestational hypertension  |  5
C0032051  |  placental insufficiency  |  3
C0040034  |  thrombocytopenia  |  3
C0032962  |  pregnancy complications  |  3
C0035309  |  retinopathy  |  2
C0740394  |  hyperuricemia  |  2
C0040053  |  thrombosis  |  2
C0547030  |  visual disturbance  |  2
C0042396  |  vasospasm  |  1
C0000832  |  placental abruption  |  1
C0015934  |  fetal growth retardation  |  1
C0009951  |  convulsions  |  1
C0028961  |  oliguria  |  1
C0024141  |  le syndrome  |  1
C0023895  |  liver disease  |  1
C0019080  |  hemorrhage  |  1
C0022658  |  nephropathy  |  1
C1455728  |  fatty liver of pregnancy  |  1
C0038454  |  stroke  |  1
C0020598  |  hypoglycemia  |  1
C0494475  |  grand mal seizures  |  1
C0034063  |  pulmonary edema  |  1
Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)
Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)
All Snps(Total Genotypes:3)
snpId pubmedId geneId geneSymbol diseaseId sourceId sentence score Year geneSymbol_dbSNP CHROMOSOME POS REF ALT
rs11617740235510112259FGF14umls:C0032914GWASCATGenome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.0.122013FGF1413102027776GA
rs283944023551011150142ZNF295-AS1umls:C0032914GWASCATGenome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.0.122013ZNF295-AS12142023389CT
rs73227222355101123077MYCBP2umls:C0032914GWASCATGenome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.0.122013MYCBP21377305241GA
GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)
GWASdb Snp Trait(Total Genotypes:49)
CHR POS SNPID REF ALT ORI_SNPID PMID P_VALUE P_VALUE_TEXT OR/BETA CI95_TEXT GWAS_INITIAL_SAMPLE_SIZE SUB_POPULATION SUPER_POPULATION GWAS_TRAIT HPO_ID HPO_TERM DO_ID DO_TERM MESH_ID MESH_TERM EFO_ID EFO_TERM DOLITE_TERM RISK_ALLELE PUBLICATION_TYPE AA GENE_SYMBOL TYPE REFGENE
1217185265rs17686866CArs17686866227480010.0000038NANANA293 Caucasian femalesCaucasian(293)ALL(293)EUR(293)ALL(293)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tC
1217185265rs17686866CArs17686866235510118.99E-06Caucasian2.78[1.79-4.35]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1224916592rs6660579CTrs6660579224320410.0000078NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tC
226322040rs9332419AGrs9332419224320410.00000617NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tA
226344787rs11126375GArs11126375224320410.00000913NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tA
246746963rs4952830AGrs4952830224320410.00000674NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tA
2105877870rs17636747CTrs17636747235510114.00E-06Hispanic8.35[3.41-20.46]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
2108415702rs6542736GArs6542736224320410.00000731NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tG
2121118031rs7576192AGrs7576192224320410.000000148NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tG
2121118124rs7579169TCrs7579169224320410.000000358NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tC
2121123383rs12711941TGrs12711941224320410.000000426NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tG
38571110rs9831647GArs9831647227480010.00000936NANANA293 Caucasian femalesCaucasian(293)ALL(293)EUR(293)ALL(293)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tG
387257423rs17024019AGrs17024019224320410.00000957NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tG
387276699rs2279720CTrs2279720224320410.00000866NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tG
387299075rs1044499ACrs1044499224320410.00000866NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tA
3149250589rs17787940TCrs17787940235510113.00E-06EA3.17[1.95-5.16]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
437173944rs1426409GArs1426409227480010.00000314NANANA293 Caucasian femalesCaucasian(293)ALL(293)EUR(293)ALL(293)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tT
498965696rs7677523TCrs7677523224320410.00000951NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tT
4182609865rs12641856GArs12641856235510112.00E-06Afro-Caribbean15.19[4.98-46.35]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
630976219rs28360974GArs28360974235510113.00E-06Afro-Caribbean10.13[3.85-26.67]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
725612661rs975369GArs975369235510118.00E-06Afro-Caribbean4.55[2.34-8.83]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
820246758rs17412740GArs17412740235510112.00E-06Hispanic6.08[2.88-12.81]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
820263408rs1016646GArs1016646235510119.45E-06Hispanic5.68[2.63-12.25]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
9102808685rs7028939AGrs7028939235510113.00E-06EA3.17[1.95-5.15]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
9102854188rs7849323TCrs7849323235510113.42E-06EA3.15[1.94-5.11]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
9102911706rs1415927TCrs1415927235510113.48E-06EA3.15[1.94-5.11]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
9102918306rs7047693TCrs7047693235510113.31E-06EA3.16[1.94-5.12]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
9102922307rs10988989TCrs10988989235510113.31E-06EA3.16[1.94-5.12]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
9102958736rs7020780GArs7020780235510112.66E-06EA3.19[1.96-5.17]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
9102976541rs10989019TCrs10989019235510112.00E-06EA3.21[1.98-5.20]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1029027223rs1248993AGrs1248993235510116.00E-06Afro-Caribbean4.27[2.28-8.01]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
10105884116rs10883969CTrs10883969235510113.00E-06EA2.97[1.88-4.69]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
11118031986rs11600901GArs11600901235510119.00E-06Afro-Caribbean9.83[3.58-27.00]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1225660579rs10743565AGrs10743565227480010.0000164NANANA293 Caucasian femalesCaucasian(293)ALL(293)EUR(293)ALL(293)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tA
1225660579rs10743565AGrs10743565235510116.77E-06Caucasian2.44[1.67-3.70]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1339903243rs6563695GTrs6563695235510115.00E-06EA3.65[2.09-6.36]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1377488736rs12431203GArs12431203224320410.00000245NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tG
1377622818rs624575CTrs624575235510111.50E-06EA2.9[1.88-4.48]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1377723410rs7337686GArs7337686235510116.60E-06EA2.68[1.74-4.11]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1377862984rs9530631GArs9530631235510115.91E-06EA2.69[1.75-4.12]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1377879376rs7322722GArs7322722235510111.00E-06EA2.93[1.90-4.52]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
13102680126rs11617740GArs11617740235510117.00E-07Afro-Caribbean16.69[5.53-51.97]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
1544774202rs2453274CTrs2453274224320410.00000232NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tC
1676043201rs7199697AGrs7199697235510119.59E-06Hispanic3.98[2.16-7.33]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
204215557rs1556832CTrs1556832235510119.00E-06Afro-Caribbean4.33[2.27-8.27]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
205949534rs4815879GArs4815879235510112.00E-06Afro-Caribbean14.57[4.81-44.17]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
2122188735rs2826538CTrs2826538224320410.00000593NANANA538 European ancestry cases; 540 European ancestry controlsEuropean(1078)ALL(1078)EUR(1078)ALL(1078)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-EclampsiaNAResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tC
2136208062rs9976946CTrs9976946235510115.00E-06EA5.5[2.65-11.39]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
2143443498rs2839440CTrs2839440235510111.00E-06Afro-Caribbean5.31[2.70-10.42]21 Afro-Caribbean cases; 1,010 Afro-Caribbean controls; 50 European ancestry cases; 1,202 European ancestry controls; 62 Hispanic cases; 658 Hispanic controlsAfro-Caribbean(1031)European(1252)Hispanic(720)ALL(3003)HIS(720)AFR(1031)EUR(1252)ALL(3003)PreeclampsiaHPOID:0100602PreeclampsiaDOID:10591pre-eclampsiaD011225Pre-EclampsiaNANAPre-Eclampsia
Mapped by lexical matching(Total Items:3)
HP ID HP Name MP ID MP Name Annotation
HP:0002910Elevated hepatic transaminasesMP:0002628hepatic steatosisan accumulation of fat deposits in the liver
HP:0008071Maternal hypertensionMP:0004217salt-sensitive hypertensionsustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet
HP:0001511Intrauterine growth retardationMP:0011109lethality throughout fetal growth and development, incomplete penetrancethe appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)
Mapped by homologous gene(Total Items:10)
HP ID HP Name MP ID MP Name Annotation
HP:0100601EclampsiaMP:0006144increased systemic arterial systolic blood pressureabnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries
HP:0000969EdemaMP:0020154impaired humoral immune responseimpaired response of the immune system that mediates secreted antibodies produced in B cells
HP:0002910Elevated hepatic transaminasesMP:0020234decreased basal metabolismdecrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state
HP:0100602PreeclampsiaMP:0014169decreased brown adipose tissue massdecreased physical bulk or volume of brown adipose tissue
HP:0008071Maternal hypertensionMP:0011442abnormal renal sodium ion transportany anomaly in the directed movement of sodium ions (Na+) by the kidney
HP:0000093ProteinuriaMP:0020216decreased circulating complement protein levelless than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes
HP:0001511Intrauterine growth retardationMP:0020329decreased capillary densityreduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0001250SeizuresMP:3000003abnormal Ebner's gland morphologyany structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l
HP:0001873ThrombocytopeniaMP:0020329decreased capillary densityreduction in the number of capillaries in a given cross-sectional area of a tissue
HP:0000822HypertensionMP:0020216decreased circulating complement protein levelless than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes
Disease ID 182
Disease pre-eclampsia
Case(Waiting for update.)