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	oligodendroglioma

Disease ID	663
Disease	oligodendroglioma
Definition	A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
Synonym	oligodendrogliomas
Orphanet	ORPHANET:251627
DOID	DOID:3181
UMLS	C0028945
MeSH	D009837
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:14) C0017636 \| glioblastoma \| 13 C0017636 \| glioblastomas \| 4 C0206716 \| ganglioglioma \| 3 C0334583 \| pilocytic astrocytoma \| 2 C0004114 \| astrocytoma \| 2 C0004114 \| astrocytomas \| 2 C0555198 \| malignant glioma \| 1 C0280793 \| oligoastrocytoma \| 1 C0555198 \| malignant gliomas \| 1 C0011649 \| mature cystic teratoma \| 1 C1368903 \| cystic teratoma \| 1 C0206719 \| central neurocytoma \| 1 C0007102 \| colon cancer \| 1 C0030312 \| pancytopenia \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:10) 3417 \| IDH1 \| CTD_human 5728 \| PTEN \| UNIPROT 3418 \| IDH2 \| CTD_human;ORPHANET 25913 \| POT1 \| ORPHANET 57212 \| TP73-AS1 \| CTD_human 2668 \| GDNF \| CTD_human 1755 \| DMBT1 \| UNIPROT 1840 \| DTX1 \| CTD_human 23462 \| HEY1 \| CTD_human 3280 \| HES1 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:8) 1029 \| CDKN2A \| CIPHER 3418 \| IDH2 \| CTD_human 3417 \| IDH1 \| CTD_human 57212 \| TP73-AS1 \| CTD_human 1840 \| DTX1 \| CTD_human 2668 \| GDNF \| CTD_human 23462 \| HEY1 \| CTD_human 3280 \| HES1 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:134) 20 \| ABCA2 \| 1.435 \| DISEASES 199 \| AIF1 \| 1.994 \| DISEASES 55966 \| AJAP1 \| 2.638 \| DISEASES 54840 \| APTX \| 1.743 \| DISEASES 9048 \| ARTN \| 3.517 \| DISEASES 430 \| ASCL2 \| 1.268 \| DISEASES 121549 \| ASCL4 \| 2.614 \| DISEASES 647219 \| ASCL5 \| 3.135 \| DISEASES 10396 \| ATP8A1 \| 2.181 \| DISEASES 546 \| ATRX \| 4.165 \| DISEASES 63827 \| BCAN \| 1.246 \| DISEASES 55859 \| BEX1 \| 1.674 \| DISEASES 84707 \| BEX2 \| 1.674 \| DISEASES 768 \| CA9 \| 1.139 \| DISEASES 55799 \| CACNA2D3 \| 1.894 \| DISEASES 815 \| CAMK2A \| 1.385 \| DISEASES 816 \| CAMK2B \| 2.131 \| DISEASES 137196 \| CCDC26 \| 3.185 \| DISEASES 917 \| CD3G \| 1.107 \| DISEASES 1029 \| CDKN2A \| 3.11 \| DISEASES 3075 \| CFH \| 4.113 \| DISEASES 163732 \| CITED4 \| 2.332 \| DISEASES 25932 \| CLIC4 \| 1.269 \| DISEASES 23019 \| CNOT1 \| 1.902 \| DISEASES 1267 \| CNP \| 2.721 \| DISEASES 1351 \| COX8A \| 2.569 \| DISEASES 1454 \| CSNK1E \| 1.338 \| DISEASES 1677 \| DFFB \| 1.404 \| DISEASES 1729 \| DIAPH1 \| 1.2 \| DISEASES 1730 \| DIAPH2 \| 1.429 \| DISEASES 9077 \| DIRAS3 \| 1.109 \| DISEASES 1809 \| DPYSL3 \| 1.15 \| DISEASES 30845 \| EHD3 \| 1.741 \| DISEASES 2068 \| ERCC2 \| 1.562 \| DISEASES 389549 \| FEZF1 \| 1.078 \| DISEASES 752 \| FMNL1 \| 1.634 \| DISEASES 22862 \| FNDC3A \| 1.152 \| DISEASES 8880 \| FUBP1 \| 5.162 \| DISEASES 85476 \| GFM1 \| 1.019 \| DISEASES 2673 \| GFPT1 \| 1.201 \| DISEASES 29998 \| GLTSCR1 \| 2.613 \| DISEASES 2778 \| GNAS \| 1.496 \| DISEASES 392862 \| GRID2IP \| 2.356 \| DISEASES 3020 \| H3F3A \| 3.345 \| DISEASES 3039 \| HBA1 \| 1.154 \| DISEASES 8350 \| HIST1H3A \| 1.552 \| DISEASES 8352 \| HIST1H3C \| 1.339 \| DISEASES 8351 \| HIST1H3D \| 1.552 \| DISEASES 8353 \| HIST1H3E \| 1.344 \| DISEASES 8968 \| HIST1H3F \| 1.552 \| DISEASES 8355 \| HIST1H3G \| 1.552 \| DISEASES 8357 \| HIST1H3H \| 1.552 \| DISEASES 8354 \| HIST1H3I \| 1.552 \| DISEASES 8356 \| HIST1H3J \| 1.342 \| DISEASES 3231 \| HOXD1 \| 2.011 \| DISEASES 3400 \| ID4 \| 2.556 \| DISEASES 3418 \| IDH2 \| 4.868 \| DISEASES 11009 \| IL24 \| 1.09 \| DISEASES 9118 \| INA \| 2.724 \| DISEASES 79191 \| IRX3 \| 1.254 \| DISEASES 57670 \| KIAA1549 \| 3.974 \| DISEASES 377007 \| KLHL30 \| 3.599 \| DISEASES 8022 \| LHX3 \| 1.024 \| DISEASES 4004 \| LMO1 \| 1.2 \| DISEASES 9860 \| LRIG2 \| 3.199 \| DISEASES 121227 \| LRIG3 \| 1.841 \| DISEASES 55534 \| MAML3 \| 1.989 \| DISEASES 4133 \| MAP2 \| 2.509 \| DISEASES 4134 \| MAP4 \| 1.289 \| DISEASES 4155 \| MBP \| 2.479 \| DISEASES 4193 \| MDM2 \| 2.185 \| DISEASES 4194 \| MDM4 \| 1.399 \| DISEASES 27030 \| MLH3 \| 1.029 \| DISEASES 4336 \| MOBP \| 1.685 \| DISEASES 4337 \| MOCS1 \| 1.951 \| DISEASES 10608 \| MXD4 \| 3.306 \| DISEASES 23040 \| MYT1L \| 1.809 \| DISEASES 10763 \| NES \| 2.128 \| DISEASES 4763 \| NF1 \| 1.53 \| DISEASES 4821 \| NKX2-2 \| 2.711 \| DISEASES 388677 \| NOTCH2NL \| 1.735 \| DISEASES 4857 \| NOVA1 \| 1.589 \| DISEASES 4862 \| NPAS2 \| 1.097 \| DISEASES 4916 \| NTRK3 \| 1.082 \| DISEASES 116448 \| OLIG1 \| 3.202 \| DISEASES 10215 \| OLIG2 \| 5.134 \| DISEASES 4983 \| OPHN1 \| 1.367 \| DISEASES 64098 \| PARVG \| 2.581 \| DISEASES 57326 \| PBXIP1 \| 2.294 \| DISEASES 9141 \| PDCD5 \| 1.123 \| DISEASES 5154 \| PDGFA \| 1.692 \| DISEASES 5155 \| PDGFB \| 2.575 \| DISEASES 5178 \| PEG3 \| 1.059 \| DISEASES 23187 \| PHLDB1 \| 1.777 \| DISEASES 8605 \| PLA2G4C \| 2.365 \| DISEASES 5329 \| PLAUR \| 1.116 \| DISEASES 58473 \| PLEKHB1 \| 1.657 \| DISEASES 11284 \| PNKP \| 1.532 \| DISEASES 5422 \| POLA1 \| 2.295 \| DISEASES 5424 \| POLD1 \| 1.139 \| DISEASES 5451 \| POU2F1 \| 1.336 \| DISEASES 57580 \| PREX1 \| 1.49 \| DISEASES 8842 \| PROM1 \| 1.295 \| DISEASES 5728 \| PTEN \| 3.212 \| DISEASES 5787 \| PTPRB \| 1.32 \| DISEASES 5803 \| PTPRZ1 \| 1.978 \| DISEASES 9444 \| QKI \| 1.413 \| DISEASES 146713 \| RBFOX3 \| 3.068 \| DISEASES 23186 \| RCOR1 \| 1.409 \| DISEASES 9699 \| RIMS2 \| 2.058 \| DISEASES 8153 \| RND2 \| 2.215 \| DISEASES 6135 \| RPL11 \| 1.146 \| DISEASES 6141 \| RPL18 \| 1.133 \| DISEASES 57142 \| RTN4 \| 1.69 \| DISEASES 6280 \| S100A9 \| 1.042 \| DISEASES 6565 \| SLC15A2 \| 1.647 \| DISEASES 9353 \| SLIT2 \| 1.651 \| DISEASES 6586 \| SLIT3 \| 1.564 \| DISEASES 84631 \| SLITRK2 \| 2.661 \| DISEASES 139065 \| SLITRK4 \| 2.669 \| DISEASES 26050 \| SLITRK5 \| 2.177 \| DISEASES 84189 \| SLITRK6 \| 2.212 \| DISEASES 6663 \| SOX10 \| 1.597 \| DISEASES 55553 \| SOX6 \| 1.109 \| DISEASES 79582 \| SPAG16 \| 1.83 \| DISEASES 10252 \| SPRY1 \| 1.686 \| DISEASES 55959 \| SULF2 \| 1.043 \| DISEASES 6938 \| TCF12 \| 2.034 \| DISEASES 284486 \| THEM5 \| 1.1 \| DISEASES 8848 \| TSC22D1 \| 2.454 \| DISEASES 7317 \| UBA1 \| 1.108 \| DISEASES 7316 \| UBC \| 1.398 \| DISEASES 7422 \| VEGFA \| 1.268 \| DISEASES 84619 \| ZGPAT \| 2.503 \| DISEASES
Locus	Symbol \| Locus(Total Locus:2) IDH2 \| 15q26.1 POT1 \| 7q31.33

Disease ID	663
Disease	oligodendroglioma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:8) HP:0100843 \| Glioblastoma \| 14 HP:0002664 \| Neoplasia \| 9 HP:0009592 \| Astrocytoma \| 2 HP:0030692 \| Brain tumor \| 2 HP:0009733 \| Glioma \| 2 HP:0001250 \| Seizures \| 1 HP:0001876 \| Low blood cell count \| 1 HP:0003003 \| Colon cancer \| 1

Disease ID	663
Disease	oligodendroglioma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:3) C1608408 \| malignant transformation C1417325 \| multiple sclerosis C0036572 \| seizures
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:13)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs1042522	18393224	7157	TP53	umls:C0028945	BeFree	Aiming to study the role of TP53 Pro47Ser and Arg72Pro on glioma susceptibility and oncologic prognosis of patients, we investigated the genotype distribution of these SNPs in 94 gliomas (81 astrocytomas, 8 ependymomas and 5 oligodendrogliomas) and in 100 healthy subjects by the polymerase chain reaction-restriction fragment length polymorphism approach.	0.020878618	2008	TP53	17	7676154	G	T,C
rs11133391	24135790	9575	CLOCK	umls:C0028945	BeFree	The variant allele for CLOCK rs11133391 under a recessive model increased risk of oligodendroglioma (OR 2.41; 95 % CI 1.31-4.42; p = 0.005), though not other glioma subtypes (p for heterogeneity = 0.0033).	0.000271442	2013	CLOCK	4	55501788	T	C
rs11540654	18393224	7157	TP53	umls:C0028945	BeFree	Aiming to study the role of TP53 Pro47Ser and Arg72Pro on glioma susceptibility and oncologic prognosis of patients, we investigated the genotype distribution of these SNPs in 94 gliomas (81 astrocytomas, 8 ependymomas and 5 oligodendrogliomas) and in 100 healthy subjects by the polymerase chain reaction-restriction fragment length polymorphism approach.	0.020878618	2008	TP53	17	7676040	C	T,G,A
rs118101777	25277207	3418	IDH2	umls:C0028945	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.245895776	2015	IDH2	15	90087472	C	T
rs118101777	25277207	3417	IDH1	umls:C0028945	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.138783028	2015	IDH2	15	90087472	C	T
rs121913500	23934175	3417	IDH1	umls:C0028945	BeFree	We evaluated nuclear cMYC protein levels and IDH1 (R132H) by immunohistochemistry in patients with oligodendroglioma/oligoastrocytomas (n = 20), astrocytomas (grade II) (n = 19), anaplastic astrocytomas (n = 21) or glioblastomas (n = 111).	0.138783028	2013	IDH1	2	208248388	C	T
rs121913500	25277207	3417	IDH1	umls:C0028945	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.138783028	2015	IDH1	2	208248388	C	T
rs121913500	25277207	3418	IDH2	umls:C0028945	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.245895776	2015	IDH1	2	208248388	C	T
rs121913500	22385787	3417	IDH1	umls:C0028945	BeFree	The mutation analysis performed on the latter case with DNA separately sampled from the oligodendroglioma- like area and the astrocytoma-like area detected IDH1 G395A in both areas.	0.138783028	2012	IDH1	2	208248388	C	T
rs121913500	23527265	3417	IDH1	umls:C0028945	BeFree	This glioma xenograft is the first to display a pure oligodendroglioma histology and expression of R132H.	0.138783028	2013	IDH1	2	208248388	C	T
rs121913503	25277207	3418	IDH2	umls:C0028945	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.245895776	2015	IDH2	15	90088606	C	T
rs121913503	25277207	3417	IDH1	umls:C0028945	BeFree	The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).	0.138783028	2015	IDH2	15	90088606	C	T
rs1800371	18393224	7157	TP53	umls:C0028945	BeFree	Aiming to study the role of TP53 Pro47Ser and Arg72Pro on glioma susceptibility and oncologic prognosis of patients, we investigated the genotype distribution of these SNPs in 94 gliomas (81 astrocytomas, 8 ependymomas and 5 oligodendrogliomas) and in 100 healthy subjects by the polymerase chain reaction-restriction fragment length polymorphism approach.	0.020878618	2008	TP53	17	7676230	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	663
Disease	oligodendroglioma
Case	(Waiting for update.)

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