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	poliomyelitis

Disease ID	543
Disease	poliomyelitis
Definition	An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
Synonym	[x]acute poliomyelitis, unspecified [x]acute poliomyelitis, unspecified (disorder) acute polio acute poliomyelitis acute poliomyelitis (disorder) acute poliomyelitis nos acute poliomyelitis nos (disorder) acute poliomyelitis, epidemic acute poliomyelitis, nos acute poliomyelitis, unspecified epidemic acute poliomyelitis epidemic acute poliomyelitis (disorder) epidemic acute poliomyelitis, nos heine-medin disease pm - poliomyelitis polia polio poliomyelitis (disorder) poliomyelitis [disease/finding] poliomyelitis, acute poliomyelitis, epidemic acute poliomyelitis, nos polios
Orphanet	ORPHANET:2912
DOID	DOID:4953
ICD10	ICD10CM:A80.9
UMLS	C0032371
MeSH	D011051
SNOMED-CT	SNOMEDCT_US_2016_09_01:398256009;SNOMEDCT_US_2016_09_01:398102009
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:21) C0740441 \| acute diarrhea \| 3 C0039614 \| tetanus \| 2 C0011991 \| diarrhea \| 2 C0036439 \| scoliosis \| 2 C0004096 \| asthma \| 1 C0024530 \| malaria \| 1 C0027059 \| myocarditis \| 1 C0011570 \| depression \| 1 C0025290 \| aseptic meningitis \| 1 C0020538 \| hypertension \| 1 C1145670 \| respiratory failure \| 1 C0014877 \| esotropia \| 1 C0017160 \| gastroenteritis \| 1 C0035258 \| restless legs syndrome \| 1 C0029456 \| osteoporosis \| 1 C0023418 \| leukemia \| 1 C0025289 \| meningitis \| 1 C0026846 \| muscle atrophy \| 1 C0037317 \| sleep disturbance \| 1 C0037317 \| sleep disturbances \| 1 C0032285 \| pneumoniae \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 5817 \| PVR \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:4) 2212 \| FCGR2A \| CIPHER 2214 \| FCGR3A \| CIPHER 2215 \| FCGR3B \| CIPHER 5817 \| PVR \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:57) 64746 \| ACBD3 \| 3.116 \| DISEASES 11332 \| ACOT7 \| 2.449 \| DISEASES 103 \| ADAR \| 1.129 \| DISEASES 270 \| AMPD1 \| 1.796 \| DISEASES 9138 \| ARHGEF1 \| 5.074 \| DISEASES 617 \| BCS1L \| 1.001 \| DISEASES 146227 \| BEAN1 \| 2.245 \| DISEASES 51297 \| BPIFA1 \| 1.663 \| DISEASES 55028 \| C17orf80 \| 4.131 \| DISEASES 720 \| C4A \| 1.637 \| DISEASES 820 \| CAMP \| 1.35 \| DISEASES 930 \| CD19 \| 1.43 \| DISEASES 959 \| CD40LG \| 3.557 \| DISEASES 55636 \| CHD7 \| 1.002 \| DISEASES 1139 \| CHRNA7 \| 1.442 \| DISEASES 10488 \| CREB3 \| 2.511 \| DISEASES 11218 \| DDX20 \| 2.137 \| DISEASES 23586 \| DDX58 \| 2.221 \| DISEASES 9191 \| DEDD \| 1.773 \| DISEASES 1805 \| DPT \| 6.472 \| DISEASES 1907 \| EDN2 \| 1.246 \| DISEASES 30816 \| ERVW-1 \| 2.157 \| DISEASES 2316 \| FLNA \| 1.884 \| DISEASES 2550 \| GABBR1 \| 1.841 \| DISEASES 23426 \| GRIP1 \| 2.293 \| DISEASES 2987 \| GUK1 \| 2.204 \| DISEASES 2994 \| GYPB \| 1.683 \| DISEASES 2996 \| GYPE \| 1.313 \| DISEASES 102723508 \| KANTR \| 3.109 \| DISEASES 8570 \| KHSRP \| 4.977 \| DISEASES 23008 \| KLHDC10 \| 4.092 \| DISEASES 3980 \| LIG3 \| 1.933 \| DISEASES 65108 \| MARCKSL1 \| 2.669 \| DISEASES 57506 \| MAVS \| 2.871 \| DISEASES 27030 \| MLH3 \| 1.792 \| DISEASES 4600 \| MX2 \| 1.603 \| DISEASES 4637 \| MYL6 \| 2.39 \| DISEASES 25915 \| NDUFAF3 \| 2.542 \| DISEASES 378884 \| NHLRC1 \| 1.387 \| DISEASES 4893 \| NRAS \| 1.089 \| DISEASES 4923 \| NTSR1 \| 2.604 \| DISEASES 5094 \| PCBP2 \| 2.18 \| DISEASES 5799 \| PTPRN2 \| 1.346 \| DISEASES 5817 \| PVR \| 4.534 \| DISEASES 22821 \| RASA3 \| 2.999 \| DISEASES 6005 \| RHAG \| 1.27 \| DISEASES 54938 \| SARS2 \| 1.668 \| DISEASES 55315 \| SLC29A3 \| 1.517 \| DISEASES 55974 \| SLC50A1 \| 2.851 \| DISEASES 29110 \| TBK1 \| 1.177 \| DISEASES 51567 \| TDP2 \| 2.371 \| DISEASES 26136 \| TES \| 2.222 \| DISEASES 7124 \| TNF \| 1.6 \| DISEASES 9652 \| TTC37 \| 2.077 \| DISEASES 51175 \| TUBE1 \| 2.472 \| DISEASES 7415 \| VCP \| 1.62 \| DISEASES 79971 \| WLS \| 2.648 \| DISEASES
Locus	(Waiting for update.)

Disease ID	543
Disease	poliomyelitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:23) HP:0003470 \| Inability to move \| 8 HP:0012531 \| Pain \| 5 HP:0012378 \| Fatigue \| 5 HP:0002650 \| Scoliosis \| 3 HP:0002014 \| Diarrhea \| 2 HP:0001297 \| Cerebral vascular events \| 2 HP:0000939 \| Osteoporosis \| 1 HP:0001909 \| Leukemia \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0001324 \| Muscular weakness \| 1 HP:0002385 \| Paraparesis \| 1 HP:0001287 \| Meningitis \| 1 HP:0000822 \| Hypertension \| 1 HP:0040078 \| Axonal degeneration \| 1 HP:0002360 \| Sleep disturbance \| 1 HP:0001618 \| Dysphonia \| 1 HP:0002878 \| Respiratory failure \| 1 HP:0000565 \| Inward turning of one or both eyes \| 1 HP:0002527 \| Falls \| 1 HP:0000716 \| Depression \| 1 HP:0002099 \| Asthma \| 1 HP:0012819 \| Myocarditis \| 1 HP:0003202 \| Neurogenic muscle atrophy, especially in the lower limbs \| 1

Disease ID	543
Disease	poliomyelitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:65) C2598155 \| pain C2364133 \| infection C2364118 \| weakness C2364103 \| sensory deficit C2364051 \| fatigue C2364050 \| hypothermia C1971021 \| potassium depletion C1963138 \| hypertension C1963064 \| anxiety C1962971 \| myocarditis C1801950 \| g syndrome C1510420 \| cavities C1456822 \| lameness C1330961 \| acidity C1145670 \| respiratory failure C1145628 \| disorders of the autonomic nervous system C0877389 \| gonarthrosis C0876973 \| pulmonary infections C0869523 \| carditis C0865850 \| acute respiratory insufficiency C0700208 \| scoliosis C0700201 \| sleep disturbance C0600033 \| kyphoscoliosis C0522224 \| palsy C0451641 \| urinary lithiasis C0278134 \| sensory loss C0270814 \| spastic syndrome C0262471 \| ent problem C0231796 \| respiratory abnormalities C0221163 \| motor disorders C0205721 \| hospital infections C0205721 \| hospital infection C0155288 \| papilledema C0154703 \| upper extremity paralysis C0151311 \| cranial nerve paralysis C0085620 \| flaccid paralysis C0042749 \| viremia C0041834 \| erythema C0037763 \| spasm C0037763 \| muscle spasms C0037763 \| muscle spasm C0035229 \| respiratory insufficiency C0035204 \| respiratory disorders C0035204 \| respiration disorders C0034372 \| quadriplegia C0034065 \| pulmonary embolism C0030824 \| allergy to penicillin C0030442 \| bulbar paralysis C0027709 \| nephrocalcinosis C0027122 \| myositis ossificans C0026650 \| movement disorders C0022408 \| arthrosis C0020701 \| hysteria C0020538 \| high blood pressure C0019087 \| hemorrhagic diathesis C0018524 \| hallucinations C0015469 \| facial paralysis C0015469 \| facial nerve paralysis C0014070 \| encephalomyelitis C0014059 \| acute disseminated encephalomyelitis C0014038 \| encephalitis C0013949 \| embryopathy C0013404 \| breathing difficulties C0004044 \| asphyxia C0003881 \| arthrodesis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:11) C0085620 \| flaccid paralysis \| 6 C0015672 \| fatigue \| 5 C0036439 \| scoliosis \| 3 C0009450 \| infection \| 3 C1145670 \| respiratory failure \| 1 C0021311 \| infections \| 1 C0231443 \| musculoskeletal symptoms \| 1 C0037317 \| sleep disturbance \| 1 C0011168 \| dysphagia \| 1 C0004093 \| weakness \| 1 C0030193 \| pain \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
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All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
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Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	543
Disease	poliomyelitis
Case	(Waiting for update.)

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