eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| polymyositis | ||||
| Disease ID | 322 |
|---|---|
| Disease | polymyositis |
| Definition | Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9) |
| Synonym | multiple myositis myositides, multiple myositis, multiple neuromyositis neuromyositis-retired neuromyositis-retired (disorder) pm - polymyositis polymyositides polymyositis (disorder) polymyositis [disease/finding] |
| Orphanet | |
| DOID | |
| UMLS | C0085655 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:57) C0024115 | lung disease | 12 C0206062 | interstitial lung disease | 12 C0019158 | hepatitis | 4 C0026848 | myopathy | 3 C0003873 | rheumatoid arthritis | 3 C0009782 | connective tissue disorder | 3 C0007102 | colon cancer | 2 C0011633 | dermatomyositis | 2 C0020538 | hypertension | 2 C0019163 | hepatitis b | 2 C0027121 | myositis | 2 C0241910 | autoimmune hepatitis | 2 C0009782 | connective tissue disorders | 2 C0027059 | myocarditis | 2 C0032285 | pneumonia | 2 C0003864 | arthritis | 2 C0026896 | myasthenia gravis | 2 C0010346 | crohn's disease | 1 C0242379 | lung cancer | 1 C0027726 | nephrotic syndrome | 1 C0334254 | lymphoepithelioma | 1 C0020676 | hypothyroidism | 1 C0034065 | pulmonary embolism | 1 C0206062 | interstitial lung diseases | 1 C0008312 | primary biliary cirrhosis | 1 C0026850 | muscular dystrophies | 1 C0020626 | hypoparathyroidism | 1 C0024115 | lung diseases | 1 C0009782 | connective tissue diseases | 1 C0235974 | pancreatic cancer | 1 C0011570 | depression | 1 C0026846 | muscle atrophy | 1 C0020550 | hyperthyroidism | 1 C1527336 | sjogren's syndrome | 1 C0018213 | graves' disease | 1 C0026764 | myeloma | 1 C0376545 | hematological malignancy | 1 C0677607 | hashimoto's thyroiditis | 1 C0456845 | non-secretory myeloma | 1 C0021053 | immune disease | 1 C0006142 | breast cancer | 1 C0024299 | lymphoma | 1 C0027121 | muscle inflammation | 1 C1145670 | respiratory failure | 1 C0032461 | polycythaemia | 1 C0019204 | hepatocellular carcinoma | 1 C0032463 | polycythaemia vera | 1 C0020542 | pulmonary hypertension | 1 C0042769 | virus infection | 1 C0009782 | connective tissue disease | 1 C0085278 | antiphospholipid antibody syndrome | 1 C0026850 | muscular dystrophy | 1 C0026848 | myopathies | 1 C0752166 | bardet-biedl syndrome | 1 C0027121 | inflammatory myopathies | 1 C0039590 | testicular cancer | 1 C0027121 | inflammatory myopathy | 1 |
| Curated Gene | Entrez_id | Symbol | Resource(Total Genes:5) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 322 |
|---|---|
| Disease | polymyositis |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:90) C2697391 | rheumatoid arthritis C2609059 | antisynthetase syndrome C2364133 | infection C2364118 | weakness C1963229 | retinal detachment C1963220 | pulmonary hypertension C1962972 | proteinuria C1962971 | myocarditis C1962966 | retinopathy C1512411 | hepatocellular carcinoma C1420725 | thymoma C1384514 | primary aldosteronism C1290344 | nonspecific interstitial pneumonia C1145670 | respiratory failure C1112565 | pneumatosis intestinalis C0878544 | myocardial disease C0865681 | chronic myocarditis C0852949 | arteriopathy C0748159 | pulmonary involvement C0549225 | myasthenic syndrome C0520463 | chronic active hepatitis C0520459 | necrotizing enterocolitis C0442874 | neuropathy C0432474 | klinefelter's syndrome C0403457 | myoglobinuric acute renal failure C0403416 | crescentic glomerulonephritis C0398367 | kikuchi-fujimoto disease C0268123 | myoadenylate deaminase deficiency C0264886 | conduction disorders C0264886 | conduction defects C0264886 | cardiac conduction defects C0264490 | acute respiratory failure C0242770 | bronchiolitis obliterans organizing pneumonia C0238183 | atrophic thyroiditis C0235896 | pulmonary infiltrates C0231443 | musculoskeletal symptoms C0206180 | ki-1 lymphoma C0206062 | interstitial lung diseases C0206062 | interstitial lung disease C0206061 | interstitial pneumonitis C0206061 | interstitial pneumonia C0205969 | malignant thymoma C0155686 | acute myocarditis C0085786 | fibrosing alveolitis C0042769 | viral infection C0042721 | virus hepatitis C0042338 | herpes zoster C0038463 | strongyloidiasis C0037116 | silicosis C0035222 | adult respiratory distress syndrome C0034902 | pure red cell aplasia C0034155 | thrombotic thrombocytopenic purpura C0034069 | pulmonary fibrosis C0032285 | pneumonitis C0032285 | pneumonia C0032266 | pneumatosis cystoides intestinalis C0030472 | paraneoplastic syndrome C0030326 | panniculitis C0029118 | opportunistic infections C0027831 | von recklinghausen's disease C0027122 | muscle calcification C0027121 | muscle inflammation C0026916 | mycobacterium avium-intracellulare infection C0025063 | mediastinal tumor C0024305 | non-hodgkin's lymphoma C0024299 | malignant lymphoma C0024282 | lymphocytosis C0024115 | lung disease C0023283 | cutaneous leishmaniasis C0023241 | legionnaires' disease C0022660 | acute renal failure C0022408 | arthropathy C0019829 | hodgkin's disease C0018802 | congestive heart failure C0018794 | heart block C0018213 | graves' disease C0017668 | focal glomerulosclerosis C0017658 | glomerulonephritis C0017152 | gastritis C0014858 | esophageal motility disorder C0014858 | esophageal dysmotility C0011168 | dysphagia C0010403 | cryoglobulinemia C0010266 | cranial neuropathy C0008521 | choroidopathy C0008312 | primary biliary cirrhosis C0007193 | dilated cardiomyopathy C0007134 | renal cell carcinoma C0004245 | av block C0003490 | aortic arch syndrome |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:17) C0024115 | lung disease | 11 C0206062 | interstitial lung disease | 10 C0003873 | rheumatoid arthritis | 3 C0004093 | weakness | 3 C0032285 | pneumonia | 2 C0027059 | myocarditis | 2 C1145670 | respiratory failure | 1 C0020542 | pulmonary hypertension | 1 C2609059 | antisynthetase syndrome | 1 C0009450 | infection | 1 C0008312 | primary biliary cirrhosis | 1 C0018213 | graves' disease | 1 C0206062 | interstitial lung diseases | 1 C0019204 | hepatocellular carcinoma | 1 C0027121 | muscle inflammation | 1 C0442874 | neuropathy | 1 C0206061 | interstitial pneumonia | 1 |
Manually Genotype(Total Text Mining Genotypes:0) |
|---|
| (Waiting for update.) |
Text Mining Genotype(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
All Snps(Total Genotypes:15) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| snpId | pubmedId | geneId | geneSymbol | diseaseId | sourceId | sentence | score | Year | geneSymbol_dbSNP | CHROMOSOME | POS | REF | ALT |
| rs10069690 | 26320593 | 7015 | TERT | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | TERT | 5 | 1279675 | C | T |
| rs10069690 | 26320593 | 2065 | ERBB3 | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | TERT | 5 | 1279675 | C | T |
| rs11171739 | 26320593 | 7015 | TERT | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | NA | 12 | 56076841 | C | T |
| rs11171739 | 26320593 | 2065 | ERBB3 | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | NA | 12 | 56076841 | C | T |
| rs13277113 | 24632671 | 640 | BLK | umls:C0085655 | BeFree | The C8orf13-BLK rs13277113A allele was associated with overall polymyositis/dermatomyositis (P<0.001, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.19-1.73), as well as polymyositis (P = 0.011, OR 1.32, 95% CI 1.06-1.64) and dermatomyositis (P<0.001, OR 1.64, 95% CI 1.26-2.12). | 0.000542884 | 2014 | NA | 8 | 11491677 | G | A |
| rs13277113 | 24632671 | 83648 | FAM167A | umls:C0085655 | BeFree | The C8orf13-BLK rs13277113A allele was associated with overall polymyositis/dermatomyositis (P<0.001, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.19-1.73), as well as polymyositis (P = 0.011, OR 1.32, 95% CI 1.06-1.64) and dermatomyositis (P<0.001, OR 1.64, 95% CI 1.26-2.12). | 0.000542884 | 2014 | NA | 8 | 11491677 | G | A |
| rs2292239 | 26320593 | 7015 | TERT | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | ERBB3 | 12 | 56088396 | T | G |
| rs2292239 | 26320593 | 2065 | ERBB3 | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | ERBB3 | 12 | 56088396 | T | G |
| rs2492358 | 26320593 | 2065 | ERBB3 | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | NA | 9 | 34737831 | C | T |
| rs2492358 | 26320593 | 7015 | TERT | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | NA | 9 | 34737831 | C | T |
| rs2853676 | 26320593 | 2065 | ERBB3 | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | TERT | 5 | 1288432 | T | C |
| rs2853676 | 26320593 | 7015 | TERT | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | TERT | 5 | 1288432 | T | C |
| rs951005 | 26320593 | 2065 | ERBB3 | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | NA | 9 | 34743684 | G | A |
| rs951005 | 26320593 | 6366 | CCL21 | umls:C0085655 | BeFree | A single-nucleotide polymorphism of CCL21 rs951005 T>C is associated with susceptibility of polymyositis and such patients with interstitial lung disease in a Chinese Han population. | 0.003267234 | 2015 | NA | 9 | 34743684 | G | A |
| rs951005 | 26320593 | 7015 | TERT | umls:C0085655 | BeFree | Chinese polymyositis (PM) patients (n =291), dermatomyositis (DM) patients (n=526) and ethnically-matched healthy controls (n =968) were genotyped for the CCL21 region SNPs (rs951005 and rs2492358), ERBB3 (rs2292239 and rs11171739), and TERT (rs2853676 and rs10069690), by using the Sequenom MassArray system. | 0.000271442 | 2015 | NA | 9 | 34743684 | G | A |
GWASdb Annotation(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
GWASdb Snp Trait(Total Genotypes:0) | |
|---|---|
| (Waiting for update.) | |
Mapped by lexical matching(Total Items:15) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0005150 | Abnormal atrioventricular conduction | MP:0003137 | abnormal impulse conducting system conduction | any functional anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart |
| HP:0000091 | Abnormality of the renal tubule | MP:0011665 | d-loop transposition of the great arteries | complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and th |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0012305 | umbilical cord hemorrhage | bleeding into or from the umbilical cord |
| HP:0003701 | Proximal muscle weakness | MP:0000748 | progressive muscle weakness | increasing loss of muscle strength over time |
| HP:0001608 | Abnormality of the voice | MP:0013283 | failure of ventral body wall closure | failure of the lateral body wall folds (a combination of mesoderm and ectoderm arising on each side of the embryo) to progress ventrally and meet in the midline and/or fuse to close the ventral body wall; normally, this closure is aided by growth of the h |
| HP:0001639 | Hypertrophic cardiomyopathy | MP:0005330 | cardiomyopathy | diseases of the heart (myocardium); may result from many causes |
| HP:0003236 | Elevated serum creatine phosphokinase | MP:0020280 | increased creatine kinase level | increased level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine |
| HP:0003002 | Breast carcinoma | MP:0010367 | increased spindle cell carcinoma incidence | greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle s |
| HP:0001252 | Muscular hypotonia | MP:0004144 | hypotonia | decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness |
| HP:0001633 | Abnormality of the mitral valve | MP:0010919 | increased number of pulmonary neuroendocrine bodies | greater number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the air |
| HP:0001644 | Dilated cardiomyopathy | MP:0005330 | cardiomyopathy | diseases of the heart (myocardium); may result from many causes |
| HP:0001824 | Weight loss | MP:0005114 | premature hair loss | release of fur at an earlier than expected time |
| HP:0002206 | Pulmonary fibrosis | MP:0009419 | skeletal muscle fibrosis | formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process |
| HP:0006530 | Interstitial pulmonary disease | MP:0002295 | abnormal pulmonary circulation | any anomaly in the circulation of blood through the lungs |
| HP:0001635 | Congestive heart failure | MP:0011925 | abnormal heart echocardiography feature | any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features |
Mapped by homologous gene(Total Items:39) | ||||
|---|---|---|---|---|
| HP ID | HP Name | MP ID | MP Name | Annotation |
| HP:0001252 | Muscular hypotonia | MP:3000003 | abnormal Ebner's gland morphology | any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete l |
| HP:0012735 | Cough | MP:0014185 | cerebellum atrophy | acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal |
| HP:0001945 | Fever | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0011675 | Arrhythmia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0001369 | Arthritis | MP:0020316 | decreased vascular endothelial cell proliferation | decrease in the expansion rate of any vascular endothelial cell population by cell division |
| HP:0001288 | Gait disturbance | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0002206 | Pulmonary fibrosis | MP:0014233 | bile duct epithelium hyperplasia | |
| HP:0002633 | Vasculitis | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0000091 | Abnormality of the renal tubule | MP:0020234 | decreased basal metabolism | decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state |
| HP:0002240 | Hepatomegaly | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0002093 | Respiratory insufficiency | MP:0020254 | decreased collagen level | decreased level of the main structural protein of the various connective tissues in animals |
| HP:0002960 | Autoimmunity | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001701 | Pericarditis | MP:0011405 | tubulointerstitial nephritis | diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease |
| HP:0001618 | Dysphonia | MP:0013659 | abnormal erythroid lineage cell morphology | any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes |
| HP:0002239 | Gastrointestinal hemorrhage | MP:0020215 | impaired blood coagulation | impaired ability of the blood to clot |
| HP:0000934 | Chondrocalcinosis | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0001639 | Hypertrophic cardiomyopathy | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0005150 | Abnormal atrioventricular conduction | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0012378 | Fatigue | MP:0013659 | abnormal erythroid lineage cell morphology | any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes |
| HP:0003701 | Proximal muscle weakness | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001644 | Dilated cardiomyopathy | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0002039 | Anorexia | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0003236 | Elevated serum creatine phosphokinase | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0001824 | Weight loss | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0002829 | Arthralgia | MP:0020154 | impaired humoral immune response | impaired response of the immune system that mediates secreted antibodies produced in B cells |
| HP:0002027 | Abdominal pain | MP:0020220 | decreased tear production | decreased production of the amount of fluid produced in the eye |
| HP:0001608 | Abnormality of the voice | MP:0020214 | susceptible to malignant hyperthermia | increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine |
| HP:0006530 | Interstitial pulmonary disease | MP:0011846 | decreased kidney collecting duct number | smaller than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electroly |
| HP:0001633 | Abnormality of the mitral valve | MP:0014164 | abnormal ciliary process morphology | any structural anomaly of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; these processes increase in thickness as they advance from the orbiculus ciliaris to the exter |
| HP:0003326 | Myalgia | MP:0020309 | increased creatine kinase activity | increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). |
| HP:0002020 | Gastroesophageal reflux | MP:0014178 | increased brain apoptosis | increase in the number of cells of the brain undergoing programmed cell death |
| HP:0002875 | Exertional dyspnea | MP:0013405 | increased circulating lactate level | greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase |
| HP:0003457 | EMG abnormality | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0004936 | Venous thrombosis | MP:0014166 | ectopic cranial bone | the appearance of an extra bone structure at an atypical location in or near the cranium |
| HP:0001635 | Congestive heart failure | MP:0020329 | decreased capillary density | reduction in the number of capillaries in a given cross-sectional area of a tissue |
| HP:0001658 | Myocardial infarction | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| HP:0002019 | Constipation | MP:0020234 | decreased basal metabolism | decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state |
| HP:0003002 | Breast carcinoma | MP:0020039 | increased bone ossification | increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance |
| HP:0001315 | Reduced tendon reflexes | MP:0020137 | decreased bone mineralization | decrease in the rate at which minerals are deposited into bone |
| Disease ID | 322 |
|---|---|
| Disease | polymyositis |
| Case | (Waiting for update.) |