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	pleural mesothelioma

Disease ID	1111
Disease	pleural mesothelioma
Definition	A malignant neoplasm that arises from mesothelial cells in the pleura and shows a diffuse growth pattern. It arises on the parietal and sometimes visceral pleura as multiple small nodules that later become confluent and invade the chest wall adipose tissue and muscle. Asbestos exposure is the main cause for the development of pleural malignant mesothelioma. It usually affects patients over sixty years of age. The latency period is long. Patients usually present with pleural effusion, dyspnea and chest wall pain. Additional signs and symptoms include chills, sweating, weight loss, and weakness. Morphologic variants include epithelioid, desmoplastic, sarcomatoid, and biphasic mesothelioma. The clinical course is usually aggressive.
Synonym	malignant mesothelioma of pleura malignant mesothelioma of pleura (disorder) malignant mesothelioma of the pleura malignant pleural mesothelioma mesothelioma (malignant) of pleura (disorder) mesothelioma of pleura mesotheliomas pleural pleura mesothelioma pleural diffuse malignant mesothelioma pleural malignant mesothelioma
Orphanet	ORPHANET:50251
DOID	DOID:7474 DOID:5157
ICD10	ICD10CM:C45.0
UMLS	C0812413
SNOMED-CT	SNOMEDCT_US_2016_09_01:254645002
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:17) C0345967 \| malignant mesothelioma \| 2 C0080032 \| malignant pleural effusion \| 1 C0032326 \| pneumothorax \| 1 C0856761 \| budd-chiari syndrome \| 1 C0220650 \| brain metastases \| 1 C0001418 \| adenocarcinomas \| 1 C0205697 \| sarcomatoid carcinoma \| 1 C0031069 \| periodic disease \| 1 C0279130 \| cns metastases \| 1 C0155912 \| pulmonary alveolar microlithiasis \| 1 C0346109 \| peritoneal mesothelioma \| 1 C0027726 \| nephrotic syndrome \| 1 C0152013 \| lung adenocarcinoma \| 1 C0036421 \| systemic sclerosis \| 1 C0014175 \| endometriosis \| 1 C0153676 \| pulmonary metastases \| 1 C0153677 \| mediastinal metastasis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:131) 10121 \| ACTR1A \| 1.042 \| DISEASES 10142 \| AKAP9 \| 1.148 \| DISEASES 220 \| ALDH1A3 \| 2.436 \| DISEASES 501 \| ALDH7A1 \| 1.019 \| DISEASES 9776 \| ATG13 \| 1.68 \| DISEASES 9334 \| B4GALT5 \| 1.17 \| DISEASES 8314 \| BAP1 \| 4.136 \| DISEASES 10018 \| BCL2L11 \| 1.06 \| DISEASES 833 \| CARS \| 1.118 \| DISEASES 841 \| CASP8 \| 1.376 \| DISEASES 842 \| CASP9 \| 1.473 \| DISEASES 857 \| CAV1 \| 1.268 \| DISEASES 6358 \| CCL14 \| 1.26 \| DISEASES 9332 \| CD163 \| 2.05 \| DISEASES 29126 \| CD274 \| 2.696 \| DISEASES 960 \| CD44 \| 1.693 \| DISEASES 942 \| CD86 \| 1.949 \| DISEASES 1029 \| CDKN2A \| 3.377 \| DISEASES 9350 \| CER1 \| 1.067 \| DISEASES 1365 \| CLDN3 \| 1.367 \| DISEASES 1364 \| CLDN4 \| 1.71 \| DISEASES 9022 \| CLIC3 \| 2.149 \| DISEASES 25932 \| CLIC4 \| 1.171 \| DISEASES 1207 \| CLNS1A \| 2.244 \| DISEASES 55748 \| CNDP2 \| 1.681 \| DISEASES 22837 \| COBLL1 \| 2.411 \| DISEASES 8451 \| CUL4A \| 2.076 \| DISEASES 317781 \| DDX51 \| 2.805 \| DISEASES 1668 \| DEFA3 \| 1.199 \| DISEASES 1719 \| DHFR \| 1.073 \| DISEASES 57628 \| DPP10 \| 1.318 \| DISEASES 1803 \| DPP4 \| 1.057 \| DISEASES 1855 \| DVL1 \| 1.721 \| DISEASES 2202 \| EFEMP1 \| 3.86 \| DISEASES 1942 \| EFNA1 \| 2.186 \| DISEASES 23741 \| EID1 \| 2.265 \| DISEASES 1964 \| EIF1AX \| 1.568 \| DISEASES 1974 \| EIF4A2 \| 1.127 \| DISEASES 1978 \| EIF4EBP1 \| 1.577 \| DISEASES 3692 \| EIF6 \| 1.726 \| DISEASES 27436 \| EML4 \| 1.462 \| DISEASES 2018 \| EMX2 \| 1.421 \| DISEASES 56943 \| ENY2 \| 2.009 \| DISEASES 1969 \| EPHA2 \| 1.857 \| DISEASES 2100 \| ESR2 \| 2.322 \| DISEASES 23265 \| EXOC7 \| 1.808 \| DISEASES 2258 \| FGF13 \| 1.233 \| DISEASES 2260 \| FGFR1 \| 1.637 \| DISEASES 22862 \| FNDC3A \| 1.144 \| DISEASES 2309 \| FOXO3 \| 1.26 \| DISEASES 50943 \| FOXP3 \| 1.152 \| DISEASES 2356 \| FPGS \| 3.059 \| DISEASES 2524 \| FUT2 \| 1.17 \| DISEASES 60674 \| GAS5 \| 1.083 \| DISEASES 27333 \| GOLIM4 \| 1.905 \| DISEASES 2939 \| GSTA2 \| 1.278 \| DISEASES 2941 \| GSTA4 \| 1.09 \| DISEASES 9235 \| IL32 \| 1.281 \| DISEASES 3619 \| INCENP \| 1.622 \| DISEASES 3664 \| IRF6 \| 1.778 \| DISEASES 3679 \| ITGA7 \| 2.502 \| DISEASES 55600 \| ITLN1 \| 1.308 \| DISEASES 81621 \| KAZALD1 \| 3.608 \| DISEASES 8284 \| KDM5D \| 2.157 \| DISEASES 3792 \| KEL \| 1.074 \| DISEASES 3932 \| LCK \| 1.068 \| DISEASES 9170 \| LPAR2 \| 1.067 \| DISEASES 10046 \| MAMLD1 \| 1.272 \| DISEASES 5609 \| MAP2K7 \| 1.066 \| DISEASES 4170 \| MCL1 \| 3.008 \| DISEASES 4193 \| MDM2 \| 1.782 \| DISEASES 4311 \| MME \| 1.503 \| DISEASES 10232 \| MSLN \| 6.256 \| DISEASES 4507 \| MTAP \| 1.548 \| DISEASES 2475 \| MTOR \| 1.342 \| DISEASES 4609 \| MYC \| 1.577 \| DISEASES 4637 \| MYL6 \| 1.618 \| DISEASES 84700 \| MYO18B \| 2.08 \| DISEASES 4771 \| NF2 \| 3.394 \| DISEASES 4798 \| NFRKB \| 2.212 \| DISEASES 7080 \| NKX2-1 \| 1.041 \| DISEASES 654364 \| NME1-NME2 \| 1.339 \| DISEASES 4831 \| NME2 \| 1.402 \| DISEASES 79400 \| NOX5 \| 1.066 \| DISEASES 8828 \| NRP2 \| 1.013 \| DISEASES 142 \| PARP1 \| 2.448 \| DISEASES 5133 \| PDCD1 \| 1.257 \| DISEASES 8682 \| PEA15 \| 1.075 \| DISEASES 23481 \| PES1 \| 2.425 \| DISEASES 5361 \| PLXNA1 \| 1.449 \| DISEASES 5366 \| PMAIP1 \| 1.564 \| DISEASES 10631 \| POSTN \| 2.156 \| DISEASES 5514 \| PPP1R10 \| 1.567 \| DISEASES 100169750 \| PRINS \| 1.415 \| DISEASES 5663 \| PSEN1 \| 1.098 \| DISEASES 5728 \| PTEN \| 1.855 \| DISEASES 5764 \| PTN \| 1.207 \| DISEASES 22827 \| PUF60 \| 1.695 \| DISEASES 5820 \| PVT1 \| 1.774 \| DISEASES 25797 \| QPCT \| 1.7 \| DISEASES 11186 \| RASSF1 \| 1.813 \| DISEASES 83593 \| RASSF5 \| 1.247 \| DISEASES 5928 \| RBBP4 \| 1.121 \| DISEASES 5931 \| RBBP7 \| 1.297 \| DISEASES 80031 \| SEMA6D \| 2.06 \| DISEASES 6513 \| SLC2A1 \| 1.651 \| DISEASES 144195 \| SLC2A14 \| 1.122 \| DISEASES 113235 \| SLC46A1 \| 1.513 \| DISEASES 23583 \| SMUG1 \| 3.9 \| DISEASES 8651 \| SOCS1 \| 1.241 \| DISEASES 6667 \| SP1 \| 2.631 \| DISEASES 6696 \| SPP1 \| 3.621 \| DISEASES 3925 \| STMN1 \| 1.011 \| DISEASES 6867 \| TACC1 \| 1.535 \| DISEASES 57451 \| TENM2 \| 1.37 \| DISEASES 7056 \| THBD \| 2.169 \| DISEASES 7058 \| THBS2 \| 1.459 \| DISEASES 161291 \| TMEM30B \| 3.459 \| DISEASES 30000 \| TNPO2 \| 2.467 \| DISEASES 7153 \| TOP2A \| 1.385 \| DISEASES 7171 \| TPM4 \| 1.337 \| DISEASES 7295 \| TXN \| 1.907 \| DISEASES 9706 \| ULK2 \| 2.037 \| DISEASES 7422 \| VEGFA \| 2.88 \| DISEASES 51322 \| WAC \| 1.806 \| DISEASES 7482 \| WNT2B \| 1.207 \| DISEASES 7490 \| WT1 \| 2.865 \| DISEASES 54739 \| XAF1 \| 1.878 \| DISEASES 331 \| XIAP \| 1.531 \| DISEASES 11260 \| XPOT \| 2.273 \| DISEASES 7702 \| ZNF143 \| 1.394 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1111
Disease	pleural mesothelioma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:20) HP:0002664 \| Neoplasia \| 6 HP:0002202 \| Pleural effusion \| 4 HP:0100001 \| Malignant mesothelioma \| 3 HP:0012531 \| Pain \| 1 HP:0002639 \| Budd-Chiari syndrome \| 1 HP:0001907 \| Thromboembolic disease \| 1 HP:0000953 \| Hyperpigmentation of the skin \| 1 HP:0030127 \| Endometriosis \| 1 HP:0004756 \| Ventricular tachycardia \| 1 HP:0030731 \| Carcinoma \| 1 HP:0002107 \| Collapsed lung \| 1 HP:0000100 \| Nephrosis \| 1 HP:0030078 \| Lung adenocarcinoma \| 1 HP:0002835 \| Aspiration \| 1 HP:0002176 \| Spinal cord compression \| 1 HP:0012579 \| Minimal change glomerulonephritis \| 1 HP:0100003 \| Peritoneal mesothelioma \| 1 HP:0001945 \| Fever \| 1 HP:0001649 \| Tachycardia \| 1 HP:0012889 \| Cervical endometriosis \| 1

Disease ID	1111
Disease	pleural mesothelioma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:9) C2598155 \| pain C1443043 \| myeloproliferative syndrome C1262091 \| lymphocytic infiltration C0686619 \| lymph node metastases C0555278 \| cerebral metastases C0153687 \| cutaneous metastasis C0040053 \| thrombosis C0027726 \| nephrotic syndrome C0017665 \| membranous nephropathy
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:3) C0220650 \| brain metastases \| 1 C0030193 \| pain \| 1 C0027726 \| nephrotic syndrome \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs16906252	20627446	4255	MGMT	umls:C0812413	BeFree	Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP.	0.000542884	2011	MGMT	10	129467281	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1111
Disease	pleural mesothelioma
Case	(Waiting for update.)

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