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	panuveitis

Disease ID	1369
Disease	panuveitis
Definition	Inflammation in which both the anterior and posterior segments of the uvea are involved and a specific focus is not apparent. It is often severe and extensive and a serious threat to vision. Causes include systemic diseases such as tuberculosis, sarcoidosis, and syphilis, as well as malignancies. The intermediate segment of the eye is not involved.
Synonym	diffuse uveitis panuveitis (disorder) panuveitis [disease/finding]
Orphanet	ORPHANET:280898
DOID	DOID:12030
UMLS	C0030343
MeSH	D015864
SNOMED-CT	SNOMEDCT_US_2016_09_01:75614007
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:33) C0035305 \| retinal detachment \| 10 C0008526 \| choroiditis \| 6 C0035305 \| retinal detachments \| 5 C0042384 \| vasculitis \| 3 C0271051 \| macular edema \| 2 C0042164 \| uveitis \| 2 C0017601 \| glaucoma \| 2 C0042900 \| vitiligo \| 2 C0008513 \| chorioretinitis \| 1 C0035333 \| retinitis \| 1 C0035435 \| rheumatic disease \| 1 C0024441 \| macular hole \| 1 C0008513 \| retinochoroiditis \| 1 C0002170 \| alopecia \| 1 C0023788 \| whipple disease \| 1 C0456909 \| blindness \| 1 C0238463 \| papillary thyroid carcinoma \| 1 C0035328 \| retinal vein occlusion \| 1 C0042769 \| virus infection \| 1 C0024440 \| cystoid macular edema \| 1 C0003873 \| rheumatoid arthritis \| 1 C0162293 \| papillitis \| 1 C0152026 \| retinal vasculitis \| 1 C0015397 \| ocular disease \| 1 C0035435 \| rheumatic diseases \| 1 C0949691 \| spondyloarthropathy \| 1 C0022073 \| iridocyclitis \| 1 C0039128 \| syphilis \| 1 C0042167 \| posterior uveitis \| 1 C0035309 \| retinal disease \| 1 C0007115 \| thyroid ca \| 1 C0036202 \| sarcoidosis \| 1 C0549473 \| thyroid carcinoma \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:77) 125061 \| AFMID \| 2.133 \| DISEASES 567 \| B2M \| 2.497 \| DISEASES 676 \| BRDT \| 1.465 \| DISEASES 720 \| C4A \| 1.457 \| DISEASES 721 \| C4B \| 1.4 \| DISEASES 766 \| CA7 \| 1.453 \| DISEASES 9332 \| CD163 \| 1.066 \| DISEASES 959 \| CD40LG \| 3.858 \| DISEASES 966 \| CD59 \| 1.484 \| DISEASES 629 \| CFB \| 1.054 \| DISEASES 3075 \| CFH \| 2.095 \| DISEASES 3080 \| CFHR2 \| 2.032 \| DISEASES 3426 \| CFI \| 1.444 \| DISEASES 8804 \| CREG1 \| 3.066 \| DISEASES 2833 \| CXCR3 \| 1.716 \| DISEASES 51428 \| DDX41 \| 1.265 \| DISEASES 7913 \| DEK \| 2.064 \| DISEASES 1717 \| DHCR7 \| 1.281 \| DISEASES 6993 \| DYNLT1 \| 2.243 \| DISEASES 1896 \| EDA \| 1.882 \| DISEASES 64167 \| ERAP2 \| 1.235 \| DISEASES 346007 \| EYS \| 1.149 \| DISEASES 356 \| FASLG \| 1.066 \| DISEASES 50943 \| FOXP3 \| 1.125 \| DISEASES 3105 \| HLA-A \| 3.091 \| DISEASES 3106 \| HLA-B \| 4.088 \| DISEASES 3107 \| HLA-C \| 1.519 \| DISEASES 3115 \| HLA-DPB1 \| 2.605 \| DISEASES 3117 \| HLA-DQA1 \| 2.371 \| DISEASES 3119 \| HLA-DQB1 \| 1.998 \| DISEASES 3123 \| HLA-DRB1 \| 1.945 \| DISEASES 3550 \| IK \| 1.528 \| DISEASES 3586 \| IL10 \| 3.137 \| DISEASES 3605 \| IL17A \| 2.551 \| DISEASES 84639 \| IL1F10 \| 1.532 \| DISEASES 149233 \| IL23R \| 2.473 \| DISEASES 3559 \| IL2RA \| 2.327 \| DISEASES 55683 \| KANSL3 \| 1.546 \| DISEASES 3778 \| KCNMA1 \| 2.371 \| DISEASES 23046 \| KIF21B \| 1.908 \| DISEASES 4049 \| LTA \| 1.625 \| DISEASES 4155 \| MBP \| 2.755 \| DISEASES 79104 \| MEG8 \| 1.383 \| DISEASES 100507436 \| MICA \| 2.542 \| DISEASES 50488 \| MINK1 \| 2.229 \| DISEASES 81565 \| NDEL1 \| 3.649 \| DISEASES 114548 \| NLRP3 \| 1.972 \| DISEASES 4942 \| OAT \| 1.563 \| DISEASES 100506658 \| OCLN \| 1.056 \| DISEASES 5133 \| PDCD1 \| 1.199 \| DISEASES 11331 \| PHB2 \| 2.81 \| DISEASES 9600 \| PITPNM1 \| 1.157 \| DISEASES 5464 \| PPA1 \| 1.281 \| DISEASES 5698 \| PSMB9 \| 3.393 \| DISEASES 100130889 \| PSORS1C3 \| 2.725 \| DISEASES 5737 \| PTGFR \| 1.496 \| DISEASES 26191 \| PTPN22 \| 1.727 \| DISEASES 6171 \| RPL41 \| 1.705 \| DISEASES 6295 \| SAG \| 4.861 \| DISEASES 5265 \| SERPINA1 \| 2.816 \| DISEASES 55315 \| SLC29A3 \| 1.584 \| DISEASES 57153 \| SLC44A2 \| 1.853 \| DISEASES 8651 \| SOCS1 \| 1.243 \| DISEASES 23111 \| SPG20 \| 1.042 \| DISEASES 6731 \| SRP72 \| 1.548 \| DISEASES 6775 \| STAT4 \| 1.009 \| DISEASES 342898 \| SYCN \| 1.714 \| DISEASES 7096 \| TLR1 \| 1.108 \| DISEASES 7099 \| TLR4 \| 2.696 \| DISEASES 7124 \| TNF \| 4.102 \| DISEASES 7133 \| TNFRSF1B \| 4.145 \| DISEASES 8718 \| TNFRSF25 \| 1.368 \| DISEASES 7293 \| TNFRSF4 \| 1.622 \| DISEASES 9652 \| TTC37 \| 1.188 \| DISEASES 337867 \| UBAC2 \| 2.484 \| DISEASES 7422 \| VEGFA \| 2.209 \| DISEASES 7710 \| ZNF154 \| 2.278 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1369
Disease	panuveitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:29) HP:0000541 \| Detached retina \| 10 HP:0012123 \| Posterior uveitis \| 8 HP:0012231 \| Exudative retinal detachment \| 6 HP:0001045 \| Blotchy loss of skin color \| 3 HP:0002290 \| Poliosis \| 3 HP:0002633 \| Vasculitis \| 3 HP:0001596 \| Hair loss \| 2 HP:0040049 \| Macular edema \| 2 HP:0002721 \| Immunodeficiency \| 2 HP:0000554 \| Uveitis \| 2 HP:0000969 \| Dropsy \| 2 HP:0000501 \| Glaucoma \| 2 HP:0012531 \| Pain \| 1 HP:0000613 \| Extreme light sensitivity \| 1 HP:0000572 \| Visual loss \| 1 HP:0012636 \| Retinal vein occlusion \| 1 HP:0007866 \| Retinal infarction \| 1 HP:0200026 \| Ocular pain \| 1 HP:0012424 \| Chorioretinitis \| 1 HP:0000618 \| Blindness \| 1 HP:0001370 \| Rheumatoid arthritis \| 1 HP:0002895 \| Papillary thyroid carcinoma \| 1 HP:0011508 \| Macular hole \| 1 HP:0000518 \| Cataract \| 1 HP:0011505 \| Cystoid macular edema \| 1 HP:0009926 \| Epiphora \| 1 HP:0008052 \| Retinal fold \| 1 HP:0002890 \| Thyroid carcinoma \| 1 HP:0001094 \| Iridocyclitis \| 1

Disease ID	1369
Disease	panuveitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:6) C2364133 \| infection C1843274 \| acute tubulointerstitial nephritis C1328519 \| retinal pigment epithelial tear C0151827 \| ocular pain C0042170 \| vogt-koyanagi-harada syndrome C0035321 \| retinal tears
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1061170	23497844	3075	CFH	umls:C0030343	BeFree	Carriage of the CFH Y402H polymorphism in both alleles is associated with an increased risk for posterior uveitis and panuveitis presentation.	0.000271442	2013	CFH	1	196690107	C	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1369
Disease	panuveitis
Case	(Waiting for update.)

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