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	osteomyelitis

Disease ID	948
Disease	osteomyelitis
Definition	INFLAMMATION of the bone as a result of infection. It may be caused by a variety of infectious agents, especially pyogenic (PUS - producing) BACTERIA.
Synonym	a bacterial infection of the bone or bone marrow om - osteomyelitis osteomyelitides osteomyelitis (disorder) osteomyelitis [ambiguous] osteomyelitis [disease/finding] osteomyelitis nos-unspec osteomyelitis, nos ostm - osteomyelitis pyogenic inflammation of bone pyogenic inflammation of bone, nos unspecified osteomyelitis unspecified osteomyelitis (disorder) unspecified osteomyelitis nos unspecified osteomyelitis nos (disorder) unspecified osteomyelitis of unspecified site unspecified osteomyelitis of unspecified site (disorder) unspecified osteomyelitis, site unspecified
DOID	DOID:1019
UMLS	C0029443
MeSH	D010019
SNOMED-CT	SNOMEDCT_US_2016_09_01:60168000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:101) C0002895 \| sickle cell disease \| 12 C0270629 \| epidural abscess \| 9 C0011847 \| diabetes \| 7 C0032285 \| pneumonia \| 6 C0003864 \| arthritis \| 6 C0003874 \| septic arthritis \| 4 C0025289 \| meningitis \| 4 C0010346 \| crohn's disease \| 4 C0029454 \| osteopetrosis \| 3 C0041296 \| tuberculosis \| 3 C1704275 \| pyomyositis \| 3 C0011849 \| diabetes mellitus \| 3 C0040053 \| thrombosis \| 3 C0023418 \| leukemia \| 3 C0024110 \| lung abscess \| 3 C0024299 \| lymphoma \| 3 C0238402 \| pycnodysostosis \| 2 C0238124 \| necrotizing fasciitis \| 2 C0023449 \| acute lymphoblastic leukemia \| 2 C0263859 \| sapho syndrome \| 2 C0029464 \| osteosclerosis \| 2 C0007137 \| squamous cell carcinoma \| 2 C0025229 \| melioidosis \| 2 C0028242 \| nocardiosis \| 2 C0034065 \| pulmonary embolism \| 2 C0442874 \| neuropathy \| 2 C0023448 \| lymphoblastic leukemia \| 2 C0031111 \| periostitis \| 2 C0007642 \| cellulitis \| 2 C0021355 \| otitis externa \| 2 C0017205 \| gaucher disease \| 1 C0004623 \| bacterial infection \| 1 C0040896 \| trichinellosis \| 1 C0038013 \| ankylosing spondylitis \| 1 C0001339 \| acute pancreatitis \| 1 C0034212 \| pyoderma \| 1 C0019196 \| hepatitis c \| 1 C0162871 \| abdominal aortic aneurysm \| 1 C0019621 \| langerhans cell histiocytosis \| 1 C0011881 \| diabetic nephropathy \| 1 C0085652 \| pyoderma gangrenosum \| 1 C0011127 \| pressure sores \| 1 C0376358 \| prostate cancer \| 1 C0027947 \| neutropenia \| 1 C0553580 \| ewing sarcoma \| 1 C0010414 \| cryptococcus neoformans \| 1 C0021053 \| immune disorder \| 1 C0008513 \| chorioretinitis \| 1 C0019360 \| herpes zoster \| 1 C0006309 \| brucellosis \| 1 C0272187 \| leukocyte adhesion deficiency \| 1 C0917715 \| hajdu-cheney syndrome \| 1 C0009324 \| ulcerative colitis \| 1 C0009447 \| common variable immunodeficiency \| 1 C0010674 \| cystic fibrosis \| 1 C0012813 \| diverticulitis \| 1 C0030305 \| pancreatitis \| 1 C0553730 \| calcium pyrophosphate dihydrate crystal deposition disease \| 1 C0040046 \| thrombophlebitis \| 1 C0014118 \| endocarditis \| 1 C0019618 \| histiocytosis \| 1 C0041318 \| tuberculous meningitis \| 1 C0019158 \| hepatitis \| 1 C0014236 \| endophthalmitis \| 1 C0678222 \| breast carcinoma \| 1 C0032285 \| pneumoniae \| 1 C1961099 \| t-cell acute lymphoblastic leukemia \| 1 C0024904 \| mastoiditis \| 1 C0030409 \| paracoccidioidomycosis \| 1 C0015029 \| ethmoid sinusitis \| 1 C0001175 \| acquired immunodeficiency syndrome \| 1 C0039503 \| tendinitis \| 1 C0016735 \| frontal sinusitis \| 1 C0019829 \| hodgkin's lymphoma \| 1 C0019360 \| zoster \| 1 C0024110 \| lung abscesses \| 1 C0001623 \| adrenal insufficiency \| 1 C0039103 \| synovitis \| 1 C0009186 \| coccidioidomycosis \| 1 C0079731 \| b-cell lymphoma \| 1 C0012624 \| spondylodiscitis \| 1 C0042373 \| vascular disease \| 1 C0079744 \| diffuse large b-cell lymphoma \| 1 C0022658 \| nephropathy \| 1 C0011854 \| type 1 diabetes \| 1 C0037199 \| sinusitis \| 1 C0020492 \| hyperostosis \| 1 C0026691 \| kawasaki disease \| 1 C1565489 \| renal insufficiency \| 1 C0039319 \| tarsal tunnel syndrome \| 1 C0024305 \| non-hodgkin's lymphoma \| 1 C0155862 \| pneumococcal pneumonia \| 1 C0007361 \| cat scratch disease \| 1 C0343525 \| lemierre syndrome \| 1 C0023448 \| lymphocytic leukemia \| 1 C1261473 \| sarcoma \| 1 C0018203 \| chronic granulomatous disease \| 1 C0024790 \| paroxysmal nocturnal hemoglobinuria \| 1 C0035021 \| recurrent fever \| 1 C0038012 \| spondylitis \| 1 C0014038 \| encephalitis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 581 \| BAX \| CIPHER 3552 \| IL1A \| CIPHER 3565 \| IL4 \| CIPHER 3569 \| IL6 \| CIPHER 4846 \| NOS3 \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:107) 65985 \| AACS \| 1.417 \| DISEASES 84890 \| ADO \| 1.418 \| DISEASES 249 \| ALPL \| 1.261 \| DISEASES 262 \| AMD1 \| 1.201 \| DISEASES 9179 \| AP4M1 \| 1.669 \| DISEASES 1822 \| ATN1 \| 2.012 \| DISEASES 23545 \| ATP6V0A2 \| 2.402 \| DISEASES 617 \| BCS1L \| 1.205 \| DISEASES 632 \| BGLAP \| 2.98 \| DISEASES 650 \| BMP2 \| 3.326 \| DISEASES 655 \| BMP7 \| 1.363 \| DISEASES 6046 \| BRD2 \| 1.713 \| DISEASES 720 \| C4A \| 1.443 \| DISEASES 721 \| C4B \| 1.387 \| DISEASES 796 \| CALCA \| 2.19 \| DISEASES 799 \| CALCR \| 1.357 \| DISEASES 64170 \| CARD9 \| 1.88 \| DISEASES 834 \| CASP1 \| 2.553 \| DISEASES 841 \| CASP8 \| 1.182 \| DISEASES 10575 \| CCT4 \| 1.703 \| DISEASES 959 \| CD40LG \| 2.665 \| DISEASES 1186 \| CLCN7 \| 3.032 \| DISEASES 9074 \| CLDN6 \| 1.42 \| DISEASES 2920 \| CXCL2 \| 1.103 \| DISEASES 1536 \| CYBB \| 1.94 \| DISEASES 192668 \| CYS1 \| 2.005 \| DISEASES 414325 \| DEFB103A \| 2.522 \| DISEASES 55894 \| DEFB103B \| 2.521 \| DISEASES 100289462 \| DEFB4B \| 1.974 \| DISEASES 151871 \| DPPA2 \| 1.674 \| DISEASES 2098 \| ESD \| 1.131 \| DISEASES 54751 \| FBLIM1 \| 1.931 \| DISEASES 23014 \| FBXO21 \| 2.833 \| DISEASES 389549 \| FEZF1 \| 1.088 \| DISEASES 8928 \| FOXH1 \| 1.312 \| DISEASES 2517 \| FUCA1 \| 1.298 \| DISEASES 2526 \| FUT4 \| 1.86 \| DISEASES 2591 \| GALNT3 \| 2.925 \| DISEASES 2731 \| GLDC \| 1.177 \| DISEASES 2239 \| GPC4 \| 1.606 \| DISEASES 51512 \| GTSE1 \| 1.751 \| DISEASES 9001 \| HAP1 \| 1.345 \| DISEASES 3043 \| HBB \| 2.108 \| DISEASES 81502 \| HM13 \| 1.311 \| DISEASES 3240 \| HP \| 2.019 \| DISEASES 3329 \| HSPD1 \| 1.603 \| DISEASES 338376 \| IFNE \| 1.606 \| DISEASES 3459 \| IFNGR1 \| 4.299 \| DISEASES 8517 \| IKBKG \| 2.193 \| DISEASES 3586 \| IL10 \| 1.754 \| DISEASES 3594 \| IL12RB1 \| 3.124 \| DISEASES 29949 \| IL19 \| 1.751 \| DISEASES 9636 \| ISG15 \| 1.448 \| DISEASES 102723508 \| KANTR \| 1.766 \| DISEASES 57614 \| KIAA1468 \| 2.971 \| DISEASES 64900 \| LPIN3 \| 1.931 \| DISEASES 8972 \| MGAM \| 2.272 \| DISEASES 4514 \| MT-CO3 \| 1.344 \| DISEASES 4615 \| MYD88 \| 1.282 \| DISEASES 4772 \| NFATC1 \| 1.49 \| DISEASES 27247 \| NFU1 \| 1.754 \| DISEASES 114548 \| NLRP3 \| 3.015 \| DISEASES 2649 \| NR6A1 \| 1.067 \| DISEASES 4914 \| NTRK1 \| 1.805 \| DISEASES 220323 \| OAF \| 1.794 \| DISEASES 5155 \| PDGFB \| 1.88 \| DISEASES 23556 \| PIGN \| 1.083 \| DISEASES 5453 \| POU3F1 \| 1.262 \| DISEASES 5530 \| PPP3CA \| 3.469 \| DISEASES 9051 \| PSTPIP1 \| 2.748 \| DISEASES 9050 \| PSTPIP2 \| 5.248 \| DISEASES 5745 \| PTH1R \| 1.805 \| DISEASES 5789 \| PTPRD \| 1.86 \| DISEASES 80324 \| PUS1 \| 1.697 \| DISEASES 5923 \| RASGRF1 \| 1.263 \| DISEASES 11317 \| RBPJL \| 2.419 \| DISEASES 51109 \| RDH11 \| 2.573 \| DISEASES 6164 \| RPL34 \| 2.633 \| DISEASES 860 \| RUNX2 \| 2.423 \| DISEASES 6280 \| S100A9 \| 1.009 \| DISEASES 286205 \| SCAI \| 1.094 \| DISEASES 619383 \| SCARNA9 \| 3.144 \| DISEASES 871 \| SERPINH1 \| 1.63 \| DISEASES 29072 \| SETD2 \| 1.847 \| DISEASES 6452 \| SH3BP2 \| 2.07 \| DISEASES 9467 \| SH3BP5 \| 2.151 \| DISEASES 23583 \| SMUG1 \| 4.685 \| DISEASES 26769 \| SNORD81 \| 4.191 \| DISEASES 29887 \| SNX10 \| 1.734 \| DISEASES 51429 \| SNX9 \| 1.444 \| DISEASES 6696 \| SPP1 \| 2.212 \| DISEASES 6708 \| SPTA1 \| 1.234 \| DISEASES 6772 \| STAT1 \| 2.169 \| DISEASES 6789 \| STK4 \| 1.492 \| DISEASES 25870 \| SUMF2 \| 3.519 \| DISEASES 7018 \| TF \| 1.037 \| DISEASES 284486 \| THEM5 \| 1.111 \| DISEASES 51337 \| THEM6 \| 1.279 \| DISEASES 7099 \| TLR4 \| 1.22 \| DISEASES 7124 \| TNF \| 3.34 \| DISEASES 8792 \| TNFRSF11A \| 2.231 \| DISEASES 7133 \| TNFRSF1B \| 2.255 \| DISEASES 7156 \| TOP3A \| 1.519 \| DISEASES 11169 \| WDHD1 \| 1.357 \| DISEASES 644150 \| WIPF3 \| 2.045 \| DISEASES 340152 \| ZC3H12D \| 1.802 \| DISEASES 90576 \| ZNF799 \| 3.26 \| DISEASES
Locus	(Waiting for update.)

Disease ID	948
Disease	osteomyelitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:76) HP:0100806 \| Sepsis \| 7 HP:0001369 \| Arthritis \| 7 HP:0002090 \| Pneumonia \| 6 HP:0003095 \| Septic arthritis \| 5 HP:0012531 \| Pain \| 4 HP:0100280 \| Morbus Crohn \| 4 HP:0001287 \| Meningitis \| 4 HP:0002664 \| Neoplasia \| 4 HP:0001945 \| Fever \| 3 HP:0002665 \| Lymphoma \| 3 HP:0002756 \| Pathologic fracture \| 3 HP:0000819 \| Diabetes mellitus \| 3 HP:0002625 \| Blood clot in a deep vein \| 3 HP:0001909 \| Leukemia \| 3 HP:0002719 \| infections, recurrent \| 2 HP:0004936 \| Blood clot in vein \| 2 HP:0030731 \| Carcinoma \| 2 HP:0002860 \| Squamous cell carcinoma \| 2 HP:0010885 \| Aseptic necrosis \| 2 HP:0040165 \| Periostitis \| 2 HP:0000969 \| Dropsy \| 2 HP:0011001 \| Increased bone mineral density \| 2 HP:0002721 \| Immunodeficiency \| 2 HP:0011002 \| Osteopetrosis \| 2 HP:0100774 \| Hyperostosis \| 2 HP:0006721 \| Acute lymphocytic leukemia \| 2 HP:0003419 \| Low back pain \| 1 HP:0005203 \| Spontaneous esophageal rupture \| 1 HP:0006532 \| Pneumonia, recurrent episodes \| 1 HP:0012424 \| Chorioretinitis \| 1 HP:0100727 \| Histiocytosis \| 1 HP:0000246 \| Sinus inflammation \| 1 HP:0000112 \| Nephropathy \| 1 HP:0000689 \| Misalignment of upper and lower dental arches \| 1 HP:0012190 \| T cell lymphoma \| 1 HP:0030314 \| Periostosis \| 1 HP:0004953 \| Abdominal aortic aneurysm \| 1 HP:0002653 \| Bone pain \| 1 HP:0030049 \| Brain abscess \| 1 HP:0002341 \| Cervical cord compression \| 1 HP:0012115 \| Liver inflammation \| 1 HP:0003418 \| Back pain \| 1 HP:0002383 \| Encephalitis \| 1 HP:0001733 \| Pancreatic inflammation \| 1 HP:0012189 \| Hodgkin disease \| 1 HP:0002754 \| Bone infection \| 1 HP:0012254 \| Ewing's sarcoma \| 1 HP:0000265 \| Mastoiditis \| 1 HP:0004418 \| Thrombophlebitis \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0003401 \| Paresthesia \| 1 HP:0012125 \| Prostate cancer \| 1 HP:0002797 \| Increased bone resorption \| 1 HP:0100539 \| Periorbital swelling \| 1 HP:0030757 \| Dental abscess \| 1 HP:0002617 \| Aneurysmal dilatation \| 1 HP:0100769 \| Synovitis \| 1 HP:0000999 \| Pyoderma \| 1 HP:0012191 \| B-cell lymphoma \| 1 HP:0200042 \| Skin ulcer \| 1 HP:0100242 \| Sarcoma \| 1 HP:0100584 \| Endocarditis \| 1 HP:0012399 \| Bedsore \| 1 HP:0002204 \| Pulmonary embolism \| 1 HP:0000083 \| Renal insufficiency \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0002015 \| Swallowing difficulty \| 1 HP:0000846 \| Hypoadrenalism \| 1 HP:0100658 \| Bacterial infection of skin \| 1 HP:0001875 \| Neutropenia \| 1 HP:0100246 \| Osteoma \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0004818 \| Paroxysmal nocturnal hemoglobinuria \| 1 HP:0100749 \| Thoracic pain \| 1 HP:0100279 \| Ulcerative colitis \| 1 HP:0040187 \| Neonatal sepsis \| 1

Disease ID	948
Disease	osteomyelitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:40) C2707258 \| infections C2598155 \| pain C2364133 \| infection C2240374 \| eosinophilia C2074875 \| sequestrum C1998328 \| abscess of medulla oblongata C1963077 \| bone pain C1704275 \| pyomyositis C1550639 \| fistula C1546533 \| abscess C1510420 \| cavities C1456822 \| lameness C0948162 \| bone marrow oedema C0744945 \| hip prosthesis infection C0600327 \| toxic shock syndrome C0581883 \| deafness C0426768 \| o sign C0406683 \| bullosis diabeticorum C0340708 \| deep vein thrombosis C0275901 \| nasal tuberculosis C0272412 \| splenic abscess C0238790 \| bone destruction C0221014 \| secondary amyloidosis C0152964 \| streptococcal septicaemia C0149871 \| deep venous thrombosis C0085652 \| pyoderma gangrenosum C0078048 \| varicella C0040485 \| torticollis C0038160 \| staphylococcal infection C0036420 \| localized scleroderma C0032541 \| polyneuritis C0032308 \| staphylococcal pneumonia C0027726 \| nephrotic syndrome C0023223 \| leg ulcer C0018923 \| angiosarcoma C0017661 \| iga nephropathy C0012624 \| spondylodiscitis C0010356 \| cross infections C0007361 \| cat-scratch disease C0006105 \| brain abscess
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:16) C0000833 \| abscess \| 34 C0009450 \| infection \| 30 C0021311 \| infections \| 17 C0030193 \| pain \| 4 C1704275 \| pyomyositis \| 3 C0016169 \| fistula \| 3 C0426768 \| o sign \| 3 C0149871 \| deep venous thrombosis \| 2 C0238790 \| bone destruction \| 2 C0333311 \| sequestrum \| 2 C0311395 \| lameness \| 2 C0006105 \| brain abscess \| 1 C0012624 \| spondylodiscitis \| 1 C0151825 \| bone pain \| 1 C0042487 \| deep vein thrombosis \| 1 C0085652 \| pyoderma gangrenosum \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:4)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs4986790	16487238	7097	TLR2	umls:C0029443	BeFree	Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacterial infections, we therefore studied these polymorphisms in osteomyelitis patients.	0.000814326	2006	TLR4	9	117713024	A	G
rs4986790	16487238	7099	TLR4	umls:C0029443	BeFree	The Toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis.	0.000271442	2006	TLR4	9	117713024	A	G
rs4986791	16487238	7097	TLR2	umls:C0029443	BeFree	Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacterial infections, we therefore studied these polymorphisms in osteomyelitis patients.	0.000814326	2006	TLR4	9	117713324	C	T
rs5743708	16487238	7097	TLR2	umls:C0029443	BeFree	Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacterial infections, we therefore studied these polymorphisms in osteomyelitis patients.	0.000814326	2006	TLR2	4	153705165	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	948
Disease	osteomyelitis
Case	(Waiting for update.)

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